PTM - CPLM Gene Name UniProt ID Type Position Code UHRF1; ICBP90; NP95; RNF106 Q96T88 Acetylation 399 K UHRF1; ICBP90; NP95; RNF106 Q96T88 Acetylation 546 K UHRF1; ICBP90; NP95; RNF106 Q96T88 Ubiquitination 385 K UHRF1; ICBP90; NP95; RNF106 Q96T88 Ubiquitination 50 K UHRF1; ICBP90; NP95; RNF106 Q96T88 Ubiquitination 570 K UHRF1; ICBP90; NP95; RNF106 Q96T88 Ubiquitination 600 K UHRF1; ICBP90; NP95; RNF106 Q96T88 Ubiquitination 692 K UHRF1; ICBP90; NP95; RNF106 Q96T88 Ubiquitination 525 K UHRF1; ICBP90; NP95; RNF106 Q96T88 Ubiquitination 84 K UHRF1; ICBP90; NP95; RNF106 Q96T88 Ubiquitination 500 K UHRF1; ICBP90; NP95; RNF106 Q96T88 Ubiquitination 563 K UHRF1; ICBP90; NP95; RNF106 Q96T88 Ubiquitination 592 K UHRF1; ICBP90; NP95; RNF106 Q96T88 Ubiquitination 399 K UHRF1; ICBP90; NP95; RNF106 Q96T88 Ubiquitination 599 K UHRF1; ICBP90; NP95; RNF106 Q96T88 Ubiquitination 31 K UHRF1; ICBP90; NP95; RNF106 Q96T88 Ubiquitination 24 K UHRF1; ICBP90; NP95; RNF106 Q96T88 Ubiquitination 546 K UHRF1; ICBP90; NP95; RNF106 Q96T88 Ubiquitination 408 K UHRF1; ICBP90; NP95; RNF106 Q96T88 Ubiquitination 670 K UHRF1; ICBP90; NP95; RNF106 Q96T88 Ubiquitination 233 K UHRF1; ICBP90; NP95; RNF106 Q96T88 Ubiquitination 560 K UHRF1; ICBP90; NP95; RNF106 Q96T88 Ubiquitination 568 K UHRF1; ICBP90; NP95; RNF106 Q96T88 Ubiquitination 136 K UHRF1; ICBP90; NP95; RNF106 Q96T88 Ubiquitination 626 K UHRF1; ICBP90; NP95; RNF106 Q96T88 Ubiquitination 702 K UHRF1; ICBP90; NP95; RNF106 Q96T88 Ubiquitination 622 K UHRF1; ICBP90; NP95; RNF106 Q96T88 Ubiquitination 306 K

PTM - dbPAF Gene Name UniProt ID Position Type Species UHRF1; ICBP90; NP95; RNF106 Q96T88 102 S Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 104 S Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 107 S Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 108 S Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 109 T Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 117 T Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 119 S Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 13 T Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 165 S Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 171 S Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 172 S Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 173 T Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 174 S Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 18 S Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 265 S Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 287 S Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 298 S Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 368 S Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 392 S Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 393 S Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 428 T Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 492 T Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 496 S Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 639 S Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 651 S Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 661 S Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 665 T Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 68 T Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 682 S Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 700 S Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 707 S Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 709 S Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 76 S Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 88 S Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 91 S Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 93 T Homo sapiens(Human) UHRF1; ICBP90; NP95; RNF106 Q96T88 95 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q96T88 K399-ac Acetylation SsQRDWGkGMACVGR Q96T88 K546-ac Acetylation VKGGKNSkYAPAEGN Q96T88 K650-m1 Methylation GKGKWKRksAGGGPS Q96T88 R658-m1 Methylation sAGGGPSrAGsPRRT Q96T88 T13-p Phosphorylation RTMDGRQtHTVDSLS Q96T88 T68-p Phosphorylation YEVRLNDtIQLLVRQ Q96T88 S76-p Phosphorylation IQLLVRQsLVLPHST Q96T88 S88-p Phosphorylation HSTkERDsELsDtDs Q96T88 S91-p Phosphorylation kERDsELsDtDsGCC Q96T88 T93-p Phosphorylation RDsELsDtDsGCCLG Q96T88 S95-p Phosphorylation sELsDtDsGCCLGQS Q96T88 T117-p Phosphorylation HGEAAAEtDsRPADE Q96T88 S119-p Phosphorylation EAAAEtDsRPADEDM Q96T88 S165-p Phosphorylation RVTRKAPsRDEPCSS Q96T88 S265-p Phosphorylation NVVLGDDsLNDCRII Q96T88 S287-p Phosphorylation IERPGEGsPMVDNPM Q96T88 S298-p Phosphorylation DNPMRRKsGPSCkHC Q96T88 S368-p Phosphorylation PECRNDAsEVVLAGE Q96T88 S393-p Phosphorylation MASATSSsQRDWGkG Q96T88 Y418-p Phosphorylation TIVPSNHyGPIPGIP Q96T88 T492-p Phosphorylation DLSGNKRtAEQsCDQ Q96T88 S496-p Phosphorylation NKRtAEQsCDQkLTN Q96T88 S639-p Phosphorylation QQEGGFAsPRTGKGK Q96T88 S651-p Phosphorylation KGKWKRksAGGGPSr Q96T88 S661-p Phosphorylation GGPSrAGsPRRTSKK Q96T88 S682-p Phosphorylation SLTAQQSsLIREDKS Q96T88 S707-p Phosphorylation SLkDRPAsGsPFQLF Q96T88 S709-p Phosphorylation kDRPAsGsPFQLFLS Q96T88 S751-p Phosphorylation CKDCLDRsFRAQVFS Q96T88 K24-sm Sumoylation DSLSRLTkVEELRRk Q96T88 K385-sm Sumoylation RESKKKAkMASATSS Q96T88 K399-sm Sumoylation SsQRDWGkGMACVGR Q96T88 K500-sm Sumoylation AEQsCDQkLTNTNRA Q96T88 K525-sm Sumoylation DQEGAEAkDWRSGkP Q96T88 K531-sm Sumoylation AkDWRSGkPVRVVRN Q96T88 K546-sm Sumoylation VKGGKNSkYAPAEGN Q96T88 K563-sm Sumoylation DGIYkVVkYWPEKGk Q96T88 K570-sm Sumoylation kYWPEKGkSGFLVWR Q96T88 K600-sm Sumoylation EGKDRIKkLGLTMQY Q96T88 K626-sm Sumoylation EREKENSkREEEEQQ Q96T88 K670-sm Sumoylation RRTSKKTkVEPYSLT Q96T88 K692-sm Sumoylation REDKSNAkLWNEVLA Q96T88 K24-ub Ubiquitination DSLSRLTkVEELRRk Q96T88 K31-ub Ubiquitination kVEELRRkIQELFHV Q96T88 K50-ub Ubiquitination QRLFYRGkQMEDGHT Q96T88 K84-ub Ubiquitination LVLPHSTkERDsELs Q96T88 K136-ub Ubiquitination ETELGLYkVNEYVDA Q96T88 