PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus TTC3 KIF18A 26496610 biogrid,intact exp P P P P P TTC3 TTN 23414517 intact exp P P P P UBC TTC3 19285159 innatedb,biogrid exp P P P P P TTC3 UBE2D2 20059950 biogrid exp P P FGFR1OP TTC3 26496610 biogrid,intact exp TTC3 PARD6A 26496610 biogrid,intact exp P P P P P TTC3 DSN1 26496610 biogrid,intact exp P P P P P TTC3 WAPAL 26496610 biogrid,intact exp P P P P P TTC3 AKT3 20059950 biogrid exp P P P P P NR3C1 TTC3 20195357 intact exp P P P P P ETS1 TTC3 20195357 intact exp CSNK2A2 TTC3 26496610 biogrid,intact exp TTC3 KRBOX4 26496610 biogrid,intact exp TTC3 ATF7IP 15231748 hprd,i2d,mint,intact exp P P P P P TTC3 YWHAZ 20936779 i2d exp P P P P P TTC3 GRB2 20936779 i2d exp P P P P P TTC3 SMC6 26496610 biogrid,intact exp P P P P P HSPB1 TTC3 25277244 biogrid,intact exp P P P P P AKT2 TTC3 20059950 biogrid exp P P P P P RAB5C TTC3 26496610 biogrid,intact exp P P P P P AKT1 TTC3 20059950 biogrid exp, ortho P P P P P TTC3 UBE3A 21900206, 25402006 biogrid,mint,intact exp, pred P P P P P CIT TTC3 ortho P P P P TTC3 DZIP3 23023127 pred P P P P P TTC3 ZNF638 25402006 pred P P P P P PJA2 TTC3 25402006 pred P P P P P TTC3 UBE2H 25402006 pred P P P P P UBE2L6 TTC3 25402006 pred P P P P P TTC3 CBX1 25402006 pred P P P P P TTC3 RALGAPA1 25402006 pred P P P P P UFL1 TTC3 25402006 pred P P P P P TTC3 RNF220 23023127 pred P P TRIM13 TTC3 23023127 pred P P P P TTC3 PNISR 25402006 pred P P P P P TTC3 RNF6 23023127 pred P P P P P CDC34 TTC3 23023127 pred P P P P P TTC3 UBE2K 23023127 pred P P P P P PARK2 TTC3 23023127 pred P P P P P LUC7L3 TTC3 25402006 pred P P P P P TTC3 TCHH 21836163 pred P P P P P TTC3 RNF4 23023127 pred P P TTC3 TTC37 25402006 pred P P P P P RNF103 TTC3 23023127 pred P P P P P TTC3 ZMYM4 25402006 pred P P P P P TTC3 UBE4A 23023127 pred P P P P P TTC3 UBE2R2 23023127 pred TTC3 RNF5 23023127 pred P P P P P TTC3 RNF182 23023127 pred P P P P P TTC3 BCLAF1 25402006 pred P P P P P TTC3 ITCH 23023127 pred P P P P P TTC3 NHLRC1 23023127 pred TTC3 RNF41 23023127 pred P P P P P TTC3 RNF165 23023127 pred P P P P P TTC3 UBE2E2 23023127 pred P P P P P TTC3 PJA1 23023127 pred P P P P P TTC3 USP33 25402006 pred P P P P P TTC3 TCF12 25402006 pred P P P P P DDHD2 TTC3 25402006 pred P P P P P MYC TTC3 25402006 pred P P P P P TTC3 RCHY1 23023127 pred P P P P TTC3 RLIM 23023127 pred P P P P P TTC3 UBE2G1 25402006, 23023127 pred P P P P P RNF8 TTC3 23023127 pred P P P P P NBAS TTC3 25402006 pred P P P P P TTC3 SLC25A36 25402006 pred P P P P P TTC3 STUB1 23023127 pred P P P P P TTC3 KIAA1109 25402006 pred P P P P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P53804 P0CG48 pull down 19285159 direct interaction X 2 P53804 P0CG48 affinity chromatography technology 19285159 physical association X 2 P53804 Q9Y243 affinity chromatography technology 20059950 physical association X 2 P53804 P0CG48 affinity chromatography technology 21139048 physical association X 2 P53804 P0CG48 affinity chromatography technology 21890473 physical association X 2 P53804 two hybrid 17488780 direct interaction X 2 P53804 P62837 pull down 20059950 direct interaction X 2 P53804 B3KVH4 affinity chromatography technology 20059950 physical association X 2 P53804 B4DG79 affinity chromatography technology 20059950 physical association X 2 P53804 B3KVH4 enzymatic study 20059950 direct interaction X 2 P53804 B3KVH4 pull down 20059950 direct interaction X 2 P53804 Q05086 two hybrid 21900206 direct interaction X 2 P53804 A0A024RAY1 two hybrid 15231748 - X 2 P53804 A0A024RAY1 two hybrid 15231748 - X 2 P53804 A0A024RAY1 two hybrid 15231748 physical