PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Traf4 Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA 22649194 biogrid exp G G G G G G G G G G G G G G G G G G Traf3 Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA 22649194 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA Ikbke 22851696,21822257 biogrid,intact exp, ortho G G G G G G G G G G G G G Map3k7 Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA 22649194 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Traf5 Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA 23042150,21822258,21822257 intact exp, ortho G G G G G G G G G G G G G G G G G Il17rc Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA 20554964 biogrid exp, ortho G G G G G G G G G G G G G G G G G G Il17ra Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA 22045852,17035243 innatedb,biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA Tbk1 22851696 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Traf2 Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA 21822257 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G Traf6 Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA 22649194,23042150,21822257,12459498,15102471 biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G Irf3 Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA ortho G G G G G G G G G G G G G G G G G G G G G G G G G Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA Golga2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Tnfrsf1a Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA ortho G G G G G G G G G G G G G G G G G G G G G G G G G Mdfi Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA ortho G G G Ikbkb Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA ortho G G G G G G G G G G G G G G G G G G G G G G G G G Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA Il17rb ortho G G G G G G G G G Ubc Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA ortho G G G G G G G G G G G G G G G G G G G G G G G G G Hsp90aa1 Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA ortho G G G G G G G G G G G G G G G G G G G G G G G G G Syk Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA ortho G G G G G G G G G G G G G G G G G Traf1 Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA ortho G G G Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA Qprt ortho G G G Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA Tnfrsf13c ortho G G G G G G G Cd40 Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA ortho G G G G G Chuk Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA ortho G G G G G G G G G G G G G G G G G G G G G G G G G Elavl1 Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA ortho G G G G G G G G G G G G G G G G G G G G G G G G G Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA Fhl3 ortho G Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA ortho G G G G G G G G G G G G G G G G G G G G G G G G G Hspa4 Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA ortho G G G G G G G G G G G G G G G G G G G G G G G G G Ikbkg Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA ortho G G G G G G G G G G G G G G G G G G G G G G G G G Il17a Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA ortho Mmgt1 Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA ortho Stk16 Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA ortho G G G G G G G G G G G G G G G G G G G G G G G G G Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA Ube2v1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Srsf1 Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA ortho G G G G G G G G G G G G G G G G G G G G G G G G G Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA Mrpl28 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Protein Traf3ip2, TRAF3 interacting protein 2, Traf3 interacting protein 2, cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA Trip6 ortho G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8N7N6 Q60943 affinity chromatography technology 22045852 physical association X 2 Q8N7N6 Q60943 pull down 22045852 direct interaction X 2 Q8N7N6 P70196 affinity chromatography technology 22649194 physical association X 2 Q8N7N6 affinity chromatography technology 22649194 physical association X 2 Q8N7N6 P70196 affinity chromatography technology 22649194 physical association X 2 Q61382 Q8N7N6 affinity chromatography technology 22649194 physical association X 2 Q61382 Q8N7N6 affinity chromatography technology 22649194 physical association X 2 Q8N7N6 affinity chromatography technology 20554964 physical association X 2 Q8N7N6 Q3UHJ1 affinity chromatography technology 22649194 physical association X 2 Q8N7N6 Q9WUN2 enzymatic study 22851696 direct interaction X 2 Q8N7N6 Q9R0T8 enzymatic study 22851696 direct interaction X 2 Q8N7N6 anti bait coimmunoprecipitation 21822257 association C 4 Q8N7N6 P70196 two hybrid 15102471 physical association X 2 Q8N7N6 P70196 two hybrid 15102471 physical association X 2 Q8N7N6 Q14164 protein kinase assay 21822257 phosphorylation reaction X 2 Q8N7N6 P70191 anti bait coimmunoprecipitation 21822258 physical association X 2 Q8N7N6 anti bait coimmunoprecipitation 21822257 association C 5 Q8N7N6 Q9R0T8 anti bait coimmunoprecipitation 21822257 physical association X 2 Q8N7N6 Q9R0T8 anti bait coimmunoprecipitation 21822257 physical association X 2 Q8N7N6 A0A024R8H5 anti tag coimmunoprecipitation 21822258 physical association X 2 Q8N7N6 O00463 anti tag coimmunoprecipitation 21822258 physical association X 2 Q8N7N6 Q9Y4K3 anti tag coimmunoprecipitation 21822258 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Traf4 Traf3ip2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22649194 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_327525|BIOGRID_327530 prey|bait bait|prey Traf3 Traf3ip2 MI:0004(affinity chromatography technology) 22649194 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_327524 prey bait Traf5 Traf3ip2 MI:0424(protein kinase assay)|MI:0007(anti tag coimmunoprecipitation)|MI:0424(protein kinase assay) 21822257,21822258 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association)|MI:0914(association) (intact)|(intact)|(intact) UniProt_171858|UniProt_171828|UniProt_171857 prey|prey|prey bait|bait|bait Il17ra Traf3ip2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22045852 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_321596|BIOGRID_321595 bait|bait prey|prey Map3k7 Traf3ip2 MI:0004(affinity chromatography technology) 22649194 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_327527 prey bait Traf6 Traf3ip2 MI:0424(protein kinase assay)|MI:0424(protein kinase assay)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid) 15102471,21822257,22649194 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(biogrid)|(intact)|(biogrid)|(intact) UniProt_171858|UniProt_171857|BIOGRID_327526|UniProt_162622|BIOGRID_327529|UniProt_163238 prey|prey|prey|bait|bait|bait bait|bait|bait|prey|prey|prey Traf3ip2 Tbk1 MI:0004(affinity chromatography technology) 22851696 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_327538 prey bait Traf3ip2 Ikbke MI:0424(protein kinase assay)|MI:0004(affinity chromatography technology)|MI:0424(protein kinase assay)|MI:0424(protein kinase assay) 21822257,22851696 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(intact)|(intact) UniProt_171858|BIOGRID_327539|UniProt_171855|UniProt_171856 bait|prey|bait|bait prey|bait|bait|prey Il17rc Traf3ip2 MI:0004(affinity chromatography technology) 20554964 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_321594 bait prey

PPI - HINT Gene A Gene B PMID Method Quality TRAF6 TRAF3IP2 12459498,12459498,15102471,12459498 0096,0007,0018,0018 LC TRAF3IP2 IKBKE 22851696 0415 LC TRAF3IP2 TBK1 22851696 0415 LC TRAF2 TRAF3IP2 21822257 0006 LC TRAF5 TRAF3IP2 23042150,21822257,21822258 0006,0006,0006 LC TRAF6 TRAF3IP2 12459498,23042150,12459498,22649194,12459498,21822257 0096,0006,0007,0004,0018,0006 LC TRAF3 TRAF3IP2 22649194 0004 LC IL17RA TRAF3IP2 22045852,22045852 0096,0004 LC TRAF4 TRAF3IP2 22649194 0004 LC MAP3K7 TRAF3IP2 22649194 0004 LC IL17RC TRAF3IP2 20554964 0004 LC TRAF3IP2 IKBKE 21822257 0006 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8N7N6 P70196 TRAF3IP2 TRAF6 0.183 15102471