PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Hoxa2 Brca1 20211142 biogrid exp Brca1 Uba52 19088202 dip exp G G G G G G G G G G G G G Brca1 Olig1 20211142 biogrid exp Brca1 Hoxc12 20211142 biogrid exp Etv4 Brca1 16807234 biogrid exp Brca1 Nf1 17700520 biogrid exp G G G G G G Tcf3 Brca1 20211142 biogrid exp G G G G G G G G G G G G G Brca1 Nanog 23892456 biogrid exp Atf2 Brca1 17700520 biogrid exp G G G G G G G G G G G G G Brca1 Ewsr1 20211142 biogrid exp G G G G G G G G G G G G G Brca1 Acot7 22034435 biogrid exp G G G G G G G G G G G G G Esr1 Brca1 16807234 biogrid exp, ortho G G Brca1 Ezh2 23624935 biogrid,intact exp, ortho G G G G G G G G G G G G G Chek1 Brca1 24356582 innatedb exp, ortho G G G G G G G G G G G G Brca1 Atr 15589157 biogrid exp, ortho G G G G G G G G G G G G G Brca1 Suz12 23624935 biogrid,intact exp, ortho G G G G G G G G G G G G G Pou2f1 Brca1 17700520 biogrid exp, ortho G G G G G G G G G G G G Brca1 Brca1 19088202 biogrid exp, ortho G G G G G G G G G G G G G Brca1 Mdc1 18678890 biogrid exp, ortho Brca1 Nbn 12792649 biogrid exp, ortho G G G G G G G G G G G G G Brca1 Acaca 24565757 biogrid exp, ortho G G Brca1 Npm1 18809582 biogrid exp, ortho G G G G G G G G G G G G G Brca1 Smarca2 15574597 biogrid exp, ortho G G G G G G G G G G G G G Jun Brca1 16807234 biogrid exp, ortho G G G G G G G G G G G G Brca1 Brca2 11477095,20211142 biogrid exp, ortho G G G G G G G G G G G G G Brca1 Rad51 11477095 biogrid exp, ortho G G G G G G G G G G G Brca1 Wdr6 ortho G G G G G G G G G G G G G Brca1 Hspa14 ortho G G G G G G G G G G G G G Brca1 Csnk2b ortho G G G G G G G G G G G G G Brca1 Smarca4 ortho G G G G G G G G G G G G G Brca1 Ssx2ip ortho G G G G G G G G Brca1 Rbbp8 ortho G G G G G G G G G G G G G Brca1 Rad17 ortho G G G G G G G G G G G G G Rpsa Brca1 ortho G G G G G G G G G G G G G Brca1 Ninl ortho Brca1 Casp3 ortho G G G G G G G G G G G G Brca1 Sox30 ortho Brca1 Flii ortho G G G G G G G G G G G G G Kpna6 Brca1 ortho G G G G G G Protein Cep350 Brca1 ortho G G G G G G G G G G G G G Cdkn1a Brca1 ortho G G G G G G G G G G G G G Brca1 Zzz3 ortho G G G G G G G G G G G G G H2afx Brca1 ortho G G G G G G G G G G G G G Brca1 Csnk1d ortho G G G G G G G G G G G G G Brca1 Rad18 ortho G G G G G G Brca1 Nfe2l2 ortho G G G G G G G G G G G G G Brca1 Atrip ortho Ets1 Brca1 ortho G G G G G G G G G G G G Brca1 Ybx1 ortho G G G G G G G G G G G G G Dhx9 Brca1 ortho G G G G G G G G G G G G G Ccnd1 Brca1 ortho G G G G G G G G G G G G G Dnmt1 Brca1 ortho G G G G G G G G G G G G G Brca1 Map3k3 ortho G G G G G G G G G G G G G Brca1 Bora ortho Brca1 Mlh1 ortho G G G G G G G G G G G G G Brca1 Cdk7 ortho G G G G G G G G G G G G G Brca1 Hif1a ortho G G G G G G G G G G G G G Brca1 Psma6 ortho G G G G G G G G G G G G G Brca1 Smarca5 ortho G G G G G G G G G G G G G Brca1 Polr2k ortho Brca1 Flywch1 ortho G G G G G G G G G G G G G Brca1 Ube2w ortho G G G G G G G G G G G G G Brca1 Tcea2 ortho G G G G G Marcksl1 Brca1 ortho G G G G G G G G G G G G G Brca1 Kif1b ortho G G G G G G G G G G G G Sp1 Brca1 ortho G G G G G G G G G G G G G Brca1 Prkaa2 ortho Brca1 Med17 ortho G G G G G G G G G G G G G Brca1 Ddx54 ortho G G G G G G G G G G G G G Brca1 Hormad1 ortho G Brca1 Sumo2 ortho Brca1 Ddx24 ortho G G G G G G G G G G G G G Matk Brca1 ortho G G G Brca1 Cabyr ortho G Brca1 Mrpl36 ortho G G G G G G G G G G G G G Brca1 Gnl3l ortho Brca1 Ppp6r3 ortho G G G G G G G G G G G G G Brca1 Gtf2i ortho G G G G G G G G G G G G G Brca1 Tp53bp1 ortho G G G G G G G G G G G G G Akt1 Brca1 ortho G G G G G G G G G G G G G Bard1 Brca1 ortho Brca1 Pias4 ortho G G G G G G G G G G G G G Brca1 Smarcc1 ortho G G G G G G G G G G G G G Lck Brca1 