PTM - CPLM Gene Name UniProt ID Type Position Code MDM4; MDMX O15151 Ubiquitination 328 K

PTM - dbPAF Gene Name UniProt ID Position Type Species MDM4; MDMX O15151 119 T Homo sapiens(Human) MDM4; MDMX O15151 161 S Homo sapiens(Human) MDM4; MDMX O15151 20 S Homo sapiens(Human) MDM4; MDMX O15151 263 T Homo sapiens(Human) MDM4; MDMX O15151 264 S Homo sapiens(Human) MDM4; MDMX O15151 289 S Homo sapiens(Human) MDM4; MDMX O15151 314 S Homo sapiens(Human) MDM4; MDMX O15151 340 S Homo sapiens(Human) MDM4; MDMX O15151 342 S Homo sapiens(Human) MDM4; MDMX O15151 343 T Homo sapiens(Human) MDM4; MDMX O15151 344 S Homo sapiens(Human) MDM4; MDMX O15151 365 T Homo sapiens(Human) MDM4; MDMX O15151 367 S Homo sapiens(Human) MDM4; MDMX O15151 391 S Homo sapiens(Human) MDM4; MDMX O15151 403 S Homo sapiens(Human) MDM4; MDMX O15151 55 Y Homo sapiens(Human) MDM4; MDMX O15151 96 S Homo sapiens(Human) MDM4; MDMX O15151 99 Y Homo sapiens(Human)

PTM - PhosSNP Gene Name dbSNP ID Gene Mutation AA Mutation Mutation Position Code Peptide Score Modification Type MDM4; MDMX rs28495289 AGT->GGT S->G 289 S DDLEDSKSLSDDTDV 289 Phosphorylation TypeIII- MDM4; MDMX rs41299595 AAA->CAA K->Q 367 S PDCRRTISAPVVRPK 367 Phosphorylation TypeIII- MDM4; MDMX rs4252741 ACC->ATC T->I 403 S DLAHSSESQETISSM 403 Phosphorylation TypeIII- MDM4; MDMX rs55958721 AAG->GAG K->E 342 S SKLTHSLSTSDITAI 342 Phosphorylation TypeIII-

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA O15151 S20-p Phosphorylation SDSACRIsPGQINQV O15151 Y55-p Phosphorylation TVKEVMHyLGQYIMV O15151 S96-p Phosphorylation SFSVKDPsPLyDMLR O15151 Y99-p Phosphorylation VKDPsPLyDMLRKNL O15151 T119-p Phosphorylation ATTDAAQtLALAQDH O15151 S161-p Phosphorylation DIPTLPTsEHKCIHS O15151 T263-p Phosphorylation EAADTEQtsEEVGKV O15151 S264-p Phosphorylation AADTEQtsEEVGKVS O15151 S289-p Phosphorylation DDLEDSKsLSDDTDV O15151 S314-p Phosphorylation TECKKFNsPSKRYCF O15151 S342-p Phosphorylation SKLTHSLsTSDITAI O15151 T365-p Phosphorylation DVPDCRRtIsAPVVR O15151 S367-p Phosphorylation PDCRRtIsAPVVRPK O15151 S403-p Phosphorylation DLAHSSEsQETISSM O15151 K254-sm Sumoylation EQLGVGIkVEAADTE O15151 K379-sm Sumoylation RPKDAYIkKENSKLF

PTM - dbPTM UniProt ID Position Code Type Resources References O15151 342 S Phosphorylation Swiss-Prot 1010711 16163388 O15151 367 S Phosphorylation Swiss-Prot 1010711 16163388;16511572 O15151 254 K Sumoylation Phosphositeplus.1010730 15907800 O15151 379 K Sumoylation Phosphositeplus.1010730 15907800 O15151 289 S Phosphorylation Phosphositeplus.1010730 16024788 O15151 342 S Phosphorylation Phosphositeplus.1010730 15788536;16163388;16943424;19075013;19432880;19808970 O15151 367 S Phosphorylation Phosphositeplus.1010730 15788536;16163388;16227609;16511560;16511572;16943424;18356162;19075013;19432880;19808970 O15151 403 S Phosphorylation Phosphositeplus.1010730 15788536;16163388;19432880;19808970 O15151 96 S Phosphorylation Phosphositeplus.1010730 15735705 O15151 365 T Phosphorylation Phosphositeplus.1010730 15788536 O15151 55 Y Phosphorylation Phosphositeplus.1010730 19075013 O15151 99 Y Phosphorylation Phosphositeplus.1010730 19075013 O15151 161 S Phosphorylation HPRD 9.0 16163388 O15151 367 S Phosphorylation HPRD 9.0 16511572 O15151 391 S Phosphorylation HPRD 9.0 16163388,16511560 O15151 365 T Phosphorylation HPRD 9.0 15788536 O15151 342 S Phosphorylation (AKT1) HPRD 9.0 16163388,16511560 O15151 403 S Phosphorylation (ATM) HPRD 9.0 15788536,16163388,16511560 O15151 342 S Phosphorylation (CHEK1) HPRD 9.0 16163388 O15151 367 S Phosphorylation (CHEK1) HPRD 9.0 16163388,17110929 O15151 342 S Phosphorylation (CHEK2) HPRD 9.0 16163388 O15151 367 S Phosphorylation (CHEK2) HPRD 9.0 16163388,16511560 O15151 361 D Proteolytic Cleavage HPRD 9.0 11840332

PTM - HPRD Symbol Position Code Type References MDM4 161 S Phosphorylation 16163388 MDM4 342 S Phosphorylation 16163388 MDM4 342 S Phosphorylation 16163388,16511560 MDM4 361 D Proteolytic Cleavage 11840332 MDM4 365 T Phosphorylation 15788536 MDM4 367 S Phosphorylation 16163388,16511560 MDM4 367 S Phosphorylation 16163388,17110929 MDM4 367 S Phosphorylation 16511572 MDM4 391 S Phosphorylation 16163388,16511560 MDM4 403 S Phosphorylation 15788536,16163388,16511560

PTM - UniProt UniProt ID Position Type PMIDs O15151 342 Phosphoserine; by CHEK2 23186163;16163388 O15151 367 Phosphoserine; by CHEK1 and CHEK2 23186163;16163388;16511572

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 4194 110359 - K Ubiquitination 16227609 4194 110359 - K Sumoylation 15907800 4194 110359 - K Sumoylation 15876864 4194 110359 - K Ubiquitination 12860999 4194 110359 - K Ubiquitination 20657550 4194 110359 - K Ubiquitination 19838211 4194 110359 - K Ubiquitination 20333547 4194 110359 - K Ubiquitination 22120712 4194 110359 - K Ubiquitination 20484049 4194 110359 - K Ubiquitination 21925390 4194 110359 - K Ubiquitination 12874296 4194 110359 - K Ubiquitination 17110929 4194 110359 - K Ubiquitination 23934659 4194 110359 - K Ubiquitination 16511560