PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus DDI2 METTL14 26344197 biogrid exp P P P P P P P P P P P P P P DDI2 TRMT6 26344197 biogrid exp P P P P P P P P P P P P P P P PSMA2 DDI2 19193609 biogrid exp P P P P P P P P P P P P P P P HAT1 DDI2 26344197 biogrid exp P P P P P P P P P P P P P DDI2 HYPK 22863883 biogrid exp P P P P BAG3 DDI2 23824909 biogrid exp P P P P P P P P P P P P P P P TTC4 DDI2 26344197 biogrid exp P P P P P P P P P P P P P P P DDI2 NAA15 22863883 biogrid exp P P P P P P P P P P P NR1H3 DDI2 26186194 biogrid exp P P P P P P P P P P P P P P P DDI2 TLN2 26344197 biogrid exp P P P P P P P P P P P P P P DDI2 COA7 26344197 biogrid exp P P P P P P P P P P P P P P P VPS26A DDI2 22863883 biogrid exp P P P P P P P P P P P P P P P DDI2 RDH5 26186194 biogrid exp DDI2 FAM129B 22863883 biogrid exp P P P P P P P P P P P NAA10 DDI2 22863883 biogrid exp P P P P P P P P P P P P P P CCDC6 DDI2 26344197 biogrid exp P P P P P P P P TOM1 DDI2 26344197 biogrid exp P P P P P P P P P P P P P P P TALDO1 DDI2 ortho P P P P P P P P P P P P P P P DDI2 KANSL2 ortho P P P P P P P P P P P P P P P EIF4A3 DDI2 ortho P P P P P P P P P P P P P P P DDI2 DNAH7 ortho P P P P P P P P P P P P SLC38A11 DDI2 ortho P P P P P P P P P P P P PPP2CA DDI2 ortho P P P P P P P P P P P P P P P DDI2 MED30 ortho DDI2 PUF60 ortho P P P P P P P P P P P P P P DDI2 PLXDC2 ortho P P P P P P P P P P P P P P NEDD8 DDI2 ortho P P P P P P P P P P P P P P P GUSB DDI2 ortho P P P P P P P P P P P P P GARS DDI2 ortho P P P P P P P P P P P P P P P GPC5 DDI2 ortho P P P P P P P P P P DDI2 ABCF3 ortho P P P P P P P P P P P P P P P SEPHS1 DDI2 ortho P P P P P P P P P P P P P P P CLK2 DDI2 ortho P P P P P P P P P P P P PDIA3 DDI2 ortho P P P P P P P P P P P P P P P RPS27A DDI2 ortho P P P P P P P P P P P P P P P ABCC3 DDI2 ortho P P P P P P P P P P P DNM1 DDI2 ortho P P DDI2 C4orf27 ortho P P P P P P P P P P P P DDI2 ABCD2 ortho P P P P P P P P P P P P P P P UBA52 DDI2 ortho P P P P P P P P P P P P P P P CS DDI2 ortho P P P P P P P P P P P P P P P PSMC5 DDI2 ortho P P P P P P P P P P P P P P P PKM DDI2 ortho P P P P P P P P P P P P P P GNAS DDI2 ortho P P P P DDI2 USP7 23023127 pred P P P P P P P P P P P P P P P SUMO1 DDI2 23023127 pred P P P P P P P P P P P P P P DDI2 UBA2 23023127 pred P P P P P P P P P P P P P P P DDI2 UBTD2 23023127 pred P P P P P P P P P P P P P UBE2V2 DDI2 23023127 pred DDI2 UBQLN1 23023127 pred P P P P P P P P P P P P P P P RAD23A DDI2 23023127 pred P P P P P P P P P P P P P P P UBE2E1 DDI2 23023127 pred P P P P P P P P P DDI2 SH3RF2 23023127 pred P P P P P P P P P P P P DDI2 USP21 23023127 pred P P P P P P P P P P P UBE2V1 DDI2 23023127 pred UBE2D1 DDI2 23023127 pred P P P P P P P P P P P DDI2 UHRF2 23023127 pred P P P P P P P P P P P P P P P DDI2 USP51 23023127 pred P P P P P P P P P P P P P P UBE2D2 DDI2 23023127 pred P P P P P P P P P P P DDI2 GGA3 23023127 pred P P P P P P P P P P P P P P UBC DDI2 23023127 pred RIMBP2 DDI2 23023127 pred P P P P P P P P P P P P P DDI2 DDI1 23023127 pred P P P P P P