PTM - CPLM Gene Name UniProt ID Type Position Code MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 Sumoylation 535 K MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 Sumoylation 1083 K MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 Sumoylation 1114 K MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 Ubiquitination 827 K

PTM - dbPAF Gene Name UniProt ID Position Type Species MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 1029 S Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 1033 S Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 1109 T Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 115 S Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 1240 S Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 1326 T Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 461 S Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 528 T Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 570 Y Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 574 Y Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 718 Y Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 813 T Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 814 Y Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 82 S Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 821 S Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 825 T Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 83 S Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 836 T Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 838 T Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 842 T Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 955 S Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 958 S Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 964 S Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 966 S Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 976 T Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 977 S Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 978 S Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 979 S Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 982 Y Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 984 S Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 986 S Homo sapiens(Human) MAP3K5; ASK1; MAPKKK5; MEKK5 Q99683 989 T Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q99683 K946-ac Acetylation KVSSKKKkTQPKLSA Q99683 R89-me Methylation ssVGGGSrRTTVAYV Q99683 S82-p Phosphorylation SATRGRGssVGGGSr Q99683 S83-p Phosphorylation ATRGRGssVGGGSrR Q99683 S101-p Phosphorylation AYVINEAsQGQLVVA Q99683 S115-p Phosphorylation AESEALQsLREACET Q99683 S461-p Phosphorylation KVGVKLSsLLGKKGN Q99683 T528-p Phosphorylation YKHFVKLtTEQPVAk Q99683 Y570-p Phosphorylation ILEPTKIyQPSyLSI Q99683 Y574-p Phosphorylation TKIyQPSyLSINNEV Q99683 Y718-p Phosphorylation IPERDSRySQPLHEE Q99683 T813-p Phosphorylation GDNVLINtySGVLKI Q99683 Y814-p Phosphorylation DNVLINtySGVLKIs Q99683 S821-p Phosphorylation ySGVLKIsDFGtSKR Q99683 T825-p Phosphorylation LKIsDFGtSKRLAGI Q99683 T838-p Phosphorylation GINPCTEtFTGtLQY Q99683 T842-p Phosphorylation CTEtFTGtLQYMAPE Q99683 S958-p Phosphorylation LSALSAGsNEYLRsI Q99683 S964-p Phosphorylation GsNEYLRsIsLPVPV Q99683 S966-p Phosphorylation NEYLRsIsLPVPVLV Q99683 Y982-p Phosphorylation DTSSSSEyGSVsPDT Q99683 S986-p Phosphorylation SSEyGSVsPDTELKV Q99683 S997-p Phosphorylation ELKVDPFsFKTRAKS Q99683 S1029-p Phosphorylation DENFEDHsAPPsPEE Q99683 S1033-p Phosphorylation EDHsAPPsPEEKDSG Q99683 T1059-p Phosphorylation ATLHRILtEDQDKIV Q99683 T1109-p Phosphorylation DRKIIATtLSKLkLE Q99683 S1240-p Phosphorylation DSQSAHRsLNVQLGR Q99683 T1326-p Phosphorylation VNGADEDtISRFLAE Q99683 K535-sm Sumoylation tTEQPVAkQELVDFW Q99683 K1083-sm Sumoylation GAEEPKLkWEHITTL Q99683 K1114-sm Sumoylation ATtLSKLkLELDFDS

