Mutation - TCGA Type Chromosome Start Position End Position Strand Variant Classification Variant Type Reference Allele Tumor_seq Allele 1 Tumor_seq Allele 2 Tumor Sample Barcode Matched Norm Sample Barcode Genome Change cDNA Change Codon Change Protein Change BLCA 14 105716181 105716181 + Silent SNP C C T TCGA-XF-AAMT-01A-11D-A42E-08 TCGA-XF-AAMT-10A-01D-A42H-08 g.chr14:105716181C>T c.630C>T c.(628-630)gtC>gtT p.V210V BLCA 14 105716478 105716478 + Missense_Mutation SNP C C G TCGA-E7-A97P-01A-11D-A38G-08 TCGA-E7-A97P-10A-01D-A38J-08 g.chr14:105716478C>G c.927C>G c.(925-927)caC>caG p.H309Q BRCA 14 105716214 105716214 + Silent SNP C C T TCGA-E2-A14O-01A-31D-A10Y-09 TCGA-E2-A14O-10A-01D-A110-09 g.chr14:105716214C>T c.663C>T c.(661-663)tcC>tcT p.S221S BRCA 14 105716582 105716582 + Missense_Mutation SNP C C T TCGA-GM-A2D9-01A-11D-A18P-09 TCGA-GM-A2D9-11A-42D-A18P-09 g.chr14:105716582C>T c.1031C>T c.(1030-1032)tCt>tTt p.S344F COAD 14 105716163 105716163 + Silent SNP G G A TCGA-AZ-6601-01A-11D-1771-10 TCGA-AZ-6601-11A-01D-1771-10 g.chr14:105716163G>A c.612G>A c.(610-612)acG>acA p.T204T COAD 14 105716290 105716290 + Missense_Mutation SNP G G A TCGA-AA-3492-01A-01D-1408-10 TCGA-AA-3492-11A-01D-1408-10 g.chr14:105716290G>A c.739G>A c.(739-741)Gtg>Atg p.V247M COAD 14 105716863 105716863 + Missense_Mutation SNP G G A TCGA-AD-6889-01A-11D-1924-10 TCGA-AD-6889-10A-01D-1924-10 g.chr14:105716863G>A c.1312G>A c.(1312-1314)Ggc>Agc p.G438S COADREAD 14 105716163 105716163 + Silent SNP G G A TCGA-AZ-6601-01A-11D-1771-10 TCGA-AZ-6601-11A-01D-1771-10 g.chr14:105716163G>A c.612G>A c.(610-612)acG>acA p.T204T COADREAD 14 105716290 105716290 + Missense_Mutation SNP G G A TCGA-AA-3492-01A-01D-1408-10 TCGA-AA-3492-11A-01D-1408-10 g.chr14:105716290G>A c.739G>A c.(739-741)Gtg>Atg p.V247M COADREAD 14 105716863 105716863 + Missense_Mutation SNP G G A TCGA-AD-6889-01A-11D-1924-10 TCGA-AD-6889-10A-01D-1924-10 g.chr14:105716863G>A c.1312G>A c.(1312-1314)Ggc>Agc p.G438S DLBC 14 105716854 105716854 + Missense_Mutation SNP G G A TCGA-G8-6909-01A-11D-2210-10 TCGA-G8-6909-14A-01D-2210-10 g.chr14:105716854G>A c.1303G>A c.(1303-1305)Gtc>Atc p.V435I ESCA 14 105716550 105716550 + Silent SNP C C T TCGA-VR-A8EX-01A-11D-A36J-09 TCGA-VR-A8EX-10A-01D-A36M-09 g.chr14:105716550C>T c.999C>T c.(997-999)ctC>ctT p.L333L ESCA 14 105716690 105716690 + Missense_Mutation SNP C C A TCGA-IG-A3Y9-01A-12D-A247-09 TCGA-IG-A3Y9-10A-01D-A247-09 g.chr14:105716690C>A c.1139C>A c.(1138-1140)tCt>tAt p.S380Y HNSC 14 105715748 105715748 + Silent SNP C C T TCGA-UF-A7JH-01A-21D-A34J-08 TCGA-UF-A7JH-10A-01D-A34M-08 g.chr14:105715748C>T c.358C>T c.(358-360)Ctg>Ttg p.L120L HNSC 14 105716079 105716079 + Silent SNP C C T TCGA-CV-6961-01A-21D-1912-08 TCGA-CV-6961-10A-01D-1912-08 g.chr14:105716079C>T c.528C>T c.(526-528)gtC>gtT p.V176V HNSC 14 105716585 105716585 + Missense_Mutation SNP C C A TCGA-CV-6961-01A-21D-1912-08 TCGA-CV-6961-10A-01D-1912-08 g.chr14:105716585C>A c.1034C>A c.(1033-1035)gCc>gAc p.A345D HNSC 14 105716824 105716824 + Missense_Mutation SNP G G A TCGA-MT-A67F-01A-11D-A30E-08 TCGA-MT-A67F-10A-01D-A30H-08 g.chr14:105716824G>A c.1273G>A c.(1273-1275)Gaa>Aaa p.E425K HNSC 14 105716856 105716856 + Frame_Shift_Del DEL C C - TCGA-IQ-A6SG-01A-12D-A34J-08 TCGA-IQ-A6SG-10A-01D-A34M-08 g.chr14:105716856delC c.1305delC c.(1303-1305)gtcfs p.V435fs KIPAN 14 105716270 105716270 + Missense_Mutation SNP C C T TCGA-DZ-6134-01A-11D-1961-08 TCGA-DZ-6134-10A-01D-1962-08 g.chr14:105716270C>T c.719C>T c.(718-720)gCc>gTc p.A240V KIPAN 14 105716843 105716843 + Missense_Mutation SNP C C A TCGA-B9-A8YI-01A-21D-A36X-10 TCGA-B9-A8YI-10A-01D-A370-10 g.chr14:105716843C>A c.1292C>A c.(1291-1293)aCg>aAg p.T431K KIRP 14 105716270 105716270 + Missense_Mutation SNP C C T TCGA-DZ-6134-01A-11D-1961-08 TCGA-DZ-6134-10A-01D-1962-08 g.chr14:105716270C>T c.719C>T c.