association X 2 Q7CFV5 P53804 two hybrid pooling approach 20711500 physical association X 2 F1D8N4 P53804 display technology 20195357 physical association X 2 Q81U00 P53804 two hybrid pooling approach 20711500 physical association X 2 P53804 P14921 display technology 20195357 physical association X 2 P53804 Q5NE82 two hybrid pooling approach 20711500 physical association X 2 P53804 Q05086 two hybrid 21900206 physical association X 2 P53804 Q8WZ42 two hybrid fragment pooling approach 23414517 physical association X 2 P53804 P04792 reverse ras recruitment system 25277244 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B TTC3 UBE3A MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(biogrid) UniProt_178386|UniProt_157788|BIOGRID_156560 prey|prey|prey bait|bait|bait UBC TTC3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down) 19285159,21139048,21890473 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_173415|BIOGRID_170350|BIOGRID_200683|BIOGRID_200666 bait|bait|bait|bait prey|prey|prey|prey TTC3 TTN MI:0663(confocal microscopy) 23414517 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_127497 prey bait TTC3 uniprotkb:(gene name) MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_38628 - - TTC3 UBE2D2 MI:0004(affinity chromatography technology) 20059950 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_226110 bait prey ETS1 TTC3 MI:0034(display technology) 20195357 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_105209 bait prey NR3C1 TTC3 MI:0034(display technology) 20195357 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_104508 bait prey AKT1 TTC3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20059950 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_153225|BIOGRID_153222|BIOGRID_153226 prey|bait|prey bait|prey|bait AKT2 TTC3 MI:0004(affinity chromatography technology) 20059950 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_153223 bait prey TTC3 ATF7IP MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(intact) MINT_32394|MINT_61242|UniProt_78915 prey|prey|prey bait|bait|bait TTC3 AKT3 MI:0004(affinity chromatography technology) 20059950 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_153224 prey bait

PPI - HINT Gene A Gene B PMID Method Quality FGFR1OP TTC3 26496610,26496610 0007,0004 HT CSNK2A2 TTC3 26496610,26496610 0007,0004 HT RAB5C TTC3 26496610,26496610 0007,0004 HT TTC3 KRBOX4 26496610,26496610 0007,0004 HT TTC3 WAPL 26496610,26496610 0007,0004 HT TTC3 KIF18A 26496610,26496610 0007,0004 HT TTC3 SMC6 26496610,26496610 0007,0004 HT TTC3 DSN1 26496610,26496610 0007,0004 HT TTC3 PARD6A 26496610,26496610 0007,0004 HT FGFR1OP TTC3 26496610,26496610 0007,0004 HT CSNK2A2 TTC3 26496610,26496610 0007,0004 HT RAB5C TTC3 26496610,26496610 0007,0004 HT TTC3 KRBOX4 26496610,26496610 0007,0004 HT TTC3 WAPL 26496610,26496610 0007,0004 HT TTC3 KIF18A 26496610,26496610 0007,0004 HT TTC3 SMC6 26496610,26496610 0007,0004 HT TTC3 DSN1 26496610,26496610 0007,0004 HT TTC3 PARD6A 26496610,26496610 0007,0004 HT NR3C1 TTC3 20195357 0034 LC HSPB1 TTC3 25277244 0097 LC ETS1 TTC3 20195357 0034 LC AKT1 TTC3 20059950,20059950,20059950 0415,0096,0004 LC TTC3 UBE3A 21900206 0018 HT TTC3 ATF7IP 15231748 0018 HT TTC3 TTN 23414517 0399 HT TTC3 HEL-S-102 25277244 0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5JUW0 P53804 KRBOX4 TTC3 0.126 26496610 Q5NE82 P53804 CLPB TTC3 0.126 20711500 P53804 B4URF7 TTC3 PB2 {ECO:0000256|RULEBASE:RU361246, ECO:0000313|EMBL:ACF54608.1} 0.126 unassigned1333 P62837 P53804 UBE2D2 TTC3 0.309 20059950 P53804 P14921 TTC3 ETS1 0.126 20195357 P53804 P04792 TTC3 HSPB1 0.286 25277244 