PTM - dbPTM UniProt ID Position Code Type Resources References Q99683 83 S Phosphorylation Swiss-Prot 1010711 11154276;12697749;19749799 Q99683 718 Y Phosphorylation Swiss-Prot 1010711 16407264 Q99683 813 T Phosphorylation Swiss-Prot 1010711 17937911 Q99683 836 T Phosphorylation Swiss-Prot 1010711 19369195 Q99683 838 T Phosphorylation Swiss-Prot 1010711 11689443;11920685;17210579;17937911;18948261;19369195 Q99683 842 T Phosphorylation Swiss-Prot 1010711 17937911 Q99683 958 S Phosphorylation Swiss-Prot 1010711 19369195 Q99683 966 S Phosphorylation Swiss-Prot 1010711 14688258;15094778 Q99683 976 T Phosphorylation Swiss-Prot 1010711 19369195 Q99683 977 S Phosphorylation Swiss-Prot 1010711 19369195 Q99683 978 S Phosphorylation Swiss-Prot 1010711 19369195 Q99683 979 S Phosphorylation Swiss-Prot 1010711 19369195 Q99683 984 S Phosphorylation Swiss-Prot 1010711 19369195 Q99683 986 S Phosphorylation Swiss-Prot 1010711 19369195 Q99683 989 T Phosphorylation Swiss-Prot 1010711 19369195 Q99683 1029 S Phosphorylation Swiss-Prot 1010711 18088087;18669648 Q99683 1033 S Phosphorylation Swiss-Prot 1010711 15094778;18088087;18669648;19369195 Q99683 1029 S Phosphorylation PhosphoELM.10011 18088087 Q99683 1033 S Phosphorylation PhosphoELM.10011 18088087;15094778 Q99683 966 S Phosphorylation PhosphoELM.10011 10411906 Q99683 83 S Phosphorylation PhosphoELM.10011 14500571;11154276;11154276 Q99683 838 T Phosphorylation PhosphoELM.10011 11920685;15755722 Q99683 1083 K Sumoylation Phosphositeplus.1010730 16142216 Q99683 1114 K Sumoylation Phosphositeplus.1010730 16142216 Q99683 535 K Sumoylation Phosphositeplus.1010730 16142216 Q99683 1029 S Phosphorylation Phosphositeplus.1010730 18088087;18669648;20363803 Q99683 1033 S Phosphorylation Phosphositeplus.1010730 15094778;18088087;18669648;19369195;20363803;22115753 Q99683 83 S Phosphorylation Phosphositeplus.1010730 11154276;12697749;14500571;15242986;15558056;15782121;15911620;16532036;18794113;19004820;19749799;19920149 Q99683 958 S Phosphorylation Phosphositeplus.1010730 19369195 Q99683 966 S Phosphorylation Phosphositeplus.1010730 10411906;14688258;15094778;15755722;16648474;17671211;18794113;19004820;19920149;19935702 Q99683 986 S Phosphorylation Phosphositeplus.1010730 19369195 Q99683 813 T Phosphorylation Phosphositeplus.1010730 17937911 Q99683 838 T Phosphorylation Phosphositeplus.1010730 15755722;15782121;17671211;17937911;19004820;19287004;19369195;19590015;19920149 Q99683 842 T Phosphorylation Phosphositeplus.1010730 17937911 Q99683 718 Y Phosphorylation Phosphositeplus.1010730 19287004 Q99683 814 Y Phosphorylation Phosphositeplus.1010730 18083107 Q99683 842 T Dephosphorylation HPRD 9.0 11689443 Q99683 966 S Phosphorylation HPRD 9.0 10411906 Q99683 1029 S Phosphorylation HPRD 9.0 18669648,18691976,18088087 Q99683 1033 S Phosphorylation HPRD 9.0 18669648,18088087 Q99683 842 T Phosphorylation HPRD 9.0 11920685 Q99683 83 S Phosphorylation (AKT1) HPRD 9.0 11154276 Q99683 838 T Phosphorylation (MAP3K5) HPRD 9.0 11920685 Q99683 869 C S-nitrosylation dbSNO 1.0 14668338;15688001 Q99683 1029 S Phosphorylation SysPTM 1.1 18669648;18088087 Q99683 1033 S Phosphorylation SysPTM 1.1 18669648;18088087

PTM - HPRD Symbol Position Code Type References MAP3K5 1029 S Phosphorylation 18669648,18691976,18088087 MAP3K5 1033 S Phosphorylation 18669648,18088087 MAP3K5 83 S Phosphorylation 11154276 MAP3K5 838 T Phosphorylation 11920685 MAP3K5 842 T Dephosphorylation 11689443 MAP3K5 842 T Phosphorylation 11920685 MAP3K5 966 S Phosphorylation 10411906

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q99683 838 T 11920685 LTP Phosphorylation Q99683 838 T 15755722 PDK-1 LTP Phosphorylation Q99683 1033 S 18088087 HTP Phosphorylation Q99683 1033 S 15094778 LTP Phosphorylation Q99683 83 S 14500571 PKB_group LTP Phosphorylation Q99683 83 S 11154276 PKB_group LTP Phosphorylation Q99683 83 S 11154276 PKB_beta LTP Phosphorylation Q99683 966 S 10411906 MAP3K5 LTP Phosphorylation Q99683 1029 S 18088087 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q99683 718 Phosphotyrosine 16407264 Q99683 813 Phosphothreonine; by autocatalysis 17937911 Q99683 842 Phosphothreonine; by autocatalysis 17937911 Q99683 958 Phosphoserine 23186163 Q99683 966 Phosphoserine 14688258;15094778;19590015 Q99683 1029 Phosphoserine 18088087;18669648 Q99683 1033 Phosphoserine 18088087;18669648;19369195;15094778;19590015

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type MAP3K5 IPI00412433 S 958 SALSAGpSNEYLRS phosphorylation MAP3K5 IPI00748581 S 1066 SEYGSVpSPDTELK phosphorylation MAP3K5 IPI00748581 S 1113 DHSAPPpSPEEKDS phosphorylation MAP3K5 IPI00748581 S 55 LARRARpSSPELWL phosphorylation MAP3K5 IPI00748581 S 56 ARRARSpSPELWLA phosphorylation MAP3K5 IPI00748581 T 918 INPCTEpTFTGTLQ phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 4217 110381 - K Ubiquitination 17595347 4217 110381 - K Ubiquitination 16038411 4217 110381 - K Ubiquitination 20005844 4217 110381 - K Ubiquitination 19306926 4217 110381 - K Ubiquitination 20448643 4217 110381 - K Ubiquitination 20349136