PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus APP CCIN 21832049 biogrid exp P P P P P P P P P P GP CCIN CCIN 11090452 hprd exp P P P P P P P P P P P P P P P P P P P P GP ACTA1 CCIN 11090452 hprd exp P P G NPHP4 CCIN ortho P P P P P P P G CCIN EQTN 21836163 pred GP CCIN ALX4 21836163 pred CCIN CORO1C 21836163 pred P P P P P P P P P P P P P P P P P P P P GP RASGRF2 CCIN 21836163 pred P P P P P P P P P P P P P P P P P P P P GP CCIN SPAG8 21836163 pred P P P P P P P P GP CCIN CAPZA3 21836163 pred P P P GP CCIN CASC5 21836163 pred P P P P P P P P P P GP HSPA2 CCIN 21836163 pred P P P P P P P P P P P P P P P P P P P GP CCIN PNMA1 21836163 pred P P P GP TNFAIP2 CCIN 21836163 pred P P P P P P P P P P P G CCIN CYLC2 21836163 pred G NEXN CCIN 21836163 pred P P P P P P P P P P P P P P P P P P P GP CCIN TXNDC8 21836163 pred P P P P P P P P P P P P P P P GP CCIN PPP1R9A 21836163 pred P P P P P P P P P P P P P P P P P P P GP CCIN SPATA9 21836163 pred P P P P P P P P P P P P P P P P P P GP CCIN ADAM7 21836163 pred P P P P P P P P P P P P P P P P P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q13939 P05067-7 pull down 21832049 direct interaction X 2 P68133 Q13939 in vitro 11090452 - X 2 P68133 Q13939 in vitro 11090452 - X 2 Q13939 Q13939 in vitro 11090452 - X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B APP CCIN MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229216 prey bait ACTA1 CCIN MI:0492(in vitro) 11090452 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_25114 - - CCIN CCIN MI:0492(in vitro) 11090452 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_19655 - -

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q13939 P05067 CCIN APP 0.183 21832049