PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus MDM4 C1orf111 26186194 biogrid exp G G G G P P G G G G GP G G MDM4 UBA1 20705607 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G KPNA3 MDM4 16511560 mint,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 TRIM46 22493164 biogrid,intact exp GP GP G G G GP G GP GP G GP G GP G G GP GP P GP G P GP GP GP GP G G GP G MDM4 BCL2 19521340,24445145 biogrid,mint,intact exp G G G G GP GP G G GP G GP G G GP G G GP GP G G GP GP G G G GP G G G MDM4 RFWD2 20333547 biogrid exp G G G G G GP G G GP G G G G G G G GP G G G GP G G G G G GP G G MDM4 CDKN2A 11297540 biogrid,bci exp G GP G G GP GP G G G G G G GP GP G G GP G GP G GP G G G G GP GP G G MDM4 RNF115 25416956 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MDM4 14-3-3 tau splice variant 16511572,16511560 mint,intact exp MDM4 RAD54B 25384516 biogrid exp P G GP P G GP P P P P G P P GP P G P P P P P GP P MDM4 MRE11A 24608433 biogrid exp GP P G GP P P GP P P GP GP G GP P GP P GP GP P P P GP GP GP MDM4 TRIM55 22493164 biogrid,intact exp P P GP P P GP P P P P P P GP GP P GP MDM4 PSMC5 18086887 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 PPARD 26186194 biogrid exp GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP G GP G GP GP GP GP G MDM4 MNAT1 22493164 biogrid,intact exp GP GP G P GP G G GP G GP GP GP G GP GP G P G P GP GP G GP G GP P MDM4 APP 21832049 biogrid exp G GP G G GP GP G G GP G G G G G G GP GP G GP G GP GP G G GP G G GP G MDM4 PPP1CC 23277204 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G MDM4 UBE2D1 12393902,17301054 hprd,biogrid,bci exp GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G MDM4 MKRN3 22493164 biogrid,intact exp P P P P P P P P P P P P P P P P P P P MDM4 RAD50 24608433 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP MDM4 PSMD2 18086887 biogrid exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 PRKAA1 24190973 biogrid exp GP GP G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP MDM4 RPS20 23874713 biogrid exp P P P P P P P P P P P P P P P P P P P P P MDM4 PPP1CB 23277204 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 USP22 25547493 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 PPP1CA 23277204 biogrid exp GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G MDM4 UBE2D3 19683495 biogrid exp GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G MDM4 SMARCA2 25384516 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 CD160 25416956 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G MDM4 UBE2D2 20705607,24127580 biogrid,intact exp GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G MDM4 RPS15 23874713 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G MDM4 MDM4 25888903,24755078,24127580,17301054,10218570 biogrid,dip exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 HSP90AA1 22939624 biogrid exp GP GP G G G GP G G GP G G G G G G G GP G G G GP G G G G G G GP G MDM4 RPL37 23874713 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MDM4 CAPN7 25416956 biogrid,intact exp G G G G GP GP G G GP G GP GP G GP G GP GP G GP G GP G GP G GP G GP GP G MDM4 UBC 17110929,24755078 biogrid,mint,intact exp, ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 MDM2 25384516,22120712,23028042,20473904,12370303,10608892,15604276,22333590,20705607,22266850,21988832,12860999,16055726,18219319,11606419,21925390,19432880,17159902,17301054,19619542,22493164,18566590,17616658,12393902,12874296,23946421,19838211,10827196,10218570,23671280,16227609,25809483,24813712,25512388,24755078,20484049,19683495,12483531,26001071,20724842, 25402006, 23023127, 21836163 hprd,biogrid,i2d,mint,intact,dip exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 YWHAG 24190973,21148311,22556425,16511572,16511560, 25402006, 21836163 hprd,biogrid,mint,intact exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 TP53 10075736,18485870,19521340,26186194,22807444,18677113,23028042,12370303,21075307,10608892,15604276,8895579,20705607,24127580,22266850,17110929,19153082,21925390,19432880,25464845,22374672,21088494,24445145,17875722,20515689,17301054,11223036,9226370,19305137,12393902,16024788,21965653,12874296,23946421,15916963,10827196,23671280,16227609,11528400,24659749,19075013,20724842,20174603,25609649, 25402006, 21836163 hprd,biogrid,mint,intact,dip,bci exp, ortho, pred G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G MDM4 USP7 18566590,15916963,20713061, 25402006 hprd,biogrid,i2d,intact,bci exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 CDKN1A 21148311,18086887, 25402006 biogrid exp, ortho, pred GP GP G G GP G G G GP G G G GP G G GP G G G G GP G G G GP G G GP G MDM4 SMAD4 12483531, 23023127 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP G GP GP GP GP G MDM4 PRKCD 20936779, 23023127 i2d exp, pred GP GP G G GP GP G GP GP GP P GP GP G GP GP GP GP GP GP GP P GP GP GP GP G MDM4 TP73 21088494,11223036, 25402006 hprd,biogrid,dip exp, pred G G G G G MDM4 RCHY1 20333547, 25402006 biogrid exp, pred G GP G G G GP G GP GP G GP G GP G G GP GP G GP G G G GP G GP G GP G G MDM4 EP300 12483531, 25402006, 21836163 hprd,biogrid,bci exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 ABL1 19075013, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 YWHAB 21925390,16227609,18356162,16511560, 25402006 hprd,biogrid,mint,intact exp, pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 ARF1 11297540, 21836163 hprd exp, pred GP GP G G GP GP GP GP G GP GP GP GP G GP GP G P G GP GP GP P P GP GP GP G MDM4 USP2 24445145,19838211, 25402006, 23023127 biogrid exp, pred GP G P GP G GP P G GP GP GP GP P GP GP GP G GP P GP GP GP P P GP G MDM4 CDK1 15735705, 25402006 hprd,i2d,bci exp, pred GP G GP G GP P P P GP GP GP G GP P GP GP GP GP MDM4 ATM 16163388,15788536, 25402006 hprd,bci exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 YWHAZ 18356162,16511560, 25402006, 21836163 hprd,biogrid,mint,intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 CASP3 11840332, 25402006 hprd,bci exp, pred GP G G G GP G G GP G G G GP GP G GP G G GP G GP G G G GP GP GP GP G MDM4 E2F1 12532331, 25402006 hprd,biogrid,i2d,bci exp, pred P GP G G GP GP G GP GP G GP GP GP GP GP GP GP GP G P P GP P GP P GP GP G MDM4 TP63 21088494, 25402006 biogrid exp, pred GP G G G G G G G G G G G G G G G G G G GP GP G G G G G MDM4 CHEK2 16163388, 25402006 hprd,biogrid,bci exp, pred GP GP G G P G P GP P P P P GP P GP GP G P GP P P GP GP G MDM4 YWHAH 16511560, 25402006 hprd,biogrid,mint,intact exp, pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 CSNK1A1 21925390,17110929,16024788,23028042,16511560, 25402006 hprd,biogrid,mint,intact exp, pred G G G G G G G G G G G G G G G G G G GP G G G G G G G G G G MDM4 DAXX 18566590, 25402006 intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 SFN 16511560,16511572, 25402006, 21836163 hprd,biogrid,mint,intact exp, pred GP G G G G G G G G G G G GP G G G G GP G G G GP G G G G G G G MDM4 AKT1 16163388, 25402006 hprd,bci exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 RB1 16510145, 25402006, 21836163 hprd,biogrid,i2d,mint,intact,bci exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 LRSAM1 22493164, 23023127 biogrid,intact exp, pred P GP G P GP G P GP G GP GP P GP P GP GP GP G P GP P P P GP P P G MDM4 HSP90AB1 22939624, 25402006 intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CHEK1 MDM4 16163388,16511572, 25402006 hprd,biogrid,mint,intact exp, pred G G G GP MDM4 SMAD3 12483531, 23023127, 21836163 hprd,biogrid,bci exp, pred GP GP G G G GP G G G G G G GP GP G G GP G GP G GP G G G G G G G G MDM4 YWHAE 16227609,18356162,16511572,16511560, 25402006 hprd,biogrid,mint,intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 NBN 24608433, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G MDM4 YWHAQ 17110929,18356162,16511560, 25402006 hprd,biogrid,mint,intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G MDM4 USP44 23023127 pred P P P P P P P P P P P P P GP G P P P P P P GP MDM4 BTN1A1 23023127 pred P G G G G P G G P P P P P GP G G G P P GP P GP G MDM4 CD8B 23023127 pred P P P P P P P P P P P P P P P P P P P P P P MDM4 RAD51 25402006 pred P P G GP P G P GP P GP P P GP GP GP GP GP P P P GP P GP GP MDM4 CD276 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G MDM4 KIF5B 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 RMDN3 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G MDM4 ARAP2 23023127 pred G G G GP GP G GP G GP G GP GP G GP GP GP G GP GP GP G GP G G G MDM4 NCL 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 TNS3 23023127 pred G GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP G GP GP GP GP GP GP G WWP2 MDM4 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G MDM4 BLM 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 FLNA 23023127 pred G G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP G G G G G GP GP G MDM4 ING1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 ERCC6 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MDM4 GML 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G MDM4 CREB1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 TOPBP1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 CD3E 23023127 pred G G G GP G G G G G G G G GP G G G G G G G G G G G GP G G MDM4 BBC3 25402006 pred MDM4 EGFR 25402006 pred GP GP G GP G G GP G GP GP G G G GP GP G G G GP GP G GP GP G GP GP G MDM4 FANCD2 25402006 pred G G P P GP P G G GP P G GP P P GP G GP GP MDM4 RICTOR 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G MDM4 RIN1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G MDM4 HMGB2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 CASP7 25402006 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G MDM4 PRKDC 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 CST3 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G MDM4 CSNK1E 25402006, 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G MDM4 IKBKG 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MDM4 JUND 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G MDM4 PIAS1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 SRSF3 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 EEF1A1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 TP53BP1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 GNL3 25402006 pred P GP P P P P P P P P G GP P P GP GP GP P P P P P P MDM4 RYR2 25402006 pred P G P GP G GP G GP G P P G P MDM4 PI4KB 25402006 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G MDM4 CIDEA 23023127 pred G G G G G G G G MDM4 S100A6 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 SNRNP200 25402006 pred GP G G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G MDM4 PSME3 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 EDC3 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 RYBP 25402006 pred GP G G G G G G G G G GP G GP G G GP G G GP G GP GP G GP GP G GP GP G MDM4 USP47 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 CBL 25402006 pred G GP G G GP GP G G GP G GP G GP GP G G GP GP G G G G G G G GP G GP G MDM4 RBBP8 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP G G GP GP GP GP G MDM4 S100A4 25402006 pred G G G G GP G G G G G G G GP GP G G G G G G GP G G G G GP G G G MDM4 TTN 23023127 pred GP GP G G GP GP G GP GP G P G G GP G GP GP G G G P G G GP GP G G G G MDM4 RAF1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 CEBPB 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 RPL11 25402006 pred GP GP G G GP GP G G GP G G GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G MDM4 LSR 25402006 pred GP GP P P P GP GP GP GP GP G GP P P GP G GP GP GP P GP GP GP GP G MDM4 CGRRF1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G GP GP GP GP GP G MDM4 HDAC3 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 AHSP 23023127 pred G G GP G G G G G G GP G P G G G G G G G P P G G MDM4 APTX 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 BAD 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G MDM4 CD300LG 23023127 pred GP GP G GP P G GP GP GP GP GP GP G GP P GP GP G GP P GP GP GP GP P GP G MDM4 RACGAP1 25402006 pred GP G G GP G G G GP G GP G G GP G GP G G G GP G G G GP G GP GP G MDM4 VSIG2 23023127 pred P P P GP P P G GP P P GP GP G GP GP P MDM4 EZR 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G MDM4 KIAA0930 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 KIF23 25402006 pred P P G GP P P P P P P P P P P P P P P P P P P GP MDM4 NKX3-1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G MDM4 CSNK2A1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 WEE1 25402006 pred GP GP G GP P G G GP G G GP GP G GP P GP GP G GP G G G GP GP GP GP G MDM4 KAT5 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 CCNA1 25402006 pred G G G G G G G G G G G G G G G MDM4 VSIG1 23023127 pred P P GP G G P GP GP MDM4 SRRM2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 DDB2 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP G GP GP G GP GP G MDM4 ROBO1 23023127 pred GP GP G P GP G GP GP G GP P GP GP G GP GP GP P G P GP GP GP GP GP GP GP G MDM4 TIMP3 23023127 pred GP GP G G GP GP G GP GP G G GP GP GP G GP GP GP GP G GP G GP GP GP GP GP GP G MDM4 TAB2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MDM4 WRN 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G P G GP GP GP G GP GP G MDM4 MAPKAP1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 FOXO3 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 GTF2H1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 HDAC1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G MDM4 IRS2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 S100A2 25402006 pred GP G G G G G GP G G G G G G GP G G MDM4 RNF220 25402006 pred G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G MDM4 PHB 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 INS 23023127 pred G GP G MDM4 DHFR 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 MXRA8 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 TP53RK 25402006 pred GP GP G GP P G GP GP P GP GP GP G GP P GP GP G GP GP GP GP GP GP GP GP G MDM4 TNFAIP3 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G MDM4 S100A1 25402006 pred GP GP G GP G GP GP