PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus COPS2 FBXO17 26186194 biogrid exp G G G G G G G G G G G CLPP FBXO17 26186194 biogrid exp G G G G G G G G G G G NDUFA2 FBXO17 26186194 biogrid exp G G G G G G G G G G G FBXO17 COPS3 19295130 biogrid exp G G G G G G G G G G G COPS6 FBXO17 26186194,19615732,21145461 biogrid,intact exp G G G G G G G G G G G CUL5 FBXO17 21145461 biogrid exp G G G G G G G G G G G NMT2 FBXO17 26186194 biogrid exp G G G G G G G G G G G FBXO17 SARS2 26186194 biogrid exp G G G G G G G G G G G NDUFS6 FBXO17 26186194 biogrid exp G G G G G G G G G G G HSPD1 FBXO17 26186194 biogrid exp G G G G G G G G G G G COPS5 FBXO17 26186194,19615732,21145461 biogrid,intact exp G G G G G G G G G G G FBXO17 COPS7B 26186194 biogrid exp G G G G G G G G G G G FBXO17 COPS4 19295130,26186194 biogrid exp G G G G G G G G G G G HSP90AA1 FBXO17 22939624 biogrid exp G G G G G G G G G G G NMT1 FBXO17 26186194 biogrid exp G G G G G G G G G G G SKP1 FBXO17 21640084,25416956,10531037,26186194,18203720, 25402006 hprd,biogrid,intact exp, pred G G G G G G G G G G G FBXO17 FBXW2 26186194, 25402006 biogrid exp, pred G G G G G G G G G G G RBX1 FBXO17 18203720, 25402006 biogrid exp, pred G G G G G G G G G G G CUL1 FBXO17 26186194,18203720,21145461, 25402006 biogrid exp, pred G G G G G G G G G G G FBXO17 CDCA3 25402006 pred G G G G G G G G FBXO18 FBXO17 25402006 pred G G G G G G G G G G G NFKBIE FBXO17 25402006 pred G G G G G G G G G G G FBXO17 FBXL2 25402006 pred G G G G G G G G G G FBXW7 FBXO17 25402006 pred G G G G G G G G G G FBXO17 FBXW11 25402006 pred G G G G G G G G G G G FBXO17 BTRC 25402006 pred G G G G G G G G G G G FBXO17 SUGT1 25402006 pred G G G G G G G G G G G FBXO17 FBXO4 25402006 pred G G G G G G G G G G G FBXO46 FBXO17 25402006 pred G G G G G G G G G G G FLNA FBXO17 23023127 pred G G G G G G G G G G G CUL7 FBXO17 25402006 pred G G G G G G G G G G G FBXO31 FBXO17 25402006 pred G G G G G G G G G G G FBXO17 FBXL3 25402006 pred G G G G G G G G G G G FBXO17 FBXO44 25402006 pred G G G G G G G G G G G FBXW8 FBXO17 25402006 pred FBXO17 CACYBP 25402006 pred G G G G G G G G G G G SKP2 FBXO17 25402006 pred G G G G G G G G G G G FBXL8 FBXO17 25402006 pred NFKBIA FBXO17 25402006 pred G G G G G G G G G G G ZC3HC1 FBXO17 25402006 pred G G G G G G G G G G G MAP3K1 FBXO17 23023127 pred G G G G G G G G G G G FBXW5 FBXO17 25402006 pred G G G G G G G G G G G FBXO17 CHFR 23023127 pred G G G G G G G G G G G FBXW9 FBXO17 25402006 pred G G G G G G G G G G G FBXO17 FBXO2 25402006 pred G G G G G G G G G G G FBXO17 FBXO34 25402006 pred G G G G G G G G G G G FBXO17 FBXO6 25402006 pred G G G G G G G G G G G CLN5 FBXO17 23023127 pred G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q96EF6 Q9UNS2 affinity chromatography technology 19295130 physical association X 2 Q96EF6 P07900-2 affinity chromatography technology 22939624 physical association X 2 Q9BT78 Q96EF6 affinity chromatography technology 19295130 physical association X 2 Q93034 Q96EF6 affinity chromatography technology 21145461 physical association X 2 Q7L5N1 Q96EF6 affinity chromatography technology 21145461 physical association X 2 Q7L5N1 Q96EF6 affinity chromatography technology 19615732 physical association X 2 A0A090N7U0 Q96EF6 affinity chromatography technology 18203720 physical association X 2 A0A090N7U0 Q96EF6 affinity chromatography technology 21145461 physical association X 2 P62877 Q96EF6 affinity chromatography technology 18203720 physical association X 2 A0A024R7W9 Q96EF6 affinity