PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus BMI1 UBL5 24457600 innatedb,biogrid exp UBE2N UBL5 26344197 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G EFTUD2 UBL5 25092792 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CLK1 UBL5 12705895 hprd,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PQBP1 UBL5 25092792 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TXN UBL5 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MFAP1 UBL5 25092792 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PRPF38A UBL5 25092792 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRIM27 UBL5 21516116 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SART1 UBL5 22365833,24872507,23726919,21614000,15620657,25092792 hprd,biogrid,i2d,mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G HSPB2 UBL5 12705895 biogrid exp G G G G G G G G G G G G UBL5 CLK4 12824502,12705895 hprd,biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ITGA4 UBL5 22623428 biogrid exp G G G G CRKL UBL5 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBL5 WBP11 25092792 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G COIL UBL5 23726919 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SNRPD1 UBL5 25092792 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBL5 CAB39 26344197 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CLK2 UBL5 12705895 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G VCAM1 UBL5 22623428 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SNRPD3 UBL5 25092792 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G WDR83 UBL5 22365833 biogrid,mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G PRPF8 UBL5 25092792 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CCT6A UBL5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CNBP UBL5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HSPA4 UBL5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SF3B1 UBL5 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PBDC1 UBL5 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBL5 AUP1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TMUB2 UBL5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBL4A UBL5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2D2 UBL5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TMUB1 UBL5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CLASRP UBL5 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2S UBL5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G UBQLNL UBL5 23023127 pred G G UBL4B UBL5 23023127 pred THOC7 UBL5 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G VPS41 UBL5 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBC UBL5 23023127 pred UQCRQ UBL5 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBXN2B UBL5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PPP2R1A UBL5 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2L6 UBL5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BUD31 UBL5 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBL5 UBQLN2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CTTN UBL5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SUMO2 UBL5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBL5 RNF19A 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBFD1 UBL5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBL5 NSFL1C 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBL5 RBM8A 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SREK1IP1 UBL5 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBXN2A UBL5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2V1 UBL5 23023127 pred UBL7 UBL5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBL5 UBTD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G UBTD2 UBL5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MIDN UBL5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBL5 UBE2D4 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BAG6 UBL5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBL5 MRPL17 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBL5 UBQLN3 23023127 pred G G G G G G G G SUMO4 UBL5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBAC1 