PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Rbx1 Fbxw8 16880526 biogrid exp Rbx1 Fetub 12939278 biogrid exp P Rbx1 Ywhah 21311561 intact exp P Rbx1 Lrrc41 11384984 biogrid exp P Rbx1 Cul1 12417738,16880526 innatedb,biogrid exp P Rbx1 Cul4a 19037258 biogrid,intact exp P Vhl Rbx1 23990666,15601820 innatedb,biogrid,intact exp Ube2d1 Rbx1 23871831 biogrid exp Cops2 Rbx1 19576224 biogrid exp P Rbx1 Cul3 19279002 biogrid exp P Rbx1 Ube2r2 21245377 biogrid exp P Rbx1 Keap1 19279002 biogrid exp Ptma Rbx1 19279002 biogrid exp P Ube2e3 Rbx1 21343341 biogrid exp P Rbx1 Neurl2 i2d exp Ube2g2 Rbx1 22020328,22024926,21343341,23871831 biogrid exp P Ube2d2 Rbx1 20352047 biogrid exp P Rbx1 Mcl1 21368834 biogrid exp Rbx1 Cul7 16880526 innatedb,biogrid exp P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P61077-3 P62878 pull down 23955342 direct interaction X 2 P26350 P62878 affinity chromatography technology 19279002 physical association X 2 A0A087WW00 P62878 pull down 14960280 direct interaction X 2 Q9WTX6 P62878 affinity chromatography technology 12417738 physical association X 2 Q9WTX6 P62878 affinity chromatography technology 16880526 physical association X 2 Q9Z2X8 P62878 affinity chromatography technology 19279002 physical association X 2 Q9Z2X8 P62878 affinity chromatography technology 19279002 physical association X 2 Q6YJU2 P62878 pull down 12939278 direct interaction X 2 P61202 P62878 affinity chromatography technology 19576224 physical association X 2 P40337-3 P62878 affinity chromatography technology 15601820 physical association X 2 P97287 P62878 affinity chromatography technology 21368834 physical association X 2 P62878 A0A024R475 pull down 11384984 direct interaction X 2 P62878 Q93034 pull down 11384984 direct interaction X 2 P62878 A0A024R475 affinity chromatography technology 19037258 physical association X 2 P62878 Q93034 affinity chromatography technology 19037258 physical association X 2 P61080 P62878 pull down 23871831 direct interaction X 2 P60605 P62878 pull down 22024926 direct interaction X 2 P60605 P62878 pull down 21343341 direct interaction X 2 P60605 P62878 pull down 23871831 direct interaction X 2 P62878 pull down 11384984 direct interaction X 2 Q8BIA4 P62878 affinity chromatography technology 16880526 physical association X 2 A0A090N7U0 P62878 biochemical 16275325 association X 2 A0A090N7U0 P62878 affinity chromatography technology 12417738 physical association X 2 A0A090N7U0 P62878 affinity chromatography technology 11337588 physical association X 2 A0A090N7U0 P62878 pull down 11384984 direct interaction X 2 P40338 P62878 affinity chromatography technology 23990666 physical association X 2 Q13617 P62878 pull down 11384984 direct interaction X 2 Q13617 P62878 affinity chromatography technology 19037258 physical association X 2 P62878 Q8VE73 affinity chromatography technology 16880526 physical association X 2 P62878 Q9JLV5 affinity chromatography technology 19279002 physical association X 2 P62878 Q9JLV5 affinity chromatography technology 19279002 physical association X 2 Q3TCH7 P62878 affinity chromatography technology 19037258 physical association X 2 P15732 P62878 pull down 22024926 direct interaction X 2 P15732 P62878 pull down 23707388 direct interaction X 2 P52483 P62878 pull down 21343341 direct interaction X 2 P62878 anti tag coimmunoprecipitation 11717410 association C 4 P62878 anti tag coimmunoprecipitation 12140560 association C 4 P62878 coimmunoprecipitation 14960280 association C 5 P62878 fluorescent resonance energy transfer 19945379 physical association C 3 P62878 anti tag coimmunoprecipitation 19037258 association C 6 P62878 anti tag coimmunoprecipitation 19037258 association C 6 P62878 anti tag coimmunoprecipitation 19037258 association C 3 P62878 anti bait coimmunoprecipitation 15601820 association C 5 P62878 anti tag coimmunoprecipitation 19037258 association C 5 P62878 anti tag coimmunoprecipitation 19037258 association C 3

