Mutation - TCGA Type Chromosome Start Position End Position Strand Variant Classification Variant Type Reference Allele Tumor_seq Allele 1 Tumor_seq Allele 2 Tumor Sample Barcode Matched Norm Sample Barcode Genome Change cDNA Change Codon Change Protein Change ACC 19 39440918 39440918 + Silent SNP T T C TCGA-OR-A5JA-01A-11D-A29I-10 TCGA-OR-A5JA-10A-01D-A29L-10 g.chr19:39440918T>C c.42A>G c.(40-42)ccA>ccG p.P14P ACC 19 39440918 39440918 + Silent SNP T T C TCGA-OR-A5JD-01A-11D-A29I-10 TCGA-OR-A5JD-10B-01D-A29L-10 g.chr19:39440918T>C c.42A>G c.(40-42)ccA>ccG p.P14P ACC 19 39440918 39440918 + Silent SNP T T C TCGA-OR-A5JI-01A-11D-A29I-10 TCGA-OR-A5JI-10A-01D-A29L-10 g.chr19:39440918T>C c.42A>G c.(40-42)ccA>ccG p.P14P ACC 19 39440918 39440918 + Silent SNP T T C TCGA-OR-A5JK-01A-11D-A29I-10 TCGA-OR-A5JK-10A-01D-A29L-10 g.chr19:39440918T>C c.42A>G c.(40-42)ccA>ccG p.P14P ACC 19 39440918 39440918 + Silent SNP T T C TCGA-OR-A5JP-01A-11D-A29I-10 TCGA-OR-A5JP-10A-01D-A29L-10 g.chr19:39440918T>C c.42A>G c.(40-42)ccA>ccG p.P14P ACC 19 39440918 39440918 + Silent SNP T T C TCGA-OR-A5JX-01A-11D-A29I-10 TCGA-OR-A5JX-10B-01D-A29L-10 g.chr19:39440918T>C c.42A>G c.(40-42)ccA>ccG p.P14P ACC 19 39440918 39440918 + Silent SNP T T C TCGA-OR-A5K8-01A-11D-A29I-10 TCGA-OR-A5K8-10A-01D-A29L-10 g.chr19:39440918T>C c.42A>G c.(40-42)ccA>ccG p.P14P ACC 19 39440918 39440918 + Silent SNP T T C TCGA-OR-A5KP-01A-11D-A30A-10 TCGA-OR-A5KP-10A-01D-A30A-10 g.chr19:39440918T>C c.42A>G c.(40-42)ccA>ccG p.P14P ACC 19 39440918 39440918 + Silent SNP T T C TCGA-OR-A5KU-01A-11D-A29I-10 TCGA-OR-A5KU-10A-01D-A29L-10 g.chr19:39440918T>C c.42A>G c.(40-42)ccA>ccG p.P14P ACC 19 39440918 39440918 + Silent SNP T T C TCGA-OR-A5KZ-01A-11D-A29I-10 TCGA-OR-A5KZ-10A-01D-A29L-10 g.chr19:39440918T>C c.42A>G c.(40-42)ccA>ccG p.P14P ACC 19 39440918 39440918 + Silent SNP T T C TCGA-OR-A5LP-01A-11D-A29I-10 TCGA-OR-A5LP-10A-01D-A29L-10 g.chr19:39440918T>C c.42A>G c.(40-42)ccA>ccG p.P14P ACC 19 39440918 39440918 + Silent SNP T T C TCGA-PK-A5HB-01A-11D-A29I-10 TCGA-PK-A5HB-11A-11D-A29L-10 g.chr19:39440918T>C c.42A>G c.(40-42)ccA>ccG p.P14P BLCA 19 39435635 39435635 + Missense_Mutation SNP G G T TCGA-DK-A3WW-01A-22D-A23M-08 TCGA-DK-A3WW-10A-01D-A23K-08 g.chr19:39435635G>T c.667C>A c.(667-669)Cag>Aag p.Q223K BLCA 19 39435729 39435729 + Missense_Mutation SNP C C A TCGA-UY-A78K-01A-11D-A339-08 TCGA-UY-A78K-10A-01D-A339-08 g.chr19:39435729C>A c.573G>T c.(571-573)gaG>gaT p.E191D BRCA 19 39433304 39433305 + Frame_Shift_Ins INS - - C TCGA-EW-A1IZ-01A-11D-A188-09 TCGA-EW-A1IZ-10A-01D-A13O-09 g.chr19:39433304_39433305insC c.780_781insG c.(778-783)gggcacfs p.H261fs BRCA 19 39437131 39437131 + Missense_Mutation SNP C C T TCGA-AC-A3BB-01A-21D-A19Y-09 TCGA-AC-A3BB-10A-01D-A19Y-09 g.chr19:39437131C>T c.538G>A c.