PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Traf6 Cdc34 21765415 intact exp G G G G G G G G G G G G G G G G G G G G Ppp1cc Cdc34 17274640 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp1ca Cdc34 17274640 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc34 Fbxo32 21617130 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G Cdc34 Zfand6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc34 Fbxw7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rad21 Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxw2 Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G Pparg Cdc34 ortho G G G G G G G G G G G G G G G Cdc34 Fbxo4 ortho G G G G G G G G G G G G G G G G G G G G G G G G Vhl Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Runx2 Cdc34 ortho G G G G G G G G G G G G G Cdc34 Cul2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uba1 Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc34 Nfkbia ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ing4 Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Csnk2b Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnpda1 Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dusp1 Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ifnar1 Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Myod1 Cdc34 ortho G G Btrc Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G March1 Cdc34 ortho Timm13 Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc34 Eif3k ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxl3 Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Crem Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rock1 Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxl2 Cdc34 ortho Cdc34 Wwp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc34 March2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxw11 Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc34 Rnf7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc34 Skp2 ortho G G G G G G G G G G G G G Hif1a Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxo7 Cdc34 ortho Cdc34 Cul1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pml Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G Cdc34 Tmem14c ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mybl2 Cdc34 ortho G G G G G G G Sdcbp Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdkn1b Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc34 Znrf1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp1cb Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc34 Cul3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd4l Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Hint1 Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc34 Cdk9 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rela Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Trim28 Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pim1 Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc34 Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wars Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Itch Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc34 Tbl1x ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Csnk2a1 Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rad23a Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atf5 Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8CFI2 P62137 affinity chromatography technology 17274640 physical association X 2 P63087 Q8CFI2 affinity chromatography technology 17274640 physical association X 2 Q8CFI2 anti bait coimmunoprecipitation 21765415 association C 7 Q8CFI2 P62137 antibody array 17274640 physical association X 2 P63087 Q8CFI2 antibody array 17274640 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality UBC CDC34 25471371,25471371 0114,0415 LC PPP1CA CDC34 17274640,17274640 0004,0678 LC PPP1CC CDC34 17274640,17274640 0004,0678 LC PPP1CA CDC34 17274640,17274640 0004,0678 LC PPP1CC CDC34 17274640,17274640 0004,0678 LC TRAF6 CDC34 21765415 0006 LC Q6ZWM8 CDC34 17274640 0004 LC CDC34 FBXO32 21617130 0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8CFI2 P0CG50 CDC34 UBC 0.523 25471371 Q8CFI2 P63087 CDC34 PPP1CC 0.236 17274640 Q8CFI2 P62137 CDC34 PPP1CA 0.236 17274640 Q9CPU7 Q8CFI2 FBXO32 CDC34 0.309 21617130