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Rbx1 Cul1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 12417738,16880526 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_323450|BIOGRID_329051 prey|prey bait|bait Rbx1 Cul3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19279002 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_319163|BIOGRID_319161 prey|bait bait|prey Cops2 Rbx1 MI:0004(affinity chromatography technology) 19576224 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_319732 bait prey Rbx1 Ptma MI:0004(affinity chromatography technology) 19279002 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_319175 prey bait Rbx1 Fetub MI:0415(enzymatic study) 12939278 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_324544 bait prey Ube2d1 Rbx1 MI:0004(affinity chromatography technology) 23871831 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_331187 prey bait Ube2g2 Rbx1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study) 21343341,22024926,23871831 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_331186|BIOGRID_325654|BIOGRID_323632 prey|prey|prey bait|bait|bait Vhl Rbx1 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 15601820,23990666 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_164464|BIOGRID_331566 bait|bait prey|prey Rbx1 Fbxw8 MI:0004(affinity chromatography technology) 16880526 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_329047 prey bait Rbx1 Cul4a MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 10,19037258 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association) (biogrid)|MI:0471(mint)|(intact)|(intact)|(intact) BIOGRID_319684|MINT_73992|UniProt_97848|UniProt_183302|UniProt_168994 prey|prey|prey|prey|prey bait|bait|bait|bait|bait Rbx1 Keap1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19279002 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_319162|BIOGRID_319160 bait|prey prey|bait Rbx1 Lrrc41 MI:0096(pull down) 11384984 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_311961 prey bait Rbx1 Cul7 MI:0004(affinity chromatography technology) 16880526 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_329055 prey bait Ube2e3 Rbx1 MI:0004(affinity chromatography technology) 21343341 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_325653 prey bait Rbx1 Mcl1 MI:0004(affinity chromatography technology) 21368834 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_321734 prey bait

PPI - HINT Gene A Gene B PMID Method Quality RBX1 YWHAH 21311561 0030 LC PTMA RBX1 19279002 0004 LC IRS1 RBX1 22033112 0004 LC VHL RBX1 15601820,23990666 0006,0004 LC UBE2E3 RBX1 21343341 0096 LC UBE2G2 RBX1 22020328,22024926,21343341,23871831 0096,0096,0096,0096 LC UBE2D3 RBX1 22033112 0096 LC UBE2D1 RBX1 23871831 0096 LC COPS2 RBX1 19576224 0004 LC UBE2D2 RBX1 20352047 0096 LC RBX1 MCL1 21368834 0004 LC RBX1 FBXO40 22033112 0004 LC RBX1 CUL4A 19037258,19037258 0004,0007 LC RBX1 UBE2R2 21245377 0096 LC RBX1 FBXW8 16880526 0004 LC RBX1 LRRC41 11384984 0096 LC RBX1 CUL7 16880526 0004 LC RBX1 CUL3 19279002 0004 LC RBX1 FETUB 12939278 0096 LC RBX1 CUL1 12417738,16880526 0004,0004 LC RBX1 KEAP1 19279002 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P62878 P61202 RBX1 COPS2 0.21 19576224 Q8K1C9 P62878 LRRC41 RBX1 0.309 11384984 Q63187 P62878 TCEB3 RBX1 0.21 19037258 Q8BIA4 P62878 FBXW8 RBX1 0.21 16880526 Q9WTX6 P62878 CUL1 RBX1 0.376 16880526,12417738 Q3TCH7 P62878 CUL4A RBX1 0.376 19037258 P62878 P15732 RBX1 UBC5 0.523 22024926,23707388 P62878 P40338 RBX1 VHL 0.309 15601820,23990666 Q13617 P62878 CUL2 RBX1 0.569 11384984,19037258 Q13618 P62878 CUL3 RBX1 0.569 11384984,19037258 Q93034 P62878 CUL5 RBX1 0.569 11384984,19037258 P62878 P60605 RBX1 UBE2G2 0.772 22024926,23871831,21343341,22020328 Q13616 P62878 CUL1 RBX1 0.731 16275325,19945379,11337588,11384984,12417738 Q8VE73 P62878 CUL7 RBX1 0.21 16880526 P62878 P26350 RBX1 PTMA 0.21 19279002 P62878 P35569 RBX1 IRS1 0.21 22033112 P62878 P40337 RBX1 VHL 0.126 15601820 P68510 P62878 YWHAH RBX1 0.126 21311561 Q6ZWZ2 P62878 UBE2R2 RBX1 0.309 21245377 P62878 P52483 RBX1 UBE2E3 0.309 21343341 P62878 P51668 RBX1 UBE2D1 0.309 14960280 P62878 P61077 RBX1 UBE2D3 0.309 23955342 P62878 P62838 RBX1 UBE2D2 0.309 20352047 P62878 P61080 RBX1 UBE2D1 0.309 23871831 P62878 P61079 RBX1 UBE2D3 0.309 22033112 Q9Z2X8 P62878 KEAP1 RBX1 0.376 19279002 Q9QXC1 P62878 FETUB RBX1 0.309 12939278 Q9JLV5 P62878 CUL3 RBX1 0.376 19279002 P62932 P62878 FBXO40 RBX1 0.21 22033112 P97287 P62878 MCL1 RBX1 0.21 21368834