(718-720)gCc>gTc p.A240V KIRP 14 105716843 105716843 + Missense_Mutation SNP C C A TCGA-B9-A8YI-01A-21D-A36X-10 TCGA-B9-A8YI-10A-01D-A370-10 g.chr14:105716843C>A c.1292C>A c.(1291-1293)aCg>aAg p.T431K LIHC 14 105716119 105716119 + Missense_Mutation SNP G G A TCGA-BD-A3EP-01A-11D-A22F-10 TCGA-BD-A3EP-11A-12D-A22F-10 g.chr14:105716119G>A c.568G>A c.(568-570)Gtc>Atc p.V190I LIHC 14 105716439 105716439 + Silent SNP C C T TCGA-DD-A113-01A-11D-A12Z-10 TCGA-DD-A113-10A-01D-A12Z-10 g.chr14:105716439C>T c.888C>T c.(886-888)ggC>ggT p.G296G LUAD 14 105716227 105716227 + Missense_Mutation SNP G G A TCGA-86-8673-01A-11D-2393-08 TCGA-86-8673-10A-01D-2393-08 g.chr14:105716227G>A c.676G>A c.(676-678)Gag>Aag p.E226K LUAD 14 105716248 105716248 + Missense_Mutation SNP G G A TCGA-86-8673-01A-11D-2393-08 TCGA-86-8673-10A-01D-2393-08 g.chr14:105716248G>A c.697G>A c.(697-699)Gag>Aag p.E233K LUAD 14 105716498 105716498 + Missense_Mutation SNP C C T TCGA-55-A48Y-01A-11D-A24D-08 TCGA-55-A48Y-10A-01D-A24F-08 g.chr14:105716498C>T c.947C>T c.(946-948)aCg>aTg p.T316M LUAD 14 105716559 105716559 + Silent SNP G G A TCGA-86-8673-01A-11D-2393-08 TCGA-86-8673-10A-01D-2393-08 g.chr14:105716559G>A c.1008G>A c.(1006-1008)caG>caA p.Q336Q LUAD 14 105716678 105716678 + Missense_Mutation SNP A A G TCGA-55-1595-01A-01D-0969-08 TCGA-55-1595-11A-01D-0969-08 g.chr14:105716678A>G c.1127A>G c.(1126-1128)tAt>tGt p.Y376C LUAD 14 105716710 105716710 + Missense_Mutation SNP G G A TCGA-86-A4JF-01A-11D-A24P-08 TCGA-86-A4JF-10A-01D-A24P-08 g.chr14:105716710G>A c.1159G>A c.(1159-1161)Gtg>Atg p.V387M LUSC 14 105716320 105716320 + Missense_Mutation SNP G G A TCGA-66-2783-01A-01D-1267-08 TCGA-66-2783-11A-01D-1267-08 g.chr14:105716320G>A c.769G>A c.(769-771)Gag>Aag p.E257K LUSC 14 105716777 105716777 + Missense_Mutation SNP G G T TCGA-66-2785-01A-01D-1522-08 TCGA-66-2785-11A-01D-1522-08 g.chr14:105716777G>T c.1226G>T c.(1225-1227)gGa>gTa p.G409V PRAD 14 105716611 105716611 + Missense_Mutation SNP C C T TCGA-M7-A71Y-01A-22D-A32B-08 TCGA-M7-A71Y-10A-01D-A329-08 g.chr14:105716611C>T c.1060C>T c.(1060-1062)Cgc>Tgc p.R354C SKCM 14 105716494 105716494 + Missense_Mutation SNP T T C TCGA-EE-A3AB-06A-11D-A196-08 TCGA-EE-A3AB-10A-01D-A198-08 g.chr14:105716494T>C c.943T>C c.(943-945)Tac>Cac p.Y315H SKCM 14 105716968 105716968 + Missense_Mutation SNP G G A TCGA-EE-A2MR-06A-11D-A196-08 TCGA-EE-A2MR-10A-01D-A198-08 g.chr14:105716968G>A c.1417G>A c.(1417-1419)Gtc>Atc p.V473I

Mutation - ICGC Project Code Chromosome Chromosome Start Chromosome End Mutation Type Mutated from Allele Mutated to Allele Consequence Type AA Mutation CDS Mutation BRCA-EU 14 105711080 105711080 deletion of <=200bp A - upstream_gene_variant BRCA-EU 14 105711273 105711273 single base substitution G C upstream_gene_variant BRCA-EU 14 105713013 105713013 single base substitution C T upstream_gene_variant BRCA-EU 14 105713865 105713865 single base substitution C A upstream_gene_variant BRCA-EU 14 105714932 105714932 single base substitution G C 5_prime_UTR_variant BRCA-EU 14 105714932 105714932 single base substitution G C intron_variant BRCA-EU 14 105714932 105714932 single base substitution G C upstream_gene_variant BRCA-EU 14 105715523 105715523 single base substitution T C missense_variant M7T 20T>C BRCA-EU 14 105715523 105715523 single base substitution T C missense_variant M82T 245T>C BRCA-EU 14 105715523 105715523 single base substitution T C upstream_gene_variant BRCA-EU 14 105719152 105719152 single base substitution C G downstream_gene_variant BRCA-EU 14 105719735 105719735 single base substitution C T downstream_gene_variant BRCA-EU 14 105720836 105720836 single base substitution T