ortho G G G G G G G G G G Rpl21 Brca1 ortho Brca1 Flna ortho G G G G G G G G G G G G G Brca1 Gpn1 ortho G G G G G G G G G G G G G Brca1 Eif5b ortho G G G G G G G G G G G G G Brca1 Snrnp200 ortho Hist1h2ab, Hist1h2ac, Hist1h2ad, Hist1h2ae, Hist1h2ag, Hist1h2ai, Hist1h2an, Hist1h2ao Brca1 ortho Brca1 Ush2A ortho Brca1 Msh6 ortho G G G G G G G G G G G G G Rpl28 Brca1 ortho Supt5h Brca1 ortho G G G G G G G G G G G G G Brca1 Fbxo44 ortho Brca1 Uimc1 ortho G G G G G G G G G G G G G Pcna Brca1 ortho G G G G G G G G G G G G G Tfap2a Brca1 ortho G G G Tpx2 Brca1 ortho G G G G G G G G G G G Itpr1 Brca1 ortho G G G G G G G G G G G G G Brca1 Fgfr1op ortho Protein Ercc6 Brca1 ortho Wnt2b Brca1 ortho G Brca1 Rictor ortho Brca1 Sdk2 ortho Brca1 Pphln1 ortho Odf2 Brca1 ortho G Brca1 Spata4 ortho G Brca1 Ube2n ortho Brca1 Cry2 ortho G G G G G G G G G G G Brca1 Trim24 ortho G G G G G G G G G G G G G Aurkc Brca1 ortho G G Brca1 Huwe1 ortho G G G G G G G G G G G G G Brca1 Ube2b ortho G G G G G G G G G G G G G Brca1 Creb1 ortho G G G G G G G G G G G Brca1 Pisd ortho Brca1 Aplp2 ortho G G G G G G G G G G G G G Brca1 Paf ortho G G G G G G G G G G G G G Ldhc Brca1 ortho G G G Brca1 Ppp2ca ortho G G G G G G G G G G G G G Brca1 Trim46 ortho G G G Brca1 Snx6 ortho G G G G G G G G G G G G G Brca1 Smc1a ortho G G G G G G G G G G G G Brca1 Rev1 ortho G G G G G G G G G G G Usp2 Brca1 ortho G G G G G G G G G Brca1 Cdk8 ortho G G G G G G G G G G G G G Des Brca1 ortho G G G G G G G G G G G G Brca1 Fancd2 ortho Brca1 Rpap2 ortho G G G G G G G G G G G G Rfc1 Brca1 ortho G G G G G G G G G G G G G Brca1 Orc2 ortho G G G G G G G G G G G G G Brca1 Ccne2 ortho G G G G G G G G G G Brca1 Cdkn2d ortho G G G G G G G G G G G G G Brca1 Map3k14 ortho G G G G G Brca1 Pgam5 ortho G G G G G G G G G G G G G Bcl2 Brca1 ortho G G G G G G G G Brca1 Supt16h ortho G G G G G G G G G G G G G Brca1 Hdac2 ortho G G G G G G G G G G G G G Brca1 Rfc5 ortho G G G G G G G G G G G G G Brca1 Peg3 ortho G G G G G G G G G G Brca1 Hnrnpc ortho G G G G G G G G G G G G G Brca1 Pick1 ortho G G G G G G G G G G G G G Stat1 Brca1 ortho G G G G G G G G G G G G G Brca1 Prep ortho G G G G G G G G G G G G G Brca1 Mnat1 ortho G G G G G G G G G G G G G Brca1 Rtkn2 ortho Brca1 Znf280d ortho G G G G G G G G G G G G G Brca1 Ccna1 ortho G Brca1 Pcbp2 ortho G G G G G G G G G G G G G Ncoa3 Brca1 ortho G G G G G G G G G G G G G Brca1 Taf9 ortho Cebpb Brca1 ortho G G G G G G G G G G G G Brca1 Tceb3 ortho G G G G G G G G G G G G G Brca1 Palb2 ortho Polr2j Brca1 ortho G G G G G G G G G G G G G Brca1 Ppp1r3a ortho Brca1 Bap1 ortho G G G G G G G G G G G G G Coiled-coil domain containing 120, Protein Ccdc120 Brca1 ortho G G G G G G Phb2 Brca1 ortho G G G G G G G G G G G G G Brca1 Mta2 ortho G G G G G G G G G G G G G Brca1 Ube2d3 ortho G G G G G G G G G G G G G Brca1 Pgr ortho G Brca1 Yy1 ortho G G G G G G G G G G G G G Brca1 Casp9 ortho G G G G G G G G G G G Brca1 Cstf2 ortho G G G G G G G G G G G G G Brca1 Sumo1 ortho G G G G G G G G G G G G G Brca1 Mapkap1 ortho G G G G G G G G G G G G G Brca1 Prr5 ortho G G MCG118205, isoform CRA_c, Protein Tpte Brca1 ortho G Brca1 Hivep1 ortho G G G G G G G G G G G G Brca1 Map3k1 ortho G G G G G G G G G G G G Brca1 Nufip1 ortho G G G G G G G G G G G G G Brca1 Wbscr16 ortho G G G G G G G G G G G G G Brca1 Dalrd3 ortho G G G G G G G G G G G G G Brca1 Dnajb1 ortho G G G G G G G G G G G G G Cope Brca1 ortho G G G G G G G G G G G G G Ccnb2 Brca1 ortho G G G G G G G G G G G G Brca1 Jup ortho G G G G G G G G G G G Leucine carboxyl methyltransferase 1, Leucine carboxyl methyltransferase 1, isoform CRA_b, Protein Lcmt1 Brca1 ortho G G G G G G G G G G G G G