K233-ub Ubiquitination NYNPDNPkERGFWYD Q96T88 K303-ub Ubiquitination RKsGPSCkHCkDDVN Q96T88 K306-ub Ubiquitination GPSCkHCkDDVNRLC Q96T88 K385-ub Ubiquitination RESKKKAkMASATSS Q96T88 K399-ub Ubiquitination SsQRDWGkGMACVGR Q96T88 K408-ub Ubiquitination MACVGRTkECTIVPS Q96T88 K500-ub Ubiquitination AEQsCDQkLTNTNRA Q96T88 K525-ub Ubiquitination DQEGAEAkDWRSGkP Q96T88 K546-ub Ubiquitination VKGGKNSkYAPAEGN Q96T88 K560-ub Ubiquitination NRYDGIYkVVkYWPE Q96T88 K563-ub Ubiquitination DGIYkVVkYWPEKGk Q96T88 K570-ub Ubiquitination kYWPEKGkSGFLVWR Q96T88 K592-ub Ubiquitination DEPGPWTkEGKDRIK Q96T88 K600-ub Ubiquitination EGKDRIKkLGLTMQY Q96T88 K626-ub Ubiquitination EREKENSkREEEEQQ Q96T88 K670-ub Ubiquitination RRTSKKTkVEPYSLT Q96T88 K692-ub Ubiquitination REDKSNAkLWNEVLA Q96T88 K702-ub Ubiquitination NEVLASLkDRPAsGs

PTM - dbPTM UniProt ID Position Code Type Resources References Q96T88 76 S Phosphorylation Swiss-Prot 1010711 18669648 Q96T88 91 S Phosphorylation Swiss-Prot 1010711 18669648 Q96T88 287 S Phosphorylation Swiss-Prot 1010711 17081983;18220336;18669648 Q96T88 298 S Phosphorylation Swiss-Prot 1010711 15178447 Q96T88 385 K Ubiquitylation Swiss-Prot 1010711 17370265 Q96T88 399 K Acetylation Swiss-Prot 1010711 19608861 Q96T88 546 K Acetylation Swiss-Prot 1010711 19608861 Q96T88 639 S Phosphorylation Swiss-Prot 1010711 16964243;17081983;18669648 Q96T88 707 S Phosphorylation Swiss-Prot 1010711 18669648 Q96T88 76 S Phosphorylation PhosphoELM.10011 18669648 Q96T88 91 S Phosphorylation PhosphoELM.10011 18669648 Q96T88 95 S Phosphorylation PhosphoELM.10011 18669648 Q96T88 287 S Phosphorylation PhosphoELM.10011 18669648;18220336 Q96T88 639 S Phosphorylation PhosphoELM.10011 18669648;16964243 Q96T88 707 S Phosphorylation PhosphoELM.10011 18669648 Q96T88 136 K Ubiquitylation Phosphositeplus.1010730 21906983 Q96T88 233 K Ubiquitylation Phosphositeplus.1010730 21906983 Q96T88 385 K Ubiquitylation Phosphositeplus.1010730 17370265 Q96T88 50 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q96T88 560 K Ubiquitylation Phosphositeplus.1010730 21890473 Q96T88 563 K Ubiquitylation Phosphositeplus.1010730 21906983 Q96T88 570 K Ubiquitylation Phosphositeplus.1010730 21890473 Q96T88 592 K Ubiquitylation Phosphositeplus.1010730 21906983 Q96T88 600 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q96T88 626 K Ubiquitylation Phosphositeplus.1010730 21906983 Q96T88 670 K Ubiquitylation Phosphositeplus.1010730 21906983 Q96T88 692 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q96T88 84 K Ubiquitylation Phosphositeplus.1010730 21906983 Q96T88 399 K Acetylation Phosphositeplus.1010730 19608861 Q96T88 546 K Acetylation Phosphositeplus.1010730 19608861 Q96T88 287 S Phosphorylation Phosphositeplus.1010730 17081983;17446864;18220336;18669648;19276368;19690332;20068231;21406692;22115753 Q96T88 298 S Phosphorylation Phosphositeplus.1010730 15178447 Q96T88 639 S Phosphorylation Phosphositeplus.1010730 