Mutation - TCGA Type Chromosome Start Position End Position Strand Variant Classification Variant Type Reference Allele Tumor_seq Allele 1 Tumor_seq Allele 2 Tumor Sample Barcode Matched Norm Sample Barcode Genome Change cDNA Change Codon Change Protein Change ACC 6 30126189 30126189 + Missense_Mutation SNP C C A TCGA-OR-A5KB-01A-11D-A30A-10 TCGA-OR-A5KB-11A-11D-A30A-10 g.chr6:30126189C>A c.743G>T c.(742-744)aGg>aTg p.R248M BLCA 6 30121747 30121747 + Nonstop_Mutation SNP C C G TCGA-4Z-AA7W-01A-11D-A391-08 TCGA-4Z-AA7W-10A-01D-A394-08 g.chr6:30121747C>G c.1445G>C c.(1444-1446)tGa>tCa p.*482S BLCA 6 30121796 30121796 + Missense_Mutation SNP G G T TCGA-XF-AAMZ-01A-11D-A42E-08 TCGA-XF-AAMZ-10A-01D-A42H-08 g.chr6:30121796G>T c.1396C>A c.(1396-1398)Ccc>Acc p.P466T BLCA 6 30121860 30121860 + Missense_Mutation SNP G G C TCGA-MV-A51V-01A-11D-A26M-08 TCGA-MV-A51V-10A-01D-A26K-08 g.chr6:30121860G>C c.1332C>G c.(1330-1332)ttC>ttG p.F444L BLCA 6 30126201 30126201 + Missense_Mutation SNP T T C TCGA-DK-A1A3-01A-11D-A13W-08 TCGA-DK-A1A3-10A-01D-A13W-08 g.chr6:30126201T>C c.731A>G c.(730-732)gAg>gGg p.E244G BLCA 6 30128255 30128255 + Silent SNP G G A TCGA-GU-A42P-01A-11D-A23U-08 TCGA-GU-A42P-10A-01D-A23U-08 g.chr6:30128255G>A c.381C>T c.(379-381)caC>caT p.H127H BLCA 6 30128401 30128401 + Missense_Mutation SNP C C T TCGA-FD-A6TH-01A-11D-A32B-08 TCGA-FD-A6TH-10A-01D-A329-08 g.chr6:30128401C>T c.235G>A c.(235-237)Gtg>Atg p.V79M BLCA 6 30128418 30128418 + Nonsense_Mutation SNP C C T TCGA-BT-A20N-01A-11D-A14W-08 TCGA-BT-A20N-11A-11D-A14W-08 g.chr6:30128418C>T c.218G>A c.(217-219)tGg>tAg p.W73* BRCA 6 30122026 30122026 + Missense_Mutation SNP T T A TCGA-A7-A13H-01A-11D-A228-09 TCGA-A7-A13H-10A-01D-A22A-09 g.chr6:30122026T>A c.1166A>T c.(1165-1167)cAg>cTg p.Q389L BRCA 6 30124770 30124770 + Missense_Mutation SNP G G A TCGA-BH-A0AW-01A-11W-A071-09 TCGA-BH-A0AW-10A-01W-A071-09 g.chr6:30124770G>A c.841C>T c.(841-843)Cgg>Tgg p.R281W BRCA 6 30126372 30126372 + Missense_Mutation SNP G G A TCGA-A2-A0CX-01A-21W-A019-09 TCGA-A2-A0CX-10A-01W-A021-09 g.chr6:30126372G>A c.560C>T c.(559-561)tCt>tTt p.S187F BRCA 6 30126399 30126399 + Missense_Mutation SNP A A C TCGA-A8-A0A6-01A-12W-A071-09 TCGA-A8-A0A6-10A-01W-A071-09 g.chr6:30126399A>C c.533T>G c.(532-534)gTg>gGg p.V178G CESC 6 30128238 30128238 + Missense_Mutation SNP C C T TCGA-FU-A3WB-01A-11D-A22X-09 TCGA-FU-A3WB-10A-01D-A22X-09 g.chr6:30128238C>T c.398G>A c.(397-399)cGc>cAc p.R133H COAD 6 30121959 30121959 + Silent SNP G G A TCGA-AZ-4315-01A-01D-1408-10 TCGA-AZ-4315-10A-01D-1408-10 g.chr6:30121959G>A c.1233C>T c.(1231-1233)ttC>ttT p.F411F COAD 6 30122108 30122108 + Missense_Mutation SNP C C T TCGA-A6-6780-01A-11D-1835-10 TCGA-A6-6780-10A-01D-1835-10 g.chr6:30122108C>T c.1084G>A c.(1084-1086)Ggg>Agg p.G362R COAD 6 30122190 30122190 + Missense_Mutation SNP G G T TCGA-AA-3984-01A-02W-0995-10 TCGA-AA-3984-10A-01W-0999-10 g.chr6:30122190G>T c.1002C>A c.(1000-1002)ttC>ttA p.F334L COAD 6 30122222 30122222 + Missense_Mutation SNP G G T TCGA-AA-3950-01A-02W-0995-10 TCGA-AA-3950-10A-01W-0995-10 g.chr6:30122222G>T c.970C>A c.(970-972)Ctc>Atc p.L324I COAD 6 30124770 30124770 + Missense_Mutation SNP G G A TCGA-CA-6717-01A-11D-1835-10 TCGA-CA-6717-10A-01D-1835-10 g.chr6:30124770G>A c.841C>T c.(841-843)Cgg>Tgg p.R281W COAD 6 30126365 30126365 + Silent SNP G G A TCGA-AA-A00N-01A-02W-A00E-09 TCGA-AA-A00N-10A-01W-A00E-09 g.chr6:30126365G>A c.567C>T c.(565-567)ttC>ttT p.F189F COAD 6 30128272 30128272 + Missense_Mutation SNP G G A TCGA-AA-3821-01A-01W-0995-10 TCGA-AA-3821-10A-01W-0995-10 g.chr6:30128272G>A c.364C>T c.(364-366)Cgg>Tgg p.R122W COAD 6 30128594 30128594 + Silent SNP G G T TCGA-AA-3692-01A-01W-0900-09 TCGA-AA-3692-10A-01W-0900-09 g.chr6:30128594G>T c.42C>A c.