Mutation - TCGA Type Chromosome Start Position End Position Strand Variant Classification Variant Type Reference Allele Tumor_seq Allele 1 Tumor_seq Allele 2 Tumor Sample Barcode Matched Norm Sample Barcode Genome Change cDNA Change Codon Change Protein Change BLCA 6 32146400 32146400 + Missense_Mutation SNP G G T TCGA-GV-A3JV-01A-11D-A21Z-08 TCGA-GV-A3JV-10B-01D-A21Z-08 g.chr6:32146400G>T c.112G>T c.(112-114)Gtg>Ttg p.V38L BLCA 6 32147331 32147331 + Missense_Mutation SNP C C T TCGA-DK-A1A5-01A-11D-A13W-08 TCGA-DK-A1A5-10A-01D-A13W-08 g.chr6:32147331C>T c.154C>T c.(154-156)Cat>Tat p.H52Y BLCA 6 32147490 32147490 + Silent SNP G G A TCGA-KQ-A41R-01A-21D-A34U-08 TCGA-KQ-A41R-10G-01D-A34X-08 g.chr6:32147490G>A c.222G>A c.(220-222)gaG>gaA p.E74E BLCA 6 32148014 32148014 + Silent SNP C C T TCGA-BT-A20Q-01A-11D-A14W-08 TCGA-BT-A20Q-11A-11D-A14W-08 g.chr6:32148014C>T c.454C>T c.(454-456)Ctg>Ttg p.L152L BLCA 6 32148102 32148102 + Silent SNP G G A TCGA-4Z-AA7R-01A-11D-A391-08 TCGA-4Z-AA7R-10A-01D-A394-08 g.chr6:32148102G>A c.542G>A c.(541-543)tGa>tAa p.*181* CESC 6 32148026 32148026 + Missense_Mutation SNP C C T TCGA-IR-A3LL-01A-11D-A20U-09 TCGA-IR-A3LL-10A-01D-A20U-09 g.chr6:32148026C>T c.466C>T c.(466-468)Cac>Tac p.H156Y COAD 6 32147529 32147529 + Silent SNP C C A TCGA-CM-5861-01A-01D-1650-10 TCGA-CM-5861-10A-01D-1650-10 g.chr6:32147529C>A c.261C>A c.(259-261)ccC>ccA p.P87P COAD 6 32148080 32148080 + Frame_Shift_Del DEL T T - TCGA-AZ-6598-01A-11D-1771-10 TCGA-AZ-6598-11A-01D-1771-10 g.chr6:32148080delT c.520delT c.(520-522)tttfs p.F175fs COADREAD 6 32147529 32147529 + Silent SNP C C A TCGA-CM-5861-01A-01D-1650-10 TCGA-CM-5861-10A-01D-1650-10 g.chr6:32147529C>A c.261C>A c.(259-261)ccC>ccA p.P87P COADREAD 6 32148080 32148080 + Frame_Shift_Del DEL T T - TCGA-AZ-6598-01A-11D-1771-10 TCGA-AZ-6598-11A-01D-1771-10 g.chr6:32148080delT c.520delT c.(520-522)tttfs p.F175fs GBM 6 32147882 32147882 + Missense_Mutation SNP G G A TCGA-19-1390-01A-01D-1495-08 TCGA-19-1390-10C-01D-1495-08 g.chr6:32147882G>A c.424G>A c.(424-426)Gag>Aag p.E142K GBMLGG 6 32147882 32147882 + Missense_Mutation SNP G G A TCGA-19-1390-01A-01D-1495-08 TCGA-19-1390-10C-01D-1495-08 g.chr6:32147882G>A c.424G>A c.(424-426)Gag>Aag p.E142K LIHC 6 32148076 32148076 + Silent SNP C C T TCGA-EP-A2KA-01A-11D-A183-10 TCGA-EP-A2KA-10A-01D-A183-10 g.chr6:32148076C>T c.516C>T c.(514-516)ttC>ttT p.F172F LUAD 6 32146358 32146358 + Missense_Mutation SNP A A G TCGA-64-5778-01A-01D-1625-08 TCGA-64-5778-10A-01D-1625-08 g.chr6:32146358A>G c.70A>G c.(70-72)Acc>Gcc p.T24A LUAD 6 32147882 32147882 + Missense_Mutation SNP G G A TCGA-MN-A4N4-01A-12D-A24P-08 TCGA-MN-A4N4-10A-01D-A24P-08 g.chr6:32147882G>A c.424G>A c.(424-426)Gag>Aag p.E142K LUAD 6 32148055 32148055 + Silent SNP C C T TCGA-55-A4DF-01A-11D-A24D-08 TCGA-55-A4DF-10A-01D-A24F-08 g.chr6:32148055C>T c.495C>T c.(493-495)ctC>ctT p.L165L PAAD 6 32148080 32148080 + Frame_Shift_Del DEL T T - TCGA-IB-AAUM-01A-11D-A377-08 TCGA-IB-AAUM-10A-01D-A37A-08 g.chr6:32148080delT c.520delT c.(520-522)tttfs p.F175fs

