PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ZBTB2 CREBBP 16051665 hprd,biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB2 FOXJ3 25609649 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RELA ZBTB2 25609694 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB2 ZBTB1 24657165 biogrid exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP GP GP GP GP GP G CDK2AP1 ZBTB2 26496610 biogrid,intact exp GP GP G G GP GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB2 WDR48 19615732 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G ELAVL1 ZBTB2 19322201 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G RBBP7 ZBTB2 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB2 MBD3L1 26186194 biogrid exp GP HDAC1 ZBTB2 26496610,23752268 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G ZBTB2 ZNF219 26186194 biogrid exp GP GP G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G P4HB ZBTB2 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G ELP6 ZBTB2 26186194 biogrid exp G GP G G GP GP G GP GP G GP GP GP G G G GP G GP G GP G G GP G G GP GP G NOTCH1 ZBTB2 23022380 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB2 RASSF8 26186194 biogrid exp GP GP G P GP G GP GP G GP P G P G GP GP G P G GP GP P GP GP P GP GP G SP1 ZBTB2 25609694 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB2 ZBTB2 25609694 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TP53 ZBTB2 19380588 biogrid exp G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G SUMO2 ZBTB2 19394292 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G STAT6 ZBTB2 20211142 biogrid exp GP GP G G GP GP G G GP G GP G GP GP G GP GP GP G G GP GP GP G GP GP GP GP G C9orf41 ZBTB2 26186194 biogrid exp GP GP G G GP GP GP GP GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP POU5F1 ZBTB2 ortho P P P P P P P P P P P P P P P P P P P P P P ZBTB2 SALL4 ortho P P G P GP ZBTB2 NANOG ortho P P G P G P G P GP ZBTB2 NACC1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP G GP GP GP GP G SOCS3 ZBTB2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP GP GP G GP GP G ZBTB2 BTBD7 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8N680 P46531 affinity chromatography technology 23022380 physical association X 2 Q8N680 A0A024R3Z2 affinity chromatography technology 24654937 physical association X 2 Q8N680 P61956-2 affinity chromatography technology 25027693 physical association X 2 Q8N680 P61956-2 affinity chromatography technology 19394292 physical association X 2 Q8N680 P61956-2 affinity chromatography technology 21693764 physical association X 2 Q8N680 P61956-2 affinity chromatography technology 19471022 physical association X 2 P0CG48 Q8N680 affinity chromatography technology 21139048 physical association X 2 Q8N680 Q13547 affinity chromatography technology 23752268 physical association X 2 Q8N680 Q9Y2K1-2 affinity chromatography technology 24657165 physical association X 2 Q8N680 Q8TAF3 affinity chromatography technology 19615732 physical association X 2 Q8N680 B4DQB3 two hybrid 20211142 direct interaction X 2 Q8N680 P04637-7 affinity chromatography technology 19380588 physical association X 2 Q8N680 P04637-7 pull down 19380588 direct interaction X 2 Q8N680 affinity chromatography technology 16051665 physical association X 2 Q8N680 in vivo 16051665 - X 2 Q8N680 in vivo 16051665 - X 2 Q8N680 anti tag coimmunoprecipitation 23752268 association C 91 Q8N680 anti tag coimmunoprecipitation 19615732 physical association C 59