G GP GP GP G GP GP G GP G GP G GP GP GP 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pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM4 CDK2 25402006 pred GP GP G G GP GP G GP GP G GP G G GP G GP GP G G G GP GP G G GP G GP GP G MDM4 FLT1 23023127 pred G G G GP G GP GP G G G G G G G GP G G G GP G G GP G G G G G MDM4 RAE1 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP G G GP GP GP GP GP G MDM4 RBL1 25402006 pred P P G GP P P GP P P P GP P P P P P P GP GP GP GP P MDM4 UBXN1 23023127 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP G GP GP GP GP GP G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B MDM4 RPS20 MI:0004(affinity chromatography technology) 23874713 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_283857 prey bait MDM4 p53 MI:0416(fluorescence microscopy)|MI:0416(fluorescence microscopy)|MI:0416(fluorescence microscopy)|MI:0416(fluorescence microscopy)|MI:0416(fluorescence microscopy)|MI:0416(fluorescence microscopy)|MI:0416(fluorescence microscopy)|MI:0416(fluorescence microscopy)|MI:0416(fluorescence microscopy)|MI:0084(phage display)|MI:0071(molecular sieving)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0401(biochemical)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0401(biochemical)|MI:0416(fluorescence microscopy)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0415(enzymatic study)|MI:0096(pull down)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0077(nuclear magnetic resonance)|MI:0004(affinity chromatography technology)|MI:0084(phage display)|MI:0084(phage display)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0077(nuclear magnetic resonance)|MI:0077(nuclear magnetic resonance)|MI:0416(fluorescence microscopy)|MI:0077(nuclear magnetic resonance)|MI:0077(nuclear magnetic resonance)|MI:0077(nuclear magnetic resonance)|MI:0493(in vivo)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0428(imaging technique)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0114(x-ray crystallography)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0416(fluorescence microscopy)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down)|MI:0114(x-ray crystallography)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0686(unspecified method)|MI:0114(x-ray crystallography)|MI:0096(pull down)|MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology) 10,10608892,10827196,11223036,12370303,12393902,12874296,15604276,15916963,16024788,16227609,17301054,17875722,18485870,18677113,19075013,19153082,19305137,19432880,19521340,20174603,20515689,20705607,20724842,21075307,21088494,21925390,21965653,22266850,22374672,22807444,23028042,23671280,24127580,24445145,8895579,9226370 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0220(ubiquitination reaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0914(association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0914(association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|(intact)|(intact)|MI:0471(mint)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid)|(intact)|(biogrid)|(intact)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0471(mint)|(biogrid)|(intact)|(intact)|(biogrid)|(biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|MI:0471(mint)|MI:0468(hprd)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0471(mint)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0471(mint)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0465(dip)|(biogrid) MINT_43989|MINT_43988|UniProt_101751|MINT_74230|MINT_74231|MINT_43993|MINT_74235|UniProt_101748|UniProt_101747|UniProt_92809|UniProt_108648|MINT_81417|BIOGRID_126301|BIOGRID_310142|BIOGRID_309429|BIOGRID_212112|BIOGRID_113160|BIOGRID_309428|UniProt_101746|BIOGRID_217352|UniProt_80318|BIOGRID_127322|UniProt_80319|UniProt_80317|BIOGRID_260117|BIOGRID_158915|BIOGRID_260097|BIOGRID_260099|BIOGRID_214222|BIOGRID_143350|BIOGRID_160046|BIOGRID_117684|BIOGRID_113159|BIOGRID_103006|BIOGRID_211160|BIOGRID_260129|MINT_46020|BIOGRID_214398|UniProt_92804|UniProt_92806|BIOGRID_281156|BIOGRID_259456|MINT_76655|MINT_76654|MINT_74229|UniProt_107601|UniProt_107600|MINT_46019|HPRD_4501|UniProt_81461|BIOGRID_198890|BIOGRID_198891|BIOGRID_197294|BIOGRID_141160|BIOGRID_197292|BIOGRID_259451|BIOGRID_137865|MINT_49356|BIOGRID_197833|BIOGRID_212672|BIOGRID_142563|BIOGRID_197840|BIOGRID_184290|MINT_43987|BIOGRID_310139|BIOGRID_198886|BIOGRID_198888|BIOGRID_212677|BIOGRID_212975|BIOGRID_158925|BIOGRID_212573|BIOGRID_212674|BIOGRID_144218|DIP_53173|BIOGRID_197843 prey|prey|bait|prey|prey|bait|bait|prey|prey|prey|neutral component|bait|prey|bait|bait|prey|bait|bait|neutral component|bait|bait|bait|bait|bait|bait|bait|bait|prey|bait|bait|bait|bait|prey|bait|prey|prey|neutral component|prey|prey|prey|bait|bait|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|-|bait|bait|bait|prey|prey|bait|prey|bait|bait|bait|prey|bait|bait|bait|neutral component|bait|prey|prey|bait|bait|prey|prey|bait|prey|-|prey prey|bait|prey|bait|prey|prey|prey|prey|bait|bait|neutral component|prey|bait|prey|prey|bait|prey|prey|neutral component|prey|prey|prey|prey|prey|prey|prey|prey|bait|prey|prey|prey|prey|bait|prey|bait|bait|neutral component|bait|bait|bait|prey|prey|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|-|prey|prey|prey|bait|bait|prey|bait|prey|prey|prey|bait|prey|prey|prey|neutral component|prey|bait|bait|prey|prey|bait|bait|prey|bait|-|bait MDM4 UBE2D3 MI:0004(affinity chromatography technology) 19683495 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_226030 bait prey MDM4 ARF1 MI:0493(in vivo) 11297540 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_34885 - - MDM4 SMAD3 MI:0096(pull down)|MI:0493(in vivo) 12483531 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_92044|HPRD_11396 bait|- prey|- MDM4 YWHAQ MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0019(coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16511560,17110929,18356162 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|-|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(biogrid)|MI:0471(mint)|(intact)|MI:0468(hprd)|(biogrid)|(biogrid) MINT_79117|BIOGRID_214411|MINT_47292|UniProt_85039|HPRD_31167|BIOGRID_258586|BIOGRID_214410 unspecified role|bait|unspecified role|unspecified role|-|bait|bait unspecified role|prey|unspecified role|unspecified role|-|prey|prey MDM4 RCHY1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20333547 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_153688|BIOGRID_153689 bait|prey prey|bait MDM4 CDKN1A MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18086887,21148311 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_141998|BIOGRID_142001|BIOGRID_153951|BIOGRID_142000|BIOGRID_141999|BIOGRID_142006|BIOGRID_153952 bait|bait|bait|prey|prey|prey|prey prey|prey|prey|bait|bait|bait|bait MDM4 AMPKa1 MI:0004(affinity chromatography technology) 24190973 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_310216 prey bait MDM4 MKRN3 MI:0397(two hybrid array)|MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(intact) UniProt_122642|BIOGRID_284036|UniProt_122417 