chromatography technology 21145461 physical association X 2 A0A024R7W9 Q96EF6 affinity chromatography technology 19615732 physical association X 2 P0CG48 Q96EF6 affinity chromatography technology 21139048 physical association X 2 P63208 Q96EF6 affinity chromatography technology 18203720 physical association X 2 P63208 Q96EF6 affinity chromatography technology 21640084 physical association X 2 P63208 Q96EF6 two hybrid 25416956 direct interaction X 2 P63208-2 Q96EF6 two hybrid 10531037 - X 2 P63208-2 Q96EF6 two hybrid 10531037 - X 2 Q96EF6 anti tag coimmunoprecipitation 19615732 physical association C 35 Q96EF6 anti tag coimmunoprecipitation 19615732 physical association C 55 P63208 Q96EF6 mammalian protein protein interaction trap 25416956 physical association X 2 P63208 Q96EF6 anti tag coimmunoprecipitation 25416956 physical association X 2 P63208 Q96EF6 two hybrid prey pooling approach 25416956 physical association X 2 P63208 Q96EF6 two hybrid array 25416956 physical association X 2 P63208 Q96EF6 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B COPS6 FBXO17 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_205705|BIOGRID_120792|UniProt_100633 bait|bait|bait prey|prey|prey HSP90AA1 FBXO17 MI:0004(affinity chromatography technology) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255415 bait prey FBXO17 COPS3 MI:0004(affinity chromatography technology) 19295130 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_221725 prey bait FBXO17 COPS4 MI:0004(affinity chromatography technology) 19295130 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_221726 prey bait SKP1 FBXO17 MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 10531037,18203720,21640084 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0915(physical association) (biogrid)|MI:0468(hprd)|(biogrid) BIOGRID_201340|HPRD_9129|BIOGRID_199921 prey|-|prey bait|-|bait CUL5 FBXO17 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_203441 bait prey CUL1 FBXO17 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18203720,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_204528|BIOGRID_199920 bait|prey prey|bait COPS5 FBXO17 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19615732,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid) UniProt_100632|BIOGRID_205201|BIOGRID_120791 bait|bait|bait prey|prey|prey UBC FBXO17 MI:0004(affinity chromatography technology) 21139048 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_171083 bait prey RBX1 FBXO17 MI:0004(affinity chromatography technology) 18203720 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_199922 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q96EF6 P07900 FBXO17 HSP90AA1 0.126 22939624 Q96EF6 Q8IYX7 FBXO17 FAM154A 0.236 unassigned1304 Q96EF6 Q5T749 FBXO17 KPRP 0.236 unassigned1304 Q96EF6 Q16825 FBXO17 PTPN21 0.236 unassigned1304 Q96EF6 O14771 FBXO17 ZNF213 0.236 unassigned1304 Q96EF6 O95678 FBXO17 KRT75 0.236 unassigned1304 Q96EF6 Q15056 FBXO17 EIF4H 0.236 unassigned1304 Q96EF6 Q14847 FBXO17 LASP1 0.236 unassigned1304 Q96EF6 Q86Y13 FBXO17 DZIP3 0.236 unassigned1304 Q96EF6 Q70EL1 FBXO17 USP54 0.236 unassigned1304 Q96EF6 Q86XJ5 FBXO17 Q86XJ5 0.236 unassigned1304 Q96EF6 Q8NA61 FBXO17 SPERT 0.236 unassigned1304 Q96EF6 Q01196 FBXO17 RUNX1 0.236 unassigned1304 Q96EF6 O15535 FBXO17 ZSCAN9 0.236 unassigned1304 Q96EF6 Q52LG2 FBXO17 KRTAP13-2 0.236 unassigned1304 Q96EF6 Q6UY14 FBXO17 ADAMTSL4 0.236 unassigned1304 Q96EF6 Q7L804 FBXO17 RAB11FIP2 0.236 unassigned1304 Q96EF6 P63208 