PTM - CPLM Gene Name UniProt ID Type Position Code OTUD7B; ZA20D1 Q6GQQ9 Ubiquitination 263 K OTUD7B; ZA20D1 Q6GQQ9 Ubiquitination 93 K OTUD7B; ZA20D1 Q6GQQ9 Ubiquitination 511 K OTUD7B; ZA20D1 Q6GQQ9 Ubiquitination 223 K OTUD7B; ZA20D1 Q6GQQ9 Ubiquitination 644 K OTUD7B; ZA20D1 Q6GQQ9 Ubiquitination 651 K OTUD7B; ZA20D1 Q6GQQ9 Ubiquitination 665 K OTUD7B; ZA20D1 Q6GQQ9 Ubiquitination 666 K OTUD7B; ZA20D1 Q6GQQ9 Ubiquitination 243 K

PTM - dbPAF Gene Name UniProt ID Position Type Species OTUD7B; ZA20D1 Q6GQQ9 100 S Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 103 S Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 104 S Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 105 S Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 115 S Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 149 S Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 159 S Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 218 Y Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 371 T Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 449 S Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 451 T Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 453 S Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 460 S Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 461 T Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 464 S Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 467 S Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 471 S Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 474 S Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 475 S Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 508 S Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 542 S Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 543 S Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 545 T Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 547 T Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 55 S Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 555 S Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 57 S Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 60 S Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 63 S Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 65 T Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 677 T Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 683 S Homo sapiens(Human) OTUD7B; ZA20D1 Q6GQQ9 779 Y Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q6GQQ9 R700-m1 Methylation PGDFTIPrPSGGGVH Q6GQQ9 S55-p Phosphorylation HAGNLPPsFSEGSGG Q6GQQ9 T65-p Phosphorylation EGSGGSRtPEKGFSD Q6GQQ9 T76-p Phosphorylation GFSDREPtRPPRPIL Q6GQQ9 S100-p Phosphorylation kRLSRGIsHAssSIV Q6GQQ9 S103-p Phosphorylation SRGIsHAssSIVSLA Q6GQQ9 S104-p Phosphorylation RGIsHAssSIVSLAR Q6GQQ9 S149-p Phosphorylation VYNEDFRsFIERDLI Q6GQQ9 S159-p Phosphorylation ERDLIEQsMLVALEQ Q6GQQ9 Y218-p Phosphorylation LMLRKALyALMEkGV Q6GQQ9 T371-p Phosphorylation SMEQKENtKEQAVIP Q6GQQ9 S449-p Phosphorylation APLAQPEsPtAsAGD Q6GQQ9 T451-p Phosphorylation LAQPEsPtAsAGDEP Q6GQQ9 S453-p Phosphorylation QPEsPtAsAGDEPRs Q6GQQ9 S460-p Phosphorylation sAGDEPRstPEsGDs Q6GQQ9 T461-p Phosphorylation AGDEPRstPEsGDsD Q6GQQ9 S464-p Phosphorylation EPRstPEsGDsDKEs Q6GQQ9 S467-p Phosphorylation stPEsGDsDKEsVGS Q6GQQ9 S471-p Phosphorylation sGDsDKEsVGSSSTS Q6GQQ9 S501-p Phosphorylation KDKKRADsVANKLGs Q6GQQ9 S508-p Phosphorylation sVANKLGsFGkTLGS Q6GQQ9 T547-p Phosphorylation GGSSGTEtLEKKKKN Q6GQQ9 S555-p Phosphorylation LEKKKKNsLKSWKGG Q6GQQ9 S633-p Phosphorylation EMIQRYLsDAEERFL Q6GQQ9 S745-p Phosphorylation RPYPHQDsIPSLEPG Q6GQQ9 Y779-p Phosphorylation ADSYSNGyREPPEPD Q6GQQ9 K93-ub Ubiquitination QDDIVQEkRLSRGIs Q6GQQ9 K223-ub Ubiquitination ALyALMEkGVEKEAL Q6GQQ9 K263-ub Ubiquitination KEWNELIkLASSEPR Q6GQQ9 K511-ub Ubiquitination NKLGsFGkTLGSKLK Q6GQQ9 K644-ub Ubiquitination ERFLAEQkQKEAERk Q6GQQ9 K651-ub Ubiquitination kQKEAERkIMNGGIG Q6GQQ9 K665-ub Ubiquitination GGGPPPAkkPEPDAR Q6GQQ9 K666-ub Ubiquitination GGPPPAkkPEPDARE