C downstream_gene_variant BRCA-FR 14 105719152 105719152 single base substitution C G downstream_gene_variant BRCA-FR 14 105719735 105719735 single base substitution C T downstream_gene_variant BRCA-UK 14 105719358 105719358 single base substitution C T downstream_gene_variant BRCA-US 14 105716214 105716214 single base substitution C T exon_variant BRCA-US 14 105716214 105716214 single base substitution C T synonymous_variant S146S 438C>T BRCA-US 14 105716214 105716214 single base substitution C T synonymous_variant S221S 663C>T BRCA-US 14 105716582 105716582 single base substitution C T exon_variant BRCA-US 14 105716582 105716582 single base substitution C T missense_variant S269F 806C>T BRCA-US 14 105716582 105716582 single base substitution C T missense_variant S344F 1031C>T BTCA-JP 14 105715454 105715454 single base substitution C T 5_prime_UTR_variant BTCA-JP 14 105715454 105715454 single base substitution C T intron_variant BTCA-JP 14 105715454 105715454 single base substitution C T upstream_gene_variant COAD-US 14 105715515 105715515 single base substitution C T synonymous_variant N4N 12C>T COAD-US 14 105715515 105715515 single base substitution C T synonymous_variant N79N 237C>T COAD-US 14 105715515 105715515 single base substitution C T upstream_gene_variant COAD-US 14 105716290 105716290 single base substitution G A exon_variant COAD-US 14 105716290 105716290 single base substitution G A missense_variant V172M 514G>A COAD-US 14 105716290 105716290 single base substitution G A missense_variant V247M 739G>A COAD-US 14 105716863 105716863 single base substitution G A downstream_gene_variant COAD-US 14 105716863 105716863 single base substitution G A missense_variant G363S 1087G>A COAD-US 14 105716863 105716863 single base substitution G A missense_variant G438S 1312G>A COCA-CN 14 105716034 105716034 single base substitution C T exon_variant COCA-CN 14 105716034 105716034 single base substitution C T synonymous_variant Y161Y 483C>T COCA-CN 14 105716034 105716034 single base substitution C T synonymous_variant Y86Y 258C>T COCA-CN 14 105716188 105716188 single base substitution G A exon_variant COCA-CN 14 105716188 105716188 single base substitution G A missense_variant A138T 412G>A COCA-CN 14 105716188 105716188 single base substitution G A missense_variant A213T 637G>A COCA-CN 14 105718929 105718929 single base substitution G T downstream_gene_variant ESAD-UK 14 105710174 105710174 single base substitution G T upstream_gene_variant ESAD-UK 14 105713062 105713062 single base substitution G T upstream_gene_variant ESAD-UK 14 105714552 105714552 single base substitution A T upstream_gene_variant ESAD-UK 14 105715145 105715145 single base substitution G A 5_prime_UTR_variant ESAD-UK 14 105715145 105715145 single base substitution G A upstream_gene_variant ESAD-UK 14 105716418 105716418 single base substitution C T exon_variant ESAD-UK 14 105716418 105716418 single base substitution C T synonymous_variant T214T 642C>T ESAD-UK 14 105716418 105716418 single base substitution C T synonymous_variant T289T 867C>T ESAD-UK 14 105721264 105721264 single base substitution G T downstream_gene_variant ESAD-UK 14 105721324 105721324 insertion of <=200bp - C downstream_gene_variant ESCA-CN 14 105716498 105716498 single base substitution C T exon_variant ESCA-CN 14 105716498 105716498 single base substitution C T missense_variant T241M 722C>T ESCA-CN 14 105716498 105716498 single base substitution C T missense_variant T316M 947C>T ESCA-CN 14 105718878 105718878 single base substitution C A downstream_gene_variant KIRP-US 14 105716270 105716270 single base substitution C T exon_variant KIRP-US 14 105716270 105716270 single base substitution C T missense_variant A165V 494C>T KIRP-US 14 105716270 