Disease associated variation - GWASdb Chr Pos SNP ID(dbSNP 142) Ref Alt Ori SNP ID P-value Drug Name Drug Anno GWAS Trait HPO ID DO ID AA Type Trait or Drug 9 135062771 rs870591 G A rs870591 0.0008283 INFLIXIMAB|ADALIMUMAB|IMMUNOGLOBULIN G TUMOR NECROSIS FACTOR-ALPHA|ANTIRHEUMATIC AGENTS|ANTIBODIES, MONOCLONAL, HUMANIZED|TNFR-FC FUSION PROTEIN|ANTIBODIES, MONOCLONAL|RECEPTORS, TUMOR NECROSIS FACTOR Anti-TNF treatment response in rheumatoid arthritis (by DAS-28 score change at 3 months) HPOID:0001370 DOID:7148 G intron GWASdb_drug 9 135062771 rs870591 G A rs870591 8.28E-04 LEUCOVORIN|METHOTREXATE SLCO1B1 PROTEIN, HUMAN|ORGANIC ANION TRANSPORTERS Methotrexate clearance (acute lymphoblastic leukemia) HPOID:0006721 DOID:9952|DOID:12603 G intron GWASdb_drug 9 135064702 rs11243656 G C rs11243656 0.000832 INFLIXIMAB|ADALIMUMAB|IMMUNOGLOBULIN G TUMOR NECROSIS FACTOR-ALPHA|ANTIRHEUMATIC AGENTS|ANTIBODIES, MONOCLONAL, HUMANIZED|TNFR-FC FUSION PROTEIN|ANTIBODIES, MONOCLONAL|RECEPTORS, TUMOR NECROSIS FACTOR Anti-TNF treatment response in rheumatoid arthritis (by DAS-28 score change at 3 months) HPOID:0001370 DOID:7148 G intron GWASdb_drug 9 135064702 rs11243656 G C rs11243656 8.32E-04 LEUCOVORIN|METHOTREXATE SLCO1B1 PROTEIN, HUMAN|ORGANIC ANION TRANSPORTERS Methotrexate clearance (acute lymphoblastic leukemia) HPOID:0006721 DOID:9952|DOID:12603 G intron GWASdb_drug 9 135064788 rs11243657 C T rs11243657 0.0009056 INFLIXIMAB|ADALIMUMAB|IMMUNOGLOBULIN G TUMOR NECROSIS FACTOR-ALPHA|ANTIRHEUMATIC AGENTS|ANTIBODIES, MONOCLONAL, HUMANIZED|TNFR-FC FUSION PROTEIN|ANTIBODIES, MONOCLONAL|RECEPTORS, TUMOR NECROSIS FACTOR Anti-TNF treatment response in rheumatoid arthritis (by DAS-28 score change at 3 months) HPOID:0001370 DOID:7148 T intron GWASdb_drug 9 135064788 rs11243657 C T rs11243657 9.06E-04 LEUCOVORIN|METHOTREXATE SLCO1B1 PROTEIN, HUMAN|ORGANIC ANION TRANSPORTERS Methotrexate clearance (acute lymphoblastic leukemia) HPOID:0006721 DOID:9952|DOID:12603 T intron GWASdb_drug 9 135070104 rs7870760 A G rs7870760 0.0008786 INFLIXIMAB|ADALIMUMAB|IMMUNOGLOBULIN G TUMOR NECROSIS FACTOR-ALPHA|ANTIRHEUMATIC AGENTS|ANTIBODIES, MONOCLONAL, HUMANIZED|TNFR-FC FUSION PROTEIN|ANTIBODIES, MONOCLONAL|RECEPTORS, TUMOR NECROSIS FACTOR Anti-TNF treatment response in rheumatoid arthritis (by DAS-28 score change at 3 months) HPOID:0001370 DOID:7148 G intron GWASdb_drug 9 135070104 rs7870760 A G rs7870760 8.79E-04 LEUCOVORIN|METHOTREXATE SLCO1B1 PROTEIN, HUMAN|ORGANIC ANION TRANSPORTERS Methotrexate clearance (acute lymphoblastic leukemia) HPOID:0006721 DOID:9952|DOID:12603 G intron GWASdb_drug 9 135073967 rs3739930 C T rs3739930 0.000911 INFLIXIMAB|ADALIMUMAB|IMMUNOGLOBULIN G TUMOR NECROSIS FACTOR-ALPHA|ANTIRHEUMATIC AGENTS|ANTIBODIES, MONOCLONAL, HUMANIZED|TNFR-FC FUSION PROTEIN|ANTIBODIES, MONOCLONAL|RECEPTORS, TUMOR NECROSIS FACTOR Anti-TNF treatment response in rheumatoid arthritis (by DAS-28 score change at 3 months) HPOID:0001370 DOID:7148 G cds-synon GWASdb_drug 9 135073967 rs3739930 C T rs3739930 9.11E-04 LEUCOVORIN|METHOTREXATE SLCO1B1 PROTEIN, HUMAN|ORGANIC ANION TRANSPORTERS Methotrexate