UBL5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G SAP18 UBL5 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MMGT1 UBL5 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2V2 UBL5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MAX UBL5 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G JOSD2 UBL5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RARS UBL5 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G COX6B1 UBL5 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MED8 UBL5 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BANF1 UBL5 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBL5 TRMT112 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SH3GL1 UBL5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TSN UBL5 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBL5 UBL5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UBC UBL5 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21890473,21906983,22505724,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_175065|BIOGRID_167995|BIOGRID_224760|BIOGRID_268617|BIOGRID_177421 bait|bait|bait|bait|bait prey|prey|prey|prey|prey HSPB2 UBL5 MI:0018(two hybrid) 12705895 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_89583 prey bait LMAN1 UBL5 MI:0018(two hybrid)|MI:0018(two hybrid) 21614000 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_138512|BIOGRID_7143 prey|prey bait|bait ITGA4 UBL5 MI:0004(affinity chromatography technology) 22623428 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_261378 bait prey UBL5 CLK4 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 12705895,12824502 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) MI:0468(hprd)|(biogrid)|(biogrid)|(intact)|(biogrid) HPRD_14017|BIOGRID_89579|BIOGRID_88954|UniProt_72394|BIOGRID_89582 -|bait|bait|bait|bait -|prey|prey|prey|prey WDR83 UBL5 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 22365833 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_123418|UniProt_123919 bait|prey prey|bait TXN UBL5 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_241637 bait prey CLK2 UBL5 MI:0018(two hybrid) 12705895 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_89581 prey bait SART1 UBL5 MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0428(imaging technique) 15620657,21614000,22365833,23726919 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0403(colocalization)|-|MI:0403(colocalization)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid)|(biogrid)|MI:0468(hprd)|(biogrid)|(intact)|(biogrid)|(intact)|(biogrid) UniProt_123824|BIOGRID_254402|BIOGRID_138514|HPRD_26000|BIOGRID_138515|UniProt_193636|BIOGRID_254240|UniProt_80528|BIOGRID_281367 bait|prey|prey|-|bait|prey|bait|prey|prey prey|bait|bait|-|prey|bait|prey|bait|bait CLK1 UBL5 MI:0018(two hybrid)|MI:0018(two hybrid) 12705895 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_14016|BIOGRID_89580 -|prey -|bait BMI1 UBL5 MI:0004(affinity chromatography technology) 24457600 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_307328 bait prey COIL UBL5 MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique) 23726919 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_281365|BIOGRID_281366|BIOGRID_281368 prey|prey|prey bait|bait|bait

PPI - HINT Gene A Gene B PMID Method Quality SART1 UBL5 25092792,21614000,21614000,24872507,21614000,23726919,24872507 0007,0428,0018,0004,0004,0096,0114 LC TXN UBL5 22939629 0401 HT ITGA4 UBL5 22623428 0004 HT CRKL UBL5 26496610,26496610 0007,0004 HT UBL5 CAB39 26344197 0401 HT UBL5 HEL-S-71 26344197 0401 HT TXN UBL5 22939629 0401 HT ITGA4 UBL5 22623428 0004 HT CRKL UBL5 26496610,26496610 0007,0004 HT UBL5 CAB39 26344197 0401 HT UBL5 HEL-S-71 26344197 0401 HT SART1 UBL5 25092792,21614000,21614000,24872507,21614000,23726919,24872507 0007,0428,0018,0004,0004,0096,0114 LC SART1 UBL5 22365833,15620657,21614000,21614000,24872507,21614000,24872507 0018,0018,0428,0018,0004,0004,0114 HT,LC TXN UBL5 22939629 0401 LC TRIM27 UBL5 21516116 0018 HT VCAM1 UBL5 22623428 0030 LC COIL UBL5 23726919,23726919,23726919 0004,0096,0401 LC HSPB2 UBL5 12705895 0018 LC WDR83 UBL5 22365833,22365833,22365833 0004,0018,0007 HT UBL5 CLK4 12705895,12824502,12705895 0018,0018,0096 LC UBL5 CAB39 26344197 0401 LC UBL5 HEL-S-71 26344197 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9BZL1 P61088 UBL5 UBE2N 0.081 26344197 Q9Y376 Q9BZL1 CAB39 UBL5 0.081 26344197 Q9BZL1 P10599 UBL5 TXN 0.081 22939629 Q9BZL1 P13612 UBL5 ITGA4 0.126 22623428 Q9UBX0 Q9BZL1 HESX1 UBL5 0.236 unassigned1304 Q9BZL1 Q8N7W2 UBL5 BEND7 0.236 unassigned1304 Q9UJW9 Q9BZL1 SERTAD3 UBL5 0.236 unassigned1304 Q9BZL1 Q91VJ5 UBL5 PQBP1 0.236 26496610 Q9BZL1 P78358 UBL5 CTAG1B 0.236 unassigned1304 Q9BZL1 P49901 UBL5 SMCP 0.236 unassigned1304 Q9BZL1 P49639 UBL5 HOXA1 0.236 unassigned1304 Q9BZL1 P23511 UBL5 NFYA 0.236 unassigned1304 Q9HCM9 Q9BZL1 TRIM39 UBL5 0.236 unassigned1304 Q9BZL1 Q5T4B2 UBL5 CERCAM 0.236 unassigned1304 Q9UL46 Q9BZL1 PSME2 UBL5 0.236 unassigned1304 Q9D287 Q9BZL1 BCAS2 UBL5 0.236 26496610 Q9BZL1 P46109 UBL5 CRKL 0.236 26496610 Q9BZL1 Q5T7W0 UBL5 ZNF618 0.236 unassigned1304 Q9BZL1 Q8IV36 UBL5 HID1 0.236 unassigned1304 Q9BZL1 P60410 UBL5 KRTAP10-8 0.236 unassigned1304 Q9BZL1 O43290 UBL5 SART1 0.946 23726919,15620657,25092792,21614000,22365833,24872507 Q9BZL1 P38432 UBL5 COIL 0.523 23726919 Q9HAZ1 Q9BZL1 CLK4 UBL5 0.671 12705895,12824502 Q9BZL1 O60828 UBL5 PQBP1 0.21 25092792 Q9BZL1 P14373 UBL5 TRIM27 0.183 21516116 Q9BZL1 P49759 UBL5 CLK1 0.309 12705895 Q9BZL1 P49760 UBL5 CLK2 0.309 12705895 Q9BZL1 P55081 UBL5 MFAP1 0.21 25092792 Q9BZL1 P62314 UBL5 SNRPD1 0.21 25092792 Q9BZL1 P62318 UBL5 SNRPD3 0.21 25092792 Q9BZL1 Q15029 UBL5 EFTUD2 0.21 25092792 Q9BZL1 Q16082 UBL5 HSPB2 0.309 12705895 Q9BZL1 Q6P2Q9 UBL5 PRPF8 0.21 25092792 Q9BZL1 Q8LB54 UBL5 PRP38 0.183 21614000 Q9BZL1 Q8NAV1 UBL5 PRPF38A 0.21 25092792 Q9BZL1 Q9BRX9 UBL5 WDR83 0.583 22365833 Q9Y2W2 Q9BZL1 WBP11 UBL5 0.21 25092792 Q9BZL1 P19320 UBL5 VCAM1 0.126 22623428

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 SART1 UBL5 MI:0045 experimental interaction detection MI:0461 interaction database PQBP1 UBL5 MI:0045 experimental interaction detection MI:0461 interaction database BCAS2 UBL5 MI:0362 inference MI:0461 interaction database HSPA4L UBL5 MI:0362 inference MI:0461 interaction database UBC UBL5 MI:0045 experimental interaction detection MI:0461 interaction database ITGA4 UBL5 MI:0045 experimental interaction detection MI:0461 interaction database TRIM27 UBL5 MI:0045 experimental interaction detection MI:0461 interaction database VCAM1 UBL5 MI:0045 experimental interaction detection MI:0461 interaction database TAF1 UBL5 MI:0045 experimental interaction detection MI:0461 interaction database HSPA4 UBL5 MI:0362 inference MI:0461 interaction database BMI1 UBL5 MI:0045 experimental interaction detection MI:0461 interaction database COIL UBL5 MI:0045 experimental interaction detection MI:0461 interaction database CCT6A UBL5 MI:0362 inference MI:0461 interaction database CRKL UBL5 MI:0045 experimental interaction detection MI:0461 interaction database CLK1 UBL5 MI:0045 experimental interaction detection MI:0461 interaction database CLK2 UBL5 MI:0045 experimental interaction detection MI:0461 interaction database MFAP1 UBL5 MI:0045 experimental interaction detection MI:0461 interaction database MAX UBL5 MI:0045 experimental interaction detection MI:0461 interaction database SNRPD1 UBL5 MI:0045 experimental interaction detection MI:0461 interaction database SNRPD3 UBL5 MI:0045 experimental interaction detection MI:0461 interaction database CNBP UBL5 MI:0362 inference MI:0461 interaction database EFTUD2 UBL5 MI:0045 experimental interaction detection MI:0461 interaction database HSPB2 UBL5 MI:0045 experimental interaction detection MI:0461 interaction database PRPF8 UBL5 MI:0045 experimental interaction detection MI:0461 interaction database PRPF38A UBL5 MI:0045 experimental interaction detection MI:0461 interaction database ZCCHC13 UBL5 MI:0362 inference MI:0461 interaction database CCT6B UBL5 MI:0362 inference MI:0461 interaction database HSPH1 UBL5 MI:0362 inference MI:0461 interaction database WDR83 UBL5 MI:0045 experimental interaction detection MI:0461 interaction database UBL5 CLK4 MI:0045 experimental interaction detection MI:0461 interaction database UBL5 WBP11 MI:0045 experimental interaction detection MI:0461 interaction database