PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Alx4 Ercc8 20211142 biogrid exp Ercc8 Wwtr1 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pcbd1 Ercc8 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G Tcf3 Ercc8 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ewsr1 Ercc8 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hoxa2 Ercc8 20211142 biogrid exp Protein Ssbp4, Single stranded DNA binding protein 4, isoform CRA_b Ercc8 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ncoa3 Ercc8 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G Nfe2 Ercc8 20211142 biogrid exp G G G G Ercc8 Ssbp3 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cul4b Ercc8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddb1 Ercc8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ercc8 Xab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ercc8 Uqcrq ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ercc8 Ruvbl2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ercc8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Ercc6 Ercc8 ortho Ogg1 Ercc8 ortho G Ercc8 Ddb2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Csnk2b Ercc8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cul4a Ercc8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ercc8 Dda1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cops3 Ercc8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ercc8 Cops8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Polr2a Ercc8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ercc8 Ssbp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hmgn1 Ercc8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ercc8 Cops7a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ep300 Ercc8 ortho Ercc8 Rfwd2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pcna Ercc8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ercc8 Gtf2h2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ercc8 Znf24 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ercc8 Gps1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G H1f0 Ercc8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ercc8 Cul5 ortho Top1 Ercc8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tp53 Ercc8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cops5 Ercc8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cops6 Ercc8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbr1 Ercc8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ercc8 Uvssa ortho Cops4 Ercc8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8CFD5 P31245 two hybrid 20211142 direct interaction X 2 Q8CFD5 Q05BA5 two hybrid 20211142 direct interaction X 2 Q8CFD5 two hybrid 20211142 direct interaction X 2 Q8CFD5 E9PVV2 two hybrid 20211142 direct interaction X 2 Q8CFD5 Q9EPK5 two hybrid 20211142 direct interaction X 2 Q8CFD5 O35137 two hybrid 20211142 direct interaction X 2 Q8CFD5 P61458 two hybrid 20211142 direct interaction X 2 Q8CFD5 Q61545 two hybrid 20211142 direct interaction X 2 Q8CFD5 two hybrid 20211142 direct interaction X 2 Q8CFD5 two hybrid 20211142 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Ncoa3 Ercc8 MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_313387 bait prey Ercc8 Wwtr1 MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_313762 bait prey Nfe2 Ercc8 MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_313428 bait prey Hoxa2 Ercc8 MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_313165 bait prey Ewsr1 Ercc8 MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_313071 bait prey Alx4 Ercc8 MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_312878 bait prey Pcbd1 Ercc8 MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_312979 bait prey Ssbp4 Ercc8 MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_313761 prey bait Ercc8 Ssbp3 MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_313760 bait prey Tcf3 Ercc8 MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_313593 bait prey

PPI - HINT Gene A Gene B PMID Method Quality NCOA3 ERCC8 20211142 0018 HT ALX4 ERCC8 20211142 0018 HT TCF3 ERCC8 20211142 0018 HT HOXA2 ERCC8 20211142 0018 HT PCBD1 ERCC8 20211142 0018 HT NFE2 ERCC8 20211142 0018 HT SSBP4 ERCC8 20211142 0018 HT EWSR1 ERCC8 20211142 0018 HT ERCC8 SSBP3 20211142 0018 HT ERCC8 WWTR1 20211142 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8CFD5 P15806 ERCC8 TCF3 0.183 20211142 Q8CFD5 P61458 ERCC8 PCBD1 0.183 20211142 Q8CFD5 Q61545 ERCC8 EWSR1 0.183 20211142 Q8CFD5 O35137 ERCC8 ALX4 0.183 20211142 Q9EPK5 Q8CFD5 WWTR1 ERCC8 0.183 20211142 Q9D032 Q8CFD5 SSBP3 ERCC8 0.183 20211142 Q8CFD5 P31245 ERCC8 HOXA2 0.183 20211142 Q8CFD5 Q07279 ERCC8 NFE2 0.183 20211142