Brca1 Znf423 ortho G Ctbp1 Brca1 ortho G G G G G G G G G G G G G Brca1 Ccar2 ortho G G G G G G G G G G G G G Protein Nup153 Brca1 ortho G G G G G G G G G G G G G Brca1 Kpna2 ortho G G G G G G G G G G G G G Brca1 Brsk1 ortho Brca1 Ube2t ortho G G G G G G G G G G Brca1 Tle4 ortho G G G G G G G G G G G G G Brca1 Mid2 ortho G G G G G G G G Ccng2 Brca1 ortho G G G G G G G G G G G G G Brca1 Ddx39a ortho G G G G G G G G G G G G G Brca1 Plk1 ortho G G G G G G G G G G G Brca1 Dhps ortho G G G G G G G G G G G G G Ahr Brca1 ortho G G G G G G G G G G G G Brca1 Zcchc8 ortho G G G G G G G G G G G G G Brca1 Ppp1ca ortho G G G G G G G G G G G G G Brca1 Ubxn1 ortho G G G G G G G G G G G G G Brca1 Smad2 ortho G G G G G G G G G G G G G Jund Brca1 ortho G G G G G G G G G G G G G Brca1 Dclre1c ortho Abl1 Brca1 ortho G G G G G G G G G G G G G Brca1 Trrap ortho G G G G G G G G G G G G G Gadd45a Brca1 ortho G G G G G G G G G G G G Brca1 Babam1 ortho G G G G G G G G G G G G G Brca1 Ube2e3 ortho G G G G G G G G G G G G G Brca1 Cdc7 ortho G G G G G G G G G G G G G Brca1 Polr2h ortho G G G G G G G G G G G G G Brca1 Psap ortho G G G G G G G G G G G G G Brca1 Commd1 ortho G G G G G G G G G G G G G Brca1 Runx1t1 ortho G G G Brca1 Fam161a ortho G G G G Brca1 Fam83a ortho Brca1 Zscan21 ortho G G G G G G G G G G G G Brca1 2900073G15Rik ortho G G G G G G G G G G G G G Stat3 Brca1 ortho G G G G G G G G G G G G G Fli1 Brca1 ortho G G G G G G G G G G Brca1 Atp1b3 ortho G G G G G G G G G G G G G Brca1 H2afy ortho G G G G G G G G G G G G G Brca1 Rpa1 ortho G G G G G G G G G G G G G Brca1 Mapk3 ortho G G G G G G G G G G G G G Brca1 Smarcd2 ortho G G G G G G G G G G G G G Vdr Brca1 ortho G G G G G Pik3r1 Brca1 ortho G G G G G G G G G G G G Brca1 Kif22 ortho G G G G G G G G G G G G G Brca1 Cdk9 ortho G G G G G G G G G G G G G Brca1 Smad3 ortho G G G G G G G Brca1 Rfc2 ortho G G G G G G G G G G G G G Tpm3 Brca1 ortho G G G G G G G G G G G G G Protein Lonrf1 Brca1 ortho Brca1 Rbbp7 ortho G G G G G G G G G G G G G Brca1 Smc3 ortho G G G G G G G G G G G G G Cdk1 Brca1 ortho G G G G G G G G G G G G G Brca1 Rnf8 ortho G G G G G G G G G G G G G Brca1 Slain2 ortho G G G G G G G G G G G G G Brca1 Zdhhc5 ortho G G G G G G G G G G G G G Rb1 Brca1 ortho G G G G G G G G G G G G G Brca1 Zc3hav1 ortho Brca1 Syt6 ortho G Brca1 Hist1h2bc, Hist1h2be, Hist1h2bg ortho Brca1 Vsig8 ortho Brca1 Ube2d2 ortho G G G G G G G G G G G G G Brca1 Brap ortho G G G G G G G G G G G G G Setx Brca1 ortho Brca1 Mapk1 ortho G G G G G G G G G G G G G Pabpc1 Brca1 ortho G G G G G G G G G G G G G Brca1 Cdkn2aip ortho Cdc6 Brca1 ortho G G G G G G G G Brca1 Ruvbl2 ortho G G G G G G G G G G G G G Eif4a2 Brca1 ortho G G G G G G G G G G G G G Ldb2 Brca1 ortho G G G G G G G G G G Brca1 Morf4l2 ortho G G G G G G G G G G G G G Brca1 Mre11a ortho G G G G G G G G G G G G G Brca1 Rps13 ortho G G G G G G G G G G G Brca1 Morf4l1 ortho Brca1 Ebna1bp2 ortho G G G G G G G G G G G G G Capzb Brca1 ortho G G G G G G G G G G G G G Brca1 Polr2i ortho G G G G G G G G G G G G G Brca1 Smarcb1 ortho G G G G G G G G G G G G G Stat5a Brca1 ortho G G G G G G G G G G G Brca1 Lmo4 ortho G G G G G G G G G G G G G Brca1 Tada3 ortho G G G G G G G G G G G G G Brca1 Rps27a ortho Brca1 Tars ortho G G G G G G G G G G G G G Brca1 Tctex1d2 ortho Brca1 Rpap3 ortho G G G G G G G G G G G G G Brca1 Ppp1cc ortho G G G G G G G G G G G G G Brca1 Sh2b1 ortho G G G G G G G G G G G G G Rdx Brca1 ortho G G G G G G G G G G G G G Brca1 Fbxo5 ortho Tp53 Brca1 ortho G G G G G G G G G G G G Brca1 Zbtb14 ortho G G G G G G G G G G G G Brca1 Nop2 ortho G G G G G G G G G G G G G Brca1 Tubb5 ortho G G G G G G G G G G G G G Ar