105716270 single base substitution C T missense_variant A240V 719C>T LAML-KR 14 105720873 105720873 single base substitution A T downstream_gene_variant LIHC-US 14 105715779 105715779 single base substitution C T exon_variant LIHC-US 14 105715779 105715779 single base substitution C T missense_variant P130L 389C>T LIHC-US 14 105715779 105715779 single base substitution C T missense_variant P55L 164C>T LIHC-US 14 105716119 105716119 single base substitution G A exon_variant LIHC-US 14 105716119 105716119 single base substitution G A missense_variant V115I 343G>A LIHC-US 14 105716119 105716119 single base substitution G A missense_variant V190I 568G>A LIHC-US 14 105716439 105716439 single base substitution C T exon_variant LIHC-US 14 105716439 105716439 single base substitution C T synonymous_variant G221G 663C>T LIHC-US 14 105716439 105716439 single base substitution C T synonymous_variant G296G 888C>T LINC-JP 14 105715956 105715956 single base substitution C T intron_variant LINC-JP 14 105716608 105716608 single base substitution T C exon_variant LINC-JP 14 105716608 105716608 single base substitution T C missense_variant Y278H 832T>C LINC-JP 14 105716608 105716608 single base substitution T C missense_variant Y353H 1057T>C LINC-JP 14 105717623 105717623 single base substitution A G downstream_gene_variant LIRI-JP 14 105712424 105712424 single base substitution G A upstream_gene_variant LIRI-JP 14 105713434 105713434 single base substitution G A upstream_gene_variant LIRI-JP 14 105715782 105715782 single base substitution A C exon_variant LIRI-JP 14 105715782 105715782 single base substitution A C missense_variant D131A 392A>C LIRI-JP 14 105715782 105715782 single base substitution A C missense_variant D56A 167A>C LIRI-JP 14 105716160 105716160 single base substitution G T exon_variant LIRI-JP 14 105716160 105716160 single base substitution G T synonymous_variant L128L 384G>T LIRI-JP 14 105716160 105716160 single base substitution G T synonymous_variant L203L 609G>T LIRI-JP 14 105716635 105716655 deletion of <=200bp TTTGCAGTGGACAGAAGGGTA - downstream_gene_variant LIRI-JP 14 105716635 105716655 deletion of <=200bp TTTGCAGTGGACAGAAGGGTA - inframe_deletion FAVDRRV287 LIRI-JP 14 105716635 105716655 deletion of <=200bp TTTGCAGTGGACAGAAGGGTA - inframe_deletion FAVDRRV362 LIRI-JP 14 105716805 105716805 single base substitution T G downstream_gene_variant LIRI-JP 14 105716805 105716805 single base substitution T G missense_variant F343L 1029T>G LIRI-JP 14 105716805 105716805 single base substitution T G missense_variant F418L 1254T>G LIRI-JP 14 105717302 105717302 single base substitution A G 3_prime_UTR_variant LIRI-JP 14 105717302 105717302 single base substitution A G downstream_gene_variant LUSC-KR 14 105713973 105713973 single base substitution A G upstream_gene_variant LUSC-KR 14 105716034 105716034 single base substitution C T exon_variant LUSC-KR 14 105716034 105716034 single base substitution C T synonymous_variant Y161Y 483C>T LUSC-KR 14 105716034 105716034 single base substitution C T synonymous_variant Y86Y 258C>T LUSC-KR 14 105716160 105716160 single base substitution G C exon_variant LUSC-KR 14 105716160 105716160 single base substitution G C synonymous_variant L128L 384G>C LUSC-KR 14 105716160 105716160 single base substitution G C synonymous_variant L203L 609G>C LUSC-KR 14 105717279 105717279 single base substitution T C 3_prime_UTR_variant LUSC-KR 14 105717279 105717279 single base substitution T C downstream_gene_variant LUSC-KR 14 105717448 105717448 single base substitution G C downstream_gene_variant LUSC-US 14 105716320 105716320 single base substitution G A exon_variant LUSC-US 14 105716320 105716320 single base substitution G A missense_variant E182K 544G>A