PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus IFT57 BFAR 14502241 biogrid exp G GP G G G GP G GP GP G G GP G G G GP G G G GP G G G G G GP G G UBE2D3 BFAR 21068390,19549727 biogrid,intact exp G G G G G GP G G GP G G G GP G G G GP G G G GP G G G G G GP G G BCL2L1 BFAR 10716992 biogrid exp G GP G G G GP G G G G G G G G G G GP G G G G G G G G G GP G G BCAP31 BFAR 14502241 biogrid exp G GP G G G GP G GP GP G G G GP G G G GP G G G GP G G G G G GP G G NGFR BFAR 22566094 biogrid exp G G G P G G G G G G G G G BFAR UBE2D4 19549727 biogrid,intact exp G G G G G GP G G GP G G G GP G G G GP G G G GP G G G G G GP G G UBC BFAR 21068390 biogrid exp G GP G G G GP G GP GP G G G GP G G G GP G G G GP G G G G G GP G G CASP8 BFAR 10716992 hprd,biogrid exp G GP G G P GP GP G G GP G G G P G G GP G G G G GP G G UBE2N BFAR 19549727 biogrid,intact exp G GP G G G GP G GP GP G G G GP G G G GP G G G GP G G G G G GP G G HIP1 BFAR 14502241 biogrid exp G GP G G G GP G GP GP G G G GP G G G GP G G G GP G G G G G GP G G UBE2D1 BFAR 19549727 biogrid,intact exp G G G G G GP G G GP G G G GP G G G GP G G G GP G G G G G GP G G CASP10 BFAR 10716992 hprd,biogrid exp G GP G G G GP G GP GP G G G GP G G G GP G G G GP G G G G G GP G G UBE2K BFAR 19549727 biogrid,intact exp G GP G G G GP G GP GP G G G GP G G G GP G G G GP G G G G G GP G G BCL2 BFAR 10716992 hprd,biogrid exp G G G G G GP G G GP G G G G G G G GP G G G GP G G G G G G G G TMBIM6 BFAR 21068390 biogrid exp G GP G G G GP G GP GP G G G GP G G G GP G G G GP G G G G G GP G G UBE2U BFAR 19690564 biogrid,intact exp P P P P P P P P G UBE2W BFAR 19549727 biogrid,intact exp G GP G G G GP G GP GP G G G GP G G G GP G G G GP G G G G G GP G G UBE2D2 BFAR 21068390,19549727 biogrid,intact exp G G G G G GP G G GP G G G GP G G G GP G G G GP G G G G G GP G G UNK BFAR 25737280 biogrid exp, ortho G GP G G G GP G GP GP G G G GP G G G GP G G G G G G G G G GP G G SAMSN1 BFAR 23023127 pred G GP G G P G P GP GP G G GP P G G GP CFLAR BFAR 23023127 pred G GP G G G GP G GP GP G G G GP G G G GP G G G GP G G G G G GP G G ANKS6 BFAR 23023127 pred G GP G GP G GP GP G G G GP G G GP G G G P G G G G GP G G GAREM BFAR 23023127 pred G GP G GP G GP GP G G G GP G G GP G G G GP G G G G G GP G G NFKB1 BFAR 23023127 pred G G G G G G G G GP G G G GP G G G G G G G GP G G G G G G G G EPHA2 BFAR 23023127 pred G GP G P G GP GP G G G GP G G G GP G G GP G G G G G GP G G SAMD7 BFAR 23023127 pred P P P P P P P P BFAR SFMBT1 23023127 pred G GP G G G GP G GP GP G G G GP G G G GP G G G GP G G G G G GP G G SQSTM1 BFAR 23023127 pred G GP G G G G G G GP G G G GP G G G G G G G GP G G G G G GP G G INPPL1 BFAR 23023127 pred G GP G G G GP G GP GP G G G GP G G G GP G G G GP G G G G G GP G G TP73 BFAR 23023127 pred G G G G G DGKD BFAR 23023127 pred G GP G G G GP G GP GP G G G GP G G G GP G G G GP G G G G G GP G G SAMD3 BFAR 23023127 pred GP G G P P P G GP G P G G G P G GP G CNKSR2 BFAR 23023127 pred G GP G GP G P P G P G G GP G P G G G G BFAR SAMD15 23023127 pred P P P P P P G P P G SAMD13 BFAR 23023127 pred G GP G G P G GP G G G G P G G G G G G GP G G ZAK BFAR 23023127 pred G GP G G G GP G GP GP G G G GP G G G GP G G G GP G G G G G GP G G SAMD11 BFAR 23023127 pred G GP G G G GP G GP GP G G G GP G G G GP G G G GP G G G G G GP G G ETS1 BFAR 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SARM1 BFAR 23023127 pred G G G G G GP G GP G G G G GP G G G GP G G G G G G G G G G BFAR BFAR 23023127 pred G GP G G G GP G GP GP G G G GP G G G GP G G G GP G G G G G GP G G TP63 BFAR 23023127 pred G G G G G G G G G G G G G G G G G G G