Brca1 ortho G G G Brca1 Rbl2 ortho G G G G G G G G G G G G G Brcc3 Brca1 ortho G G G G G G G G G G G G G Brca1 Rprd1b ortho G G G G G G G G G G G G G Brca1 Fanca ortho G G G G G G G G G G G G G Brca1 Hltf ortho G G G G G G G G G G G G Brca1 Orc3 ortho G G G G G G G G G G G G G Brca1 Txlna ortho Brca1 Cnrip1 ortho Brca1 Chek2 ortho G G G G G G G G G G G Brca1 Rwdd4 ortho G G G G G G G G G G G G G Brca1 Creb5 ortho Brca1 Aldh9a1 ortho G G G G G G G G G G G G G Brca1 Topbp1 ortho G G G G G G G G G G G G G Brca1 Polr2c ortho G G G G G G G G G G G G G Brca1 Npc2 ortho G G G G G G G G G G G G G Brca1 Cdk16 ortho G G G G G G G G G G G G G Brca1 Supt6h ortho G G G G G G G G G G G G G Brca1 Polr2g ortho G G G G G G G G G G G G G Brca1 Ola1 ortho G G G G G G G G G G G G G Brca1 Myzap ortho G G G G G G G G G G Brca1 Sirt1 ortho G G G G G G G G G G G G G Elk4 Brca1 ortho G G G G G G G G G G G G Brca1 Rprd1a ortho G G G G G G G G G G G G G Brca1 Tceanc ortho Brca1 Prmt1 ortho G G G G G G G G G G G G G Brca1 Rbl1 ortho G G G G G G G G G G G G G Brca1 Brat1 ortho G G G G G G G G G Brca1 Sdhb ortho G G G G G G G G G G G G G Brca1 Terf1 ortho G G G G G G G G G G G G G Brca1 Ablim3 ortho Protein Fam184a Brca1 ortho Brca1 Hibadh ortho G G G G G G G G G G G G G Polr2a Brca1 ortho G G G G G G G G G G G G G Brca1 Ash2l ortho G G G G G G G G G G G G G Brca1 Kif20a ortho G G G G G G G G G G G Brca1 Nat10 ortho Brca1 Ube2e1 ortho G G G G G G G G G G G G G Brca1 Cirh1a ortho G G G G G G G G G G G G G Brca1 Nkapl ortho G Brca1 Hspd1 ortho G G G G G G G G G G G G G Brca1 Aurka ortho G G G G G G G G G G G Brca1 Tp73 ortho Brca1 Rad23b ortho G G G G G G G G G G G G G Brca1 Ppp1r18 ortho G G G G G G G G G G G G G Brca1 Itih5 ortho G G G G G G G G G G G G G Brca1 Prkdc ortho G G G G G G G G G G G G G Ppfia1 protein, Protein Ppfia1 Brca1 ortho Brca1 Inpp1 ortho G G G G G G G G G G G G Pex5 Brca1 ortho G G G G G G G G G G G G G Brca1 Afap1 ortho Brca1 Rad50 ortho G G G G G G G G G G G G G Brca1 Gnb2l1 ortho G G G G G G G G G G G G G Brca1 Vcp ortho G G G G G G G G G G G G G Brca1 Nipbl ortho G G G G G G G G G G G G G Pias1 Brca1 ortho G G G G G G G G G G G G G Dcn Brca1 ortho G G G G G G G G G G G G G Brca1 Xrcc1 ortho G G G G G G G G G G G G G Brca1 Tfap2c ortho G G G Tp63 Brca1 ortho G G G Cenpb Brca1 ortho G G G G G G G G G G G G G Protein Mki67 Brca1 ortho G G G G G G G G G G G G G Brca1 Prkag3 ortho Brca1 Dnaja1 ortho G G G G G G G G G G G G G Hsp90aa1 Brca1 ortho G G G G G G G G G G G G G Brca1 Ssrp1 ortho G G G G G G G G G G G G G Brca1 Dync1h1 ortho G G G G G G G G G G G G G Brca1 Activator protein 4, Protein Tfap4, Transcription factor AP4 ortho G G G G G Brca1 Ube2e2 ortho G G G G G G G G G G G Brd7 Brca1 ortho G G G G G G G G G G G G G Brca1 Shfm1 ortho G G G G G G G G G G G G G Msh2 Brca1 ortho G G G G G G G G G G G G G Brca1 Bre ortho G G G G G G G G G G G G G Brca1 Bub1b ortho G G G G G G G G G G G Brca1 Hist1h4a, Hist1h4b, Hist1h4c, Hist1h4d, Hist1h4f, Hist1h4h, Hist1h4i, Hist1h4j, Hist1h4k, Hist1h4m, Hist2h4a, Hist4h4 ortho G G G G G G G Brca1 Mlf1 ortho G G G G G Brca1 Stac2 ortho G G G G Brca1 Cwf19l2 ortho Aurkb Brca1 ortho G G G G G G G G G G G Brca1 Gabpa ortho G G G G G G G G G G G G G Brca1 Eif4g1 ortho G G G G G G G G G G G G G Brca1 Rbbp4 ortho G G G G G G G G G G G G G Brca1 Hspa8 ortho G G G G G G G G G G G G G Brca1 E2f4 ortho G G G G G G G G G G G G G Brca1 Rfc4 ortho G G G G G G G G G G G G G Brca1 Eed ortho G G G G G G G G G G G G G Brca1 Ddb1 ortho G G G G G G G G G G G G G Brca1 Rnf216 ortho Nmi Brca1 ortho G G G G G G G G G G G G Brca1 Srsf1 ortho G G G G G G G G G G G G G Brca1 Ube2i ortho