PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus HOXB4 RBX1 21098278 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G GP G HOXB4 DDB1 21098278 biogrid exp G G G G GP G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 CREBBP 11585930 hprd,biogrid exp G G G G GP G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 EP300 11585930 hprd exp G G G G GP G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 CUL4A 21098278 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G MEIS1 HOXB4 15617687, 25402006, 23023127 hprd exp, pred G G G G GP G G G G G G G G G G G G G G G G G G G G G G G HOXB4 NFE2 ortho G GP G P P HOXB4 POU3F4 23023127 pred G GP G P P G HOXB8 HOXB4 23023127 pred G G G G G HOXB4 HOXA7 23023127 pred G G G G G G G G G G G G G G G G G G PAX4 HOXB4 23023127 pred G GP G G P P G SHOX2 HOXB4 23023127 pred G G G G G G G G G TCF21 HOXB4 23023127 pred G G P G G G G G G G G G G G G G GP P G HOXB4 VSX2 23023127 pred P P P HOXB4 RBM15 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 HOXD11 23023127 pred G G G G G HOXB4 HOXD9 23023127 pred G G G G G G G G G G G G G G G G HOXB4 HOXA1 23023127 pred P P LMX1B HOXB4 23023127 pred HOXB4 USF1 21836163 pred P P P HOXB4 PSME2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G HOXB4 OTX1 23023127 pred G G G G G G G G G G P HOXB4 HOXA5 23023127 pred G G G GP G G G G G G G G G G G G G G G G GP P G HOXB4 PAX9 23023127 pred G G G G P P G HOXB4 NUMB 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 NKX2-3 23023127 pred G G G G G P HOXB4 ZFHX3 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 LHX1 23023127 pred G HOXB4 ZHX3 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 TGFB2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G HOXB4 NUP98 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G HOXB4 NKX2-5 23023127 pred G G G G HOXB4 HOXA9 23023127 pred P P P HOXB4 PRRX2 23023127 pred G G P GP HOXB4 MALT1 23023127 pred G G GP G G G G G G G G G G G G G G G G G G GP G HOXB4 NR2F2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLX3 HOXB4 23023127 pred P P P HOXB4 RXRA 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 GBX2 23023127 pred ZEB2 HOXB4 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G G MTA2 HOXB4 23023127 pred P G P P HOXB4 PAX5 23023127 pred G G GP G G G G G G G G G G G G G G G G HOXB4 LRRC17 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 SATB2 23023127 pred G G G G G G G G G G G HOXB4 JAG1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 PDX1 23023127 pred P CHUK HOXB4 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP GP G HOXB5 HOXB4 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G VDR HOXB4 23023127 pred G G G G G G G G G G G G G G G G G G G G HOXB4 NCOA3 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 PRRX1 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 EMX2 23023127 pred G G P G G G G G G G P G HOXB4 NOTCH2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G GP G G HOXB4 TLX1 23023127 pred G HOXB9 HOXB4 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 EN1 23023127 pred G P G G G G G P P NKX2-2 HOXB4 23023127 pred G P G G G G G G G GP P HOXB4 NKX6-2 23023127 pred G G CRX HOXB4 23023127 pred P P P HOXB4 MIXL1 23023127 pred HOXB4 HOXD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G HOXB4 PAX7 23023127 pred G G G G G G G G HOXB4 HOPX 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G GP G HOXB4 HOXA4 23023127 pred G G G GP G G G G G G G G G G G G G GP P G HOXB4 PBX1 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 ALX4 23023127 pred G AR HOXB4 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G GP G HOXB4 HOXD13 23023127 pred G HOXB4 GSX2 23023127 pred G G G G G G HOXB4 MNX1 23023127 pred G G G G G G G G HOXB4 MEOX2 23023127 pred G G G G G G G G G G G P PDGFRB HOXB4 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 IRX5 23023127 pred G G G G G G G G G G HOXB1 HOXB4 23023127 pred G G G G G G G G G G G G G P GP G HOXB4 TGFBR2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G HOXB4 MSX1 23023127 pred G G G P G G G G G G G G G G G G G G G G G G GP P G HOXB4 OTP 23023127 pred G G GP G G G G G P P G HOXB4 NR1H4 23023127 pred G P G G G G G G G G G G P P PROP1 HOXB4 23023127 pred G G G G G G G G G G G G G G G G G G HOXB4 BSX 23023127 pred P P P HOXB4 HMBOX1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G GP G HOXB4 GSX1 23023127 pred P P HOXB4 RAX2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G HOXB4 ROBO4 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G HOXB4 PTK2B 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 EVX2 23023127 pred P P P HOXB4 USF2 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G HOXB4 PAX3 23023127 pred G GP G G G P GP PHOX2A HOXB4 23023127 