LUSC-US 14 105716320 105716320 single base substitution G A missense_variant E257K 769G>A LUSC-US 14 105716777 105716777 single base substitution G T downstream_gene_variant LUSC-US 14 105716777 105716777 single base substitution G T missense_variant G334V 1001G>T LUSC-US 14 105716777 105716777 single base substitution G T missense_variant G409V 1226G>T MALY-DE 14 105710318 105710318 single base substitution C G upstream_gene_variant MELA-AU 14 105710457 105710457 single base substitution G A upstream_gene_variant MELA-AU 14 105710556 105710556 single base substitution G A upstream_gene_variant MELA-AU 14 105711347 105711347 single base substitution A G upstream_gene_variant MELA-AU 14 105712172 105712172 single base substitution G A upstream_gene_variant MELA-AU 14 105712273 105712273 single base substitution T G upstream_gene_variant MELA-AU 14 105712601 105712602 multiple base substitution (>=2bp and <=200bp) GC AG upstream_gene_variant MELA-AU 14 105712817 105712817 single base substitution C T upstream_gene_variant MELA-AU 14 105712877 105712877 single base substitution G A upstream_gene_variant MELA-AU 14 105713428 105713428 single base substitution G A upstream_gene_variant MELA-AU 14 105713700 105713700 single base substitution G A upstream_gene_variant MELA-AU 14 105714014 105714014 single base substitution G A upstream_gene_variant MELA-AU 14 105714029 105714029 single base substitution A G upstream_gene_variant MELA-AU 14 105714271 105714271 single base substitution G A upstream_gene_variant MELA-AU 14 105714297 105714297 single base substitution G T upstream_gene_variant MELA-AU 14 105716336 105716336 single base substitution G A exon_variant MELA-AU 14 105716336 105716336 single base substitution G A missense_variant R187K 560G>A MELA-AU 14 105716336 105716336 single base substitution G A missense_variant R262K 785G>A MELA-AU 14 105716494 105716494 single base substitution T C exon_variant MELA-AU 14 105716494 105716494 single base substitution T C missense_variant Y240H 718T>C MELA-AU 14 105716494 105716494 single base substitution T C missense_variant Y315H 943T>C MELA-AU 14 105718650 105718650 single base substitution C T downstream_gene_variant ORCA-IN 14 105716945 105716945 single base substitution C T downstream_gene_variant ORCA-IN 14 105716945 105716945 single base substitution C T missense_variant S390L 1169C>T ORCA-IN 14 105716945 105716945 single base substitution C T missense_variant S465L 1394C>T OV-AU 14 105709856 105709856 single base substitution G A upstream_gene_variant OV-AU 14 105712136 105712136 single base substitution G A upstream_gene_variant PACA-CA 14 105710774 105710774 single base substitution C T upstream_gene_variant PACA-CA 14 105713131 105713131 single base substitution T C upstream_gene_variant PACA-CA 14 105716154 105716154 single base substitution C T exon_variant PACA-CA 14 105716154 105716154 single base substitution C T synonymous_variant P126P 378C>T PACA-CA 14 105716154 105716154 single base substitution C T synonymous_variant P201P 603C>T PACA-CA 14 105720241 105720241 single base substitution G A downstream_gene_variant PACA-CA 14 105721862 105721862 single base substitution G T downstream_gene_variant PACA-CA 14 105722269 105722269 single base substitution G T downstream_gene_variant PBCA-DE 14 105714860 105714860 single base substitution C G intron_variant PBCA-DE 14 105714860 105714860 single base substitution C G upstream_gene_variant PRAD-UK 14 105712449 105712449 single base substitution C T upstream_gene_variant PRAD-UK 14 105716441 105716441 single base substitution C T exon_variant PRAD-UK 14 105716441 105716441 single base substitution C T missense_variant A222V 665C>T PRAD-UK 14 105716441 105716441 single base