PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Nedd8 Senp8 14673145 biogrid exp, ortho Nedd8 Ahr i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Cul1 20937703 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Uchl3 14673145 biogrid exp, ortho P Nedd8 Cul5 19917606 biogrid exp, ortho P Nedd8 Protein Taf15, TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor ortho P Nedd8 Ube2m ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Rpl30 ortho P Nedd8 Hnrnpf ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Dcaf11 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Vprbp ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Eef1g ortho P Psmd4 Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Rpl19 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Tceb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Fbxo3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppia Nedd8 ortho P Nedd8 Rplp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Ube2d3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd14 Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MCG9018, Protein Kbtbd7 Nedd8 ortho Nedd8 Ubxn7 ortho P Nedd8 Arhgef4 ortho C1qbp Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Lgals3bp ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Kpna2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Srsf7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Hibch ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Hnrnph2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Asl ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Ercc4 ortho G G G G G G G G G G G G G G G G G G G Nedd8 Ddx1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Dctpp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rpl21 Nedd8 ortho P Nedd8 Skp2 ortho G G G G G G G G G G G G G Nedd8 Nup155 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Hspa9 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Sdha ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Psmc5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Hist1h2af ortho P Nedd8 Rps14 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Gdi1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Nae1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Cirbp ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Arih1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Shkbp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Rps6 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Krt76 ortho P Nedd8 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Cul3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Krt75 ortho P Nedd8 Rpl10a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Ybx1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Hspa4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ncl Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Cav1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Shfm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Ilf2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Srsf2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Rangap1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Ddb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Ddx17 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddi2 Nedd8 ortho P Nedd8 Rpl26 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rpl35a Nedd8 ortho P Nedd8 Casp7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G Parp1 Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Rps23 ortho P Nedd8 Ahcy ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Actbl2 ortho P Nedd8 Ssrp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Psma4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias1 Nedd8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pcna Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Eif2a ortho P Nedd8 Fbxo42 ortho GP G G G G G G G G G G G G G G G G G G G G G Protein Fbxl18 Nedd8 ortho Nedd8 Ybx3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Cops8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MCG6895, Protein 2210016F16Rik Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Krt24 Nedd8 ortho P Klhl15 protein, MCG5462, Protein Klhl15 Nedd8 ortho Tp53 Nedd8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa1l Nedd8 ortho P G G G Nedd8 Kctd3 ortho Nedd8 Bag4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Klhl12 ortho Ubc Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Igbp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Sec23a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Rps20 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Zyg11b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hist1h1c Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Maged1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Cplx1 ortho P G G G G G G G G G G G G G G G G G G G G Nedd8 Prdx1 ortho P Nedd8 Hspa8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Brap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cops6 Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Krt5 ortho GP G G G G G G G G Nedd8 Ywhae ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Gcn1l1 ortho P Nedd8 Gps1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Rps7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Slc25a20 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Klhl9 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Hspd1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Hras ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Blood vessel epicardial substance, Processing of 1, ribonuclease P/MRP family, (S. cerevisiae) ortho Dhx9 Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Eef1a2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Ctnnb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Msrb2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Kbtbd6 ortho H2afx Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ambra1 Nedd8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Ptk2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cops5 Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Flna ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Prpf3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Ston2 ortho Nedd8 Ywhag ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Btbd9 ortho Nedd8 Rpl11 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Dcun1d2 ortho Nedd8 Heterogeneous nuclear ribonucleoprotein R, Protein Hnrnpr ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Rab8b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Rpl31 ortho P Nedd8 Rps11 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Cul4a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Usp25 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Nfkbia ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Xiap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Rpl15 ortho P Nedd8 Mpi ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Pwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Memo1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Hnrnpc ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Tuba1c ortho P Nedd8 Hnrnpd ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Pias2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Hgs ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Rpl27 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Tubb4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Rpl8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sptan1 Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Scn5a ortho G G G G G G G Nedd8 Prpf40b ortho G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Skp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Clns1a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Dcun1d1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Qpct ortho G G G G G G G G G G G G G G G G G G Nedd8 Khsrp ortho P Nedd8 Krt14 ortho GP G G G G G G Nedd8 Prdx5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rps16 Nedd8 ortho P Nedd8 Nudt16l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Uba2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Hnrnpab ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cul4b Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Ddx3x ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Dnajc10 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Cops7b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Klhdc10 ortho Nedd8 Sptbn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Emg1 Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Mcm4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Rps10 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dffb