Mutation - TCGA Type Chromosome Start Position End Position Strand Variant Classification Variant Type Reference Allele Tumor_seq Allele 1 Tumor_seq Allele 2 Tumor Sample Barcode Matched Norm Sample Barcode Genome Change cDNA Change Codon Change Protein Change ACC 6 30039364 30039364 + Missense_Mutation SNP C C A TCGA-OR-A5J2-01A-11D-A29I-10 TCGA-OR-A5J2-10A-01D-A29L-10 g.chr6:30039364C>A c.787G>T c.(787-789)Ggc>Tgc p.G263C ACC 6 30039364 30039364 + Missense_Mutation SNP C C A TCGA-OR-A5JA-01A-11D-A29I-10 TCGA-OR-A5JA-10A-01D-A29L-10 g.chr6:30039364C>A c.787G>T c.(787-789)Ggc>Tgc p.G263C ACC 6 30039364 30039364 + Missense_Mutation SNP C C A TCGA-OR-A5JP-01A-11D-A29I-10 TCGA-OR-A5JP-10A-01D-A29L-10 g.chr6:30039364C>A c.787G>T c.(787-789)Ggc>Tgc p.G263C ACC 6 30039364 30039364 + Missense_Mutation SNP C C A TCGA-OR-A5KW-01A-11D-A29I-10 TCGA-OR-A5KW-10A-01D-A29L-10 g.chr6:30039364C>A c.787G>T c.(787-789)Ggc>Tgc p.G263C ACC 6 30039373 30039373 + Missense_Mutation SNP G G C TCGA-PK-A5HB-01A-11D-A29I-10 TCGA-PK-A5HB-11A-11D-A29L-10 g.chr6:30039373G>C c.778C>G c.(778-780)Ccc>Gcc p.P260A BLCA 6 30040942 30040942 + Missense_Mutation SNP C C T TCGA-XF-AAN2-01A-11D-A42E-08 TCGA-XF-AAN2-10A-01D-A42H-08 g.chr6:30040942C>T c.674G>A c.(673-675)aGa>aAa p.R225K BLCA 6 30043128 30043128 + Missense_Mutation SNP C C T TCGA-GV-A3QI-01A-11D-A21Z-08 TCGA-GV-A3QI-10A-01D-A21Z-08 g.chr6:30043128C>T c.439G>A c.(439-441)Gtg>Atg p.V147M BLCA 6 30043392 30043392 + Nonsense_Mutation SNP C C A TCGA-ZF-AA4U-01A-11D-A38G-08 TCGA-ZF-AA4U-10A-01D-A38J-08 g.chr6:30043392C>A c.175G>T c.(175-177)Gaa>Taa p.E59* BLCA 6 30043478 30043478 + Missense_Mutation SNP G G A TCGA-BT-A0YX-01A-11D-A10S-08 TCGA-BT-A0YX-10A-01D-A10S-08 g.chr6:30043478G>A c.89C>T c.(88-90)gCg>gTg p.A30V BLCA 6 30043525 30043525 + Missense_Mutation SNP C C G TCGA-DK-A2I4-01A-11D-A21A-08 TCGA-DK-A2I4-10A-01D-A21A-08 g.chr6:30043525C>G c.42G>C c.(40-42)aaG>aaC p.K14N BLCA 6 30043546 30043546 + Silent SNP C C G TCGA-K4-A4AC-01A-21D-A26M-08 TCGA-K4-A4AC-10A-01D-A26K-08 g.chr6:30043546C>G c.21G>C c.(19-21)acG>acC p.T7T CESC 6 30043421 30043421 + Missense_Mutation SNP G G A TCGA-Q1-A73R-01A-11D-A33O-09 TCGA-Q1-A73R-10B-01D-A33O-09 g.chr6:30043421G>A c.146C>T c.(145-147)gCg>gTg p.A49V CESC 6 30043424 30043424 + Missense_Mutation SNP G G C TCGA-C5-A1M6-01A-11D-A13W-08 TCGA-C5-A1M6-10A-01D-A13W-08 g.chr6:30043424G>C c.143C>G c.(142-144)tCt>tGt p.S48C COAD 6 30038956 30038956 + Missense_Mutation SNP G G A TCGA-AZ-6601-01A-11D-1771-10 TCGA-AZ-6601-11A-01D-1771-10 g.chr6:30038956G>A c.1195C>T c.(1195-1197)Cgc>Tgc p.R399C COAD 6 30040955 30040955 + Missense_Mutation SNP T T G TCGA-CA-6718-01A-11D-1835-10 TCGA-CA-6718-10A-01D-1835-10 g.chr6:30040955T>G c.661A>C c.(661-663)Aaa>Caa p.K221Q COADREAD 6 30038956 30038956 + Missense_Mutation SNP G G A TCGA-AZ-6601-01A-11D-1771-10 TCGA-AZ-6601-11A-01D-1771-10 g.chr6:30038956G>A c.1195C>T c.