Disease associated variation - GWASdb Chr Pos SNP ID(dbSNP 142) Ref Alt Ori SNP ID P-value Drug Name Drug Anno GWAS Trait HPO ID DO ID AA Type Trait or Drug 6 136884168 rs2327742 A G rs2327742 1.14E-04 ALDOSTERONE BIOLOGICAL MARKERS|NATRIURETIC PEPTIDE, BRAIN|RENIN Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 G intron GWASdb_drug 6 136884168 rs2327742 A G rs2327742 6.76E-05 ALDOSTERONE BIOLOGICAL MARKERS|NATRIURETIC PEPTIDE, BRAIN|RENIN Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 G intron GWASdb_drug 6 136909242 rs2327743 T C rs2327743 4.94E-04 ALDOSTERONE BIOLOGICAL MARKERS|NATRIURETIC PEPTIDE, BRAIN|RENIN Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 C intron GWASdb_drug 6 136909242 rs2327743 T C rs2327743 6.01E-05 ALDOSTERONE BIOLOGICAL MARKERS|NATRIURETIC PEPTIDE, BRAIN|RENIN Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 C intron GWASdb_drug 6 136909664 rs760862 T C rs760862 7.13E-05 ALDOSTERONE BIOLOGICAL MARKERS|NATRIURETIC PEPTIDE, BRAIN|RENIN Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 T,C intron GWASdb_drug 6 136909664 rs760862 T C rs760862 9.71E-04 ALDOSTERONE BIOLOGICAL MARKERS|NATRIURETIC PEPTIDE, BRAIN|RENIN Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 T,C intron GWASdb_drug 6 136913217 rs2076262 T C rs2076262 3.43E-05 ALDOSTERONE BIOLOGICAL MARKERS|NATRIURETIC PEPTIDE, BRAIN|RENIN Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 C intron GWASdb_drug 6 136913217 rs2076262 T C rs2076262 6.27E-04 ALDOSTERONE BIOLOGICAL MARKERS|NATRIURETIC PEPTIDE, BRAIN|RENIN Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 C intron GWASdb_drug 6 136939818 rs9321564 A G rs9321564 1.03E-04 ALDOSTERONE BIOLOGICAL MARKERS|NATRIURETIC PEPTIDE, BRAIN|RENIN Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 G intron GWASdb_drug 6 136939818 rs9321564 A G rs9321564 1.42E-04 ALDOSTERONE BIOLOGICAL MARKERS|NATRIURETIC PEPTIDE, BRAIN|RENIN Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 G intron GWASdb_drug 6 136944063 rs3765258 A G rs3765258 2.03E-05 ALDOSTERONE BIOLOGICAL MARKERS|NATRIURETIC PEPTIDE, BRAIN|RENIN Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 G cds-synon GWASdb_drug 6 136944063 rs3765258 A G rs3765258 5.00E-04 ALDOSTERONE BIOLOGICAL MARKERS|NATRIURETIC PEPTIDE, BRAIN|RENIN Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 G cds-synon GWASdb_drug 6 136944063 rs3765258 A G rs3765258 7.87E-04 ALDOSTERONE BIOLOGICAL MARKERS|NATRIURETIC PEPTIDE, BRAIN|RENIN Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 G cds-synon GWASdb_drug 6 136947278 rs9389418 C A rs9389418 2.00E-05 ALDOSTERONE BIOLOGICAL MARKERS|NATRIURETIC PEPTIDE, BRAIN|RENIN Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 C intron GWASdb_drug 6 136947278 rs9389418 C A rs9389418 7.75E-04 ALDOSTERONE BIOLOGICAL MARKERS|NATRIURETIC PEPTIDE, BRAIN|RENIN Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 C intron GWASdb_drug 6 136947278 rs9389418 C A rs9389418 9.39E-04 ALDOSTERONE BIOLOGICAL MARKERS|NATRIURETIC PEPTIDE, BRAIN|RENIN Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 C intron GWASdb_drug 6 136947540 rs17723608 A G rs17723608 1.92E-04 ALDOSTERONE BIOLOGICAL MARKERS|NATRIURETIC PEPTIDE, BRAIN|RENIN Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 G intron GWASdb_drug 6 137059166 rs7747030 T C rs7747030 1.26E-05 CISPLATIN DEATH-ASSOCIATED PROTEIN KINASES|ANTINEOPLASTIC AGENTS|CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES|METHYLTRANSFERASES|DAPK3 PROTEIN, HUMAN|PROTEIN SUBUNITS|RNA, SMALL INTERFERING|APOPTOSIS REGULATORY PROTEINS Response to platinum-based chemotherapy in small cell and non-small cell lung cancers HPOID:0100526 DOID:3908|DOID:5409 T intron GWASdb_drug 6 136884168 rs2327742 A G rs2327742 1.14E-04 Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 G intron GWASdb_trait 6 136884168 rs2327742 A G rs2327742 6.76E-05 Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 G intron GWASdb_trait 6 136884811 rs13203080 G A rs13203080 5.33E-05 Migraine HPOID:0002076 DOID:6364 G intron GWASdb_trait 6 136909242 rs2327743 T C rs2327743 4.94E-04 Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 C intron GWASdb_trait 6 136909242 rs2327743 T C rs2327743 6.01E-05 Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 C intron GWASdb_trait 6 136909664 rs760862 T C rs760862 2.56E-04 Multiple complex diseases HPOID:0000118 NA T,C intron GWASdb_trait 6 136909664 rs760862 T C rs760862 7.13E-05 Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 T,C intron GWASdb_trait 6 136913217 rs2076262 T C rs2076262 3.43E-05 Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 C intron GWASdb_trait 6 136913217 rs2076262 T C rs2076262 6.27E-04 Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 C intron GWASdb_trait 6 136915761 rs6926904 C G rs6926904 5.18E-05 Multiple complex diseases HPOID:0000118 NA G intron GWASdb_trait 6 136939818 rs9321564 A G rs9321564 1.03E-04 Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 G intron GWASdb_trait 6 136939818 rs9321564 A G rs9321564 1.42E-04 Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 G intron GWASdb_trait 6 136944063 rs3765258 A G rs3765258 2.03E-05 Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 G cds-synon GWASdb_trait 6 136944063 rs3765258 A G rs3765258 5.00E-04 Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 G cds-synon GWASdb_trait 6 136944063 rs3765258 A G rs3765258 7.87E-04 Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 G cds-synon GWASdb_trait 6 136944063 rs3765258 A G rs3765258 7.38E-05 Nephrolithiasis HPOID:0000787 DOID:585 G cds-synon GWASdb_trait 6 136947278 rs9389418 C A rs9389418 2.00E-05 Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 C intron GWASdb_trait 6 136947278 rs9389418 C A rs9389418 7.75E-04 Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 C intron GWASdb_trait 6 136947540 rs17723608 A G rs17723608 1.92E-04 Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 G intron GWASdb_trait 6 136963562 rs9494548 C T rs9494548 0.00048 Coronary artery calcification HPOID:0001677 DOID:3393 C intron GWASdb_trait 6 136963890 rs9376219 C T rs9376219 5.88E-05 Heart Rate HPOID:0005150|HPOID:0001645|HPOID:0001644|HPOID:0011704|HPOID:0005110 DOID:10273 C intron GWASdb_trait 6 136992379 rs9376221 T C rs9376221 3.90E-07 Atopy HPOID:0001047 DOID:0060056 T intron GWASdb_trait 6 137033706 rs911185 T C rs911185 1.15E-04 Diabetic nephropathy HPOID:0000819|HPOID:0000112 DOID:783|DOID:9352 G intron GWASdb_trait 6 137050651 rs7769773 T G rs7769773 1.10E-13 Cholesterol, total HPOID:0003107 DOID:3393|DOID:3146|DOID:2349 T intron GWASdb_trait 6 137050896 rs6570091 T C rs6570091 7.31E-06 Lymphocyte counts HPOID:0004332|HPOID:0002665 DOID:2841|DOID:1240|DOID:0060058|DOID:614|DOID:1287 T intron GWASdb_trait 6 137059166 rs7747030 T C rs7747030 1.26E-05 Response to platinum-based chemotherapy in small cell and non-small cell lung cancers HPOID:0100526 DOID:3908|DOID:5409 T intron GWASdb_trait 6 137061013 rs17654215 T C rs17654215 6.43E-04 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 T intron GWASdb_trait 6 137095679 rs9321570 G C rs9321570 8.90E-05 Diabetic nephropathy HPOID:0000819|HPOID:0000112 DOID:783|DOID:9352 C intron GWASdb_trait 6 137104793 rs9494569 C G rs9494569 5.60E-05 Diabetic nephropathy HPOID:0000819|HPOID:0000112 DOID:783|DOID:9352 G intron GWASdb_trait 6 137105400 rs9483947 C T rs9483947 5.60E-05 Diabetic nephropathy HPOID:0000819|HPOID:0000112 DOID:783|DOID:9352 T intron GWASdb_trait 6 137112633 rs3734552 A G rs3734552 1.62E-04 Attention deficit hyperactivity disorder HPOID:0007018 DOID:1094 G intron GWASdb_trait

Disease associated variation - OMIM Ensembl_gene_ID Approved Gene Symbol MIM Number ENSG00000197442.9 MAP3K5 602448