pred G G G G G G G G G G G G RARB HOXB4 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 HESX1 23023127 pred P P P HOXB4 HOXA6 23023127 pred G G G G GP G G G G G G G G G G GP P G FGFR1 HOXB4 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 BARX2 23023127 pred G G G G HOXC4 HOXB4 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G HOXA2 HOXB4 23023127 pred G HOXB4 CASP3 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 HOXD10 23023127 pred G G G G G G G G G G HOXB4 SP3 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 VAX2 23023127 pred G G G G G G G G G G G G G G MEIS2 HOXB4 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 E2F1 23023127 pred G G G GP G G G G G G G G G G G G G G G GP GP G HOXB4 KAZALD1 23023127 pred G G GP G G G G G G G G G G G G G GP P G SIX3 HOXB4 23023127 pred G G G G G HOXB4 ALX1 23023127 pred P P P HOXB4 TGIF1 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 NOTCH1 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 NKX3-1 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 TGFBR1 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP G G HOXB4 POU4F1 23023127 pred G G G G G G G G G G G G G G G G HOXB4 BARHL1 23023127 pred G P G G G G G G P GP HOXB4 ESX1 23023127 pred G GP HOXB4 POU4F3 23023127 pred P P HOXB4 POU1F1 23023127 pred G P HOXB4 HOXA13 23023127 pred G G G G HOXD8 HOXB4 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G HOXB4 PSME1 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 CASP8 23023127 pred G G G GP G G G G G G G G G G G G G G GP GP G HOXB4 HOXD3 23023127 pred G G G G HOXB4 SATB1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G GP G HOXB4 NR2E3 23023127 pred HOXB4 EPHA2 23023127 pred G G G P G G G G G G G G G G G G G G G G G G G GP GP G BCL2 HOXB4 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G G G G HOXB4 ESR2 23023127 pred G G G GP G G G G G G G G G G G G G G G G G GP GP HOXC11 HOXB4 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 HOXB13 23023127 pred G HOXB4 CDX1 23023127 pred G G G P MAP3K7 HOXB4 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 HOXC13 23023127 pred G P G HOXB4 PITX2 23023127 pred G G G G G G HOXB4 NKX3-2 23023127 pred P G G G GP P HOXB4 LHX3 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G HOXB4 SMO 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP GP G HOXA3 HOXB4 23023127 pred G G G G G G G G G G G G G G G G GP GP G HOXB4 PITX1 23023127 pred P G G G G G G GP P HOXB4 PBX3 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP G G HOXB4 BARHL2 23023127 pred P P P HOXB4 MEOX1 23023127 pred G P G G G G G G G G G GP P G HOXB4 PAX2 23023127 pred G G G G G P G LYN HOXB4 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G GP G G HOXB4 POU3F3 23023127 pred G G G G G G HOXB4 ZEB1 23023127 pred P HOXB4 POU2F3 23023127 pred G G UNCX HOXB4 23023127 pred POU2F1 HOXB4 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G GP GP G KIT HOXB4 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G G HOXB4 FZD1 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 ZHX1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G HOXB4 LBX1 23023127 pred P P P HOXB4 ZBTB16 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G GP G HOXB4 EN2 23023127 pred P G G P P HMX2 HOXB4 23023127 pred G GP G G G G G P P HOXC6 HOXB4 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G ONECUT3 HOXB4 23023127 pred G G G G G G G G G G G G G G G G HOXB4 DLX5 23023127 pred G GP G P P G RARG HOXB4 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G GP GP G HOXB4 HOXC8 23023127 pred G G G GP G G G G G G P P G HOXB4 ZHX2 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 NUMBL 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G GP G HOXB4 HOXC10 23023127 pred G G G GP G G G G G G G G G G G G G G G G P GP G HOXB4 LHX4 23023127 pred G G G G G G G G G G G G VENTX HOXB4 23023127 pred G P G G G P P G HOXB4 DMBX1 23023127 pred P P P HOXB7 HOXB4 23023127 pred G G G G G G G G G G G G G G G G G G GP GP G HOXB4 SIX1 23023127 pred G G G G G G G G GP E2F6 HOXB4 23023127 pred G G G G G G G G G G G G G G G G G G G G G G HOXB4 RHOXF1 23023127 pred G G G G G G G G G G G G G G G G G G G G G GP GP TLX2 HOXB4 23023127 pred P P HOXB4 HOXC9 23023127 pred G G G G G G G G G G G HOXB3 HOXB4 23023127 pred G G G GP G G G G G G G G G G G G G G G G G G GP GP G HOXB2 HOXB4 23023127 pred G G G G G G G G G G G G G G G G G G G G G G NKX2-8 HOXB4 23023127 pred P P HOXB4 DLX2 23023127 pred G G G G G G G G G G G G G G P GP G ESRRA HOXB4 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G HOXB4 TP63 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G HOXB4 NR1H2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G GP GP G MITF HOXB4 21836163 pred G G G G GP G G G G G G