(1195-1197)Cgc>Tgc p.R399C COADREAD 6 30040955 30040955 + Missense_Mutation SNP T T G TCGA-CA-6718-01A-11D-1835-10 TCGA-CA-6718-10A-01D-1835-10 g.chr6:30040955T>G c.661A>C c.(661-663)Aaa>Caa p.K221Q COADREAD 6 30043369 30043369 + Nonsense_Mutation SNP C C T TCGA-AG-A002-01A-01W-A00K-09 TCGA-AG-A002-10A-01W-A00K-09 g.chr6:30043369C>T c.198G>A c.(196-198)tgG>tgA p.W66* DLBC 6 30039324 30039324 + Missense_Mutation SNP G G A TCGA-RQ-A68N-01A-11D-A31X-10 TCGA-RQ-A68N-10A-01D-A31X-10 g.chr6:30039324G>A c.827C>T c.(826-828)gCg>gTg p.A276V ESCA 6 30041253 30041253 + Silent SNP A A G TCGA-VR-AA7D-01A-11D-A403-09 TCGA-VR-AA7D-10A-01D-A403-09 g.chr6:30041253A>G c.570T>C c.(568-570)gaT>gaC p.D190D HNSC 6 30043353 30043353 + Missense_Mutation SNP G G A TCGA-CN-6997-01A-11D-2012-08 TCGA-CN-6997-10A-01D-2013-08 g.chr6:30043353G>A c.214C>T c.(214-216)Ccc>Tcc p.P72S HNSC 6 30043359 30043359 + Missense_Mutation SNP C C G TCGA-CR-7374-01A-11D-2012-08 TCGA-CR-7374-10A-01D-2013-08 g.chr6:30043359C>G c.208G>C c.(208-210)Gat>Cat p.D70H HNSC 6 30043456 30043456 + Missense_Mutation SNP G G C TCGA-TN-A7HL-01A-11D-A34J-08 TCGA-TN-A7HL-10A-01D-A34M-08 g.chr6:30043456G>C c.111C>G c.(109-111)atC>atG p.I37M KICH 6 30043171 30043171 + Silent SNP G G C TCGA-KO-8405-01A-11D-2310-10 TCGA-KO-8405-11A-01D-2311-10 g.chr6:30043171G>C c.396C>G c.(394-396)ccC>ccG p.P132P KICH 6 30043356 30043356 + Missense_Mutation SNP C C T TCGA-KM-8438-01A-11D-2310-10 TCGA-KM-8438-10A-01D-2311-10 g.chr6:30043356C>T c.211G>A c.(211-213)Gcg>Acg p.A71T KIPAN 6 30039171 30039172 + Frame_Shift_Ins INS - - T TCGA-WN-A9G9-01A-12D-A36X-10 TCGA-WN-A9G9-10A-01D-A370-10 g.chr6:30039171_30039172insT c.979_980insA c.(979-981)aggfs p.R327fs KIPAN 6 30043171 30043171 + Silent SNP G G C TCGA-KO-8405-01A-11D-2310-10 TCGA-KO-8405-11A-01D-2311-10 g.chr6:30043171G>C c.396C>G c.(394-396)ccC>ccG p.P132P KIPAN 6 30043356 30043356 + Missense_Mutation SNP C C T TCGA-KM-8438-01A-11D-2310-10 TCGA-KM-8438-10A-01D-2311-10 g.chr6:30043356C>T c.211G>A c.(211-213)Gcg>Acg p.A71T KIRP 6 30039171 30039172 + Frame_Shift_Ins INS - - T TCGA-WN-A9G9-01A-12D-A36X-10 TCGA-WN-A9G9-10A-01D-A370-10 g.chr6:30039171_30039172insT c.979_980insA c.(979-981)aggfs p.R327fs LIHC 6 30039027 30039027 + Missense_Mutation SNP C C T TCGA-4R-AA8I-01A-11D-A382-10 TCGA-4R-AA8I-10B-01D-A385-10 g.chr6:30039027C>T c.1124G>A c.(1123-1125)cGc>cAc p.R375H LIHC 6 30039406 30039406 + Missense_Mutation SNP T T G TCGA-ED-A7PZ-01A-11D-A33Q-10 TCGA-ED-A7PZ-10A-01D-A33Q-10 g.chr6:30039406T>G c.745A>C c.(745-747)Agc>Cgc p.S249R LIHC 6 30043421 30043421 + Missense_Mutation SNP G G A TCGA-DD-A73D-01A-12D-A32G-10 TCGA-DD-A73D-10A-01D-A32G-10 g.chr6:30043421G>A c.146C>T c.(145-147)gCg>gTg p.A49V LUAD 6 30041008 30041008 + Missense_Mutation SNP G G A TCGA-50-5049-01A-01D-1625-08 TCGA-50-5049-10A-01D-1625-08 g.chr6:30041008G>A c.608C>T c.