PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus HSP90AA1 FBXO27 22939624 biogrid exp GP P G GP G G GP G G G G G GP G G P G G G G G GP G MGMT FBXO27 16226712 biogrid exp GP P G GP G G GP G GP G P GP G P GP G G P GP GP G GP GP GP G FBXO27 STUB1 16682404 biogrid exp GP P G GP G GP GP G GP G P GP G P GP G G P GP GP GP GP GP GP G CLN5 FBXO27 23464991 biogrid exp GP P G GP G GP GP G GP G P G G P GP G G P GP GP G GP GP GP G RBX1 FBXO27 21640084,18203720 innatedb,biogrid exp G G GP G GP G G G G P G G GP G G P GP G G G G GP G ELAVL1 FBXO27 19322201 biogrid exp GP P G GP G GP GP G GP G P GP G P GP G G P GP GP GP GP GP GP G HSP90AB1 FBXO27 22939624 intact exp GP P G GP G GP GP G GP G P GP G P GP G G P GP GP GP GP GP GP G SKP1 FBXO27 21640084,18203720, 25402006, 23023127, 21836163 innatedb,biogrid exp, pred GP P G GP G G GP G GP G P GP G P GP G G P GP GP G GP GP GP G CUL1 FBXO27 21640084,18203720, 25402006, 21836163 innatedb,biogrid exp, pred GP G GP G GP GP G GP G P G G P GP G G P GP GP GP GP GP GP G FBXO31 FBXO27 23023127 pred GP P G GP G GP GP G GP G P GP G P GP G G P GP GP GP GP GP GP G FBXO27 FBXO44 23023127 pred GP P G GP G GP GP G GP G P GP G P GP G G P GP GP GP GP GP GP G PLG FBXO27 23023127 pred P P G G P P P P FBXO27 FBXO7 23023127 pred GP P G GP G GP GP G GP G P GP G P GP G G P GP GP GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8NI29 P62877 affinity chromatography technology 18203720 physical association X 2 Q8NI29 P62877 affinity chromatography technology 21640084 physical association X 2 Q8NI29 P07900-2 affinity chromatography technology 22939624 physical association X 2 A0A024R644 Q8NI29 affinity chromatography technology 23464991 physical association X 2 Q8NI29 Q9UNE7 pull down 16682404 direct interaction X 2 A0A090N7U0 Q8NI29 affinity chromatography technology 18203720 physical association X 2 A0A090N7U0 Q8NI29 affinity chromatography technology 21640084 physical association X 2 B4DEE8 Q8NI29 affinity chromatography technology 16226712 physical association X 2 P63208 Q8NI29 affinity chromatography technology 18203720 physical association X 2 P63208 Q8NI29 affinity chromatography technology 21640084 physical association X 2 Q8NI29 A0A024RD80 luminescence based mammalian interactome mapping 22939624 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CUL1 FBXO27 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18203720,21640084 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_201332|BIOGRID_199923 prey|prey bait|bait RBX1 FBXO27 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18203720,21640084 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_201336|BIOGRID_199925 prey|prey bait|bait HSP90AB1 FBXO27 MI:0729(luminescence based mammalian interactome mapping) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_124994 prey bait FBXO27 STUB1 MI:0004(affinity chromatography technology) 16682404 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_130580 bait prey SKP1 FBXO27 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18203720,21640084 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_201341|BIOGRID_199924 prey|prey bait|bait ELAVL1 FBXO27 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_186601 bait prey MGMT FBXO27 MI:0004(affinity chromatography technology) 16226712 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_131666 bait prey HSP90AA1 FBXO27 MI:0004(affinity chromatography technology) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255417 bait prey CLN5 FBXO27 MI:0004(affinity chromatography technology) 23464991 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_273981 bait prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8NI29 P08238 FBXO27 HSP90AB1 0.126 22939624 Q8NI29 P62877 FBXO27 RBX1 0.21 21640084 Q8NI29 Q13616 FBXO27 CUL1 0.21 21640084 Q9UNE7 Q8NI29 STUB1 FBXO27 0.309 16682404 Q8NI29 P16455 FBXO27 MGMT 0.126 16226712 Q8NI29 P07900 FBXO27 HSP90AA1 0.126 22939624 Q8NI29 O75503 FBXO27 CLN5 0.126 23464991 Q8NI29 P63208 FBXO27 SKP1 0.396 unassigned1304,21640084 Q8NI29 Q15717 FBXO27 ELAVL1 0.126 19322201