PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Pcgf2 Hells 17726103 dip exp G G G Msx1 Pcgf2 22325148 intact exp G G G G Gmnn Pcgf2 14973489 mint exp G G G G G Pcgf2 Sf3b1 15741318 biogrid exp G G G G G Pcgf2 Rybp 22325148 biogrid,intact exp Pcgf2 Pax3 22325148 intact exp Pcgf2 Slc11a1 17726103 biogrid exp G G G G G Pcgf2 Gata4 22325148 intact exp G G G Pcgf2 Nkx2-2 22325148 intact exp G Pcgf2 Atoh1 22325148 intact exp G Pcgf2 Cdx2 22325148 intact exp G Hoxa7 Pcgf2 22325148 intact exp Dnmt3b Pcgf2 17726103 biogrid,dip exp G G G Pcgf2 Spata24 19515240 biogrid exp Pcgf2 Rnf2 15741318,17296600,20471950,16359901,22325148,12183370 biogrid,i2d,intact exp, ortho G G G G G Ring1 Pcgf2 16359901,22325148 biogrid,intact exp, ortho G G G G G Pcgf2 Phc1 22325148,12183370 intact exp, ortho G G G G G Pcgf2 Pcgf2 12438698 biogrid exp, ortho G G G G G Pcgf2 Phc2 16024804,12034499,22325148,12183370 innatedb,biogrid,i2d,intact exp, ortho G G G G G Pcgf2 Phc3 22325148 intact exp, ortho Pcgf2 Cbx2 22325148 intact exp, ortho G G G G G Pcgf2 Eed 24457600 biogrid exp, ortho G G G G G Cbx4 Pcgf2 22325148 intact exp, ortho G G G G G Pcgf2 Cbx7 22325148 biogrid,intact exp, ortho G G Pcgf2 Cbx8 16359901,22325148 intact exp, ortho G Pcgf2 Ccnd2 ortho G G G G G Emd Pcgf2 ortho G G G G G Pcgf2 Usp7 ortho G G G G G Pcgf2 Abhd6 ortho G G G G G Egf Pcgf2 ortho G G G Pcgf2 Rbck1 ortho G G G G G E2f6 Pcgf2 ortho G G G G G Pcgf2 Yy1 ortho G G G G G Pcgf2 Cbx6 ortho G G G G G Ubc Pcgf2 ortho G G G G G Pcgf2 Elavl1 ortho G G G G G Pcgf2 Gjb5 ortho Pcgf2 Spdef ortho G G G Pcgf2 Vhl ortho G G G G G Pcgf2 Ube2t ortho G Pcgf2 Lmna ortho G G G G G Pcgf2 Hif1a ortho G G G G G Hoxc9 Pcgf2 ortho Pcgf2 Ube2i ortho G G G G G Pcgf2 Rangap1 ortho G G G G G Pcgf2 Cd247 ortho Pcgf2 Hsf1 ortho G G G G G Pcgf2 Bmi1 ortho G G G G G Pcgf2 Pcbp1 ortho G G G G G Ube2u Pcgf2 ortho Pcgf2 Tmpo ortho G G G G G Lmnb1 Pcgf2 ortho G G G G G Pcgf2 Usp11 ortho G G G G Ctnnal1 Pcgf2 ortho G G G G G Pcgf2 Scmh1 ortho G G G G G Pcgf2 Ube2e2 ortho G G G G G Pcgf2 Hsf2 ortho Pcgf2 Ube2q2 ortho Mov10 Pcgf2 ortho G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P23798 Q9CQJ4 - 12183370 - X 2 P23798 Q9QWH1 - 12034499 - X 2 P23798 Q9CQJ4 - 12183370 - X 2 P23798 Q9QWH1 - 12183370 - X 2 P23798 O35730 affinity chromatography technology 22325148 physical association X 2 P23798 Q9CQJ4 affinity chromatography technology 22325148 physical association X 2 P23798 Q9CQJ4 affinity chromatography technology 22325148 physical association X 2 P23798 Q9CQJ4 affinity chromatography technology 22325148 physical association X 2 P23798 Q9CQJ4 affinity chromatography technology 15741318 physical association X 2 P23798 Q9CQJ4 two hybrid 12183370 direct interaction X 2 P23798 Q9CQJ4 affinity chromatography technology 12183370 physical association X 2 P23798 Q9CQJ4 affinity chromatography technology 12183370 physical association X 2 P23798 Q921E6 affinity chromatography technology 24457600 physical association X 2 P23798 Q6P926-2 pull down 19515240 direct interaction X 2 P23798 Q9CQJ4 affinity chromatography technology 17296600 physical association X 2 P23798 Q9CQJ4 affinity chromatography technology 20471950 physical association X 2 Q8CCI5 P23798 affinity chromatography technology 22325148 physical association X 2 Q8CCI5 P23798 affinity chromatography technology 22325148 physical association X 