PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus UBA7 FOXP4 25609649 intact exp P P P P P P P P P P P P P P P P P UBA7 FOXK1 25609649 intact exp P P P P P P P P P P P P P P P P P P UBA7 UBE2L3 19250909 biogrid exp P P P P P P P P P P P UBA7 FBXO15 23465077 biogrid exp UBA7 FOXA1 25609649 intact exp P P P P P UBA7 UBA7 23606334 intact exp P P P P P P P P P P P P P P P P P P ABCB1 UBA7 23465077 biogrid exp P P P P P P P UBA7 SHFM1 24811749 biogrid,intact exp FAS UBA7 8940097 hprd,bci exp P P P P P P P P P P P P P P P ISG15 UBA7 16169070,17597759,16189514,20975683,25416956,16009940,14976209,16884686,22693631, 25402006, 23023127, 21836163 innatedb,hprd,biogrid,mint,intact,dip,bci exp, ortho, pred P P P P P P P P P P P P P P P P P P UBE2L6 UBA7 19250909, 25402006 biogrid exp, pred P P P P P P P P P P P P P P P P P P UBA7 UBE2E1 16428300, 23023127 biogrid exp, pred P P P P P P P P P P P P P PGLS UBA7 ortho P P P P P P P P P P P P P P P P P UBA7 YWHAE ortho P P P P P P P P P P P P P P P P P P UBA7 PSMC5 21836163 pred P P P P P P P P P P P P P P P P P P UBA7 BTN3A2 25402006 pred P P P P P P P P P P P P P P P P P P UBA7 PARP12 25402006 pred P P P P P P P P P P P P P P P P P P UBA7 UBA52 16082366 pred P P P P P P P P P P P P P P P P P P UBA7 TBK1 25402006 pred P P P P P P P P P P P P P P P P P P HLA-E UBA7 25402006 pred P P P P P P P P P P P P P P P P HLA-A UBA7 25402006 pred ATG12 UBA7 25402006 pred P P P P P P P P P P P P P P P P P P UBA7 UBA2 23023127 pred P P P P P P P P P P P P P P P P P UBA7 LGALS3BP 25402006 pred P P P P P P P P P P P P P P UBA7 BECN1 21836163 pred P P P P P P P P P P P P P P P P P P UBA7 FBXW11 21836163 pred UBC UBA7 25402006 pred P P P P P P P P P P P P P P P P P P HLA-G UBA7 25402006 pred P CDC14B UBA7 21836163 pred P P P P P P P P P P P PPM1B UBA7 25402006 pred P P P P P P P P P P P P P P P P P P UBA7 IRF9 25402006 pred P P P P P P P P P P P P P P P P P UBA7 PSMA6 21836163 pred P P P P P P P P P P P P P P P P P HLA-F UBA7 25402006 pred UBA7 NAE1 23023127 pred P P P P P P P P P P P P P P P P P P UBA7 SNIP1 21836163 pred P P P P P P P P P P P P P P APOL1 UBA7 21836163 pred P P P P P P UBA7 PSMD4 21836163 pred P P P P P P P P P P P P P P P P UBA7 IRF4 25402006 pred P P P UBD UBA7 16082366 pred P P P P P P P P P P P P P P P P P P UBA7 PSMD2 21836163 pred P P P P P P P P P P P P P P P P P RPN1 UBA7 21836163 pred P P P P P P P P P P P P P P P BNIP3L UBA7 21836163 pred P P P P P P P P P P P P P P P P P P UBA7 SQSTM1 23023127 pred P P P P P P P P P P P P P P P P PSMD14 UBA7 21836163 pred P P P P P P P P P P P P P P SP100 UBA7 25402006 pred P P P P P P P P P P P P P P P P P P UBA7 IRF3 25402006 pred P P P P P P P P P P P P P P P P P P UBA7 PRKD2 25402006 pred P P P P P P P P P P P P P P P UBA7 UBQLN3 16082366 pred P UBA7 UHRF2 23023127 pred P P P P P P P P P P P P P P P P P P UBA7 SLC15A3 25402006 pred P P P P P P P P P P P UBA7 NEDD8 23023127, 16082366 pred P P P P P P P P P P P P P P P P P P UBA7 PHF20 21836163 pred P P P P P P P P P P P P P P P P P P UBA7 PCBP2 25402006 pred P P P P P P P P P P P P P P P P P P UBA7 SP110 25402006 pred P P P P P P P P P P P P P P P P P P UCHL3 UBA7 21836163 pred P P P P P P P P P P P P P P P P P USP1 UBA7 21836163 pred P P P P P P P P P P P P P P UBA7 NEDD4 25402006 pred P P P P P P P P P P P P P P P P P P UBA7 RNF125 25402006 pred P P P P P P P P P P P P P P P P P P UBA7 BST2 25402006 pred P P P P P P P P P P P P P P P P P PSMB8 UBA7 25402006 pred P P P P P P P P P P P P P P P P P UBA7 TRIM25 25402006 pred P P P P P P P P P P P P P P P P P UBA7 IFI35 25402006 pred PSMC3 UBA7 21836163 pred P P P P P P P P P P P P P P P P P P UBA7 CREBBP 25402006 pred P P P P P P P P P P P P P P P P P P IKBKB UBA7 16082366 pred P P P P P P P P P P P P P P P P P P UBA7 ATG5 21836163 pred P P P P P P P P P P P P P P P P P P UBA7 UBE2E2 23023127 pred P P P P P P P P P P P P P P P P P P UBA7 