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B ZBTB2 CREBBP MI:0004(affinity chromatography technology)|MI:0493(in vivo) 16051665 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_148569|HPRD_26666 prey|- bait|- SUMO2 ZBTB2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19394292,19471022,21693764 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_131020|BIOGRID_183515|BIOGRID_165952 bait|bait|bait prey|prey|prey ELAVL1 ZBTB2 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_186627 bait prey UBC ZBTB2 MI:0004(affinity chromatography technology) 21139048 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_170826 bait prey ZBTB2 ZBTB1 MI:0415(enzymatic study) 24657165 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_310264 prey bait STAT6 ZBTB2 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128683 bait prey NRF1 ZBTB2 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_296703 bait prey NOTCH1 ZBTB2 MI:0004(affinity chromatography technology) 23022380 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_246734 bait prey ZBTB2 WDR48 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120610|UniProt_100725 prey|prey bait|bait p53 ZBTB2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19380588 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_131040|BIOGRID_131039 prey|prey bait|bait HDAC1 ZBTB2 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 23752268 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_131412|BIOGRID_280560 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality CDK2AP1 ZBTB2 26496610,26496610 0007,0004 HT P4HB ZBTB2 26186194 0004 HT ELP6 ZBTB2 26186194 0004 HT HDAC1 ZBTB2 26496610,23752268,23752268,26496610 0007,0007,0004,0004 HT,LC RBBP7 ZBTB2 26186194 0004 HT CARNMT1 ZBTB2 26186194 0004 HT ZBTB2 RASSF8 26186194 0004 HT ZBTB2 WDR48 19615732,19615732 0004,0007 HT ZBTB2 MBD3L1 26186194 0004 HT ZBTB2 ZNF219 26186194 0004 HT ZBTB2 FOXJ3 25609649,25609649 0676,0004 HT CDK2AP1 ZBTB2 26496610,26496610 0007,0004 HT P4HB ZBTB2 26186194 0004 HT ELP6 ZBTB2 26186194 0004 HT HDAC1 ZBTB2 26496610,26496610 0007,0004 HT RBBP7 ZBTB2 26186194 0004 HT CARNMT1 ZBTB2 26186194 0004 HT ZBTB2 RASSF8 26186194 0004 HT ZBTB2 WDR48 19615732,19615732 0004,0007 HT ZBTB2 MBD3L1 26186194 0004 HT ZBTB2 ZNF219 26186194 0004 HT ZBTB2 FOXJ3 25609649,25609649 0676,0004 HT HDAC1 ZBTB2 23752268,23752268 0007,0004 LC STAT6 ZBTB2 20211142 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8N680 P61956 ZBTB2 SUMO2 0.309 19394292 Q8N680 Q0PNE2 ZBTB2 ELP6 0.126 26186194 Q8N680 Q8N4J0 ZBTB2 C9ORF41 0.126 26186194 Q9Y2K1 Q8N680 ZBTB1 ZBTB2 0.126 24657165 Q8N680 Q7L190 ZBTB2 DPPA4 0.126 26687479 Q8N680 P07237 ZBTB2 P4HB 0.126 26186194 Q8N680 Q8K4B0 ZBTB2 MTA1 0.236 26496610 Q9NRD5 Q8N680 PICK1 ZBTB2 0.236 unassigned1304 Q8N680 Q8N680 ZBTB2 ZBTB2 0.286 unassigned1304 Q8N680 P04637 ZBTB2 TP53 0.454 19380588 Q9UER7 Q8N680 DAXX ZBTB2 0.236 unassigned1304 Q8N680 P00540 ZBTB2 MOS 0.236 unassigned1304 Q9UHH9 Q8N680 IP6K2 ZBTB2 0.236 unassigned1304 Q9UID6 Q8N680 ZNF639 ZBTB2 0.236 unassigned1304 Q9UL63 Q8N680 MKLN1 ZBTB2 0.236 unassigned1304 Q9UPW0 Q8N680 FOXJ3 ZBTB2 0.236 25609649 Q9Y3B7 Q8N680 MRPL11 ZBTB2 0.236 unassigned1304 Q8TAF3 Q8N680 WDR48 ZBTB2 0.236 19615732 Q92993 Q8N680 KAT5 ZBTB2 0.236 unassigned1304 Q8TBB1 Q8N680 LNX1 ZBTB2 0.236 unassigned1304 Q969G2 Q8N680 LHX4 ZBTB2 0.236 unassigned1304 Q96A09 Q8N680 FAM46B ZBTB2 0.236 unassigned1304 Q96E35 Q8N680 ZMYND19 ZBTB2 0.236 unassigned1304 Q99592 Q8N680 ZBTB18 ZBTB2 0.236 unassigned1304 Q8N680 Q13526 ZBTB2 PIN1 0.236 unassigned1304 Q8N680 A4D127 ZBTB2 MEOX2 {ECO:0000313|EMBL:EAL24289.1} 0.236 unassigned1304 Q8N680 G2XKQ0 ZBTB2 G2XKQ0 0.236 unassigned1304 Q8N680 P24278 ZBTB2 ZBTB25 0.236 unassigned1304 Q8N680 B0QYN7 ZBTB2 UBE2I {ECO:0000313|ENSEMBL:ENSP00000384361} 0.236 unassigned1304 Q8N680 O43463 ZBTB2 SUV39H1 0.236 unassigned1304 Q8N680 Q6ZSB9 ZBTB2 ZBTB49 0.236 unassigned1304 Q8N680 O14519 ZBTB2 CDK2AP1 0.236 26496610 Q8N680 Q7Z403 ZBTB2 TMC6 0.236 unassigned1304 Q8N680 P60520 ZBTB2 GABARAPL2 0.236 unassigned1304 Q8N680 P63165 ZBTB2 SUMO1 0.236 