2 Q8CCI5 P23798 affinity chromatography technology 22325148 physical association X 2 Q8CCI5 P23798 affinity chromatography technology 22325148 physical association X 2 P23798 Q8VDS3 affinity chromatography technology 22325148 physical association X 2 P23798 Q8VDS3 affinity chromatography technology 22325148 physical association X 2 P23798 Q8VDS3 affinity chromatography technology 22325148 physical association X 2 P23798 Q8VDS3 affinity chromatography technology 22325148 physical association X 2 P23798 Q9QWH1-2 two hybrid 12034499 direct interaction X 2 P23798 Q9QWH1-2 affinity chromatography technology 12034499 physical association X 2 P23798 Q9QWH1-2 two hybrid 12183370 direct interaction X 2 P23798 P23798 pull down 12438698 direct interaction X 2 P23798 Q9QWH1-2 affinity chromatography technology 16024804 physical association X 2 P23798 P41251 affinity chromatography technology 17726103 physical association X 2 P23798 P41251 affinity chromatography technology 17726103 physical association X 2 P23798 affinity chromatography technology 17726103 physical association X 2 P23798 affinity chromatography technology 15741318 physical association X 2 P23798 anti tag coimmunoprecipitation 9009205 association C 4 P23798 anti bait coimmunoprecipitation 17726103 - C 4 P23798 anti bait coimmunoprecipitation 17726103 - C 4 P23798 Q60848 anti bait coimmunoprecipitation 17726103 physical association X 2 P23798 Q60848 anti bait coimmunoprecipitation 17726103 physical association X 2 P23798 O88509 anti bait coimmunoprecipitation 17726103 physical association X 2 P23798 anti tag coimmunoprecipitation 22325148 association C 10 P23798 anti bait coimmunoprecipitation 22325148 association C 4 P23798 anti tag coimmunoprecipitation 22325148 association C 4 P23798 molecular sieving 22325148 physical association C 4 P23798 anti bait coimmunoprecipitation 22325148 association C 4 P23798 anti bait coimmunoprecipitation 22325148 association C 4 P23798 pull down 17296600 association C 52 P23798 anti tag coimmunoprecipitation 22325148 association C 4 P23798 Q9QWH1 two hybrid 12034499 physical association X 2 P23798 Q9CQJ4 two hybrid 12183370 physical association X 2 P23798 Q9QWH1 two hybrid 12183370 physical association X 2 P23798 Q64028 two hybrid 12183370 physical association X 2 P23798 Q9CQJ4 pull down 12183370 physical association X 2 P23798 Q9CQJ4 pull down 12183370 physical association X 2 P23798 Q9CQJ4 anti bait coimmunoprecipitation 12183370 physical association X 2 P23798 Q9CQJ4 fluorescence microscopy 12183370 colocalization X 2 P23798 Q9CQJ4 two hybrid 12183370 physical association X 2 P23798 Q9CQJ4 two hybrid 12183370 physical association X 2 P23798 Q9QWH1 anti bait coimmunoprecipitation 16024804 physical association X 2 P23798 P51784 pull down 20601937 direct interaction X 2 P23798 anti tag coimmunoprecipitation 22325148 association C 3 P23798 anti bait coimmunoprecipitation 22325148 association C 3 P23798 anti bait coimmunoprecipitation 22325148 association C 3 P23798 anti tag coimmunoprecipitation 22325148 association C 6 P23798 anti tag coimmunoprecipitation 16359901 association C 4 P23798 anti tag coimmunoprecipitation 22325148 association C 5 P23798 anti bait coimmunoprecipitation 22325148 association C 5 P23798 anti tag coimmunoprecipitation 22325148 association C 10 P23798 Q9QWH1-2 fluorescence microscopy 12034499 