(40-42)gtC>gtA p.V14V COADREAD 6 30121959 30121959 + Silent SNP G G A TCGA-AZ-4315-01A-01D-1408-10 TCGA-AZ-4315-10A-01D-1408-10 g.chr6:30121959G>A c.1233C>T c.(1231-1233)ttC>ttT p.F411F COADREAD 6 30122009 30122009 + Missense_Mutation SNP G G A TCGA-AG-A002-01A-01W-A00K-09 TCGA-AG-A002-10A-01W-A00K-09 g.chr6:30122009G>A c.1183C>T c.(1183-1185)Cgg>Tgg p.R395W COADREAD 6 30122108 30122108 + Missense_Mutation SNP C C T TCGA-A6-6780-01A-11D-1835-10 TCGA-A6-6780-10A-01D-1835-10 g.chr6:30122108C>T c.1084G>A c.(1084-1086)Ggg>Agg p.G362R COADREAD 6 30122190 30122190 + Missense_Mutation SNP G G T TCGA-AA-3984-01A-02W-0995-10 TCGA-AA-3984-10A-01W-0999-10 g.chr6:30122190G>T c.1002C>A c.(1000-1002)ttC>ttA p.F334L COADREAD 6 30122222 30122222 + Missense_Mutation SNP G G T TCGA-AA-3950-01A-02W-0995-10 TCGA-AA-3950-10A-01W-0995-10 g.chr6:30122222G>T c.970C>A c.(970-972)Ctc>Atc p.L324I COADREAD 6 30122254 30122254 + Missense_Mutation SNP G G T TCGA-AG-A002-01A-01W-A00K-09 TCGA-AG-A002-10A-01W-A00K-09 g.chr6:30122254G>T c.938C>A c.(937-939)tCt>tAt p.S313Y COADREAD 6 30124770 30124770 + Missense_Mutation SNP G G A TCGA-CA-6717-01A-11D-1835-10 TCGA-CA-6717-10A-01D-1835-10 g.chr6:30124770G>A c.841C>T c.(841-843)Cgg>Tgg p.R281W COADREAD 6 30126365 30126365 + Silent SNP G G A TCGA-AA-A00N-01A-02W-A00E-09 TCGA-AA-A00N-10A-01W-A00E-09 g.chr6:30126365G>A c.567C>T c.(565-567)ttC>ttT p.F189F COADREAD 6 30128219 30128219 + Silent SNP C C T TCGA-AG-4008-01A-01W-1073-09 TCGA-AG-4008-10A-01W-1073-09 g.chr6:30128219C>T c.417G>A c.(415-417)gcG>gcA p.A139A COADREAD 6 30128272 30128272 + Missense_Mutation SNP G G A TCGA-AA-3821-01A-01W-0995-10 TCGA-AA-3821-10A-01W-0995-10 g.chr6:30128272G>A c.364C>T c.(364-366)Cgg>Tgg p.R122W COADREAD 6 30128594 30128594 + Silent SNP G G T TCGA-AA-3692-01A-01W-0900-09 TCGA-AA-3692-10A-01W-0900-09 g.chr6:30128594G>T c.42C>A c.(40-42)gtC>gtA p.V14V ESCA 6 30122004 30122004 + Silent SNP C C G TCGA-R6-A6Y2-01B-11D-A33E-09 TCGA-R6-A6Y2-10A-01D-A33H-09 g.chr6:30122004C>G c.1188G>C c.(1186-1188)ctG>ctC p.L396L ESCA 6 30123537 30123537 + Splice_Site SNP C C A TCGA-L7-A6VZ-01A-12D-A33E-09 TCGA-L7-A6VZ-10A-01D-A33H-09 g.chr6:30123537C>A c.e6-1 ESCA 6 30126364 30126364 + Missense_Mutation SNP C C T TCGA-VR-A8EX-01A-11D-A36J-09 TCGA-VR-A8EX-10A-01D-A36M-09 g.chr6:30126364C>T c.568G>A c.(568-570)Gca>Aca p.A190T ESCA 6 30128405 30128405 + Silent SNP G G A TCGA-IG-A5B8-01A-11D-A28B-09 TCGA-IG-A5B8-10A-01D-A28E-09 g.chr6:30128405G>A c.231C>T c.(229-231)aaC>aaT p.N77N ESCA 6 30128469 30128469 + Missense_Mutation SNP G G A TCGA-L5-A8NM-01A-11D-A37C-09 TCGA-L5-A8NM-11A-12D-A37F-09 g.chr6:30128469G>A c.167C>T c.(166-168)aCt>aTt p.T56I ESCA 6 30128472 30128472 + Missense_Mutation SNP G G A TCGA-VR-A8EZ-01A-11D-A36J-09 TCGA-VR-A8EZ-10A-01D-A36M-09 g.chr6:30128472G>A c.164C>T c.(163-165)cCt>cTt p.P55L GBM 6 30121907 30121907 + Missense_Mutation SNP G G A TCGA-28-2502-01B-01D-1494-08 TCGA-28-2502-10A-01D-1494-08 g.chr6:30121907G>A c.1285C>T c.(1285-1287)Cgg>Tgg p.R429W GBM 6 30126240 30126240 + Missense_Mutation SNP C C T TCGA-32-2495-01A-01D-1353-08 TCGA-32-2495-10B-01D-1353-08 g.chr6:30126240C>T c.692G>A c.(691-693)cGg>cAg p.R231Q GBM 6 30126364 30126364 + Missense_Mutation SNP C C T TCGA-41-5651-01A-01D-1696-08 TCGA-41-5651-10A-01D-1696-08 g.chr6:30126364C>T c.568G>A c.(568-570)Gca>Aca p.A190T GBM 6 30127012 30127012 + Missense_Mutation SNP T T C TCGA-06-0744-01A-01W-0348-08 TCGA-06-0744-10A-01W-0348-08 g.chr6:30127012T>C c.440A>G c.(439-441)cAt>cGt p.H147R GBMLGG 6 30121907 30121907 + Missense_Mutation SNP G G A TCGA-28-2502-01B-01D-1494-08 TCGA-28-2502-10A-01D-1494-08 g.chr6:30121907G>A c.1285C>T c.(1285-1287)Cgg>Tgg p.R429W GBMLGG 6 30122144 30122144 + Missense_Mutation SNP G G A TCGA-DU-6392-01A-11D-1705-08 TCGA-DU-6392-10A-01D-1705-08 g.chr6:30122144G>A c.1048C>T c.