(607-609)tCc>tTc p.S203F LUAD 6 30043110 30043110 + Missense_Mutation SNP C C A TCGA-69-7979-01A-11D-2184-08 TCGA-69-7979-10A-01D-2184-08 g.chr6:30043110C>A c.457G>T c.(457-459)Gtg>Ttg p.V153L PAAD 6 30038975 30038975 + Silent SNP C C T TCGA-IB-7651-01A-11D-2154-08 TCGA-IB-7651-10A-01D-2154-08 g.chr6:30038975C>T c.1176G>A c.(1174-1176)gcG>gcA p.A392A PAAD 6 30039014 30039014 + Silent SNP G G A TCGA-IB-7651-01A-11D-2154-08 TCGA-IB-7651-10A-01D-2154-08 g.chr6:30039014G>A c.1137C>T c.(1135-1137)taC>taT p.Y379Y PAAD 6 30041026 30041026 + Splice_Site SNP C C A TCGA-IB-7651-01A-11D-2154-08 TCGA-IB-7651-10A-01D-2154-08 g.chr6:30041026C>A c.e3-1 PAAD 6 30043491 30043491 + Missense_Mutation SNP C C T TCGA-2L-AAQI-01A-12D-A397-08 TCGA-2L-AAQI-11A-11D-A39A-08 g.chr6:30043491C>T c.76G>A c.(76-78)Gca>Aca p.A26T PAAD 6 30043491 30043491 + Missense_Mutation SNP C C T TCGA-HZ-A9TJ-01A-11D-A40W-08 TCGA-HZ-A9TJ-10A-01D-A40W-08 g.chr6:30043491C>T c.76G>A c.(76-78)Gca>Aca p.A26T READ 6 30043369 30043369 + Nonsense_Mutation SNP C C T TCGA-AG-A002-01A-01W-A00K-09 TCGA-AG-A002-10A-01W-A00K-09 g.chr6:30043369C>T c.198G>A c.(196-198)tgG>tgA p.W66* SKCM 6 30043030 30043030 + Silent SNP G G A TCGA-EE-A2MS-06A-11D-A197-08 TCGA-EE-A2MS-10A-01D-A199-08 g.chr6:30043030G>A c.537C>T c.(535-537)ccC>ccT p.P179P SKCM 6 30043031 30043031 + Missense_Mutation SNP G G A TCGA-EE-A2MS-06A-11D-A197-08 TCGA-EE-A2MS-10A-01D-A199-08 g.chr6:30043031G>A c.536C>T c.(535-537)cCc>cTc p.P179L SKCM 6 30043512 30043512 + Missense_Mutation SNP G G A TCGA-EE-A3JI-06A-11D-A21A-08 TCGA-EE-A3JI-10A-01D-A21A-08 g.chr6:30043512G>A c.55C>T c.(55-57)Cca>Tca p.P19S SKCM 6 30043513 30043513 + Silent SNP G G A TCGA-EE-A3JI-06A-11D-A21A-08 TCGA-EE-A3JI-10A-01D-A21A-08 g.chr6:30043513G>A c.54C>T c.(52-54)atC>atT p.I18I

Mutation - COSMIC Sample Name Mutation ID Mutation CDS Mutation AA Mutation Description Mutation Genome Position Mutation Strand CSCC-29-T COSM4572884 c.897T>C p.S299S Substitution - coding silent 6:30071477-30071477 - TCGA-DK-A2I4-01 COSM3777434 c.42G>C p.K14N Substitution - Missense 6:30075748-30075748 - TCGA-AA-3713-01 COSM3697726 c.314A>G p.H105R Substitution - Missense 6:30075476-30075476 - PTC-77C COSM3761787 c.396C>G p.P132P Substitution - coding silent 6:30075394-30075394 - BN40T COSM1621372 c.530G>A p.R177H Substitution - Missense 6:30075260-30075260 - B80-Tumor COSM4006267 c.69G>A p.R23R Substitution - coding silent 6:30075721-30075721 - TCGA-HU-A4GH-01 COSM3861346 c.1020C>T p.R340R Substitution - coding silent 6:30071354-30071354 - 722_T COSM3948959 c.575G>C p.R192T Substitution - Missense 6:30073471-30073471 - TCGA-Q1-A73R-01 COSM4856068 c.146C>T p.A49V Substitution - Missense 6:30075644-30075644 - TCGA-AY-6386-01 COSM3761783 c.802G>A p.D268N Substitution - Missense 6:30071572-30071572 - TCGA-G4-6321-01 COSM3761781 c.911C>A p.A304E Substitution - Missense 6:30071463-30071463 - CSCC-49-T COSM4461748 c.1218C>T p.T406T