prey|prey|prey bait|bait|bait MDM4 PSMD2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18086887 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_142010|BIOGRID_142013|BIOGRID_142009|BIOGRID_142017 prey|prey|bait|prey bait|bait|prey|bait MDM4 ATM MI:0493(in vivo) 15788536 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_19862 - - MDM4 SMAD4 MI:0096(pull down) 12483531 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_92045 bait prey MDM4 CSNK1A1 MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 16024788,16511560,17110929,21925390,23028042 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(biogrid)|MI:0468(hprd)|MI:0471(mint)|(biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|MI:0471(mint)|MI:0471(mint)|(intact) MINT_84375|BIOGRID_127323|HPRD_31153|MINT_51916|BIOGRID_127321|UniProt_88469|BIOGRID_158916|BIOGRID_258587|BIOGRID_260096|MINT_80982|MINT_49150|UniProt_85027 bait|prey|-|bait|bait|bait|bait|bait|bait|bait|bait|bait prey|bait|-|prey|prey|prey|prey|prey|prey|prey|prey|prey MDM4 RFWD2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20333547 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_153686|BIOGRID_153687 bait|prey prey|bait MDM4 RPS15 MI:0004(affinity chromatography technology) 23874713 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_283856 prey bait MDM4 UBE2D2 MI:0401(biochemical)|MI:0096(pull down)|MI:0071(molecular sieving) 20705607,24127580 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(intact) BIOGRID_309431|BIOGRID_207358|UniProt_108646 bait|bait|neutral component prey|prey|neutral component MDM4 YWHAZ MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0493(in vivo) 16511560,18356162 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|- MI:0471(mint)|MI:0471(mint)|(biogrid)|(intact)|MI:0468(hprd) MINT_80988|MINT_49156|BIOGRID_214414|UniProt_85033|HPRD_31169 prey|prey|prey|prey|- bait|bait|bait|bait|- MDM4 SUMO1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15876864,15907800 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_128068|BIOGRID_128056 prey|prey bait|bait MDM4 TRIM55 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122592|BIOGRID_284088 prey|prey bait|bait MDM4 TRIM46 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122577|BIOGRID_284133 prey|prey bait|bait MDM4 YWHAG MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0019(coimmunoprecipitation)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation) 16511560,16511572,21148311,22556425,24190973 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0914(association)|MI:0914(association) (biogrid)|(biogrid)|(intact)|(biogrid)|(intact)|(intact)|MI:0471(mint)|(biogrid)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint)|(biogrid)|MI:0471(mint)|MI:0468(hprd)|(biogrid)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(biogrid)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint) BIOGRID_124634|BIOGRID_124633|UniProt_84810|BIOGRID_153950|UniProt_84811|UniProt_84814|MINT_49149|BIOGRID_124632|UniProt_84816|UniProt_84815|MINT_80990|MINT_80971|BIOGRID_153953|MINT_80966|HPRD_31164|BIOGRID_211775|UniProt_85035|MINT_49144|MINT_49143|MINT_49142|MINT_49134|MINT_49139|MINT_49158|BIOGRID_310217|UniProt_84809|MINT_80981|MINT_80975|MINT_80976|MINT_80974|MINT_79118|MINT_47293 prey|bait|bait|prey|prey|bait|bait|prey|prey|bait|prey|bait|bait|prey|-|prey|prey|prey|bait|prey|prey|bait|prey|prey|prey|bait|bait|prey|prey|unspecified role|unspecified role bait|prey|prey|bait|bait|prey|prey|bait|bait|prey|bait|prey|prey|bait|-|bait|bait|bait|prey|bait|bait|prey|bait|bait|bait|prey|prey|bait|bait|unspecified role|unspecified role MDM4 RPL37 MI:0004(affinity chromatography technology) 23874713 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_283855 prey bait MDM4 YWHAH MI:0019(coimmunoprecipitation)|MI:0493(in vivo)|MI:0019(coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 16511560 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0468(hprd)|MI:0471(mint)|(intact)|(biogrid) MINT_80989|HPRD_31172|MINT_49157|UniProt_85034|BIOGRID_124639 prey|-|prey|prey|prey bait|-|bait|bait|bait MDM4 UBC MI:0006(anti bait coimmunoprecipitation)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 12860999,12874296,16227609,16511560,17110929,19838211,20333547,20484049,20657550,21925390,22120712,23934659 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0471(mint)|MI:0471(mint)|(biogrid)|(biogrid)|(biogrid)|(biogrid) UniProt_88470|BIOGRID_153925|BIOGRID_258580|BIOGRID_124640|BIOGRID_126303|BIOGRID_153756|BIOGRID_133521|BIOGRID_148203|BIOGRID_184292|MINT_84376|MINT_51917|BIOGRID_153693|BIOGRID_294500|BIOGRID_158928|BIOGRID_142147 prey|bait|prey|prey|prey|prey|prey|prey|prey|prey|prey|bait|prey|bait|prey bait|prey|bait|bait|bait|bait|bait|bait|bait|bait|bait|prey|bait|prey|bait MDM4 PPP1CB MI:0004(affinity chromatography technology) 23277204 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_248318 prey bait MDM4 PPP1CA MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23277204 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_248320|BIOGRID_248317 bait|prey prey|bait MDM4 PSMC5 MI:0004(affinity chromatography technology) 18086887 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_142007 bait prey MDM4 YWHAE MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0493(in vivo) 16227609,16511560,18356162 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|- MI:0471(mint)|(intact)|MI:0471(mint)|(biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0468(hprd) MINT_47286|UniProt_82856|MINT_47356|BIOGRID_214412|BIOGRID_124638|BIOGRID_126299|UniProt_95862|BIOGRID_214415|BIOGRID_126298|MINT_80987|MINT_79192|MINT_49155|UniProt_85032|MINT_79110|HPRD_31170 unspecified role|unspecified role|unspecified role|bait|prey|prey|unspecified role|prey|bait|prey|unspecified role|prey|prey|unspecified role|- unspecified role|unspecified role|unspecified role|prey|bait|bait|unspecified role|bait|prey|bait|unspecified role|bait|bait|unspecified role|- MDM4 USP2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19838211,24445145 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0403(colocalization)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_310138|BIOGRID_310143|BIOGRID_148205|BIOGRID_310140|BIOGRID_148204 bait|bait|bait|prey|bait prey|prey|prey|bait|prey MDM4 ABL1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19075013 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_212110|BIOGRID_212111 prey|bait bait|prey MDM4 AKT1 MI:0492(in vitro) 16163388 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_19860 - - CHEK1 MDM4 MI:0019(coimmunoprecipitation)|MI:0492(in vitro)|MI:0004(affinity chromatography technology)|MI:0019(coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0415(enzymatic study) 16163388,16511572 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0217(phosphorylation reaction)|-|MI:0407(direct interaction)|MI:0217(phosphorylation reaction)|MI:0217(phosphorylation reaction)|MI:0407(direct