PTM - dbPTM UniProt ID Position Code Type Resources References Q6GQQ9 100 S Phosphorylation Swiss-Prot 1010711 18220336;18669648;19690332 Q6GQQ9 449 S Phosphorylation Swiss-Prot 1010711 15302935 Q6GQQ9 464 S Phosphorylation Swiss-Prot 1010711 19413330 Q6GQQ9 467 S Phosphorylation Swiss-Prot 1010711 19413330 Q6GQQ9 100 S Phosphorylation PhosphoELM.10011 18669648;18220336 Q6GQQ9 449 S Phosphorylation PhosphoELM.10011 15302935 Q6GQQ9 464 S Phosphorylation PhosphoELM.10011 18669648;15302935 Q6GQQ9 467 S Phosphorylation PhosphoELM.10011 18669648 Q6GQQ9 223 K Ubiquitylation Phosphositeplus.1010730 21906983 Q6GQQ9 263 K Ubiquitylation Phosphositeplus.1010730 21890473 Q6GQQ9 644 K Ubiquitylation Phosphositeplus.1010730 21906983 Q6GQQ9 651 K Ubiquitylation Phosphositeplus.1010730 21906983 Q6GQQ9 665 K Ubiquitylation Phosphositeplus.1010730 21906983 Q6GQQ9 666 K Ubiquitylation Phosphositeplus.1010730 21906983 Q6GQQ9 93 K Ubiquitylation Phosphositeplus.1010730 21906983 Q6GQQ9 100 S Phosphorylation Phosphositeplus.1010730 18220336;18669648;19276368;19690332;20068231;20363803 Q6GQQ9 449 S Phosphorylation Phosphositeplus.1010730 15302935;21659604 Q6GQQ9 464 S Phosphorylation Phosphositeplus.1010730 16964243;18669648;21659604 Q6GQQ9 467 S Phosphorylation Phosphositeplus.1010730 16964243;18669648;21659604 Q6GQQ9 451 T Phosphorylation Phosphositeplus.1010730 16964243 Q6GQQ9 779 Y Phosphorylation Phosphositeplus.1010730 18180459 Q6GQQ9 100 S Phosphorylation HPRD 9.0 18669648,18212344,20068231 Q6GQQ9 449 S Phosphorylation HPRD 9.0 20068231 Q6GQQ9 464 S Phosphorylation HPRD 9.0 18669648,19413330,16964243 Q6GQQ9 467 S Phosphorylation HPRD 9.0 18669648,19413330 Q6GQQ9 100 S Phosphorylation SysPTM 1.1 18212344;18669648 Q6GQQ9 464 S Phosphorylation SysPTM 1.1 16964243 Q6GQQ9 467 S Phosphorylation SysPTM 1.1 16964243 Q6GQQ9 451 T Phosphorylation SysPTM 1.1 16964243

PTM - HPRD Symbol Position Code Type References OTUD7B 100 S Phosphorylation 18669648,18212344,20068231 OTUD7B 449 S Phosphorylation 20068231 OTUD7B 464 S Phosphorylation 18669648,19413330,16964243 OTUD7B 467 S Phosphorylation 18669648,19413330

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q6GQQ9 464 S 18669648 HTP Phosphorylation Q6GQQ9 464 S 15302935 HTP Phosphorylation Q6GQQ9 100 S 18669648 HTP Phosphorylation Q6GQQ9 100 S 18220336 HTP Phosphorylation Q6GQQ9 467 S 18669648 HTP Phosphorylation Q6GQQ9 449 S 15302935 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q6GQQ9 100 Phosphoserine 18220336;18669648;23186163 Q6GQQ9 467 Phosphoserine 23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type OTUD7B IPI00024658 S 114 RLSRGIpSHASSSI phosphorylation OTUD7B IPI00024658 S 463 PLAQPEpSPTASAG phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 56957 121281 - K Ubiquitination 22118674 56957 121281 - K Ubiquitination 21139048 56957 121281 - K Ubiquitination 21890473 56957 121281 - K Ubiquitination 21906983 56957 121281 - K Ubiquitination 22505724 56957 121281 - K Ubiquitination 23000965

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID OTUD7B Homo sapiens (Human) 263 "263,EWNELIKLASSEP" 263:21890473 OTUD7B Homo sapiens (Human) 223; 263; 665; 651; 666; 93; 644 "223,LYALMEKGVEKEA; 263,EWNELIKLASSEP; 665,GGPPPAKKPEPDA; 651,QKEAERKIMNGGI; 666,GPPPAKKPEPDAR; 93,DDIVQEKRLSRGI; 644,RFLAEQKQKEAER" 223:21906983; 263:21890473; 665:21906983; 651:21906983; 666:21906983; 93:21906983; 644:21906983 OTUD7B Homo sapiens (Human) 263 "263,EWNELIKLASSEP" 263:21890473