PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Protein Rasa1 Blk 8395016 mint,intact exp G G G G G Blk Ctr9 i2d exp, ortho G G G G G Blk Syk 7797565 innatedb exp, ortho G G G G G Blk Plcg2 8395016 mint,intact exp, ortho G G G G G Blk Pik3r1 8395016 mint,intact exp, ortho G G G G G Blk Usmg5 ortho G G G G G Kit Blk ortho G G G G G Blk Atp5b ortho G G G G G Blk Atp5l ortho G G G G G Blk Pkm ortho G G G G G Blk Mapk13 ortho G G G Blk Gng12 ortho G G G G G Blk Glyr1 ortho G G G G G Blk Dapk2 ortho G G G G G Phb2 Blk ortho G G G G G Blk Ankrd54 ortho G G G G G Blk Runx1 ortho G G G G G Ube3a Blk ortho G G G G G Blk Rps6ka2 ortho G G G G G Blk Rps6ka5 ortho Blk Blk ortho G G G G G Blk Glra2 ortho Blk Bcas2 ortho G G G G G Blk Btk ortho G G G G Blk Ybx3 ortho G G G G G Blk Ccdc33 ortho Blk Atp5a1 ortho G G G G G Blk Efs ortho G G Blk Map3k12 ortho Blk Cytip ortho G G G G G Mknk1 Blk ortho G G G G G Blk Atp5d ortho G G G G G Bcl2 Blk ortho G G G G G Blk Cbl ortho G G G G G Hsp90ab1 Blk ortho G G G G G Fyb Blk ortho G G G G G Blk Atp5h ortho G G G G G Blk Map4k5 ortho G G G G G Blk Stk38 ortho G G G G G Blk Fyn ortho G G G G G 9030418K01Rik Blk ortho Blk Alpha-1,4-N-acetylglucosaminyltransferase, MCG18102, Protein A4gnt ortho Blk Camk1 ortho G G G G G Srpk2 Blk ortho G G G G G Blk Eef2 ortho G G G G G Blk Bcr ortho G G G G G Blk Ick ortho G G G Blk Pink1 ortho G G G G G Blk Egfr ortho G Blk Tnik ortho Blk Zap70 ortho G G G G Cd79a Blk ortho G G G G G Blk Bcl2l1 ortho G G G G G Blk Rps6ka4 ortho G G G G G Blk Oxsr1 ortho G G G G G Blk Snrpd1 ortho Blk Map4k4 ortho G G G G G Blk Ar ortho G Blk Atp5f1 ortho G G G G G Atpif1 Blk ortho G G G G G Hsp90b1 Blk ortho G G G G G Blk Atp5j ortho G G G G G Blk Tec ortho G G G G G Blk Wnk1 ortho G G G G G Blk Atp5j2 ortho G G G G G Blk Stk4 ortho G G G Fcgr2 Blk ortho G G G G G Slc30a4 Blk ortho G G G G G Blk Erbb2 ortho G Cd79b Blk ortho G G G G G Blk Stk17b ortho G G G G G Blk Atp5c1 ortho G G G G G Blk Map4k1 ortho G G G G G Blk Mink1 ortho G G G G G Hsp90aa1 Blk ortho G G G G G Blk Stat3 ortho G G G G G Blk Eef1e1 ortho G G G G G Blk Atp5o ortho G G G G G Fcgr3 Blk ortho G G G G G Blk Gab1 ortho G G G G G Srpk1 Blk ortho G G G G G Met Blk ortho G G G G G Blk Arhgef7 ortho G G G G Blk Mapk11 ortho G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P16277 - 8636124 - X 2 P26450 P16277 pull down 8395016 physical association X 2 Q91YX7 P16277 pull down 8395016 physical association X 2 P16277 Q8CIH5 pull down 8395016 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Blk Rasa1 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 8395016 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_71821|UniProt_177298 bait|bait prey|prey Blk Pik3r1 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 8395016 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_71823|UniProt_177300 bait|bait prey|prey Blk Plcg2 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 8395016 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_71822|UniProt_177299 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality BLK SYK 7797565 0059 LC RASA1 BLK 8395016 0096 LC BLK PIK3R1 8395016 0096 LC BLK PLCG2 8395016 0096 LC