PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Hira Nanog 23892456 biogrid,intact exp Hira Creb3l4 16595651 biogrid exp G G G G G G Hira Jarid2 24074864 intact exp G G G G G G G G G G G G G G G G G G G G G G Hira Elf5 26584622 biogrid exp G G G Hira Suz12 24074864 intact exp G G G G G G G G G G G G G G G G G G G G G G Crem Hira 16595651 biogrid exp G G G G G G G G G G G G G G G G G G G G Pou5f1 Hira 20362542 biogrid,intact exp Pax3 Hira 9731536 biogrid exp G G G G Hira Whsc1 23921552 intact exp H3f3a, H3f3b Hira 20211137,24074864,9731536 biogrid,intact exp Hira Nfu1 i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G Hira Hirip3 9731536 biogrid exp, ortho Polr2a Hira 24074864 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G Pax7 Hira 9731536 biogrid exp, ortho G Hira Racgap1 ortho G G G G G G G G G G G G G G G G G Hira Git2 ortho G G G G G G G G G G G G G G G G G G G G G G Hnrnpd Hira ortho G G G G G G G G G G G G G G G G G G G G G G Tcp1 Hira ortho G G G G G G G G G G G G G G G G G G G G G G Cct6a Hira ortho G G G G G G G G G G G G G G G G G G G G G G Hist1h3b, Hist1h3c, Hist1h3d, Hist1h3e, Hist1h3f, Hist2h3b, Hist2h3c1, Hist2h3c2 Hira ortho G G G G Kif4 Hira ortho G G G G G G G G Mov10 Hira ortho G G G G G G G G G G G G G G Mef2a Hira ortho G G G G G G G G G G G G G G G G G G G G G G Hira Dnaja2 ortho G G G G G G G G G G G G G G G G G G G G G G Ube2i Hira ortho G G G G G G G G G G G G G G G G G G G G G G Hira Grk5 ortho G G G G G G G G G G G G G G G G G G G G G Cct5 Hira ortho G G G G G G G G G G G G G G G G G G G G G G Tp53 Hira ortho G G G G G G G G G G G G G G G G G G G G Ckap5 Hira ortho G G G G G G G G G G G G G G G G G G G G G G Hira Asf1a ortho G G G G G G G G G G G G G G G G G G G G G G Vdr Hira ortho G G G G G G G G Hira Mef2d ortho G G G G G G G G G G G G G G G G G G G G G G Elavl1 Hira ortho G G G G G G G G G G G G G G G G G G G G G G Pml Hira ortho G G G G G G G G G G G G G Hira Asf1b ortho G G G G G G G G G G G Hira Diras1 ortho G G G G G G G G G Chd2 Hira ortho Cct8 Hira ortho G G G G G G G G G G G G G G G G G G G G G G Hira Hdac4 ortho Cct3 Hira ortho G G G G G G G G G G G G G G G G G G G G G G Cdk2 Hira ortho G G G G G G G G G G G G G G G G G Ncam1 Hira ortho G G G G G G G G G G G Hist1h4a, Hist1h4b, Hist1h4c, Hist1h4d, Hist1h4f, Hist1h4h, Hist1h4i, Hist1h4j, Hist1h4k, Hist1h4m, Hist2h4a, Hist4h4 Hira ortho G G G G G G G G G G G Hira Nxf1 ortho G G G G G G G G G G G G G G G G G G G G G G Foxk2 Hira ortho G G G G G G G G G G G G G G G G G G G G G G Cct7 Hira ortho G G G G G G G G G G G G G G G G G G G G G G Hira Snw1 ortho G G G G G G G G G G G G G G G G G G G G G G Ubn1 Hira ortho G G G G G G G G G G G G G G G G Hira Ptbp3 ortho G G G G G G G G G G G G G G G G G G G G G G Hira Ubn2 ortho Cct4 Hira ortho G G G G G G G G G G G G G G G G G G G G G G Hira Cdc5l ortho G G G G G G G G G G G G G G G G G G G G G G Hira Upf1 ortho G G G G G G G G G G G G G G G G G G G G G Hira Hist1h2bc, Hist1h2be, Hist1h2bg ortho Ccna2 Hira ortho G G G G G G G G G G G G G G Hira Aim2 ortho G G Cct2 Hira ortho G G G G G G G G G G G G G G G G G G G G G G Hira Cul3 ortho G G G G G G G G G G G G G G G G G G G G G G Hira Hist1h2bk ortho Hira Hira ortho G G G G G G G G G G G G G G G G G G G G G G Myc Hira ortho G G G G G G G G G G G G G Hira Add1 ortho G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q61666 - 11342215 - X 2 Q61666 affinity chromatography technology 20362542 physical association X 2 Q61666 A2RS90 affinity chromatography technology 23892456 physical association X 2 Q61666 Q3TZM4 - 9731536 direct interaction X 2 Q61666 P47239 two hybrid 9731536 direct interaction X 2 Q61666 Q3TZM4 pull down 9731536 direct interaction X 2 Q61666 P47239 pull down 9731536 direct