Nedd8 ortho P G G G G G G G G G G G G Nedd8 Wdr21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Psma2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Rpl4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eef1a1 Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cops4 Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Hnrnpul1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Psma1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa5 Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Traf6 ortho G G G G G G G G G G G G G G G G G G G G Nedd8 Strbp ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Krt1 Nedd8 ortho P G G G G G G G G Dnmt3b Nedd8 ortho G G G G G G G G G G G Nedd8 Ube2d2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Ywhaz ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Fbxo30 ortho P Rplp0 Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rpl7 Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Syncrip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Atxn3 ortho P Nedd8 Ssb ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Hnrnpa0 ortho P Igf2bp1 Nedd8 ortho G G Nedd8 Sf3b3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Atp6v1f ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Asb8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Tfe3 ortho Nedd8 Ppa2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Ufc1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cops3 Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Hmgcs1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Uba3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Protein Tfg, TFG protein, Trk-fused, Trk-fused protein ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Hars ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Rps8 ortho P Nedd8 Rpl9 ortho P Nedd8 Serbp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Kctd10 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Cul2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Cdk2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Ttn Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G Nedd8 Rpl12 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Krt13 Nedd8 ortho P G G G Nedd8 Tars ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Rps26 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Rpl35 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hist1h2ab, Hist1h2ac, Hist1h2ad, Hist1h2ae, Hist1h2ag, Hist1h2ai, Hist1h2an, Hist1h2ao Nedd8 ortho P Nedd8 Fbxo4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Tkt ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Nedd4l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Rnf187 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Nub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Rpl18 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dsp Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Mcm5 ortho P G G G G G G G G G G G G G G Nedd8 Tial1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psma3 Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Klhl22 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Ddx5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Snrpd1 ortho P Nedd8 Eef2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Rpl23 ortho P Nedd8 Fbxo11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Krt16 ortho P G G Protein Klhl18 Nedd8 ortho Nedd8 Mei1 ortho Nedd8 Tnrc6b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hsp90aa1 Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Tuba4a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Tbc1d15 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Myeov2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hnrnph1 Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Ube2k ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Psma6 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Hnrnpk ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Rps13 ortho P G G G G G G G G G G G G Nedd8 Matr3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Usp13 ortho G G G G G G Nedd8 Psma7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Usp11 ortho G G G G G G G G G G G G G G G G G G G G G G Nedd8 Nit1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Ctps1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Fbxw11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Fbxo6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Tubb5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Rps15a ortho P Olfr247 Nedd8 ortho G Nedd8 Fem1b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Rpl5 ortho P Nedd8 Ctrc ortho G G Pabpc1 Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Esr1 Nedd8 ortho G G G G G Hnrnpa2b1 Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Psmd2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Ywhah ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Rufy2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Hnrnpdl ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Cops7a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Sumo3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rpl7a Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Ube2r2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Pin1 ortho P Nedd8 Yap1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Dnajc8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Actb ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Zyx ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Psma5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Tst ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Rpl24 ortho Nedd8 Rps3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Hnrnpu ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rps2 Nedd8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Cnbp ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Ilf3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Cltc ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Kars ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Arih2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Rpl14 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Klhdc3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Uchl1 ortho P G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P29595 - 12215427 - X 2 P29595 - 12215427 - X 2 P29595 Q12018 affinity chromatography technology 10318914 physical association X 2 P29595 Q9D4H8 affinity chromatography technology 24452456 physical association X 2 P29595 A2A432 affinity chromatography technology 24452456 physical association X 2 P29595 Q3UWN3 pull down 14673145 direct interaction X 2 P29595 Q9WTX6 affinity chromatography technology 20937703 physical association X 2 P29595 Q9WTX6 affinity chromatography technology 20937703 physical association X 2 P29595 Q9JHG6 affinity chromatography technology 23118980 physical association X 2 P29595 Q9JHG6 affinity chromatography technology 23118980 physical association X 2 P29595 Q9D5V5 affinity chromatography technology 19917606 physical association X 2 P29595 Q9WTX6 affinity chromatography technology 24452456 physical association X 2 P29595 Q543C0 affinity chromatography technology 23290524 physical association X 2 P29595 Q9JKB1 pull down 14673145 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Nedd8 Uchl3 MI:0096(pull down) 14673145 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_323113 bait prey Nedd8 Cul4b MI:0004(affinity chromatography technology) 24452456 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_333041 bait prey Nedd8 Ube2f MI:0004(affinity chromatography technology) 19250909 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_321774 prey bait Nedd8 Cul1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 20937703,24452456 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_324341|BIOGRID_324342|BIOGRID_333039 prey|bait|bait bait|prey|prey Nedd8 Cul5 MI:0004(affinity chromatography technology) 19917606 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_327850 bait prey Nedd8 Cul2 MI:0004(affinity chromatography technology) 24452456 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_333040 bait prey Nedd8 Senp8 MI:0096(pull down) 14673145 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_323114 bait prey Nedd8 Rcan1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23118980 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_325086|BIOGRID_325087 bait|prey prey|bait

PPI - HINT Gene A Gene B PMID Method Quality NEDD8 AHR 12215427,12215427 0019,0018 LC NEDD8 UBE2F 19250909 0004 LC NEDD8 SENP8 14673145 0096 LC NEDD8 CUL5 19917606 0004 LC NEDD8 UCHL3 14673145 0096 LC NEDD8 CUL1 20937703 0004 LC