(538-540)Gag>Aag p.E180K BRCA 19 39439300 39439300 + Missense_Mutation SNP T T C TCGA-A2-A0T5-01A-21D-A099-09 TCGA-A2-A0T5-10A-01D-A099-09 g.chr19:39439300T>C c.368A>G c.(367-369)gAg>gGg p.E123G COAD 19 39435613 39435613 + Missense_Mutation SNP C C T TCGA-CM-5868-01A-01D-1650-10 TCGA-CM-5868-10A-01D-1650-10 g.chr19:39435613C>T c.689G>A c.(688-690)cGa>cAa p.R230Q COAD 19 39435660 39435660 + Missense_Mutation SNP G G T TCGA-AA-3510-01A-01D-1408-10 TCGA-AA-3510-11A-01D-1408-10 g.chr19:39435660G>T c.642C>A c.(640-642)ttC>ttA p.F214L COAD 19 39435738 39435738 + Silent SNP G G A TCGA-AA-3672-01A-01W-0900-09 TCGA-AA-3672-10A-01W-0900-09 g.chr19:39435738G>A c.564C>T c.(562-564)ggC>ggT p.G188G COADREAD 19 39435613 39435613 + Missense_Mutation SNP C C T TCGA-CM-5868-01A-01D-1650-10 TCGA-CM-5868-10A-01D-1650-10 g.chr19:39435613C>T c.689G>A c.(688-690)cGa>cAa p.R230Q COADREAD 19 39435660 39435660 + Missense_Mutation SNP G G T TCGA-AA-3510-01A-01D-1408-10 TCGA-AA-3510-11A-01D-1408-10 g.chr19:39435660G>T c.642C>A c.(640-642)ttC>ttA p.F214L COADREAD 19 39435738 39435738 + Silent SNP G G A TCGA-AA-3672-01A-01W-0900-09 TCGA-AA-3672-10A-01W-0900-09 g.chr19:39435738G>A c.564C>T c.(562-564)ggC>ggT p.G188G GBMLGG 19 39433282 39433282 + Missense_Mutation SNP T T C TCGA-DU-6392-01A-11D-1705-08 TCGA-DU-6392-10A-01D-1705-08 g.chr19:39433282T>C c.803A>G c.(802-804)cAc>cGc p.H268R GBMLGG 19 39433383 39433383 + Silent SNP G G A TCGA-DU-6392-01A-11D-1705-08 TCGA-DU-6392-10A-01D-1705-08 g.chr19:39433383G>A c.702C>T c.(700-702)caC>caT p.H234H HNSC 19 39437135 39437135 + Missense_Mutation SNP C C G TCGA-CR-6481-01A-11D-1870-08 TCGA-CR-6481-10A-01D-1870-08 g.chr19:39437135C>G c.534G>C c.(532-534)caG>caC p.Q178H HNSC 19 39439299 39439299 + Missense_Mutation SNP C C A TCGA-HD-7229-01A-11D-2012-08 TCGA-HD-7229-10A-01D-2013-08 g.chr19:39439299C>A c.369G>T c.(367-369)gaG>gaT p.E123D KICH 19 39440795 39440795 + Frame_Shift_Del DEL C C - TCGA-KL-8344-01A-11D-2310-10 TCGA-KL-8344-11A-01D-2310-10 g.chr19:39440795delC c.165delG c.(163-165)gggfs p.G55fs KIPAN 19 39435737 39435737 + Missense_Mutation SNP C C A TCGA-4A-A93W-01A-11D-A36X-10 TCGA-4A-A93W-10A-01D-A370-10 g.chr19:39435737C>A c.565G>T c.(565-567)Gct>Tct p.A189S KIPAN 19 39440795 39440795 + Frame_Shift_Del DEL C C - TCGA-KL-8344-01A-11D-2310-10 TCGA-KL-8344-11A-01D-2310-10 g.chr19:39440795delC c.165delG c.(163-165)gggfs p.G55fs KIRP 19 39435737 39435737 + Missense_Mutation SNP C C A TCGA-4A-A93W-01A-11D-A36X-10 TCGA-4A-A93W-10A-01D-A370-10 g.chr19:39435737C>A c.565G>T c.(565-567)Gct>Tct p.A189S LGG 19 39433282 39433282 + Missense_Mutation SNP T T C TCGA-DU-6392-01A-11D-1705-08 TCGA-DU-6392-10A-01D-1705-08 g.chr19:39433282T>C c.803A>G c.(802-804)cAc>cGc p.H268R LGG 19 39433383 39433383 + Silent SNP G G A TCGA-DU-6392-01A-11D-1705-08 TCGA-DU-6392-10A-01D-1705-08 g.chr19:39433383G>A c.702C>T c.