colocalization X 2 P23798 Q93009 pull down 20601937 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Pcgf2 Cbx7 MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0071(molecular sieving)|MI:0071(molecular sieving) 22325148 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(intact) UniProt_174814|UniProt_174855|UniProt_174818|UniProt_174819|UniProt_174812|UniProt_174856|UniProt_174852|BIOGRID_320767|BIOGRID_320780|BIOGRID_320784|BIOGRID_320773|UniProt_174816|UniProt_174853 prey|prey|prey|bait|neutral component|bait|prey|bait|bait|prey|prey|bait|prey bait|bait|bait|prey|neutral component|prey|prey|prey|prey|bait|bait|prey|prey Pcgf2 Hells MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 17726103 taxid:10090(Mus musculus) taxid:10090(Mus musculus) -|MI:0915(physical association) MI:0465(dip)|MI:0465(dip) DIP_677|DIP_681 -|- -|- Pcgf2 Eed MI:0004(affinity chromatography technology) 24457600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_331848 prey bait Gmnn Pcgf2 MI:0018(two hybrid) 14973489 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) MI:0471(mint) MINT_86484 unspecified role unspecified role Ring1 Pcgf2 MI:0071(molecular sieving)|MI:0004(affinity chromatography technology)|MI:0071(molecular sieving)|MI:0007(anti tag coimmunoprecipitation) 16359901,22325148 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association) (intact)|(biogrid)|(intact)|(intact) UniProt_174819|BIOGRID_320764|UniProt_174857|UniProt_165958 prey|prey|prey|prey bait|bait|bait|bait Pcgf2 Phc1 MI:0018(two hybrid)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving) 12183370,22325148 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association) (intact)|(intact)|(intact)|(intact)|(intact) UniProt_162048|UniProt_174819|UniProt_174857|UniProt_174816|UniProt_174853 bait|bait|bait|bait|prey prey|prey|prey|prey|prey Pcgf2 Phc2 MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0006(anti bait coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid) 12034499,12183370,16024804,22325148 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association) (intact)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(intact)|(intact)|(intact) UniProt_174819|UniProt_174857|BIOGRID_325461|BIOGRID_325462|BIOGRID_328951|BIOGRID_314791|UniProt_162047|UniProt_163868|UniProt_160599|UniProt_160598 bait|bait|bait|bait|prey|bait|bait|bait|neutral component|bait prey|prey|prey|prey|bait|prey|prey|prey|null|prey Pcgf2 Spata24 MI:0686(unspecified method) 19515240 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_313865 prey bait Pcgf2 Sf3b1 MI:0004(affinity chromatography technology) 15741318 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_328621 bait prey Dnmt3b Pcgf2 MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation) 17726103 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|- MI:0465(dip)|(biogrid)|MI:0465(dip) DIP_696|BIOGRID_316261|DIP_678 -|bait|- -|prey|- Pcgf2 Rybp MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving) 22325148 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) BIOGRID_320779|BIOGRID_320781|BIOGRID_320766|BIOGRID_320772|UniProt_174817|UniProt_174815|UniProt_174854|UniProt_174851|UniProt_174819|UniProt_174856|UniProt_174812|UniProt_174852|UniProt_174857|UniProt_174816|UniProt_174853 bait|prey|bait|prey|prey|prey|prey|prey|bait|bait|neutral component|prey|bait|bait|prey