GP G G G G G G IARS2 BFAR 21836163 pred G GP G G G GP G GP GP G G G GP G G G GP G G G GP G G G G G GP G G BIRC5 BFAR 23023127 pred G G P GP GP G G P P G GP G ARAP3 BFAR 23023127 pred G GP G G G GP G G GP G G G GP G G G GP G G G G G G G G G GP G G SHANK3 BFAR 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G SAMD9 BFAR 23023127 pred G GP G G P G GP GP G GP G G G P G P G G GP SASH3 BFAR 23023127 pred G G G G G GP G G GP G G G GP G G G GP G G G GP G G G G G GP G G ANKS3 BFAR 23023127 pred G GP G GP G P GP G G G P G G GP G G GP G G G GP G G FADD BFAR 23023127 pred G GP G G G GP G GP GP G G G GP G G G GP G G G GP G G G G G GP G G SAMD10 BFAR 23023127 pred G GP G G G GP G GP GP G G G GP G G G GP G G GP G G G G G GP G G RIPK1 BFAR 23023127 pred G GP G G G GP G GP GP G G G GP G G G GP G G G GP G G G G G GP G G SASH1 BFAR 23023127 pred G GP G G G GP G GP GP G G G GP G G G GP G G G GP G G G G G GP G G NKX2-5 BFAR 23023127 pred G G G G SMO BFAR 23023127 pred G GP G G G GP G GP GP G G G GP G G G GP G G G GP G G G G G GP G G GABPA BFAR 23023127 pred G GP G G G GP G G G G G G GP G G G GP G G GP G G G G G GP G SGMS1 BFAR 23023127 pred G GP G G G GP G GP GP G G G GP G G G GP G G G GP G G G G G GP G G EPHB4 BFAR 23023127 pred G GP G G G GP G GP GP G G G GP G G G GP G G G GP G G G G G GP G G ANKS4B BFAR 23023127 pred P P P G P G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P61086 Q9NZS9 two hybrid 19549727 direct interaction X 2 Q9NZS9 Q92851-7 affinity chromatography technology 10716992 physical association X 2 Q9NZS9 O00291 affinity chromatography technology 14502241 physical association X 2 Q9NZS9 P62837 pull down 21068390 direct interaction X 2 Q9NZS9 two hybrid 19690564 direct interaction X 2 Q9NZS9 P62837 two hybrid 19549727 direct interaction X 2 P0CG48 Q9NZS9 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q9NZS9 enzymatic study 21068390 direct interaction X 2 P0CG48 Q9NZS9 affinity chromatography technology 21068390 physical association X 2 P0CG48 Q9NZS9 affinity chromatography technology 21890473 physical association X 2 P0CG48 Q9NZS9 affinity chromatography technology 21906983 physical association X 2 P60605 Q9NZS9 affinity chromatography technology 21068390 physical association X 2 A0A024R2B3 Q9NZS9 affinity chromatography technology 10716992 physical association X 2 A0A024R2B3 Q9NZS9 two hybrid 10716992 direct interaction X 2 Q9NZS9 affinity chromatography technology 10716992 physical association X 2 Q9NZS9 Q14790-9 affinity chromatography technology 10716992 physical association X 2 Q9NZS9 Q9NWB7 affinity chromatography technology 14502241 physical association X 2 Q9NZS9 P51572 affinity chromatography technology 14502241 physical association X 2 Q9NZS9 P08138 two hybrid 22566094 direct interaction X 2 Q9NZS9 P08138 pull down 22566094 direct interaction X 2 Q9NZS9 P08138 affinity chromatography technology 22566094 physical association X 2 Q9NZS9 P61077-3 pull down 21068390 direct interaction X 2 Q9NZS9 P61088 two hybrid 19549727 direct interaction X 2 Q9NZS9 A0A087WW00 two hybrid 19549727 direct interaction X 2 Q9NZS9 P61077-3 two hybrid 19549727 direct interaction X 2 Q9NZS9 A0A024RA90 two hybrid 19549727 direct interaction X 2 Q9NZS9 Q96FI0 two hybrid 19549727 direct interaction X 2 Q9NZS9 A0A024R0Z5 affinity chromatography technology 21068390 physical association X 2 Q9NZS9 A0A024R0Z5 affinity chromatography technology 21068390 physical association X 2 Q9NZS9 coimmunoprecipitation 10716992 association C 3 Q14790-5 Q9NZS9 in vivo 10716992 - X 2 Q14790-5 Q9NZS9 in vitro 