Mutation - COSMIC Sample Name Mutation ID Mutation CDS Mutation AA Mutation Description Mutation Genome Position Mutation Strand TCGA-IR-A3LL-01 COSM4849967 c.466C>T p.H156Y Substitution - Missense 6:32180249-32180249 + TCGA-33-4547-01 COSM596123 c.407C>T p.T136I Substitution - Missense 6:32180088-32180088 + SC_9076 COSM596123 c.407C>T p.T136I Substitution - Missense 6:32180088-32180088 + CCC5 COSM3662412 c.222G>T p.E74D Substitution - Missense 6:32179713-32179713 + TCGA-A5-A0GP-01 COSM1077832 c.85A>C p.I29L Substitution - Missense 6:32178596-32178596 + TCGA-AB-2807-03 COSM1319108 c.32C>T p.P11L Substitution - Missense 6:32178543-32178543 + T3306 COSM4722208 c.351C>T p.T117T Substitution - coding silent 6:32180032-32180032 + BCM265T COSM4955172 c.276A>G p.L92L Substitution - coding silent 6:32179880-32179880 + TCGA-AZ-6598-01 COSM1443580 c.520delT p.W176fs*>5 Deletion - Frameshift 6:32180303-32180303 + SC_9076 COSM5569127 c.351C>A p.T117T Substitution - coding silent 6:32180032-32180032 + T368 COSM3994866 c.174G>A p.R58R Substitution - coding silent 6:32179665-32179665 + RK170_C01 COSM1634735 c.319A>G p.S107G Substitution - Missense 6:32179923-32179923 + TCGA-CD-8536-01 COSM3872939 c.30C>G p.G10G Substitution - coding silent 6:32178541-32178541 + TCGA-AM-5820-01 COSM3761921 c.315G>A p.P105P Substitution - coding silent 6:32179919-32179919 + CCC5T COSM3662412 c.222G>T p.E74D Substitution - Missense 6:32179713-32179713 + SNUH_G39_S1 COSM3684266 c.141-1G>T p.? Unknown 6:32179540-32179540 + TCGA-B9-5155-01 COSM3994866 c.174G>A p.R58R Substitution - coding silent 6:32179665-32179665 + TCGA-CG-5733-01 COSM1077834 c.409G>A p.V137I Substitution - Missense 6:32180090-32180090 + WT014 COSM5351813 c.160-4C>T p.? Unknown 6:32179647-32179647 + TCGA-22-1002-01 COSM596123 c.407C>T p.T136I Substitution - Missense 6:32180088-32180088 + Pat_76_A COSM5870297 c.291delC p.Q99fs*>82 Deletion - Frameshift 6:32179895-32179895 + BD5T COSM3662412 c.222G>T p.E74D Substitution - Missense 6:32179713-32179713 + TCGA-AM-5820-01 COSM3761923 c.471A>G p.P157P Substitution - coding silent 6:32180254-32180254 + TCGA-CM-5861-01 COSM1443579 c.261C>A p.P87P Substitution - coding silent 6:32179752-32179752 + TCGA-A5-A0GH-01 COSM1077834 c.409G>A p.V137I Substitution - Missense 6:32180090-32180090 + I2L-P19Ta-Tumor-Biopsy COSM5357004 c.397delT p.F134fs*>47 Deletion - Frameshift 6:32180078-32180078 + TCGA-19-1390-01 COSM3410977 c.424G>A p.E142K Substitution - Missense 6:32180105-32180105 + I2L-P19Ta-Tumor-Organoid COSM5357004 c.397delT p.F134fs*>47 Deletion - Frameshift 6:32180078-32180078 + BCM265T COSM4955172 c.276A>G p.L92L Substitution - coding silent 6:32179880-32179880 + ESO-224 COSM1264404 c.194C>A p.P65Q Substitution - Missense 6:32179685-32179685 + TCGA-AP-A0LM-01 COSM1077833 c.248G>T p.G83V Substitution - Missense 6:32179739-32179739 + WT031 COSM5351957 c.160-5C>A p.? Unknown 6:32179646-32179646 + TCGA-BT-A20Q-01 COSM421383 c.454C>T p.L152L Substitution - coding silent 6:32180237-32180237 + TCGA-DK-A1A5-01 COSM421384 c.154C>T p.H52Y Substitution - Missense 6:32179554-32179554 + TCGA-GV-A3JV-01 COSM1312048 c.112G>T p.V38L Substitution - Missense 6:32178623-32178623 + H1672 COSM314861 c.225G>A p.K75K Substitution - coding silent 6:32179716-32179716 + TCGA-EQ-8122-01 COSM3872941 c.117C>T p.V39V Substitution - coding silent 6:32178628-32178628 +

Mutation - CGAP UNIGENE CYTOBAND OMIM SNP Hs.731768;Hs.731769;Hs.731774 6p21.3 602677

Mutation - IntOGen Mutated from(ref) Mutated to(alt) Consequence Type AA Mutation CDS Mutation Chr Pos Cancer A C Missense p.I29L c.85A>C 6 32146373 UCEC A G Missense p.T24A c.70A>G 6 32146358 LUAD C A Missense p.P65Q c.194C>A 6 32147462 ESCA CC AA Missense p.P11Q c.32_33delinsAA 6 32146320 CM CG AT Missense p.R35M c.103_104delinsAT 6 32146391 CM C T Missense p.H52Y c.154C>T 6 32147331 BLCA C T Missense p.T136I c.407C>T 6 32147865 LUAD C T Missense p.T136I c.407C>T 6 32147865 LUSC C T Synonymous p.L152L c.454C>T 6 32148014 BLCA G A Missense p.E142K c.424G>A 6 32147882 GBM G A Missense p.V137I c.409G>A 6 32147867 STAD G A Missense p.V137I c.409G>A 6 32147867 UCEC G T Missense p.V38L c.112G>T 6 32146400 BLCA