Ubiquitin C variant 16082366 pred UBA7 UBE4A 21836163 pred P P P P P P P P P P P P P P P P P PSMB9 UBA7 25402006 pred P P P P P P P P P P P P P P P P P PSMC2 UBA7 21836163 pred P P P P P P P P P P P P P P P P P P PSMD9 UBA7 21836163 pred P P P P P P P P P P P P P P P P P P UBA7 ADRM1 21836163 pred P P P P P P P P P P P P P P P P P P UBA7 RAD23B 21836163 pred P P P P P P P P P P P P P P P P P P UBA7 MAP1LC3A 21836163 pred P P P P P P P P UBA7 UFD1L 21836163 pred P P P P P P P P P P P P P UBA7 COPS8 21836163 pred P P P P UBL4A UBA7 16082366 pred P P P P P P P P P P UBA7 UBQLN2 21836163 pred P P P P P P P P P P P P P P P P P P UBA6 UBA7 23023127 pred P UBA7 SPNS1 21836163 pred P P P P P P P P P P P P P P P P UBA7 PSMC1 21836163 pred P P P P P P P P P P P P P P P P P P UBA7 PSME4 21836163 pred P P P P P P P P P P P P P P P P P P UBA7 RAD23A 21836163, 16082366 pred P P P P P P P P P P P P P P P P P P UBA7 STAT1 25402006 pred P P P P P P P P P P P P P UBA7 USP5 21836163 pred P P P P P P P P P P P P P P P P P UBA7 UBA3 23023127 pred P P P P P P P P P P P P P P P P P P UBB UBA7 21836163 pred P P P P P P P P P P P P P P P P P P UBA7 CUL1 21836163 pred P P P P P P P P P P P P P P P P BTN3A3 UBA7 25402006 pred P P P P P P P P P P P P P P P P P P UBA7 CAND1 21836163 pred P P P P P P P P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A4D1D2 P41226 affinity chromatography technology 23465077 physical association X 2 P41226 P05161 two hybrid 16189514 direct interaction X 2 P41226 P05161 affinity chromatography technology 16009940 physical association X 2 P41226 P05161 affinity chromatography technology 22693631 physical association X 2 P41226 P05161 pull down 18356159 direct interaction X 2 P41226 P05161 affinity chromatography technology 14976209 physical association X 2 P41226 P05161 two hybrid 20975683 direct interaction X 2 P41226 P05161 two hybrid 25416956 direct interaction X 2 P41226 O14933-2 enzymatic study 19250909 direct interaction X 2 P41226 P05161 affinity chromatography technology 16884686 physical association X 2 A0A024R1A4 P41226 enzymatic study 19250909 direct interaction X 2 P41226 A0A024R389 affinity chromatography technology 23465077 physical association X 2 P60896 P41226 affinity chromatography technology 24811749 physical association X 2 P0CG48 P41226 affinity chromatography technology 22505724 physical association X 2 P41226 P05161 comigration in sds page 17597759 direct interaction X 2 P41226 in vivo 16872604 - C 4 P41226 in vivo 16872604 - C 4 P41226 in vivo 16872604 - C 4 P41226 in vivo 16872604 - C 4 P41226 P05161 in vivo 14976209,16169070 - X 2 P41226 P05161 two hybrid 14976209,16169070 - X 2 P41226 P05161 in vivo 14976209,16169070 - X 2 P41226 P05161 two hybrid 14976209,16169070 - X 2 P41226 P25445-2 two hybrid 8940097 - X 2 P41226 P25445-2 in vitro 8940097 - X 2 P41226 P25445-2 two hybrid 8940097 - X 2 P41226 P25445-2 in vitro 8940097 - X 2 P41226 anti tag coimmunoprecipitation 24811749 association C 66 P41226 P05161 two hybrid pooling approach 16189514 physical association X 2 P41226 P05161 two hybrid prey pooling approach 25416956 physical association X 2 P41226 P05161 two hybrid prey pooling approach 25416956 physical association X 2 P41226 P05161 two hybrid array 25416956 physical association X 2 P41226 P05161 two hybrid array 25416956 physical association X 2 P41226 P05161 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UBC UBA7 MI:0004(affinity chromatography technology) 22505724 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_225035 bait prey ABCB1 UBA7 MI:0004(affinity chromatography technology) 23465077 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_272792 bait prey FAS UBA7 MI:0492(in vitro) 8940097 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_33959 - - UBA7 FBXO15 MI:0004(affinity chromatography technology) 23465077 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_272791 