interaction X 2 Q61666 Q3TZM4 affinity chromatography technology 9731536 physical association X 2 Q61666 Q3TZM4 pull down 9731536 direct interaction X 2 Q61666 D3Z7M6 affinity chromatography technology 16595651 physical association X 2 Q61666 D3Z7M6 affinity chromatography technology 16595651 physical association X 2 Q8BLH7 Q61666 two hybrid 9731536 direct interaction X 2 Q9D2A5 Q61666 affinity chromatography technology 16595651 physical association X 2 Q61666 P84244 two hybrid 9731536 direct interaction X 2 Q61666 P84244 pull down 9731536 direct interaction X 2 Q61666 tandem affinity purification 20362542 association C 94 Q61666 anti tag coimmunoprecipitation 23892456 association C 143 Q61666 anti tag coimmunoprecipitation 24074864 association C 5 Q61666 pull down 20211137 physical association C 32 Q61666 anti bait coimmunoprecipitation 23921552 association C 3 Q61666 anti tag coimmunoprecipitation 20211137 physical association C 4

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Hira Hirip3 MI:0018(two hybrid) 9731536 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_311784 bait prey H3f3a Hira MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down) 20211137,24074864,9731536 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0914(association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(intact)|(biogrid)|(biogrid)|(intact) UniProt_170609|UniProt_176333|BIOGRID_311787|BIOGRID_311790|UniProt_170606 bait|prey|prey|prey|bait prey|bait|bait|bait|prey Hira Creb3l4 MI:0004(affinity chromatography technology) 16595651 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_314609 prey bait Pou5f1 Hira MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology) 20362542 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_170860|BIOGRID_314388 prey|bait prey|prey Hira Nanog MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 23892456 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_177306|BIOGRID_331337 prey|prey bait|bait Pax3 Hira MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 9731536 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_311788|BIOGRID_311785|BIOGRID_311791|BIOGRID_311792 prey|prey|bait|bait bait|bait|prey|prey Pax7 Hira MI:0018(two hybrid)|MI:0018(two hybrid) 9731536 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_311789|BIOGRID_311786 prey|prey bait|bait Crem Hira MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16595651 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_314620|BIOGRID_314608 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality PAX3 HIRA 9731536,9731536,9731536 0018,0096,0004 LC PAX7 HIRA 9731536,9731536 0018,0096 LC H3F3A|H3F3B HIRA 9731536,9731536 0018,0096 LC HIRA HIRIP3 9731536 0018 LC POLR2A HIRA 24074864 0007 LC POU5F1 HIRA 20362542,20362542 0676,0004 LC PAX3 HIRA 9731536,9731536,9731536 0018,0096,0004 LC CREM HIRA 16595651 0004 LC PAX7 HIRA 9731536,9731536 0018,0096 LC H3F3A|H3F3B HIRA 9731536,24074864,9731536,20211137,20211137 0018,0007,0096,0007,0096 LC HIRA JARID2 24074864 0007 LC HIRA SUZ12 24074864 0007 LC HIRA NANOG 23892456,23892456 0007,0004 LC HIRA WHSC1 23921552 0006 LC HIRA ELF5 26584622 0004 LC HIRA CREB3L4 16595651 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q61666 P08775 HIRA POLR2A 0.21 24074864 Q62315 Q61666 JARID2 HIRA 0.21 24074864 Q80U70 Q61666 SUZ12 HIRA 0.21 24074864 Q8BLH7 Q61666 HIRIP3 HIRA 0.309 9731536 Q8VDK3 Q61666 ELF5 HIRA 0.126 26584622 Q8BVE8 Q61666 WHSC1 HIRA 0.21 23921552 Q61666 P20263 HIRA POU5F1 0.236 20362542 Q61666 P84244 HIRA H3F3B 0.712 24074864,20211137,9731536 Q61666 P24610 HIRA PAX3 0.74 9731536 Q61666 P47239 HIRA PAX7 0.523 9731536 Q80Z64 Q61666 NANOG HIRA 0.236 23892456 Q9D2A5 Q61666 CREB3L4 HIRA 0.21 16595651 Q61666 P27699 HIRA CREM 0.21 16595651