PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus BTBD6 NXF1 22658674 biogrid exp G G G G GP G G G GP G G G G GP G GP G G G G G G G GP GP G G G G SHMT2 BTBD6 22658674 biogrid exp G G G G GP G G G GP G G G G GP G GP G G G G G G G G GP G G G G BTBD6 DAXX 21988832,21573799 biogrid,intact exp G G G G GP G G G GP G G G G GP G GP G G G G G G G GP GP G G G G PAXIP1 BTBD6 22990118 biogrid exp G G G G GP G G G GP G G G G GP G GP G G G G G G G GP GP G G G G SOCS5 BTBD6 23023127 pred G G G G GP G G G GP G G G G GP G GP G G G G G G G GP GP G G G G KLHL22 BTBD6 23023127 pred G G G G G G G G GP G G G G G G GP G G G G G G G GP GP G G G G BTBD6 BTBD10 23023127 pred G G G G GP G G G GP G G G G GP G G G G G G G G G G G G G G G ZBTB45 BTBD6 23023127 pred G G G G GP G G G GP G G G G GP G GP G G G G G G G GP GP G G G G KBTBD6 BTBD6 23023127 pred G G G G GP G G G GP G G G G GP G G G G G G G G G G G G G G G KCNA3 BTBD6 23023127 pred G G G G G G BTBD6 FBXL2 23023127 pred G G G G G G G G G G G G G G G G G G G G G KCNA2 BTBD6 23023127 pred G G G G G P G P G GP G G G P G SOCS3 BTBD6 23023127 pred G G G G GP G G G GP G G G G G G GP G G G G G G G GP GP G G G G BTBD6 BTBD9 23023127 pred G G G GP G G G GP G G G G GP G G G G G G G G G G G G G BTBD6 KLHL15 23023127 pred G G G G GP G G G GP G G G G GP G GP G G G G G G G GP GP G G G G KLHL23 BTBD6 23023127 pred G G G G G G G G G G G G G ZBTB6 BTBD6 23023127 pred P P P P P P KLHL26 BTBD6 23023127 pred G G P G G GP G G GP G GP G G G G G GP GP G G G BTBD6 GAN 23023127 pred P P P P P KLHL12 BTBD6 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BTBD6 KLHL3 23023127 pred G G G G G G G G GP G G G G G G GP G G G G G G G GP GP G G G G KLHL24 BTBD6 23023127 pred G G G G G G G G G G G G G G G GP G G G G G G G G GP G G G G KLHL18 BTBD6 23023127 pred G G G G GP G G G GP G G G G G G GP G G G G G G GP GP G G G G BTBD6 MYNN 23023127 pred G G G G GP G G G GP G G G G GP G GP G G G G G G G GP GP G G G G KLHL2 BTBD6 23023127 pred G G G G G G G G G G G G G G G GP G G G G G G G G GP G G G G ZBTB10 BTBD6 23023127 pred G G G P G G G GP G G G G GP G GP G G G G G G G GP GP G G G G BTBD6 KLHL11 23023127 pred P P P P P G ZBTB8A BTBD6 23023127 pred G G G G GP G G G GP G G G G GP G GP G G G G G G G GP GP G G G G KCNV1 BTBD6 23023127 pred G G G HIC2 BTBD6 23023127 pred G G G G GP G G G GP G G G G G G GP G G G G G G G GP GP G G G G BTBD6 KLHL14 23023127 pred G GP P G GP P P P G KCTD16 BTBD6 23023127 pred G G G G G P G G P G P KCNC4 BTBD6 23023127 pred G G G G GP G G G GP G G G G GP G GP G G G G G G GP GP G G G G BTBD6 BTBD3 23023127 pred G G G G GP G G G GP G G G G GP G GP G G G G G G G G GP G G G G KLHL36 BTBD6 23023127 pred G G G G GP G G G GP G G G G GP G GP G G G G G G G GP GP G G G G ZBTB16 BTBD6 23023127 pred G G G G G G G G GP G G G G G G GP G G G G G G G G GP G G G G KBTBD3 BTBD6 23023127 pred G G G G G G G G G G G G G G G G G G GP G G G G G BTBD6 KLHL1 23023127 pred G G G P BTBD6 KLHL31 23023127 pred G G G P G G GP G G G G G G G G GP G G FBXW5 BTBD6 23023127 pred G G G G GP G G G GP G G G G G G GP G G G G G G G GP GP G G G G BTBD6 KLHL28 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BTBD6 KCNS2 23023127 pred G G G GP G GP G G P P G G G GP GP G BTBD6 ZBTB18 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BTBD6 KLHL25 23023127 