FBXO17 SKP1 0.884 25416956,27705803,18203720,unassigned1304,21640084,26186194 Q96EF6 Q93034 FBXO17 CUL5 0.126 21145461 Q96EF6 O43678 FBXO17 NDUFA2 0.126 26186194 Q96EF6 O60551 FBXO17 NMT2 0.126 26186194 Q96EF6 O75380 FBXO17 NDUFS6 0.126 26186194 Q96EF6 P10809 FBXO17 HSPD1 0.126 26186194 Q96EF6 P30419 FBXO17 NMT1 0.126 26186194 Q96EF6 P61201 FBXO17 COPS2 0.126 26186194 Q96EF6 P62877 FBXO17 RBX1 0.21 18203720 Q96EF6 Q16740 FBXO17 CLPP 0.126 26186194 Q96EF6 Q7L5N1 FBXO17 COPS6 0.416 21145461,26186194,19615732 Q96EF6 Q92905 FBXO17 COPS5 0.416 21145461,26186194,19615732 Q9BT78 Q96EF6 COPS4 FBXO17 0.236 19295130,26186194 Q9H9Q2 Q96EF6 COPS7B FBXO17 0.126 26186194 Q9NP81 Q96EF6 SARS2 FBXO17 0.126 26186194 Q9UKT8 Q96EF6 FBXW2 FBXO17 0.126 26186194 Q9UNS2 Q96EF6 COPS3 FBXO17 0.126 19295130 Q96EF6 Q13616 FBXO17 CUL1 0.396 18203720,21145461,26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 SIAH2 FBXO17 MI:0362 inference MI:1106 pathways database NDUFA2 FBXO17 MI:0045 experimental interaction detection MI:0461 interaction database NMT2 FBXO17 MI:0045 experimental interaction detection MI:0461 interaction database NDUFS6 FBXO17 MI:0045 experimental interaction detection MI:0461 interaction database FBXO21 FBXO17 MI:0362 inference MI:1106 pathways database HSP90AA1 FBXO17 MI:0045 experimental interaction detection MI:0461 interaction database UBB FBXO17 MI:0362 inference MI:1106 pathways database UBC FBXO17 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database HSPD1 FBXO17 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 FBXO17 MI:0362 inference MI:1106 pathways database NMT1 FBXO17 MI:0045 experimental interaction detection MI:0461 interaction database CCNF FBXO17 MI:0362 inference MI:1106 pathways database UBE2A FBXO17 MI:0362 inference MI:1106 pathways database FBXW4 FBXO17 MI:0362 inference MI:1106 pathways database COPS2 FBXO17 MI:0045 experimental interaction detection MI:0461 interaction database RBX1 FBXO17 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RPS27A FBXO17 MI:0362 inference MI:1106 pathways database UBA52 FBXO17 MI:0362 inference MI:1106 pathways database SKP1 FBXO17 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SKP2 FBXO17 MI:0362 inference MI:1106 pathways database CUL1 FBXO17 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TRIP12 FBXO17 MI:0362 inference MI:1106 pathways database CLPP FBXO17 MI:0045 experimental interaction detection MI:0461 interaction database LONRF1 FBXO17 MI:0362 inference MI:1106 pathways database HECTD2 FBXO17 MI:0362 inference MI:1106 pathways database FBXO31 FBXO17 MI:0362 inference MI:1106 pathways database FBXW9 FBXO17 MI:0362 inference MI:1106 pathways database FBXW10 FBXO17 MI:0362 inference MI:1106 pathways database RNF213 FBXO17 MI:0362 inference MI:1106 pathways database FBXL22 FBXO17 MI:0362 inference MI:1106 pathways database FBXL19 FBXO17 MI:0362 inference MI:1106 pathways database FBXW12 FBXO17 MI:0362 inference MI:1106 pathways database RNF19B FBXO17 MI:0362 inference MI:1106 pathways database COPS6 FBXO17 MI:0045 experimental interaction detection MI:0461 interaction database RNF144B FBXO17 MI:0362 inference MI:1106 pathways database RBBP6 FBXO17 MI:0362 inference MI:1106 pathways database HUWE1 FBXO17 MI:0362 inference MI:1106 pathways database TRIM69 FBXO17 MI:0362 inference MI:1106 pathways database SIAH1 FBXO17 MI:0362 inference MI:1106 pathways database HERC6 FBXO17 MI:0362 inference MI:1106 pathways database UBR2 FBXO17 MI:0362 inference MI:1106 