PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RPIA RNF208 25416956 biogrid,intact exp G GP G G G GP G GP G GP GP P GP P GP GP G GP G GP P P P GP G TRIM32 RNF208 22493164 biogrid,intact exp G GP G G G GP G GP G GP GP GP P GP GP G GP G GP P P P GP G RNF208 UBQLN1 25416956 biogrid,intact exp G GP G G G GP G GP G GP GP P GP P GP GP G GP G GP P P P GP G DAZAP2 RNF208 25416956,16189514 biogrid,mint,intact exp G G G G G G G G G G G G G G G G G G G G NECAB3 RNF208 23023127 pred G G G G G G G G G G G G G G G G G G G G UBE2E2 RNF208 23023127 pred G GP G G G GP G GP G GP GP P GP P GP GP G GP G GP P P P GP G UBE2M RNF208 23023127 pred G GP G G G GP G GP G GP G P GP P GP GP G GP G GP P P P GP G NGEF RNF208 23023127 pred GP G GP G P G GP GP P GP P GP GP P P P P P GP G MAPK8IP2 RNF208 23023127 pred G GP G G G GP G GP G GP GP P GP P GP GP G GP G GP P P P GP G APBB1 RNF208 23023127 pred G GP G G G GP G GP G GP GP P G GP GP G GP G GP P P GP G DCTN1 RNF208 25402006 pred G GP G G G GP G GP G GP GP P GP P GP GP G GP G GP P P P GP G MYCBP2 RNF208 23023127 pred G GP G G G GP G GP G G G P GP P GP GP G G G G P GP G RNF220 RNF208 23023127 pred G GP G G G GP G G G GP GP P G GP GP G GP G GP P G G RUSC1 RNF208 23023127 pred G GP G G G GP G GP G GP GP P GP P GP GP G GP G GP P P GP G RNF208 BSN 23023127 pred G GP G P G P P GP P G P P P P VAMP2 RNF208 25402006 pred G G G G G G G G G G G G G G G G G G G G TRIM54 RNF208 23023127 pred P GP P P P G P GP P P P FSTL5 RNF208 23023127 pred P G GP G P G P P P P P GP P G P P P P P P TRIM37 RNF208 23023127 pred G GP G G G GP G G G GP G P G P GP GP G GP G G P P GP G DZIP3 RNF208 23023127 pred G GP G G G GP G GP G GP G P GP P GP GP G P G GP P P GP G SH3RF2 RNF208 23023127 pred P P GP P P P P P P P P GP UBE2K RNF208 23023127 pred G GP G G G GP G GP G GP GP P GP P GP GP G GP G GP P P P GP G RNF208 STMN3 23023127 pred G G G G G GP G G G GP G P G GP GP G G G GP G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9H0X6 Q15038-2 two hybrid 25416956 direct interaction X 2 Q9H0X6 P49247 two hybrid 25416956 direct interaction X 2 Q9H0X6 A0A024R843 two hybrid 22493164 direct interaction X 2 Q9H0X6 A0A024R284 two hybrid 25416956 direct interaction X 2 Q9H0X6 Q15038-3 two hybrid 16189514 - X 2 Q9H0X6 Q15038-3 two hybrid 16189514 - X 2 Q9H0X6 P49247 two hybrid prey pooling approach 25416956 physical association X 2 Q9H0X6 P49247 two hybrid array 25416956 physical association X 2 Q9H0X6 P49247 validated two hybrid 25416956 physical association X 2 Q9H0X6 A0A024R843 two hybrid array 22493164 physical association X 2 Q9H0X6 A0A024R284 two hybrid prey pooling approach 25416956 physical association X 2 Q9H0X6 A0A024R284 two hybrid array 25416956 physical association X 2 Q9H0X6 A0A024R284 validated two hybrid 25416956 physical association X 2 A0A024R110 Q9H0X6 two hybrid pooling approach 16189514 physical association X 2 A0A024R110 Q9H0X6 two hybrid prey pooling approach 25416956 physical association X 2 A0A024R110 Q9H0X6 two hybrid array 25416956 physical association X 2 A0A024R110 Q9H0X6 validated two hybrid 25416956 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality RPIA RNF208 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TRIM32 RNF208 22493164,22493164 0018,0397 HT DAZAP2 RNF208 16189514,25416956,25416956,25416956,16189514,25416956 0398,1112,0397,0018,0018,1356 HT RNF208 UBQLN1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9UHD9 Q9H0X6 UBQLN2 RNF208 0.236 unassigned1304 Q9H0X6 Q8TDS5 RNF208 OXER1 0.236 unassigned1304 Q9H0X6 Q15038 RNF208 DAZAP2 0.636 25416956,16189514,unassigned1304 Q9H0X6 B8A4K4 RNF208 CYSRT1 {ECO:0000313|ENSEMBL:ENSP00000386453} 0.236 unassigned1304 Q9H0X6 P49247 RNF208 RPIA 0.454 25416956 Q9H0X6 P49639 RNF208 HOXA1 0.236 unassigned1304 Q9H0X6 Q6PEX3 RNF208 KRTAP26-1 0.236 unassigned1304 Q9H0X6 Q3LI76 RNF208 KRTAP15-1 0.236 unassigned1304 Q9H0X6 Q70EL1 RNF208 USP54 0.236 unassigned1304 Q9UMX0 Q9H0X6 UBQLN1 RNF208 0.454 25416956 Q9H0X6 Q13049 RNF208 TRIM32 0.286 22493164

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 RPIA RNF208 MI:0045 experimental interaction detection MI:0461 interaction database TRIM32 RNF208 MI:0045 experimental interaction detection MI:0461 interaction database DAZAP2 RNF208 MI:0045 experimental interaction detection MI:0461 interaction database RNF208 UBQLN1 MI:0045 experimental interaction detection MI:0461 interaction database