PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Kmt2a Dbp 21113167 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Siglec10 23374343 intact exp Kmt2a Arntl 21113167 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G Per2 Kmt2a 21113167 biogrid exp G G G G G G G G G G G G G G G G G G G G G G Clock Kmt2a 21113167 biogrid,dip exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Rbbp5 21335234 intact exp, ortho Kmt2a Kmt2a 21670200 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Hcfc1 21670200 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Runx1 ortho G G G G G G G G G G G G G G G G Tcte1 Kmt2a ortho G G G G G G G Ell Kmt2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Set ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a E2f4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Nfat5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Wdr5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ctbp1 Kmt2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Kat6a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Taf9 ortho Kmt2a Leo1 ortho Ncl Kmt2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Nfyc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Pkn1 ortho Kmt2a Ran ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Ppie ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Rbbp7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a E2f2 ortho Kmt2a Pax5 ortho G G Kmt2a Hist1h4a, Hist1h4b, Hist1h4c, Hist1h4d, Hist1h4f, Hist1h4h, Hist1h4i, Hist1h4j, Hist1h4k, Hist1h4m, Hist2h4a, Hist4h4 ortho G G G G G G G G G G G G G G Kmt2a Mllt4 ortho Kmt2a Rbbp4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Ash2l ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hoxa5 Kmt2a ortho G G G G G G G G G G G G Kmt2a Ccnt1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Asb2 ortho Kmt2a Sbf1 ortho Kmt2a Ctr9 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Msx2 ortho G G G Myb Kmt2a ortho G G G G G G G G G G G G G G G Kmt2a Top1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nr3c1 Kmt2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Hdac2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Cbfb ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Myc Kmt2a ortho G G G G G G G G G G G G G G G G G G G G G Sap30 Kmt2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E2f6 Kmt2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ins2 Kmt2a ortho G G Kmt2a Sympk ortho Kmt2a Hcfc2 ortho Men1 Kmt2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2b Kmt2a ortho Mllt3 Kmt2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Kmt2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Cdc42bpa ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp1r15a Kmt2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdkn1b Kmt2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Was ortho G G G G G G G G G Kmt2a Svil ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Asb14 ortho G G G G G Kmt2a Tasp1 ortho G G G G G G G G G G G G G G Hoxa9 Kmt2a ortho G G G G G G G G G G G G G G Oxt Kmt2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Btk-PH-domain binding protein, Myeloid/lymphoid or mixed-lineage leukemia (Trithorax homolog, Drosophila) translocated to, 1, Protein Mllt1 ortho G G G G G G G G G G G G G G G G G G G G G G G G Tbp Kmt2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tp53 Kmt2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Asb7 ortho G G Kmt2a Plxnb1 ortho Hoxa7 Kmt2a ortho G G G G G Kmt2a Kif11 ortho G G G G G G G G G Kmt2a Senp3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Creb1 ortho G G G G G G G G G G G G G G G G G G G G G G Kmt2a Utp18 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Hist1h2bc, Hist1h2be, Hist1h2bg ortho Nfkb1 Kmt2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Ing4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nfatc1 Kmt2a ortho G G G G G G G G G G G G G G G G G G G G G G G Aff1 Kmt2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Psip1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Pih1d1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Cul5 ortho Avp Kmt2a ortho G G G G G G G G Faslg Kmt2a ortho G Kmt2a Mbd3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Taf1 ortho Kmt2a Kat8 ortho Kmt2a Wdr61 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Tceb1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Smarcc2 ortho Kmt2a Smarcc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Hist1h3b, Hist1h3c, Hist1h3d, Hist1h3e, Hist1h3f, Hist2h3b, Hist2h3c1, Hist2h3c2 ortho G G G G Kmt2a Cdk9 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rel Kmt2a ortho G G G G Ar Kmt2a ortho G G G G G G G G G G G G G G G G Kmt2a Rnf2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Sin3a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Histone-lysine N-methyltransferase, H3 lysine-79 specific ortho Kmt2a Asb10 ortho G G G G G Kmt2a Smarca2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Aff4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Taf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Sirt7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Cbx8 ortho G G G G G G G G G G G Protein Chd3 Kmt2a ortho Hdac1 Kmt2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Kmt2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Snw1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bmi1 Kmt2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Smarcb1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lgr4 Kmt2a ortho Kmt2a Ptk2b ortho G G G G G G G G G G G G G G G G G G G G G G G G G Polr2a Kmt2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Syk Kmt2a ortho G G G G G G G G G G G G G G G G G Csnk2a2 Kmt2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Crebbp Kmt2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Hecw2 ortho Kmt2a Cdc73 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Ctnnb1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Skp2 ortho G G G G G G G G G G G G Kmt2a Asb18 ortho Kmt2a Cxxc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Mtm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kmt2a Paf1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Per2 Mll MI:0004(affinity chromatography technology) 21113167 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_316471 prey bait Mll Hcfc1 MI:0004(affinity chromatography technology) 21670200 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_321350 bait prey Mll Dbp MI:0004(affinity chromatography technology) 21113167 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_316470 bait prey Mll Arntl MI:0004(affinity chromatography technology) 21113167 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_316469 bait prey

PPI - HINT Gene A Gene B PMID Method Quality CLOCK KMT2A 21113167,21113167 0004,0006 LC GATA2 KMT2A 21186366 0007 LC TAL1 KMT2A 21186366 0007 LC KMT2A KMT2A 21670200 0004 LC KMT2A LDB1 21186366 0007 LC KMT2A DBP 21113167 0004 LC KMT2A HCFC1 21670200 0004 LC KMT2A RBBP5 21335234 0006 LC KMT2A Q8C8R0 21113167 0004 LC KMT2A ARNTL 21113167 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8BX09 P55200 RBBP5 KMT2A 0.21 21335234 P55200 O08785 KMT2A CLOCK 0.21 21113167 P55200 O54943 KMT2A PER2 0.21 21113167 Q60925 P55200 DBP KMT2A 0.21 21113167 Q9WTL8 P55200 ARNTL KMT2A 0.21 21113167