substitution C T missense_variant A297V 890C>T RECA-EU 14 105716470 105716470 single base substitution G T exon_variant RECA-EU 14 105716470 105716470 single base substitution G T stop_gained E232* 694G>T RECA-EU 14 105716470 105716470 single base substitution G T stop_gained E307* 919G>T SKCA-BR 14 105712044 105712044 single base substitution G A upstream_gene_variant SKCA-BR 14 105714855 105714855 single base substitution G A intron_variant SKCA-BR 14 105714855 105714855 single base substitution G A upstream_gene_variant SKCA-BR 14 105714993 105714993 single base substitution C G 5_prime_UTR_variant SKCA-BR 14 105714993 105714993 single base substitution C G intron_variant SKCA-BR 14 105714993 105714993 single base substitution C G upstream_gene_variant SKCA-BR 14 105721016 105721016 single base substitution A C downstream_gene_variant SKCM-US 14 105716494 105716494 single base substitution T C exon_variant SKCM-US 14 105716494 105716494 single base substitution T C missense_variant Y240H 718T>C SKCM-US 14 105716494 105716494 single base substitution T C missense_variant Y315H 943T>C SKCM-US 14 105716968 105716968 single base substitution G A downstream_gene_variant SKCM-US 14 105716968 105716968 single base substitution G A missense_variant V398I 1192G>A SKCM-US 14 105716968 105716968 single base substitution G A missense_variant V473I 1417G>A STAD-US 14 105716119 105716119 single base substitution G A exon_variant STAD-US 14 105716119 105716119 single base substitution G A missense_variant V115I 343G>A STAD-US 14 105716119 105716119 single base substitution G A missense_variant V190I 568G>A STAD-US 14 105716187 105716187 single base substitution C T exon_variant STAD-US 14 105716187 105716187 single base substitution C T synonymous_variant D137D 411C>T STAD-US 14 105716187 105716187 single base substitution C T synonymous_variant D212D 636C>T STAD-US 14 105716436 105716436 single base substitution C T exon_variant STAD-US 14 105716436 105716436 single base substitution C T synonymous_variant N220N 660C>T STAD-US 14 105716436 105716436 single base substitution C T synonymous_variant N295N 885C>T STAD-US 14 105716569 105716569 single base substitution C T exon_variant STAD-US 14 105716569 105716569 single base substitution C T stop_gained R265* 793C>T STAD-US 14 105716569 105716569 single base substitution C T stop_gained R340* 1018C>T STAD-US 14 105716945 105716945 single base substitution C T downstream_gene_variant STAD-US 14 105716945 105716945 single base substitution C T missense_variant S390L 1169C>T STAD-US 14 105716945 105716945 single base substitution C T missense_variant S465L 1394C>T THCA-SA 14 105713449 105713449 single base substitution C T upstream_gene_variant THCA-SA 14 105713973 105713973 single base substitution A G upstream_gene_variant THCA-SA 14 105715515 105715515 single base substitution C T synonymous_variant N4N 12C>T THCA-SA 14 105715515 105715515 single base substitution C T synonymous_variant N79N 237C>T THCA-SA 14 105715515 105715515 single base substitution C T upstream_gene_variant THCA-SA 14 105716034 105716034 single base substitution C T exon_variant THCA-SA 14 105716034 105716034 single base substitution C T synonymous_variant Y161Y 483C>T THCA-SA 14 105716034 105716034 single base substitution C T synonymous_variant Y86Y 258C>T THCA-SA 14 105717279 105717279 single base substitution T C 3_prime_UTR_variant THCA-SA 14 105717279 105717279 single base substitution T C downstream_gene_variant UCEC-US 14 105716288 105716288 single base substitution C T exon_variant UCEC-US 14 105716288 105716288 single base substitution C T missense_variant A171V 512C>T UCEC-US 14 105716288 105716288 single base substitution C T missense_variant A246V 737C>T