16964243;17081983;18669648;20068231;21659604;22115753;22411829 Q96T88 651 S Phosphorylation Phosphositeplus.1010730 21406692 Q96T88 661 S Phosphorylation Phosphositeplus.1010730 22072796 Q96T88 707 S Phosphorylation Phosphositeplus.1010730 18669648;19276368;20068231 Q96T88 709 S Phosphorylation Phosphositeplus.1010730 19276368 Q96T88 76 S Phosphorylation Phosphositeplus.1010730 18669648;20068231 Q96T88 91 S Phosphorylation Phosphositeplus.1010730 18669648;21659604 Q96T88 93 T Phosphorylation Phosphositeplus.1010730 21406692 Q96T88 399 K Acetylation HPRD 9.0 19608861 Q96T88 546 K Acetylation HPRD 9.0 19608861 Q96T88 18 S Phosphorylation HPRD 9.0 20068231 Q96T88 76 S Phosphorylation HPRD 9.0 18669648,20068231 Q96T88 88 S Phosphorylation HPRD 9.0 17081983 Q96T88 91 S Phosphorylation HPRD 9.0 18669648,18452278,20068231 Q96T88 95 S Phosphorylation HPRD 9.0 17081983,18669648,18452278 Q96T88 104 S Phosphorylation HPRD 9.0 18669648,18452278,20068231 Q96T88 108 S Phosphorylation HPRD 9.0 17081983,18669648,18452278 Q96T88 171 S Phosphorylation HPRD 9.0 17081983 Q96T88 287 S Phosphorylation HPRD 9.0 17081983,18669648,19651622,18452278,20068231 Q96T88 639 S Phosphorylation HPRD 9.0 17081983,18669648,20068231 Q96T88 661 S Phosphorylation HPRD 9.0 18767875 Q96T88 707 S Phosphorylation HPRD 9.0 18669648,20068231 Q96T88 93 T Phosphorylation HPRD 9.0 17081983 Q96T88 109 T Phosphorylation HPRD 9.0 17081983 Q96T88 428 T Phosphorylation HPRD 9.0 20068231 Q96T88 76 S Phosphorylation SysPTM 1.1 18669648 Q96T88 88 S Phosphorylation SysPTM 1.1 17081983 Q96T88 91 S Phosphorylation SysPTM 1.1 18669648 Q96T88 95 S Phosphorylation SysPTM 1.1 17081983 Q96T88 171 S Phosphorylation SysPTM 1.1 17081983 Q96T88 287 S Phosphorylation SysPTM 1.1 18669648;17081983 Q96T88 639 S Phosphorylation SysPTM 1.1 17081983;18669648;16964243 Q96T88 707 S Phosphorylation SysPTM 1.1 18669648 Q96T88 93 T Phosphorylation SysPTM 1.1 17081983 Q96T88 109 T Phosphorylation SysPTM 1.1 17081983

PTM - HPRD Symbol Position Code Type References UHRF1 101 S Phosphorylation 17081983 UHRF1 104 S Phosphorylation 18669648,18452278,20068231 UHRF1 106 T Phosphorylation 17081983 UHRF1 108 S Phosphorylation 17081983,18669648,18452278 UHRF1 109 T Phosphorylation 17081983 UHRF1 122 T Phosphorylation 17081983 UHRF1 171 S Phosphorylation 17081983 UHRF1 18 S Phosphorylation 20068231 UHRF1 184 S Phosphorylation 17081983 UHRF1 287 S Phosphorylation 17081983,18669648,19651622,18452278,20068231 UHRF1 300 S Phosphorylation 17081983,18669648,19651622,18452278,20068231 UHRF1 31 S Phosphorylation 20068231 UHRF1 399 K Acetylation 19608861 UHRF1 412 K Acetylation 19608861 UHRF1 428 T Phosphorylation 20068231 UHRF1 441 T Phosphorylation 20068231 UHRF1 546 K Acetylation 19608861 UHRF1 559 K Acetylation 19608861 UHRF1 639 S Phosphorylation 17081983,18669648,20068231 UHRF1 652 S Phosphorylation 17081983,18669648,20068231 UHRF1 661 S Phosphorylation 18767875 UHRF1 674 S Phosphorylation 18767875 UHRF1 707 S Phosphorylation 18669648,20068231 UHRF1 720 S Phosphorylation 18669648,20068231 UHRF1 76 S Phosphorylation 18669648,20068231 UHRF1 88 S Phosphorylation 17081983 UHRF1 89 S Phosphorylation 18669648,20068231 UHRF1 91 S Phosphorylation 18669648,18452278,20068231 UHRF1 93 T Phosphorylation 17081983 UHRF1 95 S Phosphorylation 17081983,18669648,18452278