(1048-1050)Cgg>Tgg p.R350W GBMLGG 6 30126240 30126240 + Missense_Mutation SNP C C T TCGA-32-2495-01A-01D-1353-08 TCGA-32-2495-10B-01D-1353-08 g.chr6:30126240C>T c.692G>A c.(691-693)cGg>cAg p.R231Q GBMLGG 6 30126364 30126364 + Missense_Mutation SNP C C T TCGA-41-5651-01A-01D-1696-08 TCGA-41-5651-10A-01D-1696-08 g.chr6:30126364C>T c.568G>A c.(568-570)Gca>Aca p.A190T GBMLGG 6 30127012 30127012 + Missense_Mutation SNP T T C TCGA-06-0744-01A-01W-0348-08 TCGA-06-0744-10A-01W-0348-08 g.chr6:30127012T>C c.440A>G c.(439-441)cAt>cGt p.H147R HNSC 6 30121897 30121897 + Missense_Mutation SNP C C T TCGA-CV-A45Z-01A-21D-A25D-08 TCGA-CV-A45Z-10A-01D-A25E-08 g.chr6:30121897C>T c.1295G>A c.(1294-1296)aGg>aAg p.R432K HNSC 6 30122024 30122024 + Missense_Mutation SNP G G A TCGA-BA-A6DL-01A-21D-A30E-08 TCGA-BA-A6DL-10A-01D-A30H-08 g.chr6:30122024G>A c.1168C>T c.(1168-1170)Cgg>Tgg p.R390W HNSC 6 30122127 30122127 + Silent SNP C C A TCGA-CN-5369-01A-01D-1434-08 TCGA-CN-5369-10A-01D-1434-08 g.chr6:30122127C>A c.1065G>T c.(1063-1065)ctG>ctT p.L355L HNSC 6 30122152 30122152 + Missense_Mutation SNP C C T TCGA-BA-6872-01A-11D-1870-08 TCGA-BA-6872-10A-01D-1870-08 g.chr6:30122152C>T c.1040G>A c.(1039-1041)cGt>cAt p.R347H HNSC 6 30126364 30126364 + Missense_Mutation SNP C C T TCGA-P3-A6SW-01A-11D-A34J-08 TCGA-P3-A6SW-10A-01D-A34M-08 g.chr6:30126364C>T c.568G>A c.(568-570)Gca>Aca p.A190T HNSC 6 30126982 30126982 + Missense_Mutation SNP C C G TCGA-CR-6484-01A-11D-1870-08 TCGA-CR-6484-10A-01D-1870-08 g.chr6:30126982C>G c.470G>C c.(469-471)aGa>aCa p.R157T HNSC 6 30128347 30128347 + Missense_Mutation SNP C C T TCGA-KU-A66S-01A-21D-A30E-08 TCGA-KU-A66S-10A-01D-A30H-08 g.chr6:30128347C>T c.289G>A c.(289-291)Gat>Aat p.D97N KIPAN 6 30126177 30126177 + Splice_Site SNP G G T TCGA-B8-5159-01A-01D-1421-08 TCGA-B8-5159-10A-01D-1421-08 g.chr6:30126177G>T c.755C>A c.(754-756)aCg>aAg p.T252K KIRC 6 30126177 30126177 + Splice_Site SNP G G T TCGA-B8-5159-01A-01D-1421-08 TCGA-B8-5159-10A-01D-1421-08 g.chr6:30126177G>T c.755C>A c.(754-756)aCg>aAg p.T252K LGG 6 30122144 30122144 + Missense_Mutation SNP G G A TCGA-DU-6392-01A-11D-1705-08 TCGA-DU-6392-10A-01D-1705-08 g.chr6:30122144G>A c.1048C>T c.(1048-1050)Cgg>Tgg p.R350W LIHC 6 30121749 30121749 + Silent SNP G G T TCGA-EP-A2KB-01A-11D-A183-10 TCGA-EP-A2KB-10A-01D-A183-10 g.chr6:30121749G>T c.1443C>A c.(1441-1443)tcC>tcA p.S481S LIHC 6 30121896 30121896 + Missense_Mutation SNP C C A TCGA-EP-A2KB-01A-11D-A183-10 TCGA-EP-A2KB-10A-01D-A183-10 g.chr6:30121896C>A c.1296G>T c.(1294-1296)agG>agT p.R432S LIHC 6 30121906 30121906 + Missense_Mutation SNP C C T TCGA-DD-AAVW-01A-11D-A40R-10 TCGA-DD-AAVW-10A-01D-A40U-10 g.chr6:30121906C>T c.1286G>A c.(1285-1287)cGg>cAg p.R429Q LIHC 6 30122220 30122220 + Silent SNP G G T TCGA-DD-AADO-01A-11D-A40R-10 TCGA-DD-AADO-10A-01D-A40U-10 g.chr6:30122220G>T c.972C>A c.(970-972)ctC>ctA p.L324L LUAD 6 30121521 30121521 + 3'UTR SNP C C A TCGA-NJ-A4YF-01A-12D-A25L-08 TCGA-NJ-A4YF-10A-01D-A25L-08 g.chr6:30121521C>A LUAD 6 30121889 30121889 + Missense_Mutation SNP G G C TCGA-44-5644-01A-21D-2036-08 TCGA-44-5644-10A-01D-2036-08 g.chr6:30121889G>C c.1303C>G c.(1303-1305)Ctt>Gtt p.L435V LUAD 6 30121946 30121946 + Missense_Mutation SNP C C A TCGA-91-6828-01A-11D-1855-08 TCGA-91-6828-10A-01D-1855-08 g.chr6:30121946C>A c.1246G>T c.(1246-1248)Ggc>Tgc p.G416C LUAD 6 30121975 30121975 + Missense_Mutation SNP C C T TCGA-05-5428-01A-01D-1625-08 TCGA-05-5428-10A-01D-1625-08 g.chr6:30121975C>T c.1217G>A c.(1216-1218)aGg>aAg p.R406K LUAD 6 30122175 30122175 + Silent SNP C C T TCGA-17-Z026-01A-01W-0746-08 TCGA-17-Z026-11A-01W-0746-08 g.chr6:30122175C>T c.1017G>A c.(1015-1017)caG>caA p.Q339Q LUAD 6 30124746 30124746 + Missense_Mutation SNP G G T TCGA-62-A46O-01A-11D-A24D-08 TCGA-62-A46O-10A-01D-A24F-08 g.chr6:30124746G>T c.865C>A c.