PTM - CPLM Gene Name UniProt ID Type Position Code DDI2 Q5TDH0 Ubiquitination 153 K DDI2 Q5TDH0 Ubiquitination 170 K DDI2 Q5TDH0 Ubiquitination 67 K DDI2 Q5TDH0 Ubiquitination 77 K DDI2 Q5TDH0 Ubiquitination 283 K DDI2 Q5TDH0 Ubiquitination 289 K DDI2 Q5TDH0 Ubiquitination 389 K DDI2 Q5TDH0 Ubiquitination 338 K DDI2 Q5TDH0 Ubiquitination 337 K DDI2 Q5TDH0 Ubiquitination 205 K

PTM - dbPAF Gene Name UniProt ID Position Type Species DDI2 Q5TDH0 104 T Homo sapiens(Human) DDI2 Q5TDH0 105 S Homo sapiens(Human) DDI2 Q5TDH0 106 S Homo sapiens(Human) DDI2 Q5TDH0 115 T Homo sapiens(Human) DDI2 Q5TDH0 118 S Homo sapiens(Human) DDI2 Q5TDH0 120 S Homo sapiens(Human) DDI2 Q5TDH0 121 S Homo sapiens(Human) DDI2 Q5TDH0 126 T Homo sapiens(Human) DDI2 Q5TDH0 127 S Homo sapiens(Human) DDI2 Q5TDH0 128 S Homo sapiens(Human) DDI2 Q5TDH0 150 S Homo sapiens(Human) DDI2 Q5TDH0 194 S Homo sapiens(Human) DDI2 Q5TDH0 98 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q5TDH0 R108-m1 Methylation VPGtssPrQRQPPGt Q5TDH0 R182-m1 Methylation LVEQQQDrARREQER Q5TDH0 S98-p Phosphorylation LPRIDFSsIAVPGts Q5TDH0 T104-p Phosphorylation SsIAVPGtssPrQRQ Q5TDH0 S105-p Phosphorylation sIAVPGtssPrQRQP Q5TDH0 S106-p Phosphorylation IAVPGtssPrQRQPP Q5TDH0 T115-p Phosphorylation rQRQPPGtQQsHSsP Q5TDH0 S118-p Phosphorylation QPPGtQQsHSsPGEI Q5TDH0 S121-p Phosphorylation GtQQsHSsPGEITss Q5TDH0 S127-p Phosphorylation SsPGEITssPQGLDN Q5TDH0 S128-p Phosphorylation sPGEITssPQGLDNP Q5TDH0 S150-p Phosphorylation LANPHELsLLkERNP Q5TDH0 S194-p Phosphorylation QERIRLFsADPFDLE Q5TDH0 K67-ub Ubiquitination SLASYGLkDGDVVIL Q5TDH0 K77-ub Ubiquitination DVVILRQkENADPRP Q5TDH0 K153-ub Ubiquitination PHELsLLkERNPPLA Q5TDH0 K170-ub Ubiquitination LLSGDLEkFSRVLVE Q5TDH0 K205-ub Ubiquitination FDLEAQAkIEEDIRQ Q5TDH0 K283-ub Ubiquitination RRWAGIAkGVGTQkI Q5TDH0 K289-ub Ubiquitination AkGVGTQkIIGRVHL Q5TDH0 K337-ub Ubiquitination HQCSIDLkkNVLVIG Q5TDH0 K338-ub Ubiquitination QCSIDLkkNVLVIGT Q5TDH0 K389-ub Ubiquitination ELAEALQkSAEDAER

PTM - dbPTM UniProt ID Position Code Type Resources References Q5TDH0 106 S Phosphorylation Swiss-Prot 1010711 18669648;19413330;19690332 Q5TDH0 128 S Phosphorylation Swiss-Prot 1010711 19690332 Q5TDH0 194 S Phosphorylation Swiss-Prot 1010711 17081983;18669648;19690332 Q5TDH0 106 S Phosphorylation PhosphoELM.10011 18669648 Q5TDH0 120 S Phosphorylation PhosphoELM.10011 18669648 Q5TDH0 121 S Phosphorylation PhosphoELM.10011 18669648 Q5TDH0 128 S Phosphorylation PhosphoELM.10011 18669648 Q5TDH0 194 S Phosphorylation PhosphoELM.10011 18669648;17081983 Q5TDH0 153 K Ubiquitylation Phosphositeplus.1010730 20639865;21890473;21906983 Q5TDH0 170 K Ubiquitylation Phosphositeplus.1010730 20639865;20972266;21890473;21906983 Q5TDH0 205 K Ubiquitylation Phosphositeplus.1010730 21906983 Q5TDH0 283 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q5TDH0 289 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q5TDH0 389 K Ubiquitylation Phosphositeplus.1010730 21906983 Q5TDH0 67 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q5TDH0 77 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q5TDH0 105 S Phosphorylation Phosphositeplus.1010730 18187866 Q5TDH0 106 S Phosphorylation Phosphositeplus.1010730 17446864;18187866;18669648;19664995;19690332;20068231;20230923;21659604;22115753 Q5TDH0 121 S Phosphorylation Phosphositeplus.1010730 21659604 Q5TDH0 128 S Phosphorylation Phosphositeplus.1010730 19690332 Q5TDH0 150 S Phosphorylation Phosphositeplus.1010730 20068231 Q5TDH0 194 S Phosphorylation Phosphositeplus.1010730 17081983;18669648;19690332;20068231;21406692 Q5TDH0 104 T Phosphorylation Phosphositeplus.1010730 18187866;19664995 Q5TDH0 105 S Phosphorylation HPRD 9.0 20230923 Q5TDH0 106 S Phosphorylation HPRD 9.0 18669648,19413330,19664995,20230923,20068231 Q5TDH0 118 S Phosphorylation HPRD 9.0 20068231 Q5TDH0 120 S Phosphorylation HPRD 9.0 18669648,20068231 Q5TDH0 121 S Phosphorylation HPRD 9.0 18669648,20068231 Q5TDH0 128 S Phosphorylation HPRD 9.0 18669648,20068231 Q5TDH0 150 S Phosphorylation HPRD 9.0 20068231 Q5TDH0 194 S Phosphorylation HPRD 9.0 17081983,18669648,20068231 Q5TDH0 104 T Phosphorylation HPRD 9.0 19664995,20068231 Q5TDH0 115 T Phosphorylation HPRD 9.0 20068231 Q5TDH0 106 S Phosphorylation SysPTM 1.1 18669648 Q5TDH0 194 S Phosphorylation SysPTM 1.1 18669648;17081983