UCEC-US 14 105716459 105716459 single base substitution T C exon_variant UCEC-US 14 105716459 105716459 single base substitution T C missense_variant L228P 683T>C UCEC-US 14 105716459 105716459 single base substitution T C missense_variant L303P 908T>C UCEC-US 14 105716570 105716570 single base substitution G A exon_variant UCEC-US 14 105716570 105716570 single base substitution G A missense_variant R265Q 794G>A UCEC-US 14 105716570 105716570 single base substitution G A missense_variant R340Q 1019G>A UCEC-US 14 105716634 105716634 single base substitution G T downstream_gene_variant UCEC-US 14 105716634 105716634 single base substitution G T missense_variant Q286H 858G>T UCEC-US 14 105716634 105716634 single base substitution G T missense_variant Q361H 1083G>T UCEC-US 14 105716665 105716665 single base substitution G T downstream_gene_variant UCEC-US 14 105716665 105716665 single base substitution G T missense_variant G297W 889G>T UCEC-US 14 105716665 105716665 single base substitution G T missense_variant G372W 1114G>T UCEC-US 14 105716946 105716946 single base substitution G A downstream_gene_variant UCEC-US 14 105716946 105716946 single base substitution G A synonymous_variant S390S 1170G>A UCEC-US 14 105716946 105716946 single base substitution G A synonymous_variant S465S 1395G>A UCEC-US 14 105718886 105718886 single base substitution G T downstream_gene_variant

Mutation - COSMIC Sample Name Mutation ID Mutation CDS Mutation AA Mutation Description Mutation Genome Position Mutation Strand CRC-35T COSM3765741 c.258C>T p.Y86Y Substitution - coding silent 14:105249697-105249697 + CSCC-44-T COSM4491942 c.163C>T p.P55S Substitution - Missense 14:105249441-105249441 + RK077_C01 COSM3744247 c.167A>C p.D56A Substitution - Missense 14:105249445-105249445 + TCGA-DD-A11A-01 COSM4940301 c.164C>T p.P55L Substitution - Missense 14:105249442-105249442 + TCGA-E2-A14O-01 COSM432754 c.438C>T p.S146S Substitution - coding silent 14:105249877-105249877 + SK00072_M COSM1599895 c.711C>A p.F237L Substitution - Missense 14:105250150-105250150 + TCGA-BR-A4QL-01 COSM2027584 c.660C>T p.N220N Substitution - coding silent 14:105250099-105250099 + 8 COSM1368691 c.1087G>A p.G363S Substitution - Missense 14:105250526-105250526 + LUAD-CHTN-MAD06-00668 COSM358906 c.117C>T p.A39A Substitution - coding silent 14:105249395-105249395 + TCGA-CG-5728-01 COSM4049548 c.793C>T p.R265* Substitution - Nonsense 14:105250232-105250232 + LUAD-S01345 COSM396908 c.152A>T p.E51V Substitution - Missense 14:105249430-105249430 + TCGA-66-2783-01 COSM697777 c.544G>A p.E182K Substitution - Missense 14:105249983-105249983 + CHC205T COSM3765741 c.258C>T p.Y86Y Substitution - coding silent 14:105249697-105249697 + TCGA-AD-6889-01 COSM1368691 c.1087G>A p.G363S Substitution - Missense 14:105250526-105250526 + TCGA-BD-A3EP-01 COSM4049546 c.343G>A p.V115I Substitution - Missense 14:105249782-105249782 + LUAD-B02216 COSM335385 c.839G>T p.G280V Substitution - Missense 14:105250278-105250278 + TCGA-AP-A054-01 COSM953974 c.512C>T p.A171V Substitution - Missense 14:105249951-105249951 + TCGA-BR-4184-01 COSM4049547 c.411C>T p.D137D Substitution - coding silent 14:105249850-105249850 + C0038T COSM4422767 c.694G>T p.E232* Substitution - Nonsense 14:105250133-105250133 + T1154 COSM4666349 c.1078G>A p.V360I Substitution - Missense 14:105250517-105250517 + SC_9047 COSM5570831 c.530T>C p.V177A Substitution - Missense 14:105249969-105249969 + TCGA-D1-A17Q-01 COSM953975 c.683T>C p.L228P Substitution - Missense 14:105250122-105250122 + TCGA-AP-A059-01 COSM953979 c.1170G>A p.S390S Substitution - coding silent 14:105250609-105250609 + TCGA-AP-A0LM-01 COSM953976 c.794G>A p.R265Q Substitution - Missense 14:105250233-105250233 + TCGA-BR-6452-01 