(865-867)Ccg>Acg p.P289T LUAD 6 30127012 30127012 + Missense_Mutation SNP T T C TCGA-62-8399-01A-21D-2323-08 TCGA-62-8399-10A-01D-2323-08 g.chr6:30127012T>C c.440A>G c.(439-441)cAt>cGt p.H147R LUAD 6 30128385 30128385 + Missense_Mutation SNP C C T TCGA-44-8117-01A-11D-2238-08 TCGA-44-8117-10A-01D-2238-08 g.chr6:30128385C>T c.251G>A c.(250-252)cGc>cAc p.R84H LUAD 6 30128393 30128393 + Missense_Mutation SNP G G T TCGA-44-8117-01A-11D-2238-08 TCGA-44-8117-10A-01D-2238-08 g.chr6:30128393G>T c.243C>A c.(241-243)aaC>aaA p.N81K LUAD 6 30128459 30128459 + Silent SNP G G T TCGA-17-Z031-01A-01W-0746-08 TCGA-17-Z031-11A-01W-0746-08 g.chr6:30128459G>T c.177C>A c.(175-177)ctC>ctA p.L59L LUAD 6 30128538 30128538 + Missense_Mutation SNP T T G TCGA-62-8394-01A-11D-2323-08 TCGA-62-8394-10A-01D-2323-08 g.chr6:30128538T>G c.98A>C c.(97-99)cAc>cCc p.H33P LUAD 6 30128630 30128630 + Silent SNP G G T TCGA-05-5420-01A-01D-1625-08 TCGA-05-5420-11A-01D-1625-08 g.chr6:30128630G>T c.6C>A c.(4-6)gcC>gcA p.A2A LUSC 6 30121868 30121868 + Missense_Mutation SNP C C A TCGA-33-4583-01A-01D-1441-08 TCGA-33-4583-11A-01D-1441-08 g.chr6:30121868C>A c.1324G>T c.(1324-1326)Gtg>Ttg p.V442L LUSC 6 30122115 30122115 + Silent SNP G G A TCGA-51-4080-01A-01D-1458-08 TCGA-51-4080-11A-01D-1458-08 g.chr6:30122115G>A c.1077C>T c.(1075-1077)ggC>ggT p.G359G LUSC 6 30122178 30122178 + Missense_Mutation SNP C C A TCGA-43-5668-01A-01D-1632-08 TCGA-43-5668-11A-01D-1632-08 g.chr6:30122178C>A c.1014G>T c.(1012-1014)tgG>tgT p.W338C LUSC 6 30128523 30128523 + Missense_Mutation SNP G G T TCGA-34-5234-01A-01D-1632-08 TCGA-34-5234-10A-01D-1632-08 g.chr6:30128523G>T c.113C>A c.(112-114)gCc>gAc p.A38D OV 6 30128543 30128543 + Silent SNP G G A TCGA-20-1687-01A-01W-0633-09 TCGA-20-1687-10A-01W-0633-09 g.chr6:30128543G>A c.93C>T c.(91-93)tgC>tgT p.C31C PAAD 6 30126398 30126398 + Silent SNP C C G TCGA-IB-A5SS-01A-11D-A32N-08 TCGA-IB-A5SS-10A-01D-A32N-08 g.chr6:30126398C>G c.534G>C c.(532-534)gtG>gtC p.V178V PRAD 6 30121516 30121516 + 3'UTR SNP G G A TCGA-HC-7232-01A-11D-2114-08 TCGA-HC-7232-10A-01D-2115-08 g.chr6:30121516G>A PRAD 6 30124743 30124743 + Silent SNP G G A TCGA-KK-A8ID-01A-11D-A364-08 TCGA-KK-A8ID-11A-12D-A362-08 g.chr6:30124743G>A c.868C>T c.(868-870)Ctg>Ttg p.L290L PRAD 6 30128254 30128254 + Missense_Mutation SNP C C T TCGA-XK-AAIW-01A-11D-A41K-08 TCGA-XK-AAIW-10A-01D-A41N-08 g.chr6:30128254C>T c.382G>A c.(382-384)Gct>Act p.A128T PRAD 6 30128486 30128486 + Missense_Mutation SNP G G T TCGA-YL-A8SQ-01B-11D-A377-08 TCGA-YL-A8SQ-10A-01D-A37A-08 g.chr6:30128486G>T c.150C>A c.(148-150)gaC>gaA p.D50E READ 6 30122009 30122009 + Missense_Mutation SNP G G A TCGA-AG-A002-01A-01W-A00K-09 TCGA-AG-A002-10A-01W-A00K-09 g.chr6:30122009G>A c.1183C>T c.(1183-1185)Cgg>Tgg p.R395W READ 6 30122254 30122254 + Missense_Mutation SNP G G T TCGA-AG-A002-01A-01W-A00K-09 TCGA-AG-A002-10A-01W-A00K-09 g.chr6:30122254G>T c.938C>A c.(937-939)tCt>tAt p.S313Y READ 6 30128219 30128219 + Silent SNP C C T TCGA-AG-4008-01A-01W-1073-09 TCGA-AG-4008-10A-01W-1073-09 g.chr6:30128219C>T c.417G>A c.(415-417)gcG>gcA p.A139A SKCM 6 30121774 30121774 + Missense_Mutation SNP C C T TCGA-ER-A193-06A-12D-A197-08 TCGA-ER-A193-10A-01D-A199-08 g.chr6:30121774C>T c.1418G>A c.(1417-1419)cGa>cAa p.R473Q SKCM 6 30121959 30121959 + Silent SNP G G A TCGA-EE-A2MR-06A-11D-A196-08 TCGA-EE-A2MR-10A-01D-A198-08 g.chr6:30121959G>A c.1233C>T c.(1231-1233)ttC>ttT p.F411F SKCM 6 30122033 30122033 + Missense_Mutation SNP C C T TCGA-EE-A29D-06A-11D-A197-08 TCGA-EE-A29D-10A-01D-A199-08 g.chr6:30122033C>T c.1159G>A c.(1159-1161)Gat>Aat p.D387N SKCM 6 30122210 30122210 + Missense_Mutation SNP C C T TCGA-FS-A4F9-06A-11D-A24R-08 TCGA-FS-A4F9-10A-01D-A24R-08 g.chr6:30122210C>T c.982G>A c.