PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Nbr1 Ube2o 19427866 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G Ube2o Mcam ortho GP G G G G G G G G G G G G G G Hist1h2ba Ube2o ortho Ube2o Hexim1 ortho GP G G G G G G G G G G G G G G G G G G G G G G Ube2o Syt11 ortho G G G G G G G G G G G G G G G G G G Pafah1b3 Ube2o ortho GP G G G G G G G G G G G G G G G G G G G G Slx4 Ube2o ortho Ubc Ube2o ortho GP G G G G G G G G G G G G G G G G G G G G G G Osm Ube2o ortho Ube2o Sfrp4 ortho G G G G G G G G G G G G G G G G G G G G G G G Gabarapl2 Ube2o ortho GP G G G G G G G G G G G G G G G G G G G G G G Nap1l1 Ube2o ortho GP G G G G G G G G G G G G G G G G G G G G G G Kiaa0753 Ube2o ortho Ube2o Ube2o ortho GP G G G G G G G G G G G G G G G G G G G G G G Ube2o Luc7l ortho GP G G G G G G G G G G G G G G G G G G G G G G Ube2o Cpne1 ortho P Ube2o Cbx6 ortho GP G G G G G G G G G G G G G G G G G G G G G G Ube2o Appl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G Traf2 Ube2o ortho G G G G G G G G G G G G G G G G G G Ube2o Rlim ortho G G G G G G G G G G G G G G G G G G G G G G G Sap30l Ube2o ortho GP G G G G G G G G G G G G G G G G G G G G G G Trim27 Ube2o ortho G G G G G G G G G G G G G G G G G G G G G G G Ntrk1 Ube2o ortho Protein Zfp707 Ube2o ortho G G G G Traf3 Ube2o ortho G G G G G G G G G G G G G G G G G G G G G G Rps20 Ube2o ortho GP G G G G G G G G G G G G G G G G G G G G G G Smarca4 Ube2o ortho G G G G G G G G G G G G G G G G G G G G G G G Ube2o Pnkp ortho GP G G G G G G G G G G G G G G G G G G G G G G Ube2o Cpne4 ortho P Ybx1 Ube2o ortho GP G G G G G G G G G G G G G G G G G G G G G G Ube2o Znf687 ortho Traf4 Ube2o ortho G G G G G G G G G G G G Rpl12 Ube2o ortho GP G G G G G G G G G G G G G G G G G G G G G G Ube2o Grk5 ortho G G G G G G G G G G G G G G G G G G G G G G Traf5 Ube2o ortho G G G G G G G G G G G G Ube2o Lca5 ortho Rnf10 Ube2o ortho G G G G G G G G G G G G G G G G G G G G G G G Rps7 Ube2o ortho GP G G G G G G G G G G G G G G G G G G G G G G Ube2o Ube2v1 ortho GP G G G G G G G G G G G G G G G G G G G G G G Zfp41 Ube2o ortho Frg1 Ube2o ortho GP G G G G G G G G G G G G G G G G G G G G G G Rad21 Ube2o ortho GP G G G G G G G G G G G G G G G G G G G G G G Ect2 Ube2o ortho G G G G G G G G G Ube2o Pop7 ortho GP G G G G G G G G G G G G G G G G G G G G G G Ube2o Med4 ortho G G G G G G G G G G G G G G G G G G G G G G G Smad6 Ube2o ortho G G G G G G G G G G G G G G G Cpne2 Ube2o ortho G G G G G G G G G G G G G G G Ube2o Ankrd1 ortho G G G G Pola2 Ube2o ortho G G G G G G G G G G G G Ube2o Luc7l2 ortho GP G G G G G G G G G G G G G G G G G G G G G G Ube2o Nxf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G Ube2o Hnrnpab ortho GP G G G G G G G G G G G G G G G G G G G G G G Traf1 Ube2o ortho G G Ube2o Wdr26 ortho GP G G G G G G G G G G G G G G G G G G G G G G Ube2o Wbscr22 ortho GP G G G G G G G G G G G G G G G G G G G G G G Ube2o Hist1h2bc, Hist1h2be, Hist1h2bg ortho P Ube2o Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G Ube2o Nol12 ortho G G G G G G G G G G G G G G G G G G G G G G G Ube2o Sirt7 ortho G G G G G G G G G G G G G G G G G G G G G G G Traf6 Ube2o ortho G G G G G G G G G G G G G G Ube2o Itgb3bp ortho G G G G G G G G G G G Ube2o Bap1 ortho G G G G G G G G G G G G G G G G G G G G G G G Shbg Ube2o ortho G G Jun Ube2o ortho G G G G G G G G G G G G G G G G G G G G G G Ube2o Chd1l ortho GP G G G G G G G G G G G G G G G G G G G G G G Ube2o Ftsj3 ortho GP G G G G G G G G G G G G G G G G G G G G Smad7 Ube2o ortho G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q6ZPJ3 Q96FN4 two hybrid 12522145 direct interaction X 2 Q6ZPJ3 Q96A23 two hybrid 12522145 direct interaction X 2 Q6ZPJ3 Q96A23 pull down 12522145 direct interaction X 2 Q6ZPJ3 two hybrid 19427866 direct interaction X 2 Q6ZPJ3 B0QZ18 two hybrid 12522145 direct interaction X 2 Q6ZPJ3 B0QZ18 pull down 12522145 direct interaction X 2 Q6ZPJ3 A0A024R1V3 two hybrid 19427866 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality NBR1 UBE2O 19427866 0018 LC UBE2O RAB36 26885862 0676 LC UBE2O RAB40C 26885862 0676 LC UBE2O DLGAP1 27507650 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q6ZPJ3 Q14596 UBE2O NBR1 0.309 19427866 Q8CAM5 Q6ZPJ3 RAB36 UBE2O 0.126 26885862 Q8VHQ4 Q6ZPJ3 RAB40C UBE2O 0.126 26885862 Q96A23 Q6ZPJ3 CPNE4 UBE2O 0.332 12522145 Q96FN4 Q6ZPJ3 CPNE2 UBE2O 0.183 12522145 Q99829 Q6ZPJ3 CPNE1 UBE2O 0.332 12522145 Q9D415 Q6ZPJ3 DLGAP1 UBE2O 0.126 27507650 Q6ZPJ3 P97432 UBE2O NBR1 0.309 19427866