10716992 - X 2 Q14790-5 Q9NZS9 in vitro 10716992 - X 2 Q14790-5 Q9NZS9 in vivo 10716992 - X 2 Q92851-3 Q9NZS9 in vivo 10716992 - X 2 Q92851-3 Q9NZS9 in vitro 10716992 - X 2 Q92851-3 Q9NZS9 in vivo 10716992 - X 2 Q92851-3 Q9NZS9 in vitro 10716992 - X 2 A0A024R2C4 Q9NZS9 in vivo 10716992 - X 2 A0A024R2C4 Q9NZS9 in vivo 10716992 - X 2 Q9NZS9 P62837 two hybrid 19549727 physical association X 2 Q9NZS9 P62837 two hybrid array 19549727 physical association X 2 Q9NZS9 Q5NIJ1 two hybrid pooling approach 20711500 physical association X 2 B3KSH4 Q9NZS9 two hybrid array 19549727 physical association X 2 A0A024QZJ2 Q9NZS9 two hybrid 19549727 physical association X 2 A0A024QZJ2 Q9NZS9 two hybrid array 19549727 physical association X 2 Q9NZS9 A0A024RDH2 two hybrid 19549727 physical association X 2 Q9NZS9 P61088 two hybrid 19549727 physical association X 2 Q9NZS9 A0A024RDH2 two hybrid array 19549727 physical association X 2 Q9NZS9 A0A024RA90 two hybrid array 19549727 physical association X 2 Q9NZS9 Q5VVX9 two hybrid array 19690564 physical association X 2 Q96B02 Q9NZS9 two hybrid array 19549727 physical association X 2 Q96B02 Q9NZS9 two hybrid 19549727 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UBE2D1 BFAR MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(biogrid) UniProt_100793|UniProt_101238|BIOGRID_124263 bait|bait|bait prey|prey|prey BFAR HIP2 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100976 prey bait UBE2K BFAR MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_124031 bait prey UBE2D2 BFAR MI:0018(two hybrid)|MI:0415(enzymatic study)|MI:0018(two hybrid)|MI:0018(two hybrid) 19549727,21068390 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid)|(intact)|(biogrid) UniProt_101261|BIOGRID_223169|UniProt_100810|BIOGRID_124264 bait|prey|bait|bait prey|bait|prey|prey TMBIM6 BFAR MI:0415(enzymatic study)|MI:0415(enzymatic study) 21068390 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_164644|BIOGRID_164646 prey|bait bait|prey CASP8 BFAR MI:0493(in vivo)|MI:0004(affinity chromatography technology) 10716992 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_9802|BIOGRID_210159 -|prey -|bait BCL2 BFAR MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0004(affinity chromatography technology) 10716992 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|-|MI:0915(physical association) (biogrid)|MI:0468(hprd)|(biogrid) BIOGRID_305619|HPRD_37016|BIOGRID_210157 prey|-|prey bait|-|bait UBE2U BFAR MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102630|BIOGRID_123641 bait|bait prey|prey UBE2N BFAR MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100872 bait prey UBE2D3 BFAR MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0415(enzymatic study)|MI:0018(two hybrid) 19549727,21068390 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(intact)|(biogrid)|(biogrid) UniProt_101286|UniProt_100821|BIOGRID_309356|BIOGRID_124265 bait|bait|prey|bait prey|prey|bait|prey BCAP31 BFAR MI:0004(affinity chromatography technology) 14502241 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_211826 bait prey NGFR BFAR MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 22566094 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_260084|BIOGRID_260082|BIOGRID_260083 prey|bait|bait bait|prey|prey HIP1 BFAR MI:0004(affinity chromatography technology) 14502241 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_211824 bait prey IFT57 BFAR MI:0004(affinity chromatography technology) 14502241 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_211825 bait prey BCL2L1 