(982-984)Gac>Aac p.D328N SKCM 6 30122264 30122264 + Splice_Site SNP C C T TCGA-EE-A2MF-06A-11D-A21A-08 TCGA-EE-A2MF-10B-01D-A21A-08 g.chr6:30122264C>T c.e7-1 SKCM 6 30124729 30124729 + Missense_Mutation SNP C C T TCGA-EE-A3AE-06A-11D-A196-08 TCGA-EE-A3AE-10A-01D-A198-08 g.chr6:30124729C>T c.882G>A c.(880-882)atG>atA p.M294I SKCM 6 30124759 30124759 + Silent SNP G G A TCGA-EE-A3J7-06A-11D-A20D-08 TCGA-EE-A3J7-10A-01D-A20D-08 g.chr6:30124759G>A c.852C>T c.(850-852)ccC>ccT p.P284P SKCM 6 30126183 30126183 + Missense_Mutation SNP A A G TCGA-EE-A17Y-06A-11D-A196-08 TCGA-EE-A17Y-10B-01D-A198-08 g.chr6:30126183A>G c.749T>C c.(748-750)cTc>cCc p.L250P SKCM 6 30126277 30126277 + Missense_Mutation SNP C C T TCGA-EE-A29D-06A-11D-A197-08 TCGA-EE-A29D-10A-01D-A199-08 g.chr6:30126277C>T c.655G>A c.(655-657)Gat>Aat p.D219N SKCM 6 30126365 30126365 + Silent SNP G G A TCGA-FW-A3R5-06A-11D-A23B-08 TCGA-FW-A3R5-10A-01D-A23B-08 g.chr6:30126365G>A c.567C>T c.(565-567)ttC>ttT p.F189F SKCM 6 30128312 30128312 + Silent SNP G G A TCGA-EE-A29S-06A-11D-A197-08 TCGA-EE-A29S-10A-01D-A199-08 g.chr6:30128312G>A c.324C>T c.(322-324)ttC>ttT p.F108F SKCM 6 30128328 30128328 + Missense_Mutation SNP C C T TCGA-GF-A6C9-06A-11D-A30X-08 TCGA-GF-A6C9-10A-01D-A30X-08 g.chr6:30128328C>T c.308G>A c.(307-309)gGa>gAa p.G103E SKCM 6 30128351 30128351 + Silent SNP C C T TCGA-FS-A1ZM-06A-12D-A197-08 TCGA-FS-A1ZM-10A-01D-A199-08 g.chr6:30128351C>T c.285G>A c.(283-285)gaG>gaA p.E95E SKCM 6 30128370 30128370 + Missense_Mutation SNP G G A TCGA-FS-A4F9-06A-11D-A24R-08 TCGA-FS-A4F9-10A-01D-A24R-08 g.chr6:30128370G>A c.266C>T c.(265-267)tCc>tTc p.S89F SKCM 6 30128443 30128443 + Missense_Mutation SNP G G A TCGA-ER-A193-06A-12D-A197-08 TCGA-ER-A193-10A-01D-A199-08 g.chr6:30128443G>A c.193C>T c.(193-195)Cgt>Tgt p.R65C SKCM 6 30128480 30128480 + Silent SNP C C T TCGA-D9-A3Z1-06A-11D-A23B-08 TCGA-D9-A3Z1-10A-01D-A23B-08 g.chr6:30128480C>T c.156G>A c.(154-156)gaG>gaA p.E52E SKCM 6 30128513 30128513 + Silent SNP G G A TCGA-EE-A29X-06A-11D-A196-08 TCGA-EE-A29X-10A-01D-A198-08 g.chr6:30128513G>A c.123C>T c.(121-123)acC>acT p.T41T SKCM 6 30128563 30128563 + Missense_Mutation SNP C C T TCGA-EE-A3J5-06A-11D-A20D-08 TCGA-EE-A3J5-10A-01D-A20D-08 g.chr6:30128563C>T c.73G>A c.(73-75)Gag>Aag p.E25K

Mutation - COSMIC Sample Name Mutation ID Mutation CDS Mutation AA Mutation Description Mutation Genome Position Mutation Strand PD4132a COSM4809614 c.664G>C p.D222H Substitution - Missense 6:30158491-30158491 - LS411 COSM3251046 c.1234G>A p.V412I Substitution - Missense 6:30154181-30154181 - TCGA-HU-A4GN-01 COSM3861370 c.1113A>G p.I371M Substitution - Missense 6:30154302-30154302 - CSCC-11-T COSM4525246 c.1318G>A p.G440S Substitution - Missense 6:30154097-30154097 - TCGA-EE-A29D-06 COSM3624143 c.1159G>A p.D387N Substitution - Missense 6:30154256-30154256 - TCGA-BH-A0AW-01 COSM1442977 c.841C>T p.R281W Substitution - Missense 6:30156993-30156993 - TCGA-FW-A3R5-06 COSM3251099 c.567C>T p.F189F Substitution - coding silent 6:30158588-30158588 - TCGA-EE-A3J7-06 COSM3921300 c.852C>T p.P284P Substitution - coding silent 6:30156982-30156982 - BD121T COSM3251099 c.567C>T p.F189F Substitution - coding silent 6:30158588-30158588 - TCGA-AZ-4315-01 COSM1442971 c.1233C>T p.F411F Substitution - coding silent 6:30154182-30154182 - TCGA-B8-5159-01 COSM3366442 c.755C>A p.T252K Substitution - Missense 6:30158400-30158400 - TCGA-AX-A05Z-01 COSM1077311 c.1017G>T p.Q339H Substitution - Missense 6:30154398-30154398 - CSCC-44-T COSM4517256 c.307_308GG>AA p.G103K Substitution - Missense 6:30160551-30160552 - ESCC_BICR_007T COSM5434186 c.256C>T p.Q86* Substitution - Nonsense 6:30160603-30160603 - SNUH_G16_S1 COSM3684188 c.1371T>C p.T457T Substitution - coding silent 6:30154044-30154044 - Gp5D COSM4586556 c.314_316delAGA p.K105delK Deletion - In frame 6:30160543-30160545 - WT049 COSM5352111 c.194G>A p.R65H Substitution - Missense 6:30160665-30160665 - PTC-7C COSM4160540 c.756G>A p.T252T Substitution - coding silent 6:30158399-30158399 - HCC106T COSM1621377 c.386C>T p.T129I Substitution - Missense 6:30160473-30160473 - TCGA-DK-A1A3-01 COSM4812267 c.731A>G p.E244G Substitution - Missense 6:30158424-30158424 - TCGA-06-0744 COSM2151632 c.440A>G p.H147R Substitution - Missense 6:30159235-30159235 - CSCC-42-T COSM4557883 c.745G>A p.E249K Substitution - Missense 6:30158410-30158410 - PTC-54C COSM4160543 c.377A>G p.E126G Substitution - Missense 6:30160482-30160482 - CHLA-258 COSM4586555 c.1183C>T p.R395W Substitution - Missense 6:30154232-30154232 - TCGA-EM-A1YB-01 COSM1442971 c.1233C>T p.F411F Substitution - coding silent 6:30154182-30154182 - Pat_26_A COSM5870017 c.682delG p.E228fs*24 Deletion - Frameshift 6:30158473-30158473 - CSCC-20-T COSM4455355 c.741A>G p.A247A Substitution - coding silent 6:30158414-30158414 - C135 COSM4618589 c.78G>A p.P26P Substitution - coding silent 6:30160781-30160781 - TCGA-BR-4363-01 COSM3861376 c.138A>G p.I46M Substitution - Missense 6:30160721-30160721 - TCGA-D1-A17B-01 COSM1077315 c.213C>A p.P71P Substitution - coding silent 6:30160646-30160646 - T2932 COSM4735906 c.1417C>T p.R473* Substitution - Nonsense 6:30153998-30153998 - C086 COSM5540787 c.184G>A p.E62K Substitution - Missense 6:30160675-30160675 - TCGA-41-5651-01 COSM3410899 c.568G>A p.A190T Substitution - Missense 6:30158587-30158587 - Pat_28_B COSM5870014 c.925C>T p.P309S Substitution - Missense 6:30155730-30155730 - ccRCC-49 COSM1664673 c.1436T>A p.L479Q Substitution - Missense 6:30153979-30153979 - TCGA-FS-A1ZM-06 COSM3624163 c.285G>A p.E95E Substitution - coding silent 6:30160574-30160574 - TCGA-B7-5816-01 COSM3861373 c.978C>T p.S326S Substitution - coding silent 6:30154437-30154437 - TCGA-33-4583-01 COSM4858562 c.1324G>T p.V442L Substitution - Missense 6:30154091-30154091 - TCGA-BR-6566-01 COSM3861366 c.1341T>G p.A447A Substitution - coding silent 6:30154074-30154074 - TCGA-ER-A193-06 COSM3251044 c.1418G>A p.R473Q Substitution - Missense 6:30153997-30153997 - TCGA-32-2495-01 COSM3410896 c.692G>A p.R231Q Substitution - Missense 6:30158463-30158463 - TCGA-EE-A17Y-06 COSM3921303 c.749T>C p.L250P Substitution - Missense 6:30158406-30158406 - TCGA-43-5668-01 COSM4861598 c.1014G>T p.W338C Substitution - Missense 6:30154401-30154401 - Pat_53_B COSM5870020 c.652C>T p.R218W Substitution - Missense 6:30158503-30158503 - C086 COSM5540784 c.310G>A p.E104K Substitution - Missense 6:30160549-30160549 - 08-P1004 COSM4586556 c.314_316delAGA p.K105delK Deletion - In frame 6:30160543-30160545 - TCGA-EE-A3J5-06 COSM3624181 c.73G>A p.E25K Substitution - Missense 6:30160786-30160786 - Pat_16_A COSM5870009 c.1138A>G p.T380A Substitution - Missense 6:30154277-30154277 - TCGA-EB-A3XC-01 COSM3624169 c.213C>T p.P71P Substitution - coding silent 6:30160646-30160646 - TCGA-24-2260-01 COSM120010 c.124C>T p.R42C Substitution - Missense 6:30160735-30160735 - TCGA-A2-A0CX-01 COSM4816065 c.560C>T p.S187F Substitution - Missense 6:30158595-30158595 - CHEWS004 COSM4586559 c.204C>T p.S68S Substitution - coding silent 6:30160655-30160655 - AOCS-149-1-7 COSM4153205 c.183A>C p.K61N Substitution - Missense 6:30160676-30160676 - ESCC_BICR_003T COSM5442723 c.949C>G p.Q317E Substitution - Missense 6:30154466-30154466 - KPOPBR-03-T COSM5965622 c.784G>T p.E262* Substitution - Nonsense 6:30157050-30157050 - PD4119a COSM4810429 c.364C>T p.R122W Substitution - Missense 6:30160495-30160495 - BD217T COSM5495386 c.350T>C p.L117S Substitution - Missense 6:30160509-30160509 - SW1463 COSM3251051 c.1168C>T p.R390W Substitution - Missense 6:30154247-30154247 - TCGA-20-1687-01 COSM1329117 c.93C>T p.C31C Substitution - coding silent 