(700-702)caC>caT p.H234H LIHC 19 39435635 39435635 + Nonsense_Mutation SNP G G A TCGA-5R-AAAM-01A-12D-A40R-10 TCGA-5R-AAAM-10A-01D-A40U-10 g.chr19:39435635G>A c.667C>T c.(667-669)Cag>Tag p.Q223* LIHC 19 39437164 39437164 + Missense_Mutation SNP C C G TCGA-ZP-A9D4-01A-11D-A36X-10 TCGA-ZP-A9D4-10A-01D-A370-10 g.chr19:39437164C>G c.505G>C c.(505-507)Gtg>Ctg p.V169L LUAD 19 39433327 39433327 + Missense_Mutation SNP C C G TCGA-75-6214-01A-41D-1945-08 TCGA-75-6214-10A-01D-1946-08 g.chr19:39433327C>G c.758G>C c.(757-759)aGa>aCa p.R253T LUAD 19 39435614 39435614 + Nonsense_Mutation SNP G G A TCGA-86-8055-01A-11D-2238-08 TCGA-86-8055-10A-01D-2238-08 g.chr19:39435614G>A c.688C>T c.(688-690)Cga>Tga p.R230* LUAD 19 39440854 39440854 + Missense_Mutation SNP G G T TCGA-86-8358-01A-11D-2323-08 TCGA-86-8358-10A-01D-2323-08 g.chr19:39440854G>T c.106C>A c.(106-108)Cgc>Agc p.R36S PAAD 19 39437163 39437163 + Missense_Mutation SNP A A G TCGA-IB-7651-01A-11D-2154-08 TCGA-IB-7651-10A-01D-2154-08 g.chr19:39437163A>G c.506T>C c.(505-507)gTg>gCg p.V169A SKCM 19 39439219 39439221 + In_Frame_Del DEL ACG ACG - TCGA-FR-A3YN-06A-11D-A23B-08 TCGA-FR-A3YN-10A-01D-A23B-08 g.chr19:39439219_39439221delACG c.447_449delCGT c.(445-450)ttcgtg>ttg p.149_150FV>L

Mutation - COSMIC Sample Name Mutation ID Mutation CDS Mutation AA Mutation Description Mutation Genome Position Mutation Strand PD4127a COSM161009 c.655G>T p.E219* Substitution - Nonsense 19:38945034-38945034 - TCGA-AA-3510-01 COSM1393493 c.669C>A p.F223L Substitution - Missense 19:38945020-38945020 - TCGA-A6-6138-01 COSM5090534 c.252C>T p.Y84Y Substitution - coding silent 19:38950095-38950095 - TCGA-D1-A17Q-01 COSM996204 c.427G>T p.E143* Substitution - Nonsense 19:38948628-38948628 - KYSE-410 COSM3223295 c.392G>A p.W131* Substitution - Nonsense 19:38948663-38948663 - TCGA-AX-A2H5-01 COSM996200 c.730G>A p.V244I Substitution - Missense 19:38942742-38942742 - S01020 COSM5665027 c.82G>T p.D28Y Substitution - Missense 19:38950265-38950265 - TCGA-A5-A0GP-01 COSM996199 c.768T>G p.S256S Substitution - coding silent 19:38942704-38942704 - S00936 COSM311127 c.556G>A p.A186T Substitution - Missense 19:38946500-38946500 - TCGA-AY-A71X-01 COSM5137395 c.531G>A p.G177G Substitution - coding silent 19:38946525-38946525 - 2492700 COSM5600416 c.721-1G>A p.? Unknown 19:38942752-38942752 - TCGA-A6-3809-01 COSM5086994 c.104T>G p.L35R Substitution - Missense 19:38950243-38950243 - Pat_66_A COSM5855697 c.368delG p.C123fs*20 Deletion - Frameshift 19:38949979-38949979 - sysucc-834T COSM5486043 c.167G>A p.R56H Substitution - Missense 19:38950180-38950180 - TCGA-AC-A3BB-01 COSM3822999 c.565G>A p.E189K Substitution - Missense 19:38946491-38946491 - 2492701 COSM5600416 c.721-1G>A p.? Unknown 19:38942752-38942752 - ATL041 COSM5707014 c.631C>T p.R211C Substitution - Missense 19:38945058-38945058 - SC_9076 COSM5561902 