G G G G G G G G G G G G G G G G G HMX3 HOXB4 23023127 pred HOXB4 BARX1 23023127 pred G G G G G HOXB4 HOXC5 23023127 pred P G G G G P P HOXB4 POU3F2 23023127 pred G G G G G G G G HOXD4 HOXB4 23023127 pred G G G G G G G G G G G G G G G G G G G G G G HOXB4 NKX2-4 23023127 pred HOXB4 GSC 23023127 pred HOXB4 LBX2 23023127 pred P P HOXB4 HOXA11 23023127 pred G G G G G G G G G GP G HOXB4 VSX1 23023127 pred ALX3 HOXB4 23023127 pred G G G G HOXB4 HOXB6 23023127 pred G G P G G G G G G G G GP P G HOXB4 RAX 23023127 pred HOXB4 CUX1 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 HOXC12 23023127 pred G G HOXB4 LAMA1 23023127 pred P G G G G G P GP HOXB4 PBX2 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 POU4F2 23023127 pred G G G G G G G G G G G HOXB4 HOXA10 23023127 pred G G G GP G G G G G G G G G P P G HOXB4 POU5F1 23023127 pred P P P HOXB4 PAFAH1B1 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP GP G HOXB4 LEF1 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G HOXB4 NKX2-1 23023127 pred G G G G HOXB4 VAX1 23023127 pred P P ESR1 HOXB4 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G HOXB4 EVX1 23023127 pred G G G G G G G G G G G G G G G G G G G G HOXB4 DLX1 23023127 pred G G G G P P HOXB4 POU3F1 23023127 pred G G G G G G G G G HOXB4 HHEX 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP G HOXB4 MSX2 23023127 pred P G G P GP G CDX4 HOXB4 23023127 pred HOXB4 ONECUT1 23023127 pred G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P17483 pull down 11585930 direct interaction X 2 P17483 B2RBV7 affinity chromatography technology 21098278 physical association X 2 P17483 P62877 affinity chromatography technology 21098278 physical association X 2 P17483 Q16531 affinity chromatography technology 21098278 physical association X 2 P17483 in vivo 11585930 - X 2 P17483 in vitro 11585930 - X 2 P17483 O00470 two hybrid 15617687 - X 2 P17483 Q09472 in vivo 11585930 - X 2 P17483 Q09472 in vitro 11585930 - X 2 P17483 Q09472 in vitro 11585930 - X 2 P17483 Q09472 in vivo 11585930 - X 2 P17483 in vivo 11585930 - X 2 P17483 in vitro 11585930 - X 2 P17483 O00470 two hybrid 15617687 - X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B HOXB4 CUL4A MI:0004(affinity chromatography technology) 21098278 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_184708 bait prey HOXB4 EP300 MI:0492(in vitro) 11585930 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_26617 - - HOXB4 RBX1 MI:0004(affinity chromatography technology) 21098278 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_184707 bait prey HOXB4 CREBBP MI:0096(pull down)|MI:0492(in vitro) 11585930 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_147159|HPRD_26712 prey|- bait|- HOXB4 DDB1 MI:0004(affinity chromatography technology) 21098278 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_184709 bait prey MEIS1 HOXB4 MI:0493(in vivo) 15617687 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_27797 - -

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 MEIS1 HOXB4 MI:0362 inference MI:0461 interaction database ACOX3 HOXB4 MI:0362 inference MI:0461 interaction database ORC4 HOXB4 MI:0362 inference MI:0461 interaction database CDK4 HOXB4 MI:0362 inference MI:0461 interaction database HOXB4 CDK2 MI:0362 inference MI:0461 interaction database HOXB4 POLR2I MI:0362 inference MI:0461 interaction database HOXB4 PBX1 MI:0362 inference MI:0461 interaction database HOXB4 PBX2 MI:0362 inference MI:0461 interaction database HOXB4 PBX3 MI:0362 inference MI:0461 interaction database HOXB4 CCNG1 MI:0362 inference MI:0461 interaction database HOXB4 PLK1 MI:0362 inference MI:0461 interaction database HOXB4 NUDT6 MI:0362 inference MI:0461 interaction database HOXB4 RBX1 MI:0045 experimental interaction detection MI:0461 interaction database HOXB4 CDK3 MI:0362 inference MI:0461 interaction database HOXB4 CDK6 MI:0362 inference MI:0461 interaction database HOXB4 CDK5 MI:0362 inference MI:0461 interaction database HOXB4 MAD2L1 MI:0362 inference MI:0461 interaction database HOXB4 EIF3I MI:0362 inference MI:0461 interaction database HOXB4 CUL3 MI:0362 inference MI:0461 interaction database HOXB4 CUL4A MI:0045 experimental interaction detection MI:0461 interaction database HOXB4 DDB1 MI:0045 experimental interaction detection MI:0461 interaction database HOXB4 NFE2 MI:0362 inference MI:0461 interaction database HOXB4 CPEB4 MI:0362 inference MI:0461 interaction database HOXB4 MPPE1 MI:0362 inference MI:0461 interaction database HOXB4 CPEB2 MI:0362 inference MI:0461 interaction database HOXB4 CPEB3 MI:0362 inference MI:0461 interaction database HOXB4 CREBBP MI:0045 experimental interaction detection MI:0461 interaction database HOXB4 RTEL1 MI:0362 inference MI:0461 interaction database