prey bait ISG15 UBA7 MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid) 14976209,16009940,16189514,16872604,16884686,18356159,20975683,22693631 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0468(hprd)|(biogrid)|MI:0471(mint)|(biogrid)|MI:0468(hprd)|(biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0471(mint) HPRD_39803|BIOGRID_196747|MINT_69566|BIOGRID_81110|HPRD_19279|BIOGRID_122988|UniProt_153935|BIOGRID_206106|BIOGRID_196243|BIOGRID_197220|BIOGRID_199605|MINT_40193 -|prey|prey|prey|-|bait|unspecified role|bait|bait|bait|bait|prey -|bait|bait|bait|-|prey|unspecified role|prey|prey|prey|prey|bait

PPI - HINT Gene A Gene B PMID Method Quality ISG15 UBA7 14976209,18356159,14976209,16009940,22693631,16884686 0004,0096,0018,0004,0004,0004 LC UBA7 FOXA1 25609649,25609649 0676,0004 HT UBA7 FOXK1 25609649,25609649 0676,0004 HT UBA7 FOXP4 25609649,25609649 0676,0004 HT UBA7 FOXA1 25609649,25609649 0676,0004 HT UBA7 FOXK1 25609649,25609649 0676,0004 HT UBA7 FOXP4 25609649,25609649 0676,0004 HT ISG15 UBA7 14976209,18356159,14976209,16009940,22693631,16884686 0004,0096,0018,0004,0004,0004 LC UBE2L6 UBA7 19250909 0415 LC ISG15 UBA7 17597759,16189514,16169070,20975683,14976209,25416956,25416956,25416956,16189514,25416956,14976209 0808,0398,0018,0018,0004,1112,0397,0018,0018,1356,0018 LC,HT FAS UBA7 8940097 0018 LC UBA7 UBE2E1 16428300 0415 LC UBA7 UBE2L3 19250909 0415 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8NCQ5 P41226 FBXO15 UBA7 0.21 23465077 P41226 P08183 UBA7 ABCB1 0.21 23465077 P85037 P41226 FOXK1 UBA7 0.236 25609649 P55317 P41226 FOXA1 UBA7 0.236 25609649 Q8IVH2 P41226 FOXP4 UBA7 0.236 25609649 P60896 P41226 SHFM1 UBA7 0.236 24811749 P41226 P05161 UBA7 ISG15 0.922 25416956,16189514,22693631,20975683,14976209,unassigned1304,16884686,16009940 P68036 P41226 UBE2L3 UBA7 0.309 19250909 P41226 O14933 UBA7 UBE2L6 0.309 19250909 P51965 P41226 UBE2E1 UBA7 0.309 16428300

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 UBE2L6 UBA7 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database DDX58 UBA7 MI:0362 inference MI:1106 pathways database ISG15 UBA7 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database ABCB1 UBA7 MI:0045 experimental interaction detection MI:0461 interaction database UBB UBA7 MI:0362 inference MI:1106 pathways database UBC UBA7 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database PCNA UBA7 MI:0362 inference MI:1106 pathways database RPA2 UBA7 MI:0362 inference MI:1106 pathways database RPA1 UBA7 MI:0362 inference MI:1106 pathways database RPA3 UBA7 MI:0362 inference MI:1106 pathways database RFC4 UBA7 MI:0362 inference MI:1106 pathways database RFC2 UBA7 MI:0362 inference MI:1106 pathways database RFC1 UBA7 MI:0362 inference MI:1106 pathways database RFC5 UBA7 MI:0362 inference MI:1106 pathways database RFC3 UBA7 MI:0362 inference MI:1106 pathways database UBA7 UBE2E1 MI:0045 experimental interaction detection MI:0461 interaction database UBA7 FOXA1 MI:0045 experimental interaction detection MI:0461 interaction database UBA7 SHFM1 MI:0045 experimental interaction detection MI:0461 interaction database UBA7 RPS27A MI:0362 inference MI:1106 pathways database UBA7 UBA52 MI:0362 inference MI:1106 pathways database UBA7 UBE2L3 MI:0045 experimental interaction detection MI:0461 interaction database UBA7 FOXK1 MI:0045 experimental interaction detection MI:0461 interaction database UBA7 TRIM25 MI:0362 inference MI:1106 pathways database UBA7 FOXP4 MI:0045 experimental interaction detection MI:0461 interaction database UBA7 FBXO15 MI:0045 experimental interaction detection MI:0461 interaction database UBA7 POLK MI:0362 inference MI:1106 pathways database UBA7 REV1 MI:0362 inference MI:1106 pathways database UBA7 HERC5 MI:0362 inference MI:1106 pathways database UBA7 POLI MI:0362 inference MI:1106 pathways database UBA7 POLH MI:0362 inference MI:1106 pathways database