DDI2 FAF1 23023127 pred P P P P P P P P P P P P P P USP2 DDI2 23023127 pred P P P P P P P P P P P P P P DDI2 EPS8L3 23023127 pred P P P P P P P TCEB1 DDI2 23023127 pred USP5 DDI2 23023127 pred P P P P P P P P P P P P P P RAD23B DDI2 25402006, 23023127 pred P P P P P P P P P P P P P P P UCHL3 DDI2 23023127 pred P P P P P P P P P P P P P P USP14 DDI2 23023127 pred P P P P P P P P P P P P P P P NCK1 DDI2 23023127 pred P P P P P P P P P P P P P P P DDI2 SENP2 23023127 pred P P P P P P P P P P P P P P P DDI2 UBL4B 23023127 pred P P P P P P P P P P P P P UBE2D3 DDI2 23023127 pred P P P P P P P P P P P UBE2G2 DDI2 23023127 pred P P P P P P P P P P P P P DDI2 UBQLN2 23023127 pred P P P P P P P P P P P P P P P UBXN2A DDI2 23023127 pred UBE2K DDI2 23023127 pred P P P P P P P P P P P P P P P UBE2I DDI2 23023127 pred P P P P P P P P P P P P P P DDI2 UBL7 23023127 pred P P P P P P P P P P P P P P P UBE2B DDI2 23023127 pred PARK2 DDI2 23023127 pred P P P P P P P P P P P P DDI2 CD2AP 23023127 pred P P P P P P P P P P P P P P DDI2 NSFL1C 23023127 pred P P P P P P P P P P P P P P P UBE2G1 DDI2 23023127 pred P P P P P P P P P P P P P P P ATXN3 DDI2 23023127 pred P P P P P P P P P P P P P P BAG6 DDI2 23023127 pred P P P P P P P P P P P P P P P DDI2 SENP1 23023127 pred P P P P P P P P P P P P P P P DDI2 USP44 23023127 pred P P P P P P P P P P P P P P DDI2 UBQLN3 23023127 pred UBXN2B DDI2 23023127 pred P P P P P P P P SUMO2 DDI2 23023127 pred P P P P P P P P P P P P P P P

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B BAG3 DDI2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23824909 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_282752|BIOGRID_282944 bait|bait prey|prey UBC DDI2 MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20639865,20972266,21139048,21890473,21906983,21963094,21987572,22053931,22505724,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_162857|BIOGRID_180213|BIOGRID_160136|BIOGRID_225324|BIOGRID_223155|BIOGRID_264345|BIOGRID_164245|BIOGRID_170997|BIOGRID_175512|BIOGRID_268012 bait|bait|bait|bait|bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey|prey|prey|prey|prey DDI2 HYPK MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_298790 bait prey DDI2 NAA15 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_299267 prey bait NAA10 DDI2 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_299266 bait prey PSMA2 DDI2 MI:0004(affinity chromatography technology) 19193609 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_200359 bait prey DDI2 FAM129B MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_299265 prey bait VPS26A DDI2 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304927 prey bait