prey|bait|prey|bait|bait|bait|bait|bait|prey|prey|neutral component|prey|prey|prey|prey Pcgf2 Rnf2 MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0071(molecular sieving)|MI:0096(pull down)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0007(anti tag coimmunoprecipitation) 12183370,15741318,16359901,17296600,20471950,22325148 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association) (biogrid)|(intact)|(intact)|(intact)|(intact)|(intact)|(biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) BIOGRID_328623|UniProt_162053|UniProt_162054|UniProt_162055|UniProt_162057|UniProt_162046|BIOGRID_319382|UniProt_162050|BIOGRID_328950|BIOGRID_328952|BIOGRID_328953|BIOGRID_320778|BIOGRID_315709|BIOGRID_320765|UniProt_162049|BIOGRID_320787|UniProt_174819|UniProt_166511|UniProt_174812|UniProt_174856|UniProt_174852|UniProt_174857|UniProt_174816|UniProt_174853|UniProt_165958 bait|prey|bait|bait|neutral component|bait|prey|prey|prey|prey|bait|bait|prey|bait|bait|prey|bait|prey|neutral component|bait|prey|bait|bait|prey|bait prey|bait|prey|prey|neutral component|prey|bait|bait|bait|bait|prey|prey|bait|prey|prey|bait|prey|bait|neutral component|prey|bait|prey|prey|bait|prey Pcgf2 Slc11a1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17726103 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_316257|BIOGRID_316255 bait|prey prey|bait

PPI - HINT Gene A Gene B PMID Method Quality PCGF2 PHC1 12183370 0018 LC PCGF2 CBX7 22325148,22325148,22325148,22325148 0006,0004,0071,0007 LC PCGF2 RNF2 12183370,12183370,12183370,12183370,12183370 0004,0096,0006,0018,0416 LC PCGF2 PHC2 12034499,12034499,12183370,12034499 0018,0004,0018,0416 LC RING1 PCGF2 22325148,22325148,16359901 0004,0007,0007 LC CBX4 PCGF2 22325148 0007 LC DNMT3B PCGF2 17726103,17726103 0004,0006 LC PCGF2 PCGF2 12438698 0096 LC PCGF2 CBX2 22325148 0007 LC PCGF2 SLC11A1 17726103 0004 LC PCGF2 HELLS 17726103 0006 LC PCGF2 PHC1 22325148 0007 LC PCGF2 SPATA24 19515240 0096 LC PCGF2 RYBP 22325148,22325148,22325148 0006,0004,0007 LC PCGF2 PHC3 22325148 0007 LC PCGF2 CBX7 22325148,22325148,22325148,22325148 0006,0004,0071,0007 LC PCGF2 EED 24457600 0004 LC PCGF2 SF3B1 15741318 0004 LC PCGF2 RNF2 17296600,12183370,17296600,12183370,12183370,22325148,12183370,22325148,22325148,12183370,20471950,16359901,15741318 0096,0004,0004,0096,0006,0004,0018,0006,0007,0416,0004,0007,0004 LC PCGF2 PHC2 12034499,16024804,12034499,16024804,22325148,12034499 0018,0006,0004,0004,0007,0416 LC PCGF2 CBX8 22325148,16359901 0007,0007 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P23798 O55187 PCGF2 CBX4 0.126 22325148 P23798 O88509 PCGF2 DNMT3B 0.236 17726103 P23798 P23798 PCGF2 PCGF2 0.332 12438698 P30658 P23798 CBX2 PCGF2 0.126 22325148 P51784 P23798 USP11 PCGF2 0.183 20601937 Q64028 P23798 PHC1 PCGF2 0.396 12183370,22325148 Q8CHP6 P23798 PHC3 PCGF2 0.126 22325148 Q9QXV1 P23798 CBX8 PCGF2 0.126 22325148 Q6P926 P23798 SPATA24 PCGF2 0.309 19515240 Q9QWH1 P23798 PHC2 PCGF2 0.891 12034499,12183370,22325148,16024804 P23798 O35730 PCGF2 RING1 0.236 22325148 Q60848 P23798 HELLS PCGF2 0.236 17726103 Q8CCI5 P23798 RYBP PCGF2 0.554 22325148 Q8VDS3 P23798 CBX7 PCGF2 0.61 22325148 Q9CQJ4 P23798 RNF2 PCGF2 0.978 22325148,17296600,20471950,15741318,12183370 Q93009 P23798 USP7 PCGF2 0.183 20601937 Q921E6 P23798 EED PCGF2 0.126 24457600 P41251 P23798 SLC11A1 PCGF2 0.376 17726103