unassigned1304 Q8N680 P08047 ZBTB2 SP1 0.787 25609694 Q8NHQ8 Q8N680 RASSF8 ZBTB2 0.332 unassigned1304,26186194 Q8N680 Q13547 ZBTB2 HDAC1 0.416 26496610,23752268 Q8WWY6 Q8N680 MBD3L1 ZBTB2 0.126 26186194 Q92793 Q8N680 CREBBP ZBTB2 0.126 16051665 Q9P2Y4 Q8N680 ZNF219 ZBTB2 0.126 26186194 Q8N680 P46531 ZBTB2 NOTCH1 0.126 23022380 Q8N680 P42226 ZBTB2 STAT6 0.183 20211142 Q8N680 Q01860 ZBTB2 POU5F1 0.126 26687479 Q8N680 Q15717 ZBTB2 ELAVL1 0.126 19322201 Q8N680 Q16576 ZBTB2 RBBP7 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 CDK2AP1 ZBTB2 MI:0045 experimental interaction detection MI:0461 interaction database CBFA2T2 ZBTB2 MI:0362 inference MI:0461 interaction database CBFA2T3 ZBTB2 MI:0362 inference MI:0461 interaction database TP53 ZBTB2 MI:0045 experimental interaction detection MI:0461 interaction database ENO1 ZBTB2 MI:0362 inference MI:0461 interaction database P4HB ZBTB2 MI:0045 experimental interaction detection MI:0461 interaction database SP1 ZBTB2 MI:0045 experimental interaction detection MI:0461 interaction database UBC ZBTB2 MI:0045 experimental interaction detection MI:0461 interaction database STAT3 ZBTB2 MI:0362 inference MI:0461 interaction database STAT6 ZBTB2 MI:0045 experimental interaction detection MI:0461 interaction database NOTCH1 ZBTB2 MI:0045 experimental interaction detection MI:0461 interaction database EPPK1 ZBTB2 MI:0362 inference MI:0461 interaction database MAX ZBTB2 MI:0362 inference MI:0461 interaction database SUMO2 ZBTB2 MI:0045 experimental interaction detection MI:0461 interaction database SUMO1 ZBTB2 MI:0045 experimental interaction detection MI:0461 interaction database PRKDC ZBTB2 MI:0362 inference MI:0461 interaction database POU5F1 ZBTB2 MI:0045 experimental interaction detection MI:0461 interaction database RELA ZBTB2 MI:0045 experimental interaction detection MI:0461 interaction database POU5F1B ZBTB2 MI:0362 inference MI:0461 interaction database ELP6 ZBTB2 MI:0045 experimental interaction detection MI:0461 interaction database MTA1 ZBTB2 MI:0362 inference MI:0461 interaction database TARBP1 ZBTB2 MI:0362 inference MI:0461 interaction database HDAC1 ZBTB2 MI:0045 experimental interaction detection MI:0461 interaction database ELAVL1 ZBTB2 MI:0045 experimental interaction detection MI:0461 interaction database RBBP7 ZBTB2 MI:0045 experimental interaction detection MI:0461 interaction database KNOP1 ZBTB2 MI:0362 inference MI:0461 interaction database CCDC88A ZBTB2 MI:0362 inference MI:0461 interaction database DPPA4 ZBTB2 MI:0045 experimental interaction detection MI:0461 interaction database CCAR2 ZBTB2 MI:0362 inference MI:0461 interaction database CARNMT1 ZBTB2 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB2 RASSF8 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB2 WDR48 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB2 MBD3L1 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB2 CREBBP MI:0045 experimental interaction detection MI:0461 interaction database ZBTB2 RNF2 MI:0362 inference MI:0461 interaction database ZBTB2 SORBS1 MI:0362 inference MI:0461 interaction database ZBTB2 SALL3 MI:0362 inference MI:0461 interaction database ZBTB2 PRDM14 MI:0362 inference MI:0461 interaction database ZBTB2 NANOG MI:0362 inference MI:0461 interaction database ZBTB2 SALL1 MI:0362 inference MI:0461 interaction database ZBTB2 ANKFY1 MI:0362 inference MI:0461 interaction database ZBTB2 ZNF219 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB2 ZNF639 MI:0362 inference MI:0461 interaction database ZBTB2 SALL4 MI:0362 inference MI:0461 interaction database ZBTB2 MAGED2 MI:0362 inference MI:0461 interaction database ZBTB2 FOXJ3 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB2 ZBTB1 MI:0045 experimental interaction detection MI:0461 interaction database