PPI - HINT Gene A Gene B PMID Method Quality HAT1 DDI2 26344197 0401 HT TOM1 DDI2 26344197 0401 HT VPS26A DDI2 22863883 0401 HT TTC4 DDI2 26344197 0401 HT UBC DDI2 20972266,20639865 0004,0004 LC NAA10 DDI2 22863883 0401 HT NR1H3 DDI2 26186194 0004 HT CCDC6 DDI2 26344197 0401 HT DDI2 RDH5 26186194 0004 HT DDI2 COA7 26344197 0401 HT DDI2 FAM129B 22863883 0401 HT DDI2 NAA15 22863883 0401 HT DDI2 METTL14 26344197 0401 HT DDI2 HYPK 22863883 0401 HT DDI2 TRMT6 26344197 0401 HT DDI2 TLN2 26344197 0401 HT HAT1 DDI2 26344197 0401 HT TOM1 DDI2 26344197 0401 HT VPS26A DDI2 22863883 0401 HT TTC4 DDI2 26344197 0401 HT NAA10 DDI2 22863883 0401 HT NR1H3 DDI2 26186194 0004 HT CCDC6 DDI2 26344197 0401 HT DDI2 RDH5 26186194 0004 HT DDI2 COA7 26344197 0401 HT DDI2 FAM129B 22863883 0401 HT DDI2 NAA15 22863883 0401 HT DDI2 METTL14 26344197 0401 HT DDI2 HYPK 22863883 0401 HT DDI2 TRMT6 26344197 0401 HT DDI2 TLN2 26344197 0401 HT UBC DDI2 20972266,20639865 0004,0004 LC HAT1 DDI2 26344197 0401 LC TOM1 DDI2 26344197 0401 LC VPS26A DDI2 22863883 0401 LC TTC4 DDI2 26344197 0401 LC NAA10 DDI2 22863883 0401 LC CCDC6 DDI2 26344197 0401 LC DDI2 DDI2 PDB_4RGH 0114 LC DDI2 COA7 26344197 0401 LC DDI2 FAM129B 22863883 0401 LC DDI2 NAA15 22863883 0401 LC DDI2 METTL14 26344197 0401 LC DDI2 HYPK 22863883 0401 LC DDI2 TRMT6 26344197 0401 LC DDI2 TLN2 26344197 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5TDH0 O14929 DDI2 HAT1 0.081 26344197 Q5TDH0 O60784 DDI2 TOM1 0.081 26344197 Q5TDH0 O75436 DDI2 VPS26A 0.081 22863883 Q5TDH0 O95801 DDI2 TTC4 0.081 26344197 Q5TDH0 Q16204 DDI2 CCDC6 0.081 26344197 Q96BR5 Q5TDH0 COA7 DDI2 0.081 26344197 Q9NX55 Q5TDH0 HYPK DDI2 0.081 22863883 Q9UJA5 Q5TDH0 TRMT6 DDI2 0.081 26344197 Q9Y4G6 Q5TDH0 TLN2 DDI2 0.081 26344197 Q9HCE5 Q5TDH0 METTL14 DDI2 0.081 26344197 Q5TDH0 P25787 DDI2 PSMA2 0.126 19193609 Q5TDH0 O95817 DDI2 BAG3 0.126 23824909 Q92781 Q5TDH0 RDH5 DDI2 0.126 26186194 Q9BXJ9 Q5TDH0 NAA15 DDI2 0.081 22863883 Q96TA1 Q5TDH0 FAM129B DDI2 0.081 22863883 Q5TDH0 P41227 DDI2 NAA10 0.081 22863883 Q5TDH0 Q13133 DDI2 NR1H3 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 PSMD14 DDI2 MI:0362 inference MI:0461 interaction database DVL2 DDI2 MI:0362 inference MI:0461 interaction database STX16 DDI2 MI:0362 inference MI:0461 interaction database BCL2L11 DDI2 MI:0362 inference MI:0461 interaction database VAMP4 DDI2 MI:0362 inference MI:0461 interaction database CS DDI2 MI:0362 inference MI:0461 interaction database BAG3 DDI2 MI:0045 experimental interaction detection MI:0461 interaction database CAT DDI2 MI:0362 inference MI:0461 interaction database HSP90AB1 DDI2 MI:0362 inference MI:0461 interaction database UBB DDI2 MI:0362 inference MI:0461 interaction database UBC DDI2 MI:0045 experimental interaction detection MI:0461 interaction database HSPD1 DDI2 MI:0362 inference MI:0461 interaction database PSKH1 DDI2 MI:0362 inference MI:0461 interaction database PSMC3 DDI2 MI:0362 inference MI:0461 interaction database PSMA2 DDI2 MI:0045 experimental interaction detection MI:0461 interaction database PDIA3 DDI2 MI:0362 inference MI:0461 interaction database STX2 DDI2 MI:0362 inference MI:0461 interaction database TALDO1 DDI2 MI:0362 inference MI:0461 interaction database GNAL DDI2 MI:0362 inference MI:0461 interaction database EIF4A3 DDI2 MI:0362 inference MI:0461 interaction database HNF4A DDI2 MI:0045 experimental interaction detection