Q81U00 P53804 Q81U00 TTC3 0.126 20711500 Q8WZ42 P53804 TTN TTC3 0.126 23414517 Q8NI77 P53804 KIF18A TTC3 0.126 26496610 Q9NPB6 P53804 PARD6A TTC3 0.126 26496610 Q9H410 P53804 DSN1 TTC3 0.126 26496610 Q9Y243 P53804 AKT3 TTC3 0.21 20059950 Q6VMQ6 P53804 ATF7IP TTC3 0.183 15231748 Q7CFV5 P53804 Q7CFV5 TTC3 0.126 20711500 Q7Z5K2 P53804 WAPAL TTC3 0.126 26496610 P53804 P04150 TTC3 NR3C1 0.126 20195357 P53804 O95684 TTC3 FGFR1OP 0.126 26496610 Q9WTX6 P53804 CUL1 TTC3 0.236 26496610 P53804 P0CG48 TTC3 UBC 0.454 19285159 P53804 P05214 TTC3 TUBA3B 0.236 26496610 Q96SB8 P53804 SMC6 TTC3 0.236 26496610 Q99MK9 P53804 RASSF1 TTC3 0.236 26496610 Q9DCX1 P53804 MAD2L1BP TTC3 0.236 26496610 Q9ET47 P53804 ESPN TTC3 0.236 26496610 P53804 P19784 TTC3 CSNK2A2 0.236 26496610 P97302 P53804 BACH1 TTC3 0.236 26496610 Q05086 P53804 UBE3A TTC3 0.332 21900206 Q8CI51 P53804 PDLIM5 TTC3 0.236 26496610 P53804 A2AUM9 TTC3 CEP152 0.236 26496610 P53804 P31749 TTC3 AKT1 0.623 20059950 P53804 P31751 TTC3 AKT2 0.21 20059950 P53804 P49025 TTC3 CIT 0.309 17488780 P53804 P51148 TTC3 RAB5C 0.126 26496610

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 ESPN TTC3 MI:0362 inference MI:0461 interaction database CIT TTC3 MI:0362 inference MI:0461 interaction database BACH1 TTC3 MI:0362 inference MI:0461 interaction database CEP152 TTC3 MI:0362 inference MI:0461 interaction database FGFR1OP TTC3 MI:0045 experimental interaction detection MI:0461 interaction database NR3C1 TTC3 MI:0045 experimental interaction detection MI:0461 interaction database HSPB1 TTC3 MI:0045 experimental interaction detection MI:0461 interaction database UBC TTC3 MI:0045 experimental interaction detection MI:0461 interaction database ETS1 TTC3 MI:0045 experimental interaction detection MI:0461 interaction database CSNK2A2 TTC3 MI:0045 experimental interaction detection MI:0461 interaction database AKT1 TTC3 MI:0045 experimental interaction detection MI:0461 interaction database AKT2 TTC3 MI:0045 experimental interaction detection MI:0461 interaction database RAB5C TTC3 MI:0045 experimental interaction detection MI:0461 interaction database TTC3 RHOA MI:0362 inference MI:0461 interaction database TTC3 UBE2D2 MI:0045 experimental interaction detection MI:0461 interaction database TTC3 TUBA1B MI:0362 inference MI:0461 interaction database TTC3 TUBA4A MI:0362 inference MI:0461 interaction database TTC3 UBE3A MI:0045 experimental interaction detection MI:0461 interaction database TTC3 CUL1 MI:0362 inference MI:0461 interaction database TTC3 TUBA3C MI:0362 inference MI:0461 interaction database TTC3 MAD2L1BP MI:0362 inference MI:0461 interaction database TTC3 KRBOX4 MI:0045 experimental interaction detection MI:0461 interaction database TTC3 TUBA3E MI:0362 inference MI:0461 interaction database TTC3 ATF7IP MI:0045 experimental interaction detection MI:0461 interaction database TTC3 TUBA1A MI:0362 inference MI:0461 interaction database TTC3 WAPL MI:0045 experimental interaction detection MI:0461 interaction database TTC3 KIF18A MI:0045 experimental interaction detection MI:0461 interaction database TTC3 TTN MI:0045 experimental interaction detection MI:0461 interaction database TTC3 PDLIM5 MI:0362 inference MI:0461 interaction database TTC3 SMC6 MI:0045 experimental interaction detection MI:0461 interaction database TTC3 DSN1 MI:0045 experimental interaction detection MI:0461 interaction database TTC3 PARD6A MI:0045 experimental interaction detection MI:0461 interaction database TTC3 RASSF1 MI:0362 inference MI:0461 interaction database TTC3 AKT3 MI:0045 experimental interaction detection MI:0461 interaction database