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q96T88 91 S 18669648 HTP Phosphorylation Q96T88 76 S 18669648 HTP Phosphorylation Q96T88 707 S 18669648 HTP Phosphorylation Q96T88 639 S 18669648 HTP Phosphorylation Q96T88 639 S 16964243 HTP Phosphorylation Q96T88 287 S 18669648 HTP Phosphorylation Q96T88 287 S 18220336 HTP Phosphorylation Q96T88 95 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q96T88 76 Phosphoserine 18669648;20068231;23186163 Q96T88 91 Phosphoserine 18669648;23186163 Q96T88 287 Phosphoserine 17081983;18220336;19690332;20068231;21406692;23186163 Q96T88 298 Phosphoserine; by PKA 15178447;22837395 Q96T88 368 Phosphoserine 23186163 Q96T88 399 N6-acetyllysine 19608861 Q96T88 546 N6-acetyllysine; alternate 19608861 Q96T88 639 Phosphoserine; by CDK1 16964243;17081983;20068231;23186163;22411829 Q96T88 651 Phosphoserine 21406692 Q96T88 707 Phosphoserine 18669648;20068231;23186163 Q96T88 709 Phosphoserine 23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type UHRF1 IPI00797279 S 300 ERPGEGpSPMVDNP phosphorylation UHRF1 IPI00797279 S 652 QEGGFApSPRTGKG phosphorylation UHRF1 IPI00797279 S 713 WNEVLApSLKDRPA phosphorylation UHRF1 IPI00797279 S 720 LKDRPApSGSPFQL phosphorylation UHRF1 IPI00797279 S 89 QLLVRQpSLVLPHS phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 29128 118893 - K Ubiquitination 17370265 29128 118893 - K Ubiquitination 18781797 29128 118893 - K Ubiquitination 21139048 29128 118893 - K Ubiquitination 21890473 29128 118893 - K Ubiquitination 21906983 29128 118893 - K Sumoylation 19471022 29128 118893 - K Sumoylation 21252943 29128 118893 - K Ubiquitination 22505724 29128 118893 - K Ubiquitination 21963094 29128 118893 - K Ubiquitination 23000965 29128 118893 - K Ubiquitination 24816145 29128 118893 - K Ubiquitination 25147182 29128 118893 - K Sumoylation 25391492 29128 118893 - K Ubiquitination 23677994

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID UHRF1 Homo sapiens (Human) 583; 613; 705; 63 "583,YWPEKGKSGFLVW; 613,GKDRIKKLGLTMQ; 705,EDKSNAKLWNEVL; 63,RLFYRGKQMEDGH" 583:21890473; 613:21890473; 705:21890473; 63:21890473 UHRF1 Homo sapiens (Human) 50; 600; 692; 570 "50,RLFYRGKQMEDGH; 600,GKDRIKKLGLTMQ; 692,EDKSNAKLWNEVL; 570,YWPEKGKSGFLVW" 50:21890473; 600:21890473; 692:21890473; 570:21890473 UHRF1 Homo sapiens (Human) 583; 613; 705; 63 "583,YWPEKGKSGFLVW; 613,GKDRIKKLGLTMQ; 705,EDKSNAKLWNEVL; 63,RLFYRGKQMEDGH" 583:21890473; 613:21890473; 705:21890473; 63:21890473 UHRF1 Homo sapiens (Human) 583; 613; 705; 63 "583,YWPEKGKSGFLVW; 613,GKDRIKKLGLTMQ; 705,EDKSNAKLWNEVL; 63,RLFYRGKQMEDGH" 583:21890473; 613:21890473; 705:21890473; 63:21890473