G G G G G G G G G G G G G Brca1 Mcm7 ortho G G G G G G G G G G G G G Brca1 Tsen54 ortho Brca1 Ctnnb1 ortho G G G G G G G G G G G G G Brca1 Nrip1 ortho G G G G G G G G G G G G G Brca1 Ppp6r1 ortho Cdk4 Brca1 ortho G G G G G G G G G G G G G Brca1 Tmprss12 ortho Ap1m1 Brca1 ortho G G G G G G G G G G G G G Brca1 Smarcc2 ortho Brca1 Cntn4 ortho G Brca1 Polr2d ortho G G G G G G G G G G G G G Brca1 Etv5 ortho G G G Brca1 Kat5 ortho Gtf2h4 Brca1 ortho G G G G G G G G G G G G G Brca1 Rela ortho G G G G G G G G G G G G G Brca1 Rpl31 ortho Ezr Brca1 ortho G G G G G G G G G G G G G Brca1 Herc2 ortho G G G G G G G G G G G G G Brca1 Usp7 ortho G G G G G G G G G G G G G Brca1 Ranbp9 ortho G G G G G G G G G G G G G Brca1 Ncoa1 ortho G G G G G G G G G G G G G Brca1 Ube2l3 ortho Brca1 Jak2 ortho G G G G G G G G G G G G Gfi1b Brca1 ortho G G G Brca1 Csnk2a1 ortho G G G G G G G G G G G G G Brca1 Nol11 ortho G G G G G G G G G G G G G Brca1 Ssfa2 ortho G G G G G G G G G G G G G Brca1 Med21 ortho G G G G G G G G G G G G G Brca1 Hmmr ortho G G G G G G G G G G G G Brca1 Hist1h3b, Hist1h3c, Hist1h3d, Hist1h3e, Hist1h3f, Hist2h3b, Hist2h3c1, Hist2h3c2 ortho G Ube3a Brca1 ortho G G G G G G G G G G G G G Brca1 Cit ortho Brca1 Polr2e ortho G G G G G G G G G G G G G Cbx3 Brca1 ortho G G Lmna Brca1 ortho G G G G G G G G G G G G G Brca1 Psmg1 ortho G G G G G G G G G G G G G Brca1 Wapal ortho Brca1 Cdc16 ortho G G G G G G G G G G G G G Brca1 Taf10 ortho G G G G G G G G G G G G G Brca1 Lmntd1 ortho MCG18410, isoform CRA_a, Protein Ddx23 Brca1 ortho Brca1 Ube2c ortho G G G G G G G G G G G G Brca1 Top2a ortho G G G G G G G G G G G G G Atp1b1 Brca1 ortho G G G G G G G G G G G G G Brca1 Cubn ortho G G G G G G Msn Brca1 ortho G G G G G G G G G G G G G Ctcfl Brca1 ortho Nfya Brca1 ortho G G G G G G G G G G G G G Brca1 Rbm28 ortho G G G G G G G G G G G G G Elk1 Brca1 ortho Brca1 Gcc1 ortho G G G G G G G G G G G G G Cetn1 Brca1 ortho G Brca1 Kdm1a ortho G G G G G G G G G G G G G Brca1 Bach1 ortho G G G G G G G G G G G G Mtnd1 Brca1 ortho Xrcc6 Brca1 ortho G G G G G G G G G G G G G Myc Brca1 ortho G G G G G G G G G G G Brca1 Ppp6c ortho G G G G G G G G G G G G G Rpl3 Brca1 ortho Brca1 Protein Supt3, Suppressor of Ty 3 homolog (S. cerevisiae), isoform CRA_a ortho Brca1 Usf2 ortho G G G G G G G G G G G G G Brca1 Nck1 ortho G G G G G G G G G G G G G Brca1 Jak1 ortho G G G G G G G G G G G G G Fhl2 Brca1 ortho G G G G G G G G G G G G Brca1 Fxr2 ortho G G G G G G G G G G G G G Brca1 Polh ortho Brca1 Ube2j1 ortho G G G G G G G G G G G G G Brca1 Phf12 ortho G G G G G G G G G G G G Brca1 Cdkn2a ortho Brca1 Mcrs1 ortho G G G G G G G G G G G G G Brca1 Kat2a ortho G G G G G G G G G G G G G Brca1 Foxo3 ortho G G G G G G G G G G G G G Brca1 Dbf4 ortho G G G G G G G G G G G G G Brca1 Rwdd2b ortho G G G G G G G G G G G G G Brca1 Eif3b ortho G G G G G G G G G G G G G Brca1 Ppp1cb ortho G G G G G G G G G G G G G Nfkb1 Brca1 ortho G G G G G G G G G G G G G Wiz Brca1 ortho G G G G G G G G G G G G G Brca1 Hgf ortho Brca1 Pms2 ortho G G G G G G G G G G Brca1 Skp2 ortho G G G G G G G G G G G G Brca1 Tuba4a ortho G G G G G G G G G G G G G Clk2 Brca1 ortho G G G G G G G G G G G G G Junb Brca1 ortho G G G G G G G G G G G G Crebbp Brca1 ortho G G G G G G G G G G G G Brca1 Hectd3 ortho G G G G G G G G G G G G Brca1 Cmas ortho G G G G G G G G G G G G G Ap2a1 Brca1 ortho G G G G G G G G G G G G G Brca1 Clspn ortho Snx3 Brca1 ortho G G G G G G G G G G G G G Brca1 Tonsl ortho Brca1 Antxr1 ortho G G G G G G G G G G G G Brca1 Hnrnpd ortho G G G G G G G G G G G G G Brca1 Man2c1 ortho G G G G G G G G G G G G G Brca1 Ppp1r9b ortho Brca1 Numa1 ortho G G G G G G G G G G