PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Traf3 Rnf41 19483718 innatedb,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dclk2 Rnf41 18986647 biogrid exp Irf3 Rnf41 19483718 innatedb,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf41 Cog2 18986647 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smarce1 Rnf41 18986647 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Enoph1 Rnf41 18986647 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Myd88 Rnf41 19483718 innatedb,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G Epor Rnf41 18495327 biogrid exp G G G G G G G G G G G G G G G G Rnf41 Rtn4 18986647 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hbb-b1 Rnf41 18986647 biogrid exp Cebpb Rnf41 22707723 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G Csf2rb Rnf41 18495327 biogrid exp G G G G G G G Ube2n Rnf41 19483718 biogrid exp Traf6 Rnf41 19483718 innatedb,biogrid exp G G G G G G G G G G G G G G G G G G G G Irak1 Rnf41 19483718 innatedb,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ncor1 Rnf41 18986647 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d1 Rnf41 19483718 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ticam1 Rnf41 19483718 innatedb,biogrid exp Rnf41 Sap130 18986647 biogrid exp Ogfod1 Rnf41 18986647 biogrid exp Rnf41 Tbk1 19483718 innatedb,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kdm3b Rnf41 18986647 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Rnf41 19527720 biogrid,mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Clec16a Rnf41 24949970 biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G Rnf41 Arl6ip4 18986647 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp8 Rnf41 19527720 biogrid,mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf41 Cacybp ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Soga1 Rnf41 ortho Adrb2 Rnf41 ortho G G G G G G G G G Clasp1 Rnf41 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d3 Rnf41 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rcn1 Rnf41 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mtcl1 Rnf41 ortho Mnat1 Rnf41 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2z Rnf41 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf41 Lpgat1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf41 Park2 ortho G G G G Rnf41 Rnf41 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf41 Rfc4 ortho G G G G G G G G G G G G G G G G G G G Rnf166 Rnf41 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Evi5 Rnf41 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Erbb4 Rnf41 ortho Lepr Rnf41 ortho G G G G G G G G G P4ha1 Rnf41 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf41 Rfwd3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf41 N4bp3 ortho G G G G G G G G G G G G G G G G G G Rasip1 Rnf41 ortho G G G G G G G G G G Rnf41 Sugt1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf41 Tada2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf41 Itsn2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Cep192 Rnf41 ortho Rnf41 Ttc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf41 Homer2 ortho G G G G G G G G G G G G G G G G G G G G Ube2u Rnf41 ortho Tsg101 Rnf41 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf41 Trim8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf41 Trim32 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf41 Mark4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf41 Lzts2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uncharacterized protein C1orf109 homolog Rnf41 ortho Ube2k Rnf41 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf41 Npat ortho MCG3697, isoform CRA_c, Protein Upf3a, UPF3 regulator of nonsense transcripts homolog A (Yeast) Rnf41 ortho App Rnf41 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kifc3 Rnf41 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mark2 Rnf41 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf41 C1galt1c1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf41 Vps52 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf41 Isca2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Creb3 Rnf41 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Elavl1 Rnf41 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf41 Asb6 ortho G G G G G G G G G Erbb3 Rnf41 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf41 Il23a ortho Rnf41 Nav1 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O54941 Q8BH75 two hybrid 18986647 direct interaction X 2 Q8BH75 two hybrid 18986647 direct interaction X 2 Q8BH75 affinity chromatography technology 19527720 physical association X 2 Q921L5 Q8BH75 two hybrid 18986647 direct interaction X 2 Q8BH75 two hybrid 18986647 direct interaction X 2 Q8BH75 two hybrid 18986647 direct interaction X 2 Q8BH75 Q9WUN2 affinity chromatography technology 19483718 physical association X 2 Q8BH75 P70671 affinity chromatography technology 19483718 physical association X 2 Q8BH75 Q9WUN2 enzymatic study 19483718 direct interaction X 2 Q8BH75 Q80U30-2 affinity chromatography technology 24949970 physical association X 2 Q8BH75 Q80U30-2 affinity chromatography technology 24949970 physical association X 2 Q8BH75 Q80U30-2 affinity chromatography technology 24949970 physical association X 2 Q8BH75 A2AI52 affinity chromatography technology 19527720 physical association X 2 P22366 Q8BH75 affinity chromatography technology 19483718 physical association X 2 P22366 Q8BH75 enzymatic study 19483718 direct interaction X 2 P28033 Q8BH75 affinity chromatography technology 22707723 physical association X 2 P28033 Q8BH75 affinity chromatography technology 22707723 physical association X 2 Q9JM93 Q8BH75 two hybrid 18986647 direct interaction X 2 P14753 Q8BH75 affinity chromatography technology 18495327 physical association X 2 P26955 Q8BH75 affinity chromatography technology 18495327 physical association X 2 Q8BH75 Q8BH78 two hybrid 18986647 direct interaction X 2 Q8BH75 Q3U0K8-3 two hybrid 18986647 direct interaction X 2 Q8BH75 Q8BGB7 two hybrid 18986647 direct interaction X 2 Q8BH75 two hybrid 18986647 direct interaction X 2 Q8BH75 B1AUW6 affinity chromatography technology 19483718 physical association X 2 Q8BH75 P70196