6:30160766-30160766 - TCGA-EE-A29D-06 COSM3624154 c.655G>A p.D219N Substitution - Missense 6:30158500-30158500 - TCGA-FS-A4F9-06 COSM3624166 c.266C>T p.S89F Substitution - Missense 6:30160593-30160593 - OSCC-GB_00960111 COSM4586555 c.1183C>T p.R395W Substitution - Missense 6:30154232-30154232 - ESCC-D16 COSM5045574 c.1349G>C p.R450P Substitution - Missense 6:30154066-30154066 - TCGA-06-0744-01 COSM2151632 c.440A>G p.H147R Substitution - Missense 6:30159235-30159235 - TCGA-BR-8360-01 COSM3861368 c.1340C>T p.A447V Substitution - Missense 6:30154075-30154075 - TCGA-ER-A193-06 COSM3624172 c.193C>T p.R65C Substitution - Missense 6:30160666-30160666 - 61 COSM5737522 c.1192C>T p.P398S Substitution - Missense 6:30154223-30154223 - TCGA-EE-A3AE-06 COSM3624148 c.882G>A p.M294I Substitution - Missense 6:30156952-30156952 - Pat_41_B COSM5870011 c.1105G>A p.V369M Substitution - Missense 6:30154310-30154310 - RK288_C01 COSM4780570 c.481C>A p.Q161K Substitution - Missense 6:30159194-30159194 - TCGA-EB-A3XB-01 COSM3624151 c.864C>T p.L288L Substitution - coding silent 6:30156970-30156970 - TCGA-A6-6780-01 COSM1442974 c.1084G>A p.G362R Substitution - Missense 6:30154331-30154331 - RK126_C01 COSM1634696 c.340G>A p.E114K Substitution - Missense 6:30160519-30160519 - TCGA-BR-8372-01 COSM3861364 c.1348C>T p.R450* Substitution - Nonsense 6:30154067-30154067 - S02299 COSM5690809 c.350T>A p.L117* Substitution - Nonsense 6:30160509-30160509 - HCC106 COSM1621377 c.386C>T p.T129I Substitution - Missense 6:30160473-30160473 - TCGA-FS-A4F9-06 COSM3624145 c.982G>A p.D328N Substitution - Missense 6:30154433-30154433 - TCGA-BR-8680-01 COSM3861362 c.1349G>A p.R450Q Substitution - Missense 6:30154066-30154066 - SJRHB005_D COSM3737577 c.668T>G p.L223W Substitution - Missense 6:30158487-30158487 - J76_T COSM3948961 c.1127G>T p.G376V Substitution - Missense 6:30154288-30154288 - Pat_66_A COSM5870023 c.37G>A p.E13K Substitution - Missense 6:30160822-30160822 - TCGA-GF-A6C9-06 COSM4899780 c.308G>A p.G103E Substitution - Missense 6:30160551-30160551 - CSCC-35-T COSM3624181 c.73G>A p.E25K Substitution - Missense 6:30160786-30160786 - TCGA-A8-A0A6-01 COSM3829982 c.533T>G p.V178G Substitution - Missense 6:30158622-30158622 - CSCC-27-T COSM4492802 c.403C>T p.L135L Substitution - coding silent 6:30160456-30160456 - RK120_C01 COSM3702961 c.866C>T p.P289L Substitution - Missense 6:30156968-30156968 - SC_9034 COSM5570987 c.674T>C p.V225A Substitution - Missense 6:30158481-30158481 - CRC-06T COSM120010 c.124C>T p.R42C Substitution - Missense 6:30160735-30160735 - TCGA-34-5234-01 COSM4860243 c.113C>A p.A38D Substitution - Missense 6:30160746-30160746 - 61 COSM1621377 c.386C>T p.T129I Substitution - Missense 6:30160473-30160473 - TCGA-EE-A29X-06 COSM3624178 c.123C>T p.T41T Substitution - coding silent 6:30160736-30160736 - CHC429T COSM5348919 c.745G>T p.E249* Substitution - Nonsense 6:30158410-30158410 - TCGA-EE-A29S-06 COSM3624160 c.324C>T p.F108F Substitution - coding silent 6:30160535-30160535 - S02342 COSM5692983 c.592G>T p.E198* Substitution - Nonsense 6:30158563-30158563 - TCGA-FU-A3WB-01 COSM4843812 c.398G>A p.R133H Substitution - Missense 6:30160461-30160461 - CSCC-49-T COSM4528599 c.154G>A p.E52K Substitution - Missense 6:30160705-30160705 - TCGA-EE-A2MR-06 COSM1442971 c.1233C>T p.F411F Substitution - coding silent 6:30154182-30154182 - TCGA-A5-A0VP-01 COSM1077313 c.365G>A p.R122Q Substitution - Missense 6:30160494-30160494 - CSCC-29-T COSM1442971 c.1233C>T p.F411F Substitution - coding silent 6:30154182-30154182 - sysucc-880T COSM5463535 c.819G>A p.S273S Substitution - coding silent 6:30157015-30157015 - CSCC-29-T COSM4523106 c.1198G>A p.E400K Substitution - Missense 6:30154217-30154217 - 01-P1216 COSM4586555 c.1183C>T p.R395W Substitution - Missense 6:30154232-30154232 - TCGA-BT-A20N-01 COSM4811748 c.218G>A p.W73* Substitution - Nonsense 6:30160641-30160641 - TCGA-51-4080-01 COSM4862304 c.1077C>T p.G359G Substitution - coding silent 6:30154338-30154338 - OSCC-GB_00970111 COSM4889681 c.1249T>C p.S417P Substitution - Missense 6:30154166-30154166 - TCGA-D9-A3Z1-06 COSM3624175 c.156G>A p.E52E Substitution - coding silent 6:30160703-30160703 - Pat_32_B COSM1442977 c.841C>T p.R281W Substitution - Missense 6:30156993-30156993 - Gp2D COSM4586556 c.314_316delAGA p.K105delK Deletion - In frame 6:30160543-30160545 - MedB-1 COSM4160543 c.377A>G p.E126G Substitution - Missense 6:30160482-30160482 - TCGA-EI-6917-01 COSM3430450 c.88G>A p.D30N Substitution - Missense 6:30160771-30160771 - TCGA-28-2502-01 COSM3410894 c.1285C>T p.R429W Substitution - Missense 6:30154130-30154130 - TCGA-A7-A13H-01 COSM3829980 c.1166A>T p.Q389L Substitution - Missense 6:30154249-30154249 - TCGA-EB-A4IS-01 COSM3624157 c.422C>T p.P141L Substitution - Missense 6:30160437-30160437 - TCGA-CA-6717-01 COSM1442977 c.841C>T p.R281W Substitution - Missense 6:30156993-30156993 - PD9600a COSM5801535 c.250delC p.R84fs*70 Deletion - Frameshift 6:30160609-30160609 -

Mutation - CGAP UNIGENE CYTOBAND OMIM SNP Hs.709475;Hs.709478;Hs.709479;Hs.709480;Hs.709483 6p21.3 605701

Mutation - IntOGen Mutated from(ref) Mutated to(alt) Consequence Type AA Mutation CDS Mutation Chr Pos Cancer A G Missense p.L250P c.749T>C 6 30126183 CM A G Missense p.M294T c.881T>C 6 30124730 LUAD C A Missense p.G416C c.1246G>T 6 30121946 LUAD C A Missense p.R429L c.1286G>T 6 30121906 LUAD C A Missense p.V442L c.1324G>T 6 30121868 LUSC C A Missense p.W338C c.1014G>T 6 30122178 LUSC C A Synonymous p.L355L c.1065G>T 6 30122127 HNSC C G Missense p.D222H c.664G>C 6 30126268 BRCA C G Missense p.R157T c.470G>C 6 30126982 HNSC C T Missense p.A190T c.568G>A 6 30126364 GBM C T Missense p.D113N c.337G>A 6 30128299 CM C T Missense p.E114K c.340G>A 6 30128296 HC C T Missense p.E25K c.73G>A 6 30128563 CM C T Missense p.E96K c.286G>A 6 30128350 CM C T Missense p.M294I c.882G>A 6 30124729 CM C T Missense p.R122Q c.365G>A 6 30128271 UCEC C T Missense p.R231Q c.692G>A 6 30126240 GBM C T Missense p.R347H c.1040G>A 6 30122152 HNSC C T Missense p.R406K c.1217G>A 6 30121975 LUAD C T Missense p.R473Q c.1418G>A 6 30121774 CM C T Missense p.R473Q c.1418G>A 6 30121774 OV C T Nonsense p.W73* c.218G>A 6 30128418 BLCA C T Synonymous p.A139A c.417G>A 6 30128219 COREAD C T Synonymous p.E95E c.285G>A 6 30128351 CM G A 3-UTRSNV . c.1443+242C>T 6 30121507 CM G A Missense p.P466L c.1397C>T 6 30121795 CM G A Missense p.R122W c.364C>T 6 30128272 BRCA G A Missense p.R281W c.841C>T 6 30124770 BRCA G A Missense p.R429W c.1285C>T 6 30121907 GBM G A Missense p.R42C c.124C>T 6 30128512 OV G A Missense p.R65C c.193C>T 6 30128443 CM G A Missense p.S187F c.560C>T 6 30126372 BRCA G A Synonymous p.F108F c.324C>T 6 30128312 CM G A Synonymous p.F411F c.1233C>T 6 30121959 THCA G A Synonymous p.F64F c.192C>T 6 30128444 CM G A Synonymous p.G359G c.1077C>T 6 30122115 LUSC G A Synonymous p.I18I c.54C>T 6 30128582 CM G A Synonymous p.P141P c.423C>T 6 30128213 LUAD G A Synonymous p.P284P c.852C>T 6 30124759 CM G A Synonymous p.S326S c.978C>T 6 30122214 STAD G A Synonymous p.T41T c.123C>T 6 30128513 CM G C Missense p.L91V c.271C>G 6 30128365 CM GG AA 5-UTRBlockSubstitution . c.1-53_1-52delinsTT 6 30128687 CM G T Missense p.A38D c.113C>A 6 30128523 LUSC G T Missense p.T252K c.755C>A 6 30126177 RCCC G T Synonymous p.A2A c.6C>A 6 30128630 LUAD G T Synonymous p.P71P c.213C>A 6 30128423 UCEC G T Synonymous p.V14V c.42C>A 6 30128594 COREAD T C 3-UTRSNV . c.1443+1096A>G 6 30120653 HC T C Missense p.E244G c.731A>G 6 30126201 BLCA T C Missense p.H147R c.440A>G 6 30127012 GBM T C Missense p.I46M c.138A>G 6 30128498 STAD