G G G Hnrnpa2b1 Brca1 ortho G G G G G G G G G G G G G Rngtt Brca1 ortho G G G G G G G G G G G G Brca1 Tubg1 ortho G G G G G G G G G G G G G Brca1 Ywhaz ortho G G G G G G G G G G G G G Brca1 Med1 ortho G G G G G G G G G G G G G Brca1 Ero1lb ortho G G G G G G G G G G G G G Brca1 Map4k4 ortho G G G G G G G G G G G G G Brca1 Nabp2 ortho G G G G G G G G G G G G G Brca1 Ccnh ortho G G G G G G G G G G G G G Brca1 Nelfb ortho G G G G G G G G G G G G G Brca1 Rsl1d1 ortho G G G G G G G G G G G G G Gata3 Brca1 ortho G G Brca1 Myoz1 ortho G G G G G G Drg1 Brca1 ortho G G G G G G G G G G G G G Brca1 Prpf3 ortho G G G G G G G G G G G G G Brca1 Gtf2e1 ortho Brca1 Pml ortho G G G G G G G G G G G Brca1 Zc3h11a ortho Brca1 Actg1 ortho G G G G G G G G G G G G G Brca1 Atm ortho G G G G G G G G G G G G Xrcc5 Brca1 ortho G G G G G G G G G Terf2 Brca1 ortho G G G G G G G G G G G G G Becn1 Brca1 ortho G G G G G G G G G G G G G Brca1 Dnaja3 ortho G G G G G G G G G G G G G Brca1 Ncoa2 ortho G G Brca1 Gtf3c4 ortho G G G G G G G G G G G G G Cntln Brca1 ortho G G G G G G G G G Brca1 Tardbp ortho G G G G G G G G G G G G G Brca1 Tex101 ortho G Brca1 Ankrd28 ortho G G G G G G G G G G G G G Brca1 Kdm5b ortho G G G G G G G G G G G G G Mdm2 Brca1 ortho G G G G G G G G G G G G G Brca1 Ccne1 ortho G G G G Brca1 Rcl1 ortho G G G G G G G G G G G G G Ep300 Brca1 ortho Brca1 Prkd3 ortho G G G G G G G G G G G G G Brca1 Gtf2ird1 ortho G G G G G G G G G G G G Brca1 Ppp1r13b ortho Brca1 Gtf2f1 ortho G G G G G G G G G G G G G Brca1 Thoc3 ortho G G G G G G G G G G G G G Mcm3 Brca1 ortho G G G G G G G G G G G G Msh3 Brca1 ortho G G G G G G G G G G G G G Brca1 Pomgnt1 ortho G G G G G G G G G G G G G Ubc Brca1 ortho G G G G G G G G G G G G G Bub1 Brca1 ortho G G G G G G G G G G G Brca1 Ube2d1 ortho G G G G G G G G G G G G G Brca1 Ccnf ortho G G G G G G G G G G G Brca1 Cdca2 ortho Brca1 Kpna1 ortho G G G G G G G G G G G G G Brca1 Cep57l1 ortho G G G G G G G G G G G G Brca1 Gatad2b ortho G G G G G G G G G G G G G Brca1 Ggn ortho Brca1 Cebpg ortho G G G G G G G G G G G G G Brca1 Cdk2 ortho G G G G G G G G G G G G G Protein Herc1 Brca1 ortho G G G G G G G G G G G G G Brca1 Mtor ortho G G G G G G G G G G G G G Hdac1 Brca1 ortho G G G G G G G G G G G G G Brca1 Cryzl1 ortho G G G G G G G G G G G G G Brca1 Recql5 ortho G G G G G G G G G G G G Obscn Brca1 ortho Brca1 Rpgrip1 ortho G G G G G G G G G G G G G Brca1 Xiap ortho G G G G G G G G G G G G G Protein Tatdn2, Tatdn2 protein Brca1 ortho Brca1 Abcf2 ortho G G G G G G G G G G G G G Brca1 Rps7 ortho G G G G G G G G G G G G G Blm Brca1 ortho G G G G G Col1a1 Brca1 ortho G G G G G G G G G G G G Brca1 Ftsj2 ortho G G Brca1 Brip1 ortho Ankrd44 Brca1 ortho G G G G G G G G G G G G G Brca1 Rad21 ortho G G G G G G G G G G G G G Brca1 Ube2k ortho G G G G G G G G G G G G G Brca1 Arnt ortho G G G G G G G G G G G Brca1 Fam175a ortho Tulp2 Brca1 ortho G G Brca1 Ccna2 ortho G G G G G G G G G G G G G Brca1 Gpn3 ortho G G G G G G G G G G G G G Brca1 Skp1 ortho G G G G G G G G G G G G G Brca1 Smc4 ortho G G G G G G G G G G G G G Brca1 Ankrd26 ortho Brca1 Aarsd1 ortho G G G G G G G G G G G G G Rnf169 Brca1 ortho Pax2 Brca1 ortho Brca1 Psmd9 ortho G G G G G G G G G G G G G Parp2 Brca1 ortho G G G G G G G G G G G G G Brca1 Hist2h2ac ortho Brca1 Smad4 ortho G G G G G G G G G G G G G Brca1 Cstf1 ortho G G G G G G G G G G G G G Fosl2 Brca1 ortho G G G G G G G G G Nr1i2 Brca1 ortho G G G Brca1 Ifi30 ortho G G G G G G G G G G G G G Strn Brca1 ortho G G G G G G G G G G G G Brca1 E2f1 ortho G G G Brca1 Wdr48 ortho G G G G G G G G G G G G G Brca1 Tns2 ortho G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q08297 P48754 