PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Usp25 Traf6 23042150 intact exp, ortho G G G G G G G G G G G G G G G G G G G G Usp25 Traf5 23042150 intact exp, ortho G G G G G G G G G G G G G G G G G Usp25 Crot ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp25 Cdc37l1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp25 Cul3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp25 Kctd10 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp25 Myo6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp25 Klhl9 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pip Usp25 ortho G G App Usp25 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp25 Kiaa1468 ortho Usp25 Wrnip1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hsp90b1 Usp25 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp25 Klhl13 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Usp25 Usp25 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp25 Sumo1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Krt4 Usp25 ortho G G G G Usp25 Kctd13 ortho Usp25 Senp1 ortho G G G G G G G G G G G G G G G G G G G G G G Nedd8 Usp25 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Usp25 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rad23a Usp25 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp25 Btbd9 ortho Usp25 Sumo3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp25 Acta1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Syk Usp25 ortho G G G G G G G G G G G G G G G G G Usp25 Son ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G 8030451F13Rik Usp25 ortho Usp25 Mef2c ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp25 Sumo2 ortho Usp25 Flnc ortho G G G G G G G G G G G Usp25 Tnks2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp25 Cul2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp25 Skil ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anxa1 Usp25 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp25 Ube2i ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp25 Usp28 ortho Usp25 Znf426 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P57080 P70196 anti bait coimmunoprecipitation 23042150 physical association X 2 P57080 P70191 anti bait coimmunoprecipitation 23042150 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Usp25 Traf5 MI:0006(anti bait coimmunoprecipitation) 23042150 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_173889 prey bait Usp25 Traf6 MI:0006(anti bait coimmunoprecipitation) 23042150 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_173890 prey bait

PPI - HINT Gene A Gene B PMID Method Quality UBC USP25 26811477 0004 LC USP25 TRAF5 23042150 0006 LC USP25 TRAF6 23042150 0006 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P57080 P0CG50 USP25 UBC 0.21 26811477