pathways database FBXL14 FBXO17 MI:0362 inference MI:1106 pathways database FBXW8 FBXO17 MI:0362 inference MI:1106 pathways database FBXL16 FBXO17 MI:0362 inference MI:1106 pathways database FBXO15 FBXO17 MI:0362 inference MI:1106 pathways database ZNRF1 FBXO17 MI:0362 inference MI:1106 pathways database FBXL13 FBXO17 MI:0362 inference MI:1106 pathways database FBXO22 FBXO17 MI:0362 inference MI:1106 pathways database ZNRF2 FBXO17 MI:0362 inference MI:1106 pathways database FBXO27 FBXO17 MI:0362 inference MI:1106 pathways database FBXO30 FBXO17 MI:0362 inference MI:1106 pathways database RNF217 FBXO17 MI:0362 inference MI:1106 pathways database DTX3L FBXO17 MI:0362 inference MI:1106 pathways database FBXO41 FBXO17 MI:0362 inference MI:1106 pathways database LMO7 FBXO17 MI:0362 inference MI:1106 pathways database MYLIP FBXO17 MI:0362 inference MI:1106 pathways database COPS5 FBXO17 MI:0045 experimental interaction detection MI:0461 interaction database CUL5 FBXO17 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 FBXO17 MI:0362 inference MI:1106 pathways database FBXO32 FBXO17 MI:0362 inference MI:1106 pathways database FBXW5 FBXO17 MI:0362 inference MI:1106 pathways database MIB2 FBXO17 MI:0362 inference MI:1106 pathways database SPSB1 FBXO17 MI:0362 inference MI:1106 pathways database FBXL8 FBXO17 MI:0362 inference MI:1106 pathways database FBXO17 FBXL20 MI:0362 inference MI:1106 pathways database FBXO17 FBXL18 MI:0362 inference MI:1106 pathways database FBXO17 NEDD4L MI:0362 inference MI:1106 pathways database FBXO17 COPS4 MI:0045 experimental interaction detection MI:0461 interaction database FBXO17 RBCK1 MI:0362 inference MI:1106 pathways database FBXO17 FBXL15 MI:0362 inference MI:1106 pathways database FBXO17 FBXO44 MI:0362 inference MI:1106 pathways database FBXO17 UNKL MI:0362 inference MI:1106 pathways database FBXO17 COPS7B MI:0045 experimental interaction detection MI:0461 interaction database FBXO17 SMURF2 MI:0362 inference MI:1106 pathways database FBXO17 SARS2 MI:0045 experimental interaction detection MI:0461 interaction database FBXO17 TRIM36 MI:0362 inference MI:1106 pathways database FBXO17 FBXO6 MI:0362 inference MI:1106 pathways database FBXO17 RNF19A MI:0362 inference MI:1106 pathways database FBXO17 RLIM MI:0362 inference MI:1106 pathways database FBXO17 FBXL12 MI:0362 inference MI:1106 pathways database FBXO17 FBXO40 MI:0362 inference MI:1106 pathways database FBXO17 HERC5 MI:0362 inference MI:1106 pathways database FBXO17 FBXL7 MI:0362 inference MI:1106 pathways database FBXO17 FBXO2 MI:0362 inference MI:1106 pathways database FBXO17 FBXO10 MI:0362 inference MI:1106 pathways database FBXO17 FBXO9 MI:0362 inference MI:1106 pathways database FBXO17 FBXL5 MI:0362 inference MI:1106 pathways database FBXO17 FBXL4 MI:0362 inference MI:1106 pathways database FBXO17 FBXW11 MI:0362 inference MI:1106 pathways database FBXO17 FBXO4 MI:0362 inference MI:1106 pathways database FBXO17 FBXL21 MI:0362 inference MI:1106 pathways database FBXO17 FBXL3 MI:0362 inference MI:1106 pathways database FBXO17 FBXW2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FBXO17 COPS3 MI:0045 experimental interaction detection MI:0461 interaction database FBXO17 BTRC MI:0362 inference MI:1106 pathways database FBXO17 FBXO7 MI:0362 inference MI:1106 pathways database FBXO17 RNF115 MI:0362 inference MI:1106 pathways database FBXO17 RNF114 MI:0362 inference MI:1106 pathways database FBXO17 WSB1 MI:0362 inference MI:1106 pathways database