affinity chromatography technology 11477095 physical association X 2 Q61545 P48754 two hybrid 20211142 direct interaction X 2 P48754 imaging technique 18678890 colocalization X 2 P48754 P48754 enzymatic study 19088202 direct interaction X 2 P48754 P19785 affinity chromatography technology 16807234 physical association X 2 P48754 A2RS90 affinity chromatography technology 23892456 physical association X 2 P48754 E9PVV2 two hybrid 20211142 direct interaction X 2 P48754 affinity chromatography technology 15574597 physical association X 2 P48754 Q9R207 imaging technique 12792649 colocalization X 2 Q8K5B8 P48754 two hybrid 20211142 direct interaction X 2 P0CG48 P48754 affinity chromatography technology 10500182 physical association X 2 P61077-3 P48754 pull down 19088202 direct interaction X 2 Q9JKN5 P48754 two hybrid 20211142 direct interaction X 2 Q04690 P48754 pull down 17700520 direct interaction X 2 P31245 P48754 two hybrid 20211142 direct interaction X 2 P48754 affinity chromatography technology 18809582 physical association X 2 P48754 affinity chromatography technology 22034435 physical association X 2 P48754 P05627 affinity chromatography technology 16807234 physical association X 2 P48754 affinity chromatography technology 23624935 physical association X 2 P48754 affinity chromatography technology 23624935 physical association X 2 P48754 Q80U70 affinity chromatography technology 23624935 physical association X 2 P48754 affinity chromatography technology 17700520 physical association X 2 P48754 P25425-7 affinity chromatography technology 17700520 physical association X 2 P48754 pull down 17700520 direct interaction X 2 P48754 P25425-7 pull down 17700520 direct interaction X 2 P48754 affinity chromatography technology 15589157 physical association X 2 P48754 affinity chromatography technology 15589157 physical association X 2 P28322 P48754 affinity chromatography technology 16807234 physical association X 2 P97929 P48754 affinity chromatography technology 11477095 physical association X 2 P97929 P48754 two hybrid 20211142 direct interaction X 2 P48754 P62984 comigration in non denaturing gel electrophoresis 19088202 direct interaction X 2 P48754 anti bait coimmunoprecipitation 23624935 association C 3 P48754 anti bait coimmunoprecipitation 23624935 association C 3

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Brca1 Atr MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15589157 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_315114|BIOGRID_315113 prey|bait bait|prey Brca1 Olig1 MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_312910 bait prey Brca1 Nanog MI:0004(affinity chromatography technology) 23892456 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_331376 prey bait Esr1 Brca1 MI:0004(affinity chromatography technology) 16807234 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_325916 prey bait Brca1 Hoxc12 MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_312908 bait prey Jun Brca1 MI:0004(affinity chromatography technology) 16807234 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_325917 prey bait Hoxa2 Brca1 MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_312907 prey bait Tcf3 Brca1 MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_312909 prey bait Brca1 Rad51 MI:0004(affinity chromatography technology) 11477095 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_324525 prey bait Brca1 Nbn MI:0428(imaging technique) 12792649 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization) (biogrid) BIOGRID_320294 bait prey Brca1 Ewsr1 MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_312906 bait prey Etv4 Brca1 MI:0004(affinity