PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ZBTB22 MCRS1 25416956 biogrid,intact exp GP G G G GP GP G GP GP G GP G G G G GP GP G GP G GP G G GP GP G GP GP G ZBTB22 RBM39 25416956 biogrid,intact exp GP G G G GP GP G GP GP G GP G G G G GP GP G GP G GP G G G GP G GP GP G ZBTB22 MLLT6 25416956 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB22 UBQLN4 16169070 hprd,biogrid,i2d,mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB22 GATA1 20211142 biogrid exp G GP ZBTB22 FXR2 25416956 biogrid,intact exp GP G G G GP GP G GP GP G GP G G G G GP GP G GP G GP G G GP GP G GP GP G ZBTB22 VAPA 25416956 biogrid,intact exp GP G G G GP GP G GP GP G GP G G G G GP GP G GP G GP G G GP GP G GP GP G AP4M1 ZBTB22 21988832 biogrid,intact exp G G G G G G G G ZBTB22 PIN1 25416956 biogrid,intact exp G G G G GP GP G G GP G G G G G G G GP G P G P G G G G G GP GP G ZBTB22 DNAJA3 16189514 hprd,biogrid,mint,intact exp GP G G G GP GP G GP GP G GP G G G G GP GP G GP G GP G G GP GP G GP GP G ZBTB22 ZBTB22 ortho GP G G G GP GP G GP GP G GP G G G G GP GP G GP G GP G G GP GP G GP GP G ZBTB22 MED16 ortho GP G G G GP GP G GP GP G GP G G G G GP GP G GP G GP G G GP GP G GP GP G ZBTB22 KLHL34 23023127 pred P P GP GP P P GP GP P P GP GP P P ZBTB22 ZBTB7A 23023127 pred GP G G G GP GP G GP GP G GP G G G G GP GP G GP G GP G G GP GP G GP GP G BACH1 ZBTB22 23023127 pred GP G G G GP GP G G GP G GP G G G G GP GP G GP G GP G G GP GP G GP GP G ZBTB22 BTBD2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB22 KLHL11 23023127 pred P P P P P P P P P P P P GP BTBD17 ZBTB22 23023127 pred P P P P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O15209 A0A087WW39 two hybrid 25416956 direct interaction X 2 O15209 Q9P0L0-2 two hybrid 25416956 direct interaction X 2 O15209 P51116 two hybrid 25416956 direct interaction X 2 O15209 Q9NRR5 two hybrid 16169070 direct interaction X 2 O15209 Q96EY1-2 two hybrid 16189514 direct interaction X 2 O15209 O00189 two hybrid 21988832 direct interaction X 2 O15209 Q13526 two hybrid 25416956 direct interaction X 2 O15209 E1P5S2 two hybrid 25416956 direct interaction X 2 O15209 A0A024R134 two hybrid 25416956 direct interaction X 2 O15209 P15976 two hybrid 20211142 direct interaction X 2 O15209 Q9NRR5 two hybrid 16169070 - X 2 O15209 Q9NRR5 two hybrid 16169070 - X 2 O15209 Q96EY1-2 two hybrid 16189514 - X 2 O15209 Q96EY1-2 two hybrid 16189514 - X 2 O15209 Q9NRR5 two hybrid pooling approach 16169070 physical association X 2 O15209 Q53G26 two hybrid pooling approach 16189514 physical association X 2 O15209 P51116 two hybrid prey pooling approach 25416956 physical association X 2 O15209 Q14498-3 two hybrid prey pooling approach 25416956 physical association X 2 O15209 Q6P2C6 two hybrid prey pooling approach 25416956 physical association X 2 O15209 Q96EZ8 two hybrid prey pooling approach 25416956 physical association X 2 O15209 P51116 two hybrid array 25416956 physical association X 2 O15209 Q14498-3 two hybrid array 25416956 physical association X 2 O15209 Q6P2C6 two hybrid array 25416956 physical association X 2 O15209 Q96EZ8 two hybrid array 25416956 physical association X 2 O15209 P51116 validated two hybrid 