MI:0461 interaction database RPS27 DDI2 MI:0362 inference MI:0461 interaction database PSMD8 DDI2 MI:0362 inference MI:0461 interaction database PSMB2 DDI2 MI:0362 inference MI:0461 interaction database SEPHS1 DDI2 MI:0362 inference MI:0461 interaction database DNM2 DDI2 MI:0362 inference MI:0461 interaction database GPC3 DDI2 MI:0362 inference MI:0461 interaction database RAD23A DDI2 MI:0362 inference MI:0461 interaction database RAD23B DDI2 MI:0362 inference MI:0461 interaction database PSMD4 DDI2 MI:0362 inference MI:0461 interaction database STX1B DDI2 MI:0362 inference MI:0461 interaction database PSMC5 DDI2 MI:0362 inference MI:0461 interaction database PPP2CB DDI2 MI:0362 inference MI:0461 interaction database RPS27A DDI2 MI:0362 inference MI:0461 interaction database UBA52 DDI2 MI:0362 inference MI:0461 interaction database VAMP2 DDI2 MI:0362 inference MI:0461 interaction database PPP2CA DDI2 MI:0362 inference MI:0461 interaction database GPC5 DDI2 MI:0362 inference MI:0461 interaction database ACY1 DDI2 MI:0362 inference MI:0461 interaction database DNM1 DDI2 MI:0362 inference MI:0461 interaction database NR1H3 DDI2 MI:0045 experimental interaction detection MI:0461 interaction database PSMD2 DDI2 MI:0362 inference MI:0461 interaction database STX3 DDI2 MI:0362 inference MI:0461 interaction database CUL1 DDI2 MI:0362 inference MI:0461 interaction database CUL2 DDI2 MI:0362 inference MI:0461 interaction database CAMK1 DDI2 MI:0362 inference MI:0461 interaction database VAMP3 DDI2 MI:0362 inference MI:0461 interaction database NEDD8 DDI2 MI:0362 inference MI:0461 interaction database CAMK4 DDI2 MI:0362 inference MI:0461 interaction database STX1A DDI2 MI:0362 inference MI:0461 interaction database GNPTAB DDI2 MI:0362 inference MI:0461 interaction database NOL9 DDI2 MI:0362 inference MI:0461 interaction database DDI2 PNCK MI:0362 inference MI:0461 interaction database DDI2 PLXDC2 MI:0362 inference MI:0461 interaction database DDI2 SSH2 MI:0362 inference MI:0461 interaction database DDI2 CAMK1D MI:0362 inference MI:0461 interaction database DDI2 PLXDC1 MI:0362 inference MI:0461 interaction database DDI2 DDI1 MI:0362 inference MI:0461 interaction database DDI2 DNAH7 MI:0362 inference MI:0461 interaction database DDI2 SSH1 MI:0362 inference MI:0461 interaction database DDI2 RDH5 MI:0045 experimental interaction detection MI:0461 interaction database DDI2 MED30 MI:0362 inference MI:0461 interaction database DDI2 CAMK1G MI:0362 inference MI:0461 interaction database DDI2 SCPEP1 MI:0362 inference MI:0461 interaction database DDI2 ABCF3 MI:0362 inference MI:0461 interaction database DDI2 C4orf27 MI:0362 inference MI:0461 interaction database DDI2 ABCD2 MI:0362 inference MI:0461 interaction database DDI2 PUF60 MI:0362 inference MI:0461 interaction database DDI2 PSMD13 MI:0362 inference MI:0461 interaction database DDI2 DNM3 MI:0362 inference MI:0461 interaction database DDI2 WBP11 MI:0362 inference MI:0461 interaction database DDI2 EXOSC1 MI:0362 inference MI:0461 interaction database