chromatography technology) 16807234 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_325918 prey bait Brca1 Mdc1 MI:0096(pull down) 18678890 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization) (biogrid) BIOGRID_325177 prey bait Brca1 Acot7 MI:0004(affinity chromatography technology) 22034435 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_324503 bait prey Brca1 Uba52 MI:0404(comigration in non denaturing gel electrophoresis) 19088202 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) MI:0465(dip) DIP_827 - - Brca1 Smarca2 MI:0004(affinity chromatography technology) 15574597 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_315179 bait prey Brca1 Brca2 MI:0004(affinity chromatography technology)|MI:0018(two hybrid) 11477095,20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_324526|BIOGRID_312905 prey|bait bait|prey Brca1 Npm1 MI:0004(affinity chromatography technology) 18809582 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_323889 prey bait

PPI - HINT Gene A Gene B PMID Method Quality UBC BRCA1 19088202 0404 LC TCF3 BRCA1 20211142 0018 HT HOXA2 BRCA1 20211142 0018 HT BRCA1 BRCA1 19088202 0415 LC BRCA1 UBA52 19088202 0404 LC BRCA1 BRCA2 20211142 0018 HT BRCA1 EWSR1 20211142 0018 HT BRCA1 HOXC12 20211142 0018 HT BRCA1 OLIG1 20211142 0018 HT JUN BRCA1 16807234 0004 LC ATF2 BRCA1 17700520,17700520 0096,0004 LC ESR1 BRCA1 16807234 0004 LC POU2F1 BRCA1 17700520,17700520 0096,0004 LC ETV4 BRCA1 16807234 0004 LC BRCA1 BRCA2 11477095 0004 LC BRCA1 NF1 17700520 0096 LC BRCA1 RAD51 11477095 0004 LC BRCA1 MDC1 18678890 0428 LC BRCA1 ACACA 24565757 0004 LC BRCA1 EZH2 23624935,23624935 0006,0004 LC BRCA1 NPM1 18809582 0004 LC BRCA1 SMARCA2 15574597 0004 LC BRCA1 SUZ12 23624935,23624935 0006,0004 LC BRCA1 NANOG 23892456 0004 LC BRCA1 ACOT7 22034435 0004 LC BRCA1 ATR 15589157 0004 LC BRCA1 CHAF1A 26365490 0004 LC BRCA1 NBN 12792649 0428 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5PSV9 P48754 MDC1 BRCA1 0.126 18678890 Q61937 P48754 NPM1 BRCA1 0.21 18809582 Q04690 P48754 NF1 BRCA1 0.309 17700520 Q80Z64 P48754 NANOG BRCA1 0.126 23892456 P48754 P16951 BRCA1 ATF2 0.454 17700520 Q61188 P48754 EZH2 BRCA1 0.61 23624935 Q13867 P48754 BLMH BRCA1 0.236 26496610 P61221 P48754 ABCE1 BRCA1 0.236 26496610 P48754 O43196 BRCA1 MSH5 0.236 26496610 P48754 A6NHR9 BRCA1 SMCHD1 0.236 26496610 P48754 P41208 BRCA1 CETN2 0.236 26496610 P48754 O43598 BRCA1 DNPH1 0.236 26496610 P48754 P13533 BRCA1 MYH6 0.236 26496610 Q92934 P48754 BAD BRCA1 0.236 26496610 Q80U70 P48754 SUZ12 BRCA1 0.376 23624935 Q8NAV1 P48754 PRPF38A BRCA1 0.236 26496610 Q9UBK9 P48754 UXT BRCA1 0.236 26496610 Q96NL6 P48754 SCLT1 BRCA1 0.236 26496610 Q99728 P48754 BARD1 BRCA1 0.236 26496610 Q9QWF0 P48754 CHAF1A BRCA1 0.126 26365490 P48754 E7EVJ3 BRCA1 NDST1 {ECO:0000313|ENSEMBL:ENSP00000428604} 0.126 26496610 P48754 P05627 BRCA1 JUN 0.21 16807234 P48754 P0CG48 BRCA1 UBC 0.21 10500182 P48754 P15806 BRCA1 TCF3 0.183 20211142 P48754 P19785 BRCA1 ESR1 0.21 16807234 P48754 P25425 BRCA1 POU2F1 0.454 17700520 P48754 P28322 BRCA1 ETV4 0.21 16807234 P48754 P31245 BRCA1 HOXA2 0.183 20211142 P48754 P48754 BRCA1 BRCA1 0.332 19088202 P52848 P48754 NDST1 BRCA1 0.126 26496610 P61077 P48754 UBE2D3 BRCA1 0.309 19088202 P62991 P48754 UBA52 BRCA1 0.309 19088202 P97929 P48754 BRCA2 BRCA1 0.354 20211142,11477095 Q5SWU9 P48754 ACACA BRCA1 0.21 24565757 Q61545 P48754 EWSR1 BRCA1 0.183 20211142 Q6DIC0 P48754 SMARCA2 BRCA1 0.21 15574597 Q8K5B8 P48754 HOXC12 BRCA1 0.183 20211142 Q91V12 P48754 ACOT7 BRCA1 0.21 22034435 Q9JKN5 P48754 OLIG1 BRCA1 0.183 20211142 Q9R207 P48754 NBN BRCA1 0.126 12792649 Q08297 P48754 RAD51 BRCA1 0.21 11477095