pred G G G G G G G GP G G G G GP G GP G G G G G G GP GP G G G G BTBD6 KCNS1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 BTBD6 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KBTBD11 BTBD6 23023127 pred G G G G GP G G GP G G G G GP G GP G G G GP GP G G PRKCI BTBD6 23023127 pred G G G G G G G G GP G G G G G G GP G G G G G G G G GP G G G G BTBD6 BTRC 23023127 pred G G G G GP G G G GP G G G G GP G GP G G G G G G G GP GP G G G G BTBD6 KLHL20 23023127 pred G G G G GP G G G GP G G G G GP G GP G G G G G G G GP GP G G G G BTBD6 UBQLN1 23023127 pred G G G G GP G G G GP G G G G GP G GP G G G G G G G GP GP G G G G ZBTB46 BTBD6 23023127 pred G G G G GP G G G GP G G G G GP G GP G G G G G G GP GP G G G BTBD6 ZBTB3 23023127 pred G G GP GP G G G GP G GP G G G GP GP G G G ENC1 BTBD6 23023127 pred G G G G G G G G GP G G G G GP G GP G G G G G G G G GP G G G G TNFAIP1 BTBD6 23023127 pred G G G G G G G G GP G G G G G G GP G G G G G G G G GP G G G G KLHL6 BTBD6 23023127 pred G G GP GP G GP GP P GP G G BTBD6 IPP 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BTBD6 KLHL4 23023127 pred G G P G P G G P G G P P FBXW7 BTBD6 23023127 pred G G G G GP G G G GP G G G G GP G GP G G G G G G GP GP G G G BTBD6 KCND3 23023127 pred G G G G GP G G G GP G G G G GP G GP G G G G G G G GP G G G G KLHL38 BTBD6 23023127 pred P P P P P P KCNA1 BTBD6 23023127 pred G G G G GP G G G GP G G P G GP G G G G G G GP GP G G G TCEB1 BTBD6 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BTBD6 KLHL32 23023127 pred G G P G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q96KE9 Q6ZW49 two hybrid 22990118 direct interaction X 2 Q96KE9 two hybrid 21573799 direct interaction X 2 Q96KE9 two hybrid 21988832 direct interaction X 2 Q96KE9 A0A024RCS3 two hybrid 21573799 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B BTBD6 DAXX MI:0018(two hybrid)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21573799,21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact)|(biogrid)|(intact) BIOGRID_212287|UniProt_113991|BIOGRID_286902|UniProt_119600 prey|prey|bait|unspecified role bait|bait|prey|unspecified role PAXIP1 BTBD6 MI:0004(affinity chromatography technology) 22990118 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_246251 bait prey

PPI - HINT Gene A Gene B PMID Method Quality PAXIP1 BTBD6 22990118 0018 LC BTBD6 BTBD6 PDB_2VKP 0114 LC BTBD6 DAXX 21573799,21988832 0018,0018 LC,HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q96KE9 Q6ZW49 BTBD6 PAXIP1 0.183 22990118 Q9Y5B8 Q96KE9 NME7 BTBD6 0.236 unassigned1304 Q9Y2F9 Q96KE9 BTBD3 BTBD6 0.236 unassigned1304 Q96KE9 Q15560 BTBD6 TCEA2 0.236 unassigned1304 Q96KE9 Q13618 BTBD6 CUL3 0.236 unassigned1304 Q9UBU9 Q96KE9 NXF1 BTBD6 0.126 22658674 Q9UER7 Q96KE9 DAXX BTBD6 0.681 21573799,21988832 Q96KE9 P34897 BTBD6 SHMT2 0.126 22658674

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 SHMT2 BTBD6 MI:0045 experimental interaction detection MI:0461 interaction database RBX1 BTBD6 MI:0362 inference MI:1106 pathways database CUL3 BTBD6 MI:0362 inference MI:1106 pathways database PAXIP1 BTBD6 MI:0045 experimental interaction detection MI:0461 interaction database BTBD6 NXF1 MI:0045 experimental interaction detection MI:0461 interaction database BTBD6 DAXX MI:0045 experimental interaction detection MI:0461 interaction database