PTM - HPRD Symbol Position Code Type References DDI2 104 T Phosphorylation 19664995,20068231 DDI2 105 S Phosphorylation 20230923 DDI2 106 S Phosphorylation 18669648,19413330,19664995,20230923,20068231 DDI2 115 T Phosphorylation 20068231 DDI2 118 S Phosphorylation 20068231 DDI2 120 S Phosphorylation 18669648,20068231 DDI2 121 S Phosphorylation 18669648,20068231 DDI2 128 S Phosphorylation 18669648,20068231 DDI2 150 S Phosphorylation 20068231 DDI2 194 S Phosphorylation 17081983,18669648,20068231

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q5TDH0 128 S 18669648 HTP Phosphorylation Q5TDH0 194 S 18669648 HTP Phosphorylation Q5TDH0 194 S 17081983 HTP Phosphorylation Q5TDH0 120 S 18669648 HTP Phosphorylation Q5TDH0 106 S 18669648 HTP Phosphorylation Q5TDH0 121 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q5TDH0 104 Phosphothreonine 23186163 Q5TDH0 106 Phosphoserine 18669648;19690332;20068231;23186163 Q5TDH0 121 Phosphoserine 23186163 Q5TDH0 128 Phosphoserine 19690332 Q5TDH0 150 Phosphoserine 23186163 Q5TDH0 194 Phosphoserine 17081983;19690332;20068231;21406692;23186163

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 84301 124027 - K Ubiquitination 20639865 84301 124027 - K Ubiquitination 21987572 84301 124027 - K Ubiquitination 20972266 84301 124027 - K Ubiquitination 21139048 84301 124027 - K Ubiquitination 21890473 84301 124027 - K Ubiquitination 21906983 84301 124027 - K Ubiquitination 22053931 84301 124027 - K Ubiquitination 22505724 84301 124027 - K Ubiquitination 21963094 84301 124027 - K Ubiquitination 23000965 84301 124027 - K Ubiquitination 24816145 84301 124027 - K Ubiquitination 25015289

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID DDI2 Homo sapiens (Human) 205; 153; 170; 289; 67; 283; 77; 389 "205,DLEAQAKIEEDIR; 153,HELSLLKERNPPL; 170,LSGDLEKFSRVLV; 289,KGVGTQKIIGRVH; 67,LASYGLKDGDVVI; 283,RWAGIAKGVGTQK; 77,VVILRQKENADPR; 389,LAEALQKSAEDAE" "205:21906983; 153:21890473,21906983; 170:21890473,21906983; 289:21890473,21906983; 67:21890473,21906983; 283:21890473,21906983; 77:21890473,21906983; 389:21906983" DDI2 Homo sapiens (Human) 205; 153; 170; 67; 77 "205,DLEAQAKIEEDIR; 153,HELSLLKERNPPL; 170,LSGDLEKFSRVLV; 67,LASYGLKDGDVVI; 77,VVILRQKENADPR" "205:21906983; 153:21890473,21906983; 170:21890473,21906983; 67:21890473,21906983; 77:21890473,21906983" DDI2 Homo sapiens (Human) 205; 153; 170; 289; 67; 283; 77 "205,DLEAQAKIEEDIR; 153,HELSLLKERNPPL; 170,LSGDLEKFSRVLV; 289,KGVGTQKIIGRVH; 67,LASYGLKDGDVVI; 283,RWAGIAKGVGTQK; 77,VVILRQKENADPR" "205:21906983; 153:21890473,21906983; 170:21890473,21906983; 289:21890473,21906983; 67:21890473,21906983; 283:21890473,21906983; 77:21890473,21906983" DDI2 Homo sapiens (Human) 205; 170; 153; 67 "205,DLEAQAKIEEDIR; 170,LSGDLEKFSRVLV; 153,HELSLLKERNPPL; 67,LASYGLKDGDVVI" 205:22053931; 170:22053931; 153:22053931; 67:22053931 DDI2 Homo sapiens (Human) 170 "170,LSGDLEKFSRVLV" 170:20972266