c.686C>T p.P229L Substitution - Missense 19:38945003-38945003 - S00501 COSM5658318 c.201G>A p.V67V Substitution - coding silent 19:38950146-38950146 - 19 COSM5748056 c.226C>T p.R76C Substitution - Missense 19:38950121-38950121 - TCGA-AA-3713-01 COSM3692742 c.331C>T p.R111C Substitution - Missense 19:38950016-38950016 - TCGA-A2-A0T5-01 COSM3823000 c.395A>G p.E132G Substitution - Missense 19:38948660-38948660 - TCGA-HF-7132-01 COSM266528 c.591C>T p.G197G Substitution - coding silent 19:38945098-38945098 - TCGA-AA-3672-01 COSM266528 c.591C>T p.G197G Substitution - coding silent 19:38945098-38945098 - TCGA-DM-A28G-01 COSM5170801 c.348C>A p.R116R Substitution - coding silent 19:38949999-38949999 - SC_9103 COSM5565150 c.757C>T p.R253C Substitution - Missense 19:38942715-38942715 - 084T COSM1731041 c.814G>T p.G272C Substitution - Missense 19:38942658-38942658 - T3152 COSM4723663 c.86C>T p.A29V Substitution - Missense 19:38950261-38950261 - 2492702 COSM5600416 c.721-1G>A p.? Unknown 19:38942752-38942752 - 064-0128-01TD COSM5417773 c.723C>A p.V241V Substitution - coding silent 19:38942749-38942749 - LP6005935-DNA_F01 COSM5036474 c.406G>A p.G136S Substitution - Missense 19:38948649-38948649 - HCA7 COSM3223294 c.408C>T p.G136G Substitution - coding silent 19:38948647-38948647 - CHC322T COSM3756768 c.21A>G p.L7L Substitution - coding silent 19:38950326-38950326 - Pat_24_A COSM5855696 c.443C>T p.P148L Substitution - Missense 19:38948612-38948612 - TCGA-DK-A3WW-01 COSM3797053 c.694C>A p.Q232K Substitution - Missense 19:38944995-38944995 - TCGA-AA-3697-01 COSM3756768 c.21A>G p.L7L Substitution - coding silent 19:38950326-38950326 - SC_9022 COSM5573651 c.720+2T>G p.? Unknown 19:38944967-38944967 - sysucc-1317T COSM5449274 c.227G>A p.R76H Substitution - Missense 19:38950120-38950120 - Au2 COSM5600416 c.721-1G>A p.? Unknown 19:38942752-38942752 - CHC1079T COSM4791074 c.336G>A p.A112A Substitution - coding silent 19:38950011-38950011 - KM12 COSM4639044 c.58C>T p.P20S Substitution - Missense 19:38950289-38950289 - 8068585 COSM4138228 c.850A>C p.I284L Substitution - Missense 19:38942622-38942622 - TCGA-G9-6356-01 COSM1129866 c.813T>C p.Y271Y Substitution - coding silent 19:38942659-38942659 - HCC2998 COSM3223288 c.486C>T p.F162F Substitution - coding silent 19:38948569-38948569 - AOCS-139-6-3 COSM4140619 c.862T>C p.*288Q Nonstop extension 19:38942610-38942610 - 2492703 COSM5600416 c.721-1G>A p.? Unknown 19:38942752-38942752 - TCGA-AY-6386-01 COSM3756768 c.21A>G p.L7L Substitution - coding silent 19:38950326-38950326 - TCGA-BS-A0TC-01 COSM996203 c.434A>G p.N145S Substitution - Missense 19:38948621-38948621 - CHC1079T COSM4791074 c.336G>A p.A112A Substitution - coding silent 19:38950011-38950011 - PCSI_0338_Pa_P_526 COSM4807166 c.171C>T p.A57A Substitution - coding silent 19:38950176-38950176 - TCGA-NH-A50U-01 