PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus USP5 TRIML1 19156909 biogrid exp P P P P P P P P P P P P P P P GP APP TRIML1 21832049 biogrid exp P P P P P P P P P GP TRIML1 RBCK1 22493164 biogrid,intact exp P P P P P P P P P P P P P P P GP MNAT1 TRIML1 22493164 biogrid,intact exp P P P P P P P P P P P P P FSD2 TRIML1 23023127 pred P P P P P P P P P P P P P P P P BTNL8 TRIML1 23023127 pred P P P P P P P P P P P P P P RFPL3 TRIML1 23023127 pred G TRIM16L TRIML1 23023127 pred P P RFPL4A TRIML1 23023127 pred P P P P P P P P P P P P P P P P TRIM65 TRIML1 23023127 pred P P P P P P P P P P P P P P GP

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8N9V2 two hybrid 22493164 direct interaction X 2 P45974-2 Q8N9V2 pull down 19156909 direct interaction X 2 P45974-2 Q8N9V2 affinity chromatography technology 19156909 physical association X 2 Q8N9V2 P05067-7 pull down 21832049 direct interaction X 2 Q8N9V2 two hybrid 22493164 direct interaction X 2 Q9BYM8 Q8N9V2 two hybrid array 22493164 physical association X 2 A0A024R688 Q8N9V2 two hybrid array 22493164 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B APP TRIML1 MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229614 prey bait TRIML1 RBCK1 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122534|BIOGRID_284003 prey|prey bait|bait MNAT1 TRIML1 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284007|UniProt_122487 bait|bait prey|prey USP5 TRIML1 MI:0096(pull down)|MI:0096(pull down) 19156909 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_192198|BIOGRID_192199 prey|bait bait|prey

PPI - HINT Gene A Gene B PMID Method Quality MNAT1 TRIML1 22493164,22493164 0018,0397 HT TRIML1 RBCK1 22493164,22493164 0018,0397 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8N9V2 P05067 TRIML1 APP 0.183 21832049 Q9BYM8 Q8N9V2 RBCK1 TRIML1 0.286 22493164 Q8N9V2 P51948 TRIML1 MNAT1 0.286 22493164 Q8N9V2 P45974 TRIML1 USP5 0.454 19156909

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 APP TRIML1 MI:0045 experimental interaction detection MI:0461 interaction database USP5 TRIML1 MI:0045 experimental interaction detection MI:0461 interaction database MNAT1 TRIML1 MI:0045 experimental interaction detection MI:0461 interaction database TRIML1 RBCK1 MI:0045 experimental interaction detection MI:0461 interaction database