PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Tnk2 Psmd1 17182860 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Kcnma1 20114047 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G Tnk2 Ubc 17182860 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Psmd6 17182860 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Nck1 16777958 biogrid,dip exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Tnk2 16777958 dip exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Cltc 21169560,17182860 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Pdk1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Protein Arhgap4, Rho GTPase activating protein 4, isoform CRA_f, Rho GTPase-activating protein p115 splice form 1 ortho G G G G G G Tnk2 Adrbk1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Pdpk1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Galt ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Fyn ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Rock1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ep300 Tnk2 ortho Tnk2 Yes1 ortho G G G G G G G G G G G G G G G G G G G G G G Tnk2 Ntrk1 ortho Tnk2 Cspg4 ortho G G G G G G G G G G G G G G G G Tnk2 Csnk1g2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd9 Tnk2 ortho G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Abi2 ortho Tnk2 Amph ortho G G G G G G G G G G Tnk2 Wwox ortho G G G G G G G G G G G G G G G G G G G G Tnk2 Magi3 ortho G G G G G G G G G G G G Tnk2 Kat8 ortho Tnk2 Was ortho G G G G G G G G G Tnk2 Cttn ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Mertk ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Clta Tnk2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Kat5 ortho Tnk2 Nek6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Ptprd ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Gsk3a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Smurf1 ortho Tnk2 Hsp90ab1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Grb2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Pld2 ortho G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Pak2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Nck2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Ntrk3 ortho G G G G G G G G G Tnk2 Hsh2d ortho Tnk2 Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Camk2g ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Tp53 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Rpl18a ortho Tnk2 Ywhah ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Cdc42 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Thy1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Ntrk2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Tp73 ortho G Tnk2 Dmpk ortho G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Akt1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Src ortho G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Itfg2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Atg16l1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Socs4 ortho G G G G G Tnk2 Hsp90aa1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Synj1 ortho Tnk2 Ptpn12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Ptprj ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Ltk ortho G G G G Tnk2 Mink1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Nphp1 ortho G G G G G G G G G G G G G G G G G G G Tnk2 Lyn ortho Tnk2 Egfr ortho G G G G G G G G G G G G G G G G G G Tnk2 Eea1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Nbr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Aqp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Pdgfrb ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Hck ortho G G G G G G G G G G G G G G G G G G G G Tnk2 Nedd4l ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Tnk2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Nckipsd ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Sh2d1a ortho G G Tnk2 Sez6 ortho G G G G G G Tnk2 Hecw1 ortho Tnk2 Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Kdm3a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Crk ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Rasgef1c ortho Tnk2 Gtse1 ortho G G G G G Tnk2 Cd80 ortho G G G G G G Tnk2 Alk ortho G G G G G Protein Mcf2 Tnk2 ortho G G Tnk2 Rasgrf1 ortho G G G G G G G G G G G G G G G G Tnk2 Vti1b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Ar ortho G G G G G G G G G G G G G G G G Tnk2 Fabp4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Bag3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Axl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Gak ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Kcna5 ortho G G G G G G G G G G G G Tnk2 Snx9 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Trim50 ortho Tnk2 Wwp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Siah2 ortho G G G G G G G G G G G G G G G G G G G G G Tnk2 MCG3834, Protein Zbtb16, Zinc finger and BTB domain containing 16 ortho G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O54967 Q99M51 anti bait coimmunoprecipitation 16777958 physical association X 2 O54967 Q99M51 anti bait coimmunoprecipitation 16777958 physical association X 2 O54967 O54967 pull down 16777958 physical association Y 1 O54967 P16333 anti bait coimmunoprecipitation 16777958 physical association X 2 O54967 P16333 anti bait coimmunoprecipitation 16777958 physical association X 2 O54967 anti bait coimmunoprecipitation 20114047 association C 22

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Tnk2 Cltc MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17182860,21169560 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_321255|BIOGRID_321855 bait|prey prey|bait Tnk2 Ubc MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17182860 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_321860|BIOGRID_321862 bait|prey prey|bait Tnk2 Nck1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16777958 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_322768|BIOGRID_322769 bait|prey prey|bait Tnk2 Psmd6 MI:0004(affinity chromatography technology) 17182860 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_321858 bait prey Tnk2 Psmd1 MI:0004(affinity chromatography technology) 17182860 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_321856 bait prey

PPI - HINT Gene A Gene B PMID Method Quality TNK2 TNK2 16777958 0096 LC TNK2 UBC 17182860,17182860 0096,0004 LC TNK2 KCNMA1 20114047,20114047 0004,0006 LC TNK2 PSMD1 17182860 0004 LC TNK2 CLTC 17182860,21169560 0004,0004 LC TNK2 PSMD6 17182860 0004 LC TNK2 NCK1 16777958,16777958 0006,0004 LC