Substitution - coding silent 6:30071156-30071156 - BD130T COSM5515986 c.591-1G>C p.? Unknown 6:30073249-30073249 - TCGA-F4-6855-01 COSM3761787 c.396C>G p.P132P Substitution - coding silent 6:30075394-30075394 - SNU-C2B COSM1240081 c.664delA p.M222fs*5 Deletion - Frameshift 6:30073175-30073175 - T3446 COSM4722192 c.1145G>A p.R382H Substitution - Missense 6:30071229-30071229 - OSCC-GB_01120111 COSM4884673 c.754C>A p.L252M Substitution - Missense 6:30071620-30071620 - TCGA-DD-A73D-01 COSM4856068 c.146C>T p.A49V Substitution - Missense 6:30075644-30075644 - PTC_269 COSM5960529 c.847_848insC p.R283fs*77 Insertion - Frameshift 6:30071526-30071527 - HCC25T COSM1621370 c.778C>T p.P260S Substitution - Missense 6:30071596-30071596 - ESO-859 COSM1240081 c.664delA p.M222fs*5 Deletion - Frameshift 6:30073175-30073175 - LOVO COSM4645564 c.747C>T p.S249S Substitution - coding silent 6:30071627-30071627 - HCC021T COSM5815653 c.132C>A p.G44G Substitution - coding silent 6:30075658-30075658 - sysucc-1370T COSM5472222 c.926G>A p.S309N Substitution - Missense 6:30071448-30071448 - T2269 COSM4722202 c.29G>A p.R10K Substitution - Missense 6:30075761-30075761 - Pat_66_A COSM5870007 c.573G>A p.M191I Substitution - Missense 6:30073473-30073473 - TCGA-CA-6718-01 COSM1442965 c.661A>C p.K221Q Substitution - Missense 6:30073178-30073178 - TCGA-F4-6855-01 COSM3761781 c.911C>A p.A304E Substitution - Missense 6:30071463-30071463 - 0089_CRUK_PC_0089_T1_DNA COSM4413682 c.186G>A p.A62A Substitution - coding silent 6:30075604-30075604 - TCGA-GV-A3QI-01 COSM1311944 c.439G>A p.V147M Substitution - Missense 6:30075351-30075351 - 2_RESISTANT COSM1240081 c.664delA p.M222fs*5 Deletion - Frameshift 6:30073175-30073175 - OSCC-GB_01380111 COSM5953870 c.609C>T p.S203S Substitution - coding silent 6:30073230-30073230 - HCC25 COSM1621370 c.778C>T p.P260S Substitution - Missense 6:30071596-30071596 - TCGA-AP-A0LT-01 COSM4871080 c.138G>A p.P46P Substitution - coding silent 6:30075652-30075652 - AOCS-117-3-3 COSM4153204 c.567+2T>A p.? Unknown 6:30075221-30075221 - S02284 COSM5684213 c.915C>G p.D305E Substitution - Missense 6:30071459-30071459 - TCGA-AZ-6601-01 COSM1442963 c.1195C>T p.R399C Substitution - Missense 6:30071179-30071179 - Pat_45_B COSM5870003 c.1097G>A p.R366H Substitution - Missense 6:30071277-30071277 - ML_34_T_01 COSM5038259 c.414T>C p.C138C Substitution - coding silent 6:30075376-30075376 - TCGA-ER-A194-01 COSM3624126 c.147G>A p.A49A Substitution - coding silent 6:30075643-30075643 - TCGA-BT-A0YX-01 COSM4811659 c.89C>T p.A30V Substitution - Missense 6:30075701-30075701 - TCGA-C5-A1M6-01 COSM4826734 c.143C>G p.S48C Substitution - Missense 6:30075647-30075647 - TCGA-BR-4368-01 COSM3861350 c.249G>A p.E83E Substitution - coding silent 6:30075541-30075541 - BD165T COSM5506199 c.1261T>C p.