COSM4049549 c.1169C>T p.S390L Substitution - Missense 14:105250608-105250608 + PTC-7C COSM3765741 c.258C>T p.Y86Y Substitution - coding silent 14:105249697-105249697 + TCGA-AP-A0LI-01 COSM953978 c.889G>T p.G297W Substitution - Missense 14:105250328-105250328 + HCC78T COSM1607430 c.832T>C p.Y278H Substitution - Missense 14:105250271-105250271 + ESCC-210T COSM3936437 c.722C>T p.T241M Substitution - Missense 14:105250161-105250161 + TCGA-GM-A2D9-01 COSM3814365 c.806C>T p.S269F Substitution - Missense 14:105250245-105250245 + TCGA-F4-6463-01 COSM432753 c.12C>T p.N4N Substitution - coding silent 14:105249178-105249178 + TCGA-66-2785-01 COSM697776 c.1001G>T p.G334V Substitution - Missense 14:105250440-105250440 + sysucc-1397T COSM2027577 c.412G>A p.A138T Substitution - Missense 14:105249851-105249851 + WM3211 COSM3727204 c.941T>C p.I314T Substitution - Missense 14:105250380-105250380 + TCGA-DD-A113-01 COSM4925161 c.663C>T p.G221G Substitution - coding silent 14:105250102-105250102 + T3080 COSM4666347 c.1038G>A p.P346P Substitution - coding silent 14:105250477-105250477 + Pat_59_B COSM5847703 c.1118G>A p.G373E Substitution - Missense 14:105250557-105250557 + ATL010 COSM5705648 c.688C>G p.L230V Substitution - Missense 14:105250127-105250127 + TCGA-DZ-6134-01 COSM3987536 c.494C>T p.A165V Substitution - Missense 14:105249933-105249933 + RK065_C01 COSM1629223 c.1029T>G p.F343L Substitution - Missense 14:105250468-105250468 + T3236 COSM4666345 c.392G>A p.R131H Substitution - Missense 14:105249831-105249831 + TCGA-EE-A3AB-06 COSM3494279 c.718T>C p.Y240H Substitution - Missense 14:105250157-105250157 + SJHGG010_D COSM4969071 c.780G>A p.P260P Substitution - coding silent 14:105250219-105250219 + I2L-P19Ta-Tumor-Biopsy COSM5362486 c.304A>G p.N102D Substitution - Missense 14:105249743-105249743 + EGC15 COSM5053831 c.361C>T p.R121W Substitution - Missense 14:105249800-105249800 + pfg008T COSM1640027 c.958G>A p.G320R Substitution - Missense 14:105250397-105250397 + 276T COSM1727470 c.1037C>T p.P346L Substitution - Missense 14:105250476-105250476 + TCGA-BR-8487-01 COSM4049546 c.343G>A p.V115I Substitution - Missense 14:105249782-105249782 + TCGA-AA-3492-01 COSM1368690 c.514G>A p.V172M Substitution - Missense 14:105249953-105249953 + I2L-P19Ta-Tumor-Organoid COSM5362486 c.304A>G p.N102D Substitution - Missense 14:105249743-105249743 + TCGA-EE-A2MR-06 COSM3494280 c.1192G>A p.V398I Substitution - Missense 14:105250631-105250631 + ESCC_30 COSM5627625 c.1067C>T p.T356M Substitution - Missense 14:105250506-105250506 + HCC78 COSM1607430 c.832T>C p.Y278H Substitution - Missense 14:105250271-105250271 + TCGA-AP-A051-01 COSM953977 c.858G>T p.Q286H Substitution - Missense 14:105250297-105250297 + ESCC_11 COSM5624287 c.942T>A p.I314I Substitution - coding silent 14:105250381-105250381 + CLL083 COSM1290267 c.786G>A p.R262R Substitution - coding silent 14:105250225-105250225 + OSCC-GB_01050111 COSM4049549 c.1169C>T p.S390L Substitution - Missense 14:105250608-105250608 +

Mutation - CGAP UNIGENE CYTOBAND OMIM SNP Hs.7367 14q32 2422342|CGAP|BC042525|C/T|non-coding||1805|Validated; 2422343|CGAP|BC042525|A/T|non-coding||1812|Candidate

Mutation - IntOGen Mutated from(ref) Mutated to(alt) Consequence Type AA Mutation CDS Mutation Chr Pos Cancer A G Missense p.Y376C c.1127A>G 14 105716678 LUAD C A Missense p.A345D c.1034C>A 14 105716585 HNSC C T Missense p.A246V c.737C>T 14 105716288 UCEC C T Missense p.R352W c.1054C>T 14 105716605 BRCA C T Nonsense p.R340* c.1018C>T 14 105716569 STAD G A Missense p.E257K c.769G>A 14 105716320 LUSC G A Missense p.G395R c.1183G>A 14 105716734 STAD G A Nonsense p.W417* c.1251G>A 14 105716802 CM G T Missense p.G372W c.1114G>T 14 105716665 UCEC T C Missense p.Y315H c.943T>C 14 105716494 CM