interaction) MI:0471(mint)|MI:0468(hprd)|(biogrid)|MI:0471(mint)|(intact)|(biogrid) MINT_49147|HPRD_19857|BIOGRID_124635|MINT_80979|UniProt_84818|BIOGRID_126451 neutral component|-|bait|neutral component|neutral component|bait neutral component|-|prey|neutral component|neutral component|prey MDM4 SFN MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 16511560,16511572 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0468(hprd)|(biogrid)|MI:0471(mint)|MI:0471(mint)|(intact) HPRD_31568|BIOGRID_124636|MINT_49137|MINT_80969|UniProt_84813 -|prey|prey|prey|prey -|bait|bait|bait|bait MDM4 YWHAB MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0004(affinity chromatography technology) 16227609,16511560,18356162,21925390 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association) MI:0471(mint)|(biogrid)|(intact)|MI:0471(mint)|(biogrid)|(biogrid)|MI:0468(hprd)|(biogrid) MINT_80986|BIOGRID_126302|UniProt_85031|MINT_49154|BIOGRID_214413|BIOGRID_124637|HPRD_31168|BIOGRID_158918 prey|bait|prey|prey|prey|prey|-|bait bait|prey|bait|bait|bait|bait|-|prey MDM4 E2F1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0492(in vitro) 12532331 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|- (biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_96480|BIOGRID_96479|HPRD_3844 prey|prey|- bait|bait|- MDM4 HSP90AB1 MI:0729(luminescence based mammalian interactome mapping) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_125052 bait prey MDM4 BCL2 MI:0416(fluorescence microscopy)|MI:0416(fluorescence microscopy)|MI:0416(fluorescence microscopy)|MI:0416(fluorescence microscopy)|MI:0416(fluorescence microscopy)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0416(fluorescence microscopy) 10,19521340,24445145 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(biogrid)|(biogrid)|(biogrid)|(intact) UniProt_101750|MINT_43991|MINT_43992|MINT_74234|MINT_74233|BIOGRID_310141|BIOGRID_259455|BIOGRID_259453|UniProt_101749 bait|prey|bait|bait|prey|bait|bait|prey|prey prey|bait|prey|prey|bait|prey|prey|bait|bait MDM4 HSP90AA1 MI:0004(affinity chromatography technology) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255482 prey bait MDM4 LRSAM1 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122599|BIOGRID_284059 prey|prey bait|bait MDM4 MNAT1 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122475|BIOGRID_284171 prey|prey bait|bait MDM4 USP7 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0492(in vitro)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 15916963,20713061 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association) (intact)|(intact)|(intact)|(intact)|(intact)|MI:0468(hprd)|(intact)|(intact)|(intact)|(intact)|(intact)|(biogrid)|(intact)|(intact)|(biogrid)|(intact)|(biogrid)|(intact)|(intact)|(intact)|(intact) UniProt_80297|UniProt_80298|UniProt_80299|UniProt_164435|UniProt_164434|HPRD_18490|UniProt_80309|UniProt_80306|UniProt_80316|UniProt_80307|UniProt_80308|BIOGRID_140755|UniProt_80315|UniProt_80302|BIOGRID_140754|UniProt_80303|BIOGRID_140753|UniProt_80300|UniProt_80314|UniProt_80312|UniProt_80310 prey|null|bait|bait|prey|-|bait|prey|bait|bait|prey|bait|bait|prey|prey|bait|bait|bait|prey|prey|prey bait|bait|prey|prey|bait|-|prey|bait|prey|prey|bait|prey|prey|bait|bait|prey|prey|prey|bait|bait|bait MDM4 uniprotkb:(gene name) MI:0019(coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 16511560,16511572 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact) MINT_49135|UniProt_84812|MINT_49159|MINT_80983|MINT_80992|UniProt_85029|MINT_80991|UniProt_85028|MINT_80984|MINT_80967|MINT_80985|MINT_49153|MINT_49152|UniProt_85030|MINT_49160|MINT_49151|UniProt_85037|UniProt_85036 prey|prey|prey|bait|bait|bait|prey|bait|bait|prey|prey|prey|bait|prey|bait|bait|bait|prey bait|bait|bait|prey|prey|prey|bait|prey|prey|bait|bait|bait|prey|bait|prey|prey|prey|bait MDM4 CDK1 MI:0492(in vitro) 15735705 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_25971 - - MDM4 TP73 MI:0492(in vitro)|MI:0096(pull down)|MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology) 11223036,21088494 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0468(hprd)|(biogrid)|MI:0465(dip)|(biogrid) HPRD_26376|BIOGRID_142564|DIP_53174|BIOGRID_137866 -|bait|-|bait -|prey|-|prey MDM4 RB1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0493(in vivo)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0492(in vitro) 16510145,18451149 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|- (biogrid)|(biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|(intact)|(intact)|MI:0471(mint)|MI:0468(hprd)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0468(hprd) BIOGRID_227433|BIOGRID_227434|MINT_77880|MINT_77881|MINT_77882|MINT_48595|UniProt_84715|UniProt_84717|UniProt_84716|UniProt_84718|MINT_77879|HPRD_2615|MINT_48594|MINT_48593|MINT_48592|HPRD_40056 bait|prey|prey|bait|prey|prey|bait|prey|prey|bait|bait|-|bait|prey|bait|- prey|bait|bait|prey|bait|bait|prey|bait|bait|prey|prey|-|prey|bait|prey|- MDM4 UBE2D1 MI:0018(two hybrid)|MI:0492(in vitro)|MI:0415(enzymatic study) 12393902,17301054 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|-|MI:0407(direct interaction) (biogrid)|MI:0468(hprd)|(biogrid) BIOGRID_221575|HPRD_11395|BIOGRID_103007 bait|-|bait prey|-|prey MDM4 CASP3 MI:0492(in vitro) 11840332 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_7391 - - MDM4 CDKN2A MI:0004(affinity chromatography technology) 11297540 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_109152 bait prey MDM4 TP63 MI:0096(pull down)|MI:0096(pull down) 21088494 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_142558|BIOGRID_142562 prey|bait bait|prey KPNA3 MDM4 MI:0007(anti tag coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation) 16511560 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint)|MI:0471(mint) UniProt_85038|MINT_49161|MINT_80993 bait|bait|bait prey|prey|prey MDM4 MDM2 MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0397(two hybrid array)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down)|MI:0415(enzymatic study)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0428(imaging technique)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0114(x-ray crystallography)|MI:0096(pull down)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0492(in vitro)|MI:0493(in vivo) 10218570,10608892,10827196,12370303,12393902,12483531,12860999,12874296,15604276,16055726,16227609,17159902,17301054,17616658,18219319,18382127,18451149,18566590,19432880,19619542,19683495,19838211,20473904,20484049,20724842,21925390,21988832,22120712,22266850,22333590,22493164,23028042,23671280 