BFAR MI:0004(affinity chromatography technology) 10716992 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_210158 prey bait BFAR UBE2D4 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124266|UniProt_101458 prey|prey bait|bait CASP10 BFAR MI:0493(in vivo)|MI:0004(affinity chromatography technology) 10716992 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_9775|BIOGRID_210160 -|prey -|bait UBE2W BFAR MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(intact) BIOGRID_124267|UniProt_100917|UniProt_101482 bait|bait|bait prey|prey|prey UBC BFAR MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0415(enzymatic study) 21068390,21890473,21906983,21963094 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_179319|BIOGRID_174185|BIOGRID_264082|BIOGRID_164643|BIOGRID_164642 bait|bait|bait|prey|prey prey|prey|prey|bait|bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9NZS9 P61077 BFAR UBE2D3 0.597 19549727,21068390 Q9NZS9 P61086 BFAR UBE2K 0.376 unassigned1304,19549727 Q9NZS9 Q9NWB7 BFAR IFT57 0.21 14502241 Q9NZS9 B3KSH4 BFAR HIP2 0.126 19549727 Q9NZS9 P08138 BFAR NGFR 0.623 22566094 Q9NZS9 P0CG48 BFAR UBC 0.309 21068390 Q9NZS9 P60605 BFAR UBE2G2 0.21 21068390 Q9NZS9 Q07817 BFAR BCL2L1 0.21 10716992 Q9NZS9 Q14790 BFAR CASP8 0.21 10716992 Q9NZS9 Q5NIJ1 BFAR SUCA 0.126 20711500 Q9NZS9 Q5VVX9 BFAR UBE2U 0.376 19690564 Q9NZS9 Q92851 BFAR CASP10 0.21 10716992 Q9Y2X8 Q9NZS9 UBE2D4 BFAR 0.376 19549727 Q9NZS9 P10415 BFAR BCL2 0.454 10716992 Q9NZS9 P51668 BFAR UBE2D1 0.583 19549727 Q9NZS9 Q96B02 BFAR UBE2W 0.583 19549727 Q9NZS9 P61088 BFAR UBE2N 0.332 19549727 Q9NZS9 Q9C0B0 BFAR UNK 0.126 25737280 Q9NZS9 P62837 BFAR UBE2D2 0.597 19549727,21068390 Q9NZS9 P51572 BFAR BCAP31 0.21 14502241 Q9NZS9 O00291 BFAR HIP1 0.21 14502241 Q9NZS9 P55061 BFAR TMBIM6 0.376 21068390

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 HIP1 BFAR MI:0045 experimental interaction detection MI:0461 interaction database NGFR BFAR MI:0045 experimental interaction detection MI:0461 interaction database UBC BFAR MI:0045 experimental interaction detection MI:0461 interaction database BCL2 BFAR MI:0045 experimental interaction detection MI:0461 interaction database TAF1 BFAR MI:0045 experimental interaction detection MI:0461 interaction database BCAP31 BFAR MI:0045 experimental interaction detection MI:0461 interaction database UBE2D1 BFAR MI:0045 experimental interaction detection MI:0461 interaction database TMBIM6 BFAR MI:0045 experimental interaction detection MI:0461 interaction database UBE2G2 BFAR MI:0362 inference MI:0461 interaction database UBE2D3 BFAR MI:0045 experimental interaction detection MI:0461 interaction database UBE2K BFAR MI:0045 experimental interaction detection MI:0461 interaction database UBE2N BFAR MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 BFAR MI:0045 experimental interaction detection MI:0461 interaction database BCL2L1 BFAR MI:0045 experimental interaction detection MI:0461 interaction database CASP8 BFAR MI:0045 experimental interaction detection MI:0461 interaction database UBE2U BFAR MI:0045 experimental interaction detection MI:0461 interaction database CASP10 BFAR MI:0045 experimental interaction detection MI:0461 interaction database UBE2W BFAR MI:0045 experimental interaction detection MI:0461 interaction database UNK BFAR MI:0045 experimental interaction detection MI:0461 interaction database IFT57 BFAR MI:0045 experimental interaction detection MI:0461 interaction database BFAR UBE2D4 MI:0045 experimental interaction detection MI:0461 interaction database