PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus NTNG2 LRRC4C doi:10.1038/emboj.2011.346,21946559 mint,intact exp G G G G G G G G EWSR1 NTNG2 16189514 hprd,biogrid,intact exp G G G G G G G G NTNG2 LRRC4 doi:10.1038/emboj.2011.346,21946559, 25402006 mint,intact exp, ortho, pred G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q96CW9 Q01844-6 two hybrid 16189514 direct interaction X 2 Q96CW9 unspecified method 20467438 direct interaction X 2 Q01844 Q96CW9 two hybrid 16189514 - X 2 Q01844 Q96CW9 two hybrid 16189514 - X 2 Q96CW9 Q9HCJ2 surface plasmon resonance 21946559 direct interaction X 2 Q96CW9 Q9HCJ2 surface plasmon resonance 21946559 direct interaction X 2 Q01844 Q96CW9 two hybrid pooling approach 16189514 physical association X 2 P31016 Q96CW9 peptide array 20467438 direct interaction X 2 Q9HBW1 Q96CW9 surface plasmon resonance 21946559 direct interaction X 2 Q9HBW1 Q96CW9 x-ray crystallography 21946559 direct interaction X 2 Q9HBW1 Q96CW9 surface plasmon resonance 21946559 direct interaction X 2 Q9HBW1 Q96CW9 light scattering 21946559 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B EWSR1 NTNG2 MI:0018(two hybrid)|MI:0096(pull down) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_80665|UniProt_153493 bait|unspecified role prey|unspecified role NTNG2 LRRC4 MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography) 21946559 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(intact)|(intact)|(intact) UniProt_116514|UniProt_116515|UniProt_116516|UniProt_116511 neutral component|prey|bait|neutral component neutral component|bait|prey|neutral component NTNG2 LRRC4C MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography) 21946559 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(intact) UniProt_116518|UniProt_116517 bait|prey prey|bait NTNG2 EWSR1 MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_20581 - -

PPI - HINT Gene A Gene B PMID Method Quality EWSR1 NTNG2 16189514,16189514 0398,0018 HT NTNG2 NTNG2 21946559 0114 LC NTNG2 LRRC4 21946559,21946559,21946559 0114,0107,0067 LC NTNG2 LRRC4C 21946559 0107 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9HBW1 Q96CW9 LRRC4 NTNG2 0.671 21946559 Q96CW9 P31016 NTNG2 DLG4 0.183 20467438 Q96CW9 Q01844 NTNG2 EWSR1 0.286 16189514 Q9HCJ2 Q96CW9 LRRC4C NTNG2 0.309 21946559

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 DLG4 NTNG2 MI:0362 inference MI:0461 interaction database EWSR1 NTNG2 MI:0045 experimental interaction detection MI:0461 interaction database NTNG2 LRRC4 MI:0045 experimental interaction detection MI:0461 interaction database NTNG2 LRRC4C MI:0045 experimental interaction detection MI:0461 interaction database