25416956 physical association X 2 O15209 Q14498-3 validated two hybrid 25416956 physical association X 2 O15209 Q6P2C6 validated two hybrid 25416956 physical association X 2 O15209 Q96EZ8 validated two hybrid 25416956 physical association X 2 O15209 O00189 two hybrid array 21988832 physical association X 2 O15209 A8KA83 two hybrid prey pooling approach 25416956 physical association X 2 O15209 Q13526 two hybrid prey pooling approach 25416956 physical association X 2 O15209 A8KA83 two hybrid array 25416956 physical association X 2 O15209 Q13526 two hybrid array 25416956 physical association X 2 O15209 A8KA83 validated two hybrid 25416956 physical association X 2 O15209 Q13526 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B ZBTB22 DNAJA3 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0471(mint)|MI:0468(hprd)|MI:0471(mint)|(intact) BIOGRID_81024|MINT_69402|HPRD_23393|MINT_40103|UniProt_153851 prey|prey|-|prey|unspecified role bait|bait|-|bait|unspecified role ZBTB22 GATA1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128395 prey bait AP4M1 ZBTB22 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_117536|BIOGRID_286903 unspecified role|bait unspecified role|prey ZBTB22 UBQLN4 MI:0018(two hybrid)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint) MINT_62198|MINT_33257 bait|bait prey|prey ZBTB22 UBQLN4 MI:0492(in vitro)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0915(physical association) MI:0468(hprd)|(biogrid)|(intact) HPRD_30154|BIOGRID_94106|UniProt_156683 -|bait|bait -|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality A8KA83 ZBTB22 25416956,25416956,25416956 1112,0397,1356 HT AP4M1 ZBTB22 21988832,21988832 0397,0018 HT ZBTB22 GATA1 20211142 0018 HT ZBTB22 FXR2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT ZBTB22 MLLT6 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT ZBTB22 PIN1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT ZBTB22 RBM39 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT ZBTB22 DNAJA3 16189514,16189514 0398,0018 HT ZBTB22 MCRS1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT ZBTB22 UBQLN4 16169070,16169070 0018,0398 HT ZBTB22 VAPA 25416956 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9NRR5 O15209 UBQLN4 ZBTB22 0.286 16169070 P15976 O15209 GATA1 ZBTB22 0.183 20211142 Q9P0L0 O15209 VAPA ZBTB22 0.376 unassigned1304,25416956 Q13526 O15209 PIN1 ZBTB22 0.454 25416956 O95292 O15209 VAPB ZBTB22 0.236 unassigned1304 O95995 O15209 GAS8 ZBTB22 0.236 unassigned1304 Q15560 O15209 TCEA2 ZBTB22 0.236 unassigned1304 Q8IYE1 O15209 CCDC13 {ECO:0000312|HGNC:HGNC:26358} ZBTB22 0.236 unassigned1304 Q9H0R8 O15209 GABARAPL1 ZBTB22 0.236 unassigned1304 Q9Y316 O15209 MEMO1 ZBTB22 0.236 unassigned1304 O15209 O00189 ZBTB22 AP4M1 0.286 21988832 Q96EZ8 O15209 MCRS1 ZBTB22 0.583 25416956,unassigned1304 Q06287 O15209 EMG1 ZBTB22 0.332 27107014 P40075 O15209 SCS2 ZBTB22 0.332 27107014 Q6P2C6 O15209 MLLT6 ZBTB22 0.332 25416956 Q14498 O15209 RBM39 ZBTB22 0.454 25416956 Q96EY1 O15209 DNAJA3 ZBTB22 0.286 16189514 P51116 O15209 FXR2 ZBTB22 0.454 25416956 O15209 A8KA83 ZBTB22 A8KA83 0.332 25416956 P55198 O15209 MLLT6 ZBTB22 0.183 25416956