COSM5180857 c.282C>T p.N94N Substitution - coding silent 19:38950065-38950065 - BD152T COSM5506532 c.721-3C>A p.? Unknown 19:38942754-38942754 - TCGA-EW-A1IZ-01 COSM5833723 c.807_808insG p.H270fs*>19 Insertion - Frameshift 19:38942664-38942665 - TCGA-22-1002-01 COSM711528 c.412A>G p.N138D Substitution - Missense 19:38948643-38948643 - TCGA-AA-3956-01 COSM5116285 c.177C>A p.R59R Substitution - coding silent 19:38950170-38950170 - Mel-2 COSM3726923 c.504G>C p.R168S Substitution - Missense 19:38946552-38946552 - TCGA-AP-A0LM-01 COSM996202 c.497C>T p.S166F Substitution - Missense 19:38946559-38946559 - TCGA-CM-5868-01 COSM1393492 c.716G>A p.R239Q Substitution - Missense 19:38944973-38944973 - TCGA-D1-A167-01 COSM996201 c.715C>T p.R239* Substitution - Nonsense 19:38944974-38944974 - CHC322T COSM3766338 c.69A>G p.P23P Substitution - coding silent 19:38950278-38950278 - S02351 COSM5695069 c.584+1G>C p.? Unknown 19:38946471-38946471 - AOCS-139-19-0 COSM4140619 c.862T>C p.*288Q Nonstop extension 19:38942610-38942610 - sysucc-783T COSM5484288 c.147G>A p.T49T Substitution - coding silent 19:38950200-38950200 - I2L-P10-Tumor-Organoid COSM5364824 c.474C>T p.F158F Substitution - coding silent 19:38948581-38948581 -

Mutation - CGAP UNIGENE CYTOBAND OMIM SNP Hs.531770 19q13.2 609094 2419126|CGAP|BC012385|A/G|coding|Pro14Pro|124|Candidate; 2419127|CGAP|BC012385|A/G|non-coding||76|Validated

Mutation - IntOGen Mutated from(ref) Mutated to(alt) Consequence Type AA Mutation CDS Mutation Chr Pos Cancer A C Missense p.F152V c.454T>G 19 39433344 UCEC C A Missense p.*197L c.590G>T 19 39412889 LUSC C A Missense p.E123D c.369G>T 19 39439299 HNSC C A Missense p.G114V c.341G>T 19 39435674 BRCA C A Missense p.G28C c.82G>T 19 39439299 HNSC C A Missense p.R555L c.1664G>T 19 39406347 STAD C A Missense p.W258L c.773G>T 19 39433312 LUAD C A Nonsense p.E210* c.628G>T 19 39435674 BRCA C G Missense p.D161H c.481G>C 19 39416935 COREAD C G Missense p.D83H c.247G>C 19 39437135 HNSC C G Missense p.Q178H c.534G>C 19 39437135 HNSC C T IntronicSNV . c.476-4467G>A 19 39421407 CM C T Missense p.A177T c.529G>A 19 39437140 SCLC C T Missense p.G519S c.1555G>A 19 39406677 STAD C T Missense p.R139H c.416G>A 19 39433382 UCEC C T Missense p.R331K c.992G>A 19 39409429 BRCA C T Missense p.R81H c.242G>A 19 39437140 SCLC C T Missense p.V235I c.703G>A 19 39433382 UCEC C T SpliceDonorSNV . c.1368+1G>A 19 39408363 CM G A Missense p.L453F c.1357C>T 19 39408375 GBM G A Missense p.P245L c.734C>T 19 39412175 CM G - Frameshift p.P456Rfs*189 c.1367delC 19 39408365 GBM G T Missense p.H268N c.802C>A 19 39433283 STAD G T Missense p.L137I c.409C>A 19 39433389 CLL T A Missense p.I350F c.1048A>T 19 39409138 HC T C Missense p.E33G c.98A>G 19 39439283 LUSC T C Missense p.N129D c.385A>G 19 39439283 LUSC T C Missense p.N136S c.407A>G 19 39439261 UCEC