clearance (acute lymphoblastic leukemia) HPOID:0006721 DOID:9952|DOID:12603 G cds-synon GWASdb_drug 9 135074063 rs3739929 T C rs3739929 0.0009136 INFLIXIMAB|ADALIMUMAB|IMMUNOGLOBULIN G TUMOR NECROSIS FACTOR-ALPHA|ANTIRHEUMATIC AGENTS|ANTIBODIES, MONOCLONAL, HUMANIZED|TNFR-FC FUSION PROTEIN|ANTIBODIES, MONOCLONAL|RECEPTORS, TUMOR NECROSIS FACTOR Anti-TNF treatment response in rheumatoid arthritis (by DAS-28 score change at 3 months) HPOID:0001370 DOID:7148 A intron GWASdb_drug 9 135074063 rs3739929 T C rs3739929 9.14E-04 LEUCOVORIN|METHOTREXATE SLCO1B1 PROTEIN, HUMAN|ORGANIC ANION TRANSPORTERS Methotrexate clearance (acute lymphoblastic leukemia) HPOID:0006721 DOID:9952|DOID:12603 A intron GWASdb_drug 9 135042885 rs883318 A G rs883318 6.48E-04 Multiple complex diseases HPOID:0000118 NA G intron GWASdb_trait 9 135051942 rs7851167 C A rs7851167 1.28E-05 Creatinine levels HPOID:0012100|HPOID:0000077 DOID:784 A intron GWASdb_trait 9 135053756 rs7039329 C T rs7039329 1.53E-05 Creatinine levels HPOID:0012100|HPOID:0000077 DOID:784 T intron GWASdb_trait 9 135055814 rs10116759 A C rs10116759 7.71E-05 Creatinine levels HPOID:0012100|HPOID:0000077 DOID:784 A intron GWASdb_trait 9 135062771 rs870591 G A rs870591 0.0008283 Anti-TNF treatment response in rheumatoid arthritis (by DAS-28 score change at 3 months) HPOID:0001370 DOID:7148 G intron GWASdb_trait 9 135062771 rs870591 G A rs870591 8.28E-04 Methotrexate clearance (acute lymphoblastic leukemia) HPOID:0006721 DOID:9952|DOID:12603 G intron GWASdb_trait 9 135064702 rs11243656 G C rs11243656 0.000832 Anti-TNF treatment response in rheumatoid arthritis (by DAS-28 score change at 3 months) HPOID:0001370 DOID:7148 G intron GWASdb_trait 9 135064702 rs11243656 G C rs11243656 8.32E-04 Methotrexate clearance (acute lymphoblastic leukemia) HPOID:0006721 DOID:9952|DOID:12603 G intron GWASdb_trait 9 135064788 rs11243657 C T rs11243657 9.06E-04 Methotrexate clearance (acute lymphoblastic leukemia) HPOID:0006721 DOID:9952|DOID:12603 T intron GWASdb_trait 9 135070104 rs7870760 A G rs7870760 0.0008786 Anti-TNF treatment response in rheumatoid arthritis (by DAS-28 score change at 3 months) HPOID:0001370 DOID:7148 G intron GWASdb_trait 9 135070104 rs7870760 A G rs7870760 8.79E-04 Methotrexate clearance (acute lymphoblastic leukemia) HPOID:0006721 DOID:9952|DOID:12603 G intron GWASdb_trait 9 135073967 rs3739930 C T rs3739930 9.11E-04 Methotrexate clearance (acute lymphoblastic leukemia) HPOID:0006721 DOID:9952|DOID:12603 G cds-synon GWASdb_trait 9 135074063 rs3739929 T C rs3739929 9.14E-04 Methotrexate clearance (acute lymphoblastic leukemia) HPOID:0006721 DOID:9952|DOID:12603 A intron GWASdb_trait 9 135080098 rs11243667 A G rs11243667 2.02E-04 Multiple complex diseases HPOID:0000118 NA A intron GWASdb_trait 9 135096767 rs11243676 G A rs11243676 3.00E-06 Systemic lupus erythematosus HPOID:0002725 DOID:9074 G intron GWASdb_trait 9 135099486 rs6597562 C T rs6597562 1.10E-05 Urinary metabolites HPOID:0000079 DOID:557 C intron GWASdb_trait 9 135114365 rs2274853 G A rs2274853 6.63E-04 Alcohol dependence HPOID:0000707 DOID:0050741 C intron GWASdb_trait