*421R Nonstop extension 6:30071113-30071113 - TCGA-DM-A1DA-01 COSM3761779 c.1053A>G p.E351E Substitution - coding silent 6:30071321-30071321 - sysucc-1370T COSM5472220 c.1082C>T p.P361L Substitution - Missense 6:30071292-30071292 - Pat_14_B COSM5870005 c.1045G>A p.A349T Substitution - Missense 6:30071329-30071329 - TCGA-DM-A285-01 COSM3761785 c.787G>T p.G263C Substitution - Missense 6:30071587-30071587 - SM-4B296 COSM5035592 c.153G>T p.S51S Substitution - coding silent 6:30075637-30075637 - BN24T COSM1621374 c.203C>G p.S68C Substitution - Missense 6:30075587-30075587 - AOCS-093-8-4 COSM4153202 c.1189G>T p.G397W Substitution - Missense 6:30071185-30071185 - T3225 COSM4722194 c.1031T>C p.L344P Substitution - Missense 6:30071343-30071343 - BN30T COSM1621372 c.530G>A p.R177H Substitution - Missense 6:30075260-30075260 - T3527 COSM4722198 c.529C>T p.R177C Substitution - Missense 6:30075261-30075261 - T231 COSM4722196 c.1013_1022del10 p.E338fs*>80 Deletion - Frameshift 6:30071352-30071361 - CRC-19T COSM5482042 c.1140C>T p.D380D Substitution - coding silent 6:30071234-30071234 - S01864 COSM5671819 c.697G>A p.D233N Substitution - Missense 6:30071677-30071677 - SC_9094 COSM5554969 c.64G>C p.G22R Substitution - Missense 6:30075726-30075726 - BN24 COSM1621374 c.203C>G p.S68C Substitution - Missense 6:30075587-30075587 - TCGA-BR-6452-01 COSM3861348 c.546C>T p.G182G Substitution - coding silent 6:30075244-30075244 - PTC-10C COSM4160539 c.1013A>G p.E338G Substitution - Missense 6:30071361-30071361 - T578 COSM4722200 c.134G>A p.G45D Substitution - Missense 6:30075656-30075656 - TCGA-F4-6463-01 COSM3761781 c.911C>A p.A304E Substitution - Missense 6:30071463-30071463 - TCGA-BR-6452-01 COSM3861352 c.17T>C p.L6S Substitution - Missense 6:30075773-30075773 - TCGA-EM-A3AQ-01 COSM3374185 c.46G>A p.E16K Substitution - Missense 6:30075744-30075744 -

Mutation - CGAP UNIGENE CYTOBAND OMIM SNP Hs.121108;Hs.121116;Hs.121144;Hs.121167;Hs.121178 6p21.3 607524

Mutation - IntOGen Mutated from(ref) Mutated to(alt) Consequence Type AA Mutation CDS Mutation Chr Pos Cancer - CC Frameshift p.R15Gfs*130 c.42_43insGG 6 30043525 HNSC C G Missense p.D70H c.208G>C 6 30043359 HNSC C G Missense p.K14N c.42G>C 6 30043525 BLCA C T Missense p.D215N c.643G>A 6 30040973 CM C T Missense p.E16K c.46G>A 6 30043521 THCA C T Missense p.V147M c.439G>A 6 30043128 BLCA C T Synonymous p.A49A c.147G>A 6 30043420 CM C T Synonymous p.E83E c.249G>A 6 30043318 STAD C T Synonymous p.P46P c.138G>A 6 30043429 UCEC C T Synonymous p.S51S c.153G>A 6 30043414 BRCA G A Missense p.A30V c.89C>T 6 30043478 BLCA G A Missense p.P72S c.214C>T 6 30043353 HNSC G A Missense p.S203F c.608C>T 6 30041008 LUAD G A Synonymous p.P360P c.1080C>T 6 30039071 CM GG AA Missense p.P179L c.536_537delinsTT 6 30043030 CM GG AA Missense p.P19S c.54_55delinsTT 6 30043512 CM GTGA - 3-UTRDeletion . c.1260+645_1260+648delTCAC 6 30038243 CM T C 3-UTRSNV . c.1260+21A>G 6 30038870 HC T - Frameshift p.M222Cfs*5 c.664delA 6 30040952 RCCC