PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ubb Trim21 23222971 intact exp Arid1a Ubb 21647563 biogrid exp P Ubb Polk 18162470 biogrid exp Ubb Desi1 22370726 mint,intact exp Ubb Cep290 21565611 biogrid exp Ubb Egln3 i2d exp Ubb Nbr1 19427866 biogrid exp P Ubb Dlg4 19455133 intact exp P Ubb Hdac9 15102471 intact exp Ubb Nphp4 21565611 biogrid exp Ubb Tcf3 22354994 biogrid exp Ubb Msl3 ortho Ubb Mfn2 ortho Ubb Kat8 ortho Ubb Th ortho P Ubb Epn1 ortho P Ubb Esrrg ortho Ubb Usp47 ortho P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P0CG49 Q91UZ4 - 15210114 - X 2 P59240 P0CG49 affinity chromatography technology 21565611 physical association X 2 Q9QUG2 P0CG49 pull down 18162470 direct interaction X 2 P0CG49 affinity chromatography technology 21565611 physical association X 2 P0CG49 E9PVV2 affinity chromatography technology 22354994 physical association X 2 P0CG49 two hybrid 19427866 direct interaction X 2 P0CG49 Q8C4F4 affinity chromatography technology 19844237 physical association X 2 P0CG49 Q8C4F4 affinity chromatography technology 19844237 physical association X 2 P0CG49 A0A024R730 affinity chromatography technology 17110338 physical association X 2 P0CG49 A0A024R274 affinity chromatography technology 15761153 physical association X 2 Q64337 P0CG49 pull down 21715324 direct interaction X 2 Q64337 P0CG49 affinity chromatography technology 21715324 physical association X 2 A2BH40 P0CG49 affinity chromatography technology 21647563 physical association X 2 P0CG49 Q6R3M4-2 x-ray crystallography 20944239 association X 2 P0CG49 P36897 affinity chromatography technology 15761153 physical association X 2 P0CG49 affinity chromatography technology 15761153 physical association X 2 P0CG49 anti bait coimmunoprecipitation 23222971 association C 21 Q99N13 P0CG49 two hybrid 15102471 physical association X 2 Q99N13 P0CG49 two hybrid 15102471 physical association X 2 P0CG49 A0A024R1V3 two hybrid 19427866 physical association X 2 Q9CQT7 P0CG49 two hybrid pooling approach 22370726 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Ubb Nbr1 MI:0018(two hybrid) 19427866 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_321725 prey bait Ubb Cep290 MI:0004(affinity chromatography technology) 21565611 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_326860 prey bait Ubb Desi1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 22370726 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_175288|UniProt_123170 prey|prey bait|bait Ubb Tcf3 MI:0004(affinity chromatography technology) 22354994 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_320658 prey bait Ubb Nphp4 MI:0004(affinity chromatography technology) 21565611 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_327072 prey bait Ubb Poli MI:0114(x-ray crystallography) 20944239 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association) (biogrid) BIOGRID_321585 bait prey Ubb Bace1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19844237 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_323822|BIOGRID_323821 bait|prey prey|bait Ubb Sqstm1 MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography) 21715324 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_321589|BIOGRID_321588 prey|prey bait|bait Ubb Arid1a MI:0004(affinity chromatography technology) 21647563 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_321376 prey bait Ubb Polk MI:0096(pull down) 18162470 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_312344 bait prey

PPI - HINT Gene A Gene B PMID Method Quality UBB NBR1 19427866 0018 LC UBB Q7TNX7 20944239 0114 LC UBB EGLN3 15210114,15210114 0019,0045 LC UBB HDAC9 15102471 0018 LC UBB DESI1 22370726 0398 LC ARID1A UBB 21647563 0004 LC UBB TCF3 22354994 0004 LC UBB NPHP4 21565611 0004 HT UBB DLG4 19455133 0007 LC UBB TRIM21 23222971 0006 LC UBB SQSTM1 21715324,21715324 0004,0096 LC UBB CEP290 21565611 0004 HT UBB POLK 18162470 0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P59240 P0CG49 NPHP4 UBB 0.126 21565611 P15806 P0CG49 TCF3 UBB 0.126 22354994 Q9HCE7 P0CG49 SMURF1 UBB 0.126 15761153 Q9QUG2 P0CG49 POLK UBB 0.309 18162470 Q6A078 P0CG49 CEP290 UBB 0.126 21565611 P13569 P0CG49 CFTR UBB 0.126 17110338 P36897 P0CG49 TGFBR1 UBB 0.126 15761153 Q9CQT7 P0CG49 DESI1 UBB 0.21 22370726 P0CG49 A2BH40 UBB ARID1A 0.21 21647563 Q13485 P0CG49 SMAD4 UBB 0.126 15761153 P97432 P0CG49 NBR1 UBB 0.309 19427866