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0914(association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|-|- (biogrid)|(biogrid)|MI:0471(mint)|(biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(intact)|(biogrid)|(intact)|MI:0468(hprd)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(biogrid)|(biogrid)|MI:0471(mint)|(biogrid)|MI:0471(mint)|(biogrid)|MI:0465(dip)|MI:0471(mint)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0468(hprd)|MI:0468(hprd) BIOGRID_198989|BIOGRID_199416|MINT_81418|BIOGRID_148206|UniProt_119102|BIOGRID_284008|BIOGRID_126300|BIOGRID_148884|BIOGRID_214221|BIOGRID_158919|BIOGRID_148888|BIOGRID_214220|UniProt_122390|UniProt_66820|BIOGRID_214219|UniProt_66821|HPRD_39069|BIOGRID_214217|BIOGRID_214218|UniProt_89098|BIOGRID_133522|BIOGRID_210751|BIOGRID_210750|BIOGRID_103005|BIOGRID_103004|BIOGRID_103009|BIOGRID_103008|BIOGRID_214399|BIOGRID_286562|BIOGRID_164594|BIOGRID_153757|BIOGRID_141305|BIOGRID_211159|UniProt_81463|BIOGRID_281155|BIOGRID_141161|UniProt_66819|BIOGRID_260130|BIOGRID_197291|UniProt_66818|MINT_84914|MINT_84915|MINT_49357|MINT_84917|BIOGRID_197834|BIOGRID_153926|MINT_52421|BIOGRID_147144|MINT_52422|BIOGRID_153923|DIP_53167|MINT_52424|BIOGRID_117525|BIOGRID_92047|BIOGRID_197747|BIOGRID_197841|BIOGRID_184291|UniProt_89102|BIOGRID_158922|UniProt_89100|BIOGRID_137852|BIOGRID_147146|BIOGRID_137853|UniProt_95876|MINT_39754|MINT_39753|MINT_69043|UniProt_95878|MINT_39752|UniProt_95877|MINT_69045|MINT_69044|HPRD_40056|HPRD_40068 prey|bait|bait|bait|unspecified role|prey|prey|prey|bait|bait|prey|bait|prey|prey|prey|bait|-|prey|prey|bait|prey|prey|prey|bait|prey|prey|prey|prey|prey|prey|prey|prey|prey|bait|prey|prey|bait|prey|bait|prey|bait|prey|bait|neutral component|bait|prey|bait|prey|prey|bait|-|neutral component|prey|bait|bait|prey|bait|neutral component|prey|prey|prey|bait|bait|prey|prey|prey|prey|prey|prey|prey|prey|prey|-|- bait|prey|prey|prey|unspecified role|bait|bait|bait|prey|prey|bait|prey|bait|bait|bait|prey|-|bait|bait|prey|bait|bait|bait|prey|bait|bait|bait|bait|bait|bait|bait|bait|bait|prey|bait|bait|prey|bait|prey|bait|prey|bait|prey|neutral component|prey|bait|prey|bait|bait|prey|-|neutral component|bait|prey|prey|bait|prey|neutral component|bait|bait|bait|prey|prey|bait|prey|prey|bait|prey|bait|prey|prey|prey|-|- MDM4 APP MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_228988 bait prey MDM4 CHEK2 MI:0492(in vitro)|MI:0415(enzymatic study) 16163388 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_19858|BIOGRID_126452 -|prey -|bait MDM4 EP300 MI:0493(in vivo)|MI:0096(pull down) 12483531 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_11355|BIOGRID_92046 -|bait -|prey MDM4 PPP1CC MI:0004(affinity chromatography technology) 23277204 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_248319 prey bait

PPI - HINT Gene A Gene B PMID Method Quality MDM4 MDM4 24127580,24127580,25888903,10218570 0401,0096,0004,0004 LC MDM4 TP73 11223036,21088494 0004,0096 LC MDM4 USP2 19838211,24445145,24445145,19838211 0096,0428,0004,0004 LC MDM4 TP53 22266850,15916963,9226370,22266850,21925390,19521340,10827196,15604276,12874296,21075307,21088494,19521340,19432880,16227609,17875722,16024788,21075307,17875722,25609649,11223036,21075307,18485870,20174603,17875722 0004,0096,0096,0090,0004,0416,0004,0096,0004,0004,0096,0006,0428,0004,0007,0004,0096,0096,0676,0004,0090,0096,0096,0411 LC,HT MDM4 RB1 16510145,16510145,25703327,12532331,16510145,25703327 0006,0007,0096,0004,0004,0004 LC MDM4 UBC 22120712,20333547,17110929,12874296,16511560,20657550,21925390,12860999,16227609,20484049,19838211 0004,0004,0096,0004,0096,0004,0004,0004,0004,0004,0004 LC MDM4 BCL2 19521340,19521340,24445145 0004,0006,0004 LC MDM4 YWHAQ 17110929,18356162 0004,0004 LC MDM4 YWHAB 16227609,16511560,16511560,21925390 0004,0004,0007,0004 LC MDM4 SFN 16511560,16511572 0004,0007 LC MDM4 CDKN1A 18086887,18086887,21148311,18086887 0096,0401,0004,0004 LC MDM4 CSNK1A1 17110929,21925390,16024788,25825738,16024788,16511560,23028042 0004,0004,0096,0004,0004,0007,0004 LC MDM4 UBE2D1 12393902,17301054 0096,0096 LC MDM4 YWHAG 16511560,16511572,16511572,16511572,16511572,22556425,24190973,16511572,21148311 0007,0019,0004,0007,0006,0004,0004,0096,0004 LC MDM4 YWHAE 16511560,16227609,16227609,16511560 0004,0004,0019,0007 LC MDM4 YWHAZ 18356162,16511560 0004,0007 LC MDM4 SUMO1 15876864,15907800 0004,0004 LC MDM4 MDM2 12370303,12483531,22266850,17616658,17159902,10608892,19619542,10608892,19683495,25703327,15604276,22333590,17616658,19619542,10218570,11606419,10827196,10218570,10608892,26359458,19838211,24813712,17159902,25809483,12874296,23671280,10608892,25659040,25384516,22120712,18566590,20484049,10218570,21925390,20705607,17159902,19432880,25384516,12860999,16227609,26001071,23028042,25105592,10218570,25659040,17159902,12483531,20473904,16055726,23946421,17159902,25512388,19683495,20724842,22266850,25825738 0004,0018,0004,0096,0018,0019,0096,0004,0004,0004,0007,0428,0004,0415,0004,0004,0004,0096,0018,0004,0096,0096,0006,0004,0004,0401,0096,0096,0004,0004,0006,0004,0018,0004,0096,0007,0428,0096,0004,0004,0004,0004,0004,0019,0004,0004,0096,0096,0004,0004,0428,0004,0415,0004,0090,0004 LC MDM4 PPARD 26186194 0004 HT MDM4 Q3YBA8 16511560,16511560,16511572,16511560 0096,0006,0007,0007 LC MDM4 Q53GA5 12370303,22266850,21925390,24127580,9226370,25609649,10608892,19521340,22266850,10075736,27114532,16024788,10827196,24445145,12874296,24659749,22374672,23028042,19432880,18485870,21088494,24127580,26186194,21075307,20174603,22807444,20515689,16227609,21075307,25825738,19075013,23028042,20515689,25825738,24445145,17875722,11223036,23946421,21075307,27114532,20724842 0004,0004,0004,0096,0096,0004,0004,0004,0090,0096,0096,0004,0004,0428,0004,0096,0004,0096,0428,0096,0096,0415,0004,0096,0096,0096,0096,0004,0004,0096,0004,0004,0114,0004,0004,0096,0004,0004,0090,0004,0004 LC,HT MDM4 C1ORF111 26186194 0004 HT MDM4 USP7 20713061,18566590,15916963,20713061,15916963,15916963,15916963,15916963,15916963 0114,0006,0096,0096,0019,0004,0007,0045,0006 LC MDM4 HEL2 16227609,16511560,18356162 0004,0004,0004 LC MDM4 HEL-S-1 16227609,16511560,18356162,21925390 0004,0004,0004,0004 LC MDM4 TP53 25609649 0676 HT MDM4 PPARD 26186194 0004 HT MDM4 Q53GA5 25609649,26186194 0004,0004 HT MDM4 C1ORF111 26186194 0004 HT MDM4 MDM4 24127580,24127580,25888903,10218570 0401,0096,0004,0004 LC MDM4 TP73 11223036,21088494 0004,0096 LC MDM4 USP2 19838211,24445145,24445145,19838211 0096,0428,0004,0004 LC MDM4 TP53 22266850,15916963,9226370,22266850,21925390,19521340,10827196,15604276,12874296,21075307,21088494,19521340,19432880,16227609,17875722,16024788,21075307,17875722,11223036,21075307,18485870,20174603,17875722 0004,0096,0096,0090,0004,0416,0004,0096,0004,0004,0096,0006,0428,0004,0007,0004,0096,0096,0004,0090,0096,0096,0411 LC MDM4 RB1 16510145,16510145,25703327,12532331,16510145,25703327 0006,0007,0096,0004,0004,0004 LC MDM4 UBC 22120712,20333547,17110929,12874296,16511560,20657550,21925390,12860999,16227609,20484049,19838211 0004,0004,0096,0004,0096,0004,0004,0004,0004,0004,0004 LC MDM4 BCL2 19521340,19521340,24445145 0004,0006,0004 LC MDM4 YWHAQ 17110929,18356162 0004,0004 LC MDM4 YWHAB 16227609,16511560,16511560,21925390 0004,0004,0007,0004 LC MDM4 SFN 16511560,16511572 0004,0007 LC MDM4 CDKN1A 18086887,18086887,21148311,18086887 0096,0401,0004,0004 LC MDM4 CSNK1A1 17110929,21925390,16024788,25825738,16024788,16511560,23028042 0004,0004,0096,0004,0004,0007,0004 LC MDM4 UBE2D1 12393902,17301054 0096,0096 LC MDM4 YWHAG 16511560,16511572,16511572,16511572,16511572,22556425,24190973,16511572,21148311 0007,0019,0004,0007,0006,0004,0004,0096,0004 LC MDM4 YWHAE 16511560,16227609,16227609,16511560 0004,0004,0019,0007 LC MDM4 YWHAZ 18356162,16511560 0004,0007 LC MDM4 SUMO1 15876864,15907800 0004,0004 LC MDM4 MDM2 12370303,12483531,22266850,17616658,17159902,10608892,19619542,10608892,19683495,25703327,15604276,22333590,17616658,19619542,10218570,11606419,10827196,10218570,10608892,26359458,19838211,24813712,17159902,25809483,12874296,23671280,10608892,25659040,25384516,22120712,18566590,20484049,10218570,21925390,20705607,17159902,19432880,25384516,12860999,16227609,26001071,23028042,25105592,10218570,25659040,17159902,12483531,20473904,16055726,23946421,17159902,25512388,19683495,20724842,22266850,25825738 0004,0018,0004,0096,0018,0019,0096,0004,0004,0004,0007,0428,0004,0415,0004,0004,0004,0096,0018,0004,0096,0096,0006,0004,0004,0401,0096,0096,0004,0004,0006,0004,0018,0004,0096,0007,0428,0096,0004,0004,0004,0004,0004,0019,0004,0004,0096,0096,0004,0004,0428,0004,0415,0004,0090,0004 LC MDM4 Q3YBA8 16511560,16511560,16511572,16511560 0096,0006,0007,0007 LC MDM4 Q53GA5 12370303,22266850,21925390,24127580,9226370,10608892,19521340,22266850,10075736,27114532,16024788,10827196,24445145,12874296,24659749,22374672,23028042,19432880,18485870,21088494,24127580,21075307,20174603,22807444,20515689,16227609,21075307,25825738,19075013,23028042,20515689,25825738,24445145,17875722,11223036,23946421,21075307,27114532,20724842 0004,0004,0004,0096,0096,0004,0004,0090,0096,0096,0004,0004,0428,0004,0096,0004,0096,0428,0096,0096,0415,0096,0096,0096,0096,0004,0004,0096,0004,0004,0114,0004,0004,0096,0004,0004,0090,0004,0004 LC MDM4 USP7 20713061,18566590,15916963,20713061,15916963,15916963,15916963,15916963,15916963 0114,0006,0096,0096,0019,0004,0007,0045,0006 LC MDM4 HEL2 16227609,16511560,18356162 0004,0004,0004 LC MDM4 HEL-S-1 16227609,16511560,18356162,21925390 0004,0004,0004,0004 LC B4DT73 MDM4 16511572,16163388 0415,0415 LC CHEK1 MDM4 16163388,16511572,16511572 0415,0424,0415 LC MDM4 MDM4 24127580,22745160,26148237,19910468,19084022,24127580,17301054,19255450,18219319,24755078 0401,0114,0114,0114,0114,0096,0415,0114,0114,0415 LC MDM4 CD160 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT MDM4 CHEK2 16163388 0415 LC MDM4 TP53 19255450,22266850,12393902,22266850,20705607,19521340,21075307,20515689,19521340,21965653,17301054,17875722,21075307,17875722,21075307,26812210,20515689,17875722 0065,0004,0415,0090,0997,0416,0004,0077,0006,0415,0415,0007,0096,0096,0090,0114,0065,0411 LC MDM4 CDK1 15735705,15735705 0045,0019 LC MDM4 HSP90AB1 22939624 0729 HT MDM4 UBC 24755078 0415 LC MDM4 UBA1 20705607 0997 LC MDM4 YWHAQ 16511560 0019 LC MDM4 CDKN1A 18086887,18086887,18086887 0096,0401,0004 LC MDM4 MAGEA1 25590999 0018 LC MDM4 MNAT1 22493164,22493164 0018,0397 HT MDM4 YWHAG 16511572,16511572,16511572,16511572,16511572 0019,0004,0007,0006,0096 LC MDM4 PSMC5 18086887 0401 LC MDM4 YWHAE 18356162,16227609,16227609 0019,0004,0019 LC MDM4 UBE2D2 20705607,24127580,20705607,20705607 0997,0415,0096,0071 LC MDM4 MDM2 12483531,22266850,12393902,24755078,17159902,10608892,19619542,10608892,19683495,12393902,19619542,10218570,10218570,10608892,17159902,23671280,10608892,22493164,10218570,22493164,17159902,17301054,21988832,10218570,17159902,12483531,17159902,19683495,22266850,17301054,18219319 0018,0004,0018,0114,0018,0019,0096,0004,0004,0415,0415,0004,0096,0018,0006,0401,0096,0018,0018,0397,0007,0415,0018,0019,0004,0096,0428,0415,0090,0018,0114 LC,HT MDM4 E2F1 12532331,12532331,12532331 0004,0096,0018 LC MDM4 MKRN3 22493164,22493164,22493164,27107012,27107012 0007,0018,0397,2215,1356 HT MDM4 PRKAA1 24190973 0415 LC MDM4 PSMD2 18086887,18086887,18086887 0096,0004,0401 LC MDM4 Q53GA5 25464845,22266850,24127580,12393902,22266850,19305137,24127580,18677113,21075307,21965653,17301054,20515689,21075307,20515689,21075307,23671280 0090,0004,0096,0415,0090,0114,0415,0114,0096,0415,0415,0096,0004,0114,0090,0415 LC MDM4 LRSAM1 22493164,22493164 0018,0397 HT MDM4 TRIM46 22493164,22493164 0018,0397 HT MDM4 USP7 20713061,15916963,20713061,15916963,15916963,15916963,15916963,15916963 0114,0096,0096,0019,0004,0007,0045,0006 LC MDM4 Q9BSD8 12532331,12532331 0096,0018 LC MDM4 TRIM55 22493164,22493164 0018,0397 HT MDM4 RNF115 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT MDM4 CAPN7 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P60866 O15151 RPS20 MDM4 0.21 23874713 Q5T0L3 O15151 C1ORF111 MDM4 0.126 26186194 P61927 O15151 RPL37 MDM4 0.21 23874713 Q9H3D4 O15151 TP63 MDM4 0.523 21088494 P62136 O15151 PPP1CA MDM4 0.376 23277204 O60934 O15151 NBN MDM4 0.21 24608433 P00519 O15151 ABL1 MDM4 0.376 19075013 P05067 O15151 APP MDM4 0.183 21832049 P22314 O15151 UBA1 MDM4 0.033 20705607 P42771 O15151 CDKN2A MDM4 0.21 11297540 P51531 O15151 SMARCA2 MDM4 0.309 25384516 P49959 O15151 MRE11A MDM4 0.21 24608433 Q09472 O15151 EP300 MDM4 0.309 12483531 P62195 O15151 PSMC5 MDM4 0.126 18086887 P62990 O15151 UBA52 MDM4 0.033 20705607 P84022 O15151 SMAD3 MDM4 0.309 12483531 Q92878 O15151 RAD50 MDM4 0.21 24608433 Q13485 O15151 SMAD4 MDM4 0.309 12483531 Q13200 O15151 PSMD2 MDM4 0.623 18086887 Q8NHY2 O15151 RFWD2 MDM4 0.376 20333547 Q8N726 O15151 CDKN2A MDM4 0.21 11297540 Q81LU5 O15151 SIGA MDM4 0.126 20711500 Q9Y6W3 O15151 CAPN7 MDM4 0.183 25416956 P62140 O15151 PPP1CB MDM4 0.21 23277204 Q9Y4L5 O15151 RNF115 MDM4 0.454 25416956 O75604 O15151 USP2 MDM4 0.702 19838211,24445145 P08238 O15151 HSP90AB1 MDM4 0.126 22939624 Q7Z479 O15151 CAPN7 {ECO:0000313|EMBL:AAH56202.1} MDM4 0.332 25416956 P03255 O15151 P03255 MDM4 0.569 15604276 O96017 O15151 CHEK2 MDM4 0.309 16163388 P07900 O15151 HSP90AA1 MDM4 0.126 22939624 Q9NX04 O15151 C1ORF109 MDM4 0.236 unassigned1304 Q9UER7 O15151 DAXX MDM4 0.236 18566590 Q9BRR0 O15151 ZKSCAN3 MDM4 0.236 unassigned1304 O95073 O15151 FSBP MDM4 0.454 25384516 P0CG48 O15151 UBC MDM4 0.454 17110929,24755078 P31946 O15151 YWHAB MDM4 0.692 16511560,16227609,21925390,18356162 P51668 O15151 UBE2D1 MDM4 0.523 12393902,17301054 P62258 O15151 YWHAE MDM4 0.848 16511560,16227609,18356162 Q9Y620 O15151 RAD54B MDM4 0.454 25384516 Q01094 O15151 E2F1 MDM4 0.523 12532331 Q13064 O15151 MKRN3 MDM4 0.636 27107012,unassigned1304,22493164 Q04917 O15151 YWHAH MDM4 0.376 16511560 P48729 O15151 CSNK1A1 MDM4 0.867 16024788,16511560,25825738,21925390,17110929,23028042 Q6UWE0 O15151 LRSAM1 MDM4 0.286 22493164 P51948 O15151 MNAT1 MDM4 0.286 22493164 Q7Z4K8 O15151 TRIM46 MDM4 0.286 22493164 O15151 O14972 MDM4 DSCR3 0.236 unassigned1304 P41227 O15151 NAA10 MDM4 0.236 unassigned1304 P61964 O15151 WDR5 MDM4 0.236 unassigned1304 O95971 O15151 CD160 MDM4 0.583 25416956,unassigned1304 O15350 O15151 TP73 MDM4 0.472 11223036,21088494 P06400 O15151 RB1 MDM4 0.832 16510145,25703327 P38936 O15151 CDKN1A MDM4 0.837 21148311,18086887 O15151 O14757 MDM4 CHEK1 0.539 16511572,16163388 P10415 O15151 BCL2 MDM4 0.808 19521340,24445145 Q3YBA8 O15151 Q3YBA8 MDM4 0.61 16511560,16511572 P61981 O15151 YWHAG MDM4 0.948 21148311,22556425,24190973,16511560,16511572 P62837 O15151 UBE2D2 MDM4 0.681 20705607,24127580 Q93009 O15151 USP7 MDM4 0.952 18566590,15916963,20713061 O15151 O15151 MDM4 MDM4 0.837 24127580,17301054,10218570,24755078,25888903 Q00987 O15151 MDM2 MDM4 1 10827196,10218570,23028042,21988832,22266850,20484049,25659040,17159902,19619542,25384516,21925390,12483531,18566590,10608892,25105592,25703327,25825738,23946421,24755078,11606419,26359458,20724842,25512388,18219319,16227609,19432880,17301054,23671280,15604276,25809483,22120712,12860999,22333590,22493164,19683495,26001071,20473904,19838211,12370303,24813712,12874296,12393902,16055726,17616658 P04637 O15151 TP53 MDM4 1 10827196,26148237,23028042,20705607,18485870,22266850,19153082,24445145,19521340,21925390,11223036,22374672,10075736,10608892,25825738,23946421,20515689,9226370,20724842,16024788,21088494,16227609,19432880,17301054,23671280,21075307,15604276,15916963,26186194,18677113,25464845,21965653,24127580,19075013,19305137,17875722,12370303,25609649,19255450,12874296,12393902,22807444,24659749,27114532,20174603 P36873 O15151 PPP1CC MDM4 0.21 23277204 P31947 O15151 SFN MDM4 0.376 16511572,16511560 Q96PM5 O15151 RCHY1 MDM4 0.376 20333547 Q9BYV6 O15151 TRIM55 MDM4 0.286 22493164 P27348 O15151 YWHAQ MDM4 0.507 17110929,18356162,16511560 Q9UPT9 O15151 USP22 MDM4 0.376 25547493 P62841 O15151 RPS15 MDM4 0.21 23874713 P43355 O15151 MAGEA1 MDM4 0.309 25590999 P63104 O15151 YWHAZ MDM4 0.376 16511560,18356162 P43366 O15151 MAGEB1 MDM4 0.21 25590999 Q13131 O15151 PRKAA1 MDM4 0.309 24190973 Q03181 O15151 PPARD MDM4 0.126 26186194 O15151 O00505 MDM4 KPNA3 0.21 16511560

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 KPNA3 MDM4 MI:0045 experimental interaction detection MI:0461 interaction database CHEK1 MDM4 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 TP73 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 NBN MI:0045 experimental interaction detection MI:0461 interaction database MDM4 USP2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database MDM4 FSBP MI:0045 experimental interaction detection MI:0461 interaction database MDM4 CD160 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 CHEK2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database MDM4 ABL1 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 MYC MI:0045 experimental interaction detection MI:0461 interaction database MDM4 TP53 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database MDM4 APP MI:0045 experimental interaction detection MI:0461 interaction database MDM4 RB1 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 CDK1 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 HSP90AA1 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 HSP90AB1 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 UBB MI:0362 inference MI:0461,MI:1106 interaction database,pathways database MDM4 UBC MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database MDM4 BCL2 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 TAF1 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 UBA1 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 YWHAQ MI:0045 experimental interaction detection MI:0461 interaction database MDM4 YWHAB MI:0045 experimental interaction detection MI:0461 interaction database MDM4 SFN MI:0045 experimental interaction detection MI:0461 interaction database MDM4 PPP1CC MI:0045 experimental interaction detection MI:0461 interaction database MDM4 CDKN1A MI:0045 experimental interaction detection MI:0461 interaction database MDM4 CDKN2A MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database MDM4 MAGEA1 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 MAGEB1 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 CSNK1A1 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 MRE11A MI:0045 experimental interaction detection MI:0461 interaction database MDM4 SMARCA2 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 UBE2D1 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 MNAT1 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 PTEN MI:0362 inference MI:1106 pathways database MDM4 RPS20 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 UBE2D3 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 RPL37 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 YWHAG MI:0045 experimental interaction detection MI:0461 interaction database MDM4 PPP1CA MI:0045 experimental interaction detection MI:0461 interaction database MDM4 PPP1CB MI:0045 experimental interaction detection MI:0461 interaction database MDM4 YWHAE MI:0045 experimental interaction detection MI:0461 interaction database MDM4 UBE2D2 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 RPS15 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 RPS27A MI:0362 inference MI:0461,MI:1106 interaction database,pathways database MDM4 UBA52 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database MDM4 YWHAZ MI:0045 experimental interaction detection MI:0461 interaction database MDM4 SUMO1 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 SMAD3 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 FOXO4 MI:0362 inference MI:1106 pathways database MDM4 MDM2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database MDM4 E2F1 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 PPARD MI:0045 experimental interaction detection MI:0461 interaction database MDM4 YWHAH MI:0045 experimental interaction detection MI:0461 interaction database MDM4 EP300 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 MKRN3 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 PRKAA1 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 PSMD2 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 ATM MI:0362 inference MI:1106 pathways database MDM4 SMAD4 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 C1orf111 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 LRSAM1 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 TRIM46 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 CDKN2A MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database MDM4 JMY MI:0362 inference MI:1106 pathways database MDM4 RFWD2 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 DYRK2 MI:0362 inference MI:1106 pathways database MDM4 RAD50 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 USP7 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database MDM4 RCHY1 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 TP63 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 RASSF1 MI:0362 inference MI:0461 interaction database MDM4 DAXX MI:0045 experimental interaction detection MI:0461 interaction database MDM4 USP22 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 RNF115 MI:0045 experimental interaction detection MI:0461 interaction database MDM4 RAD54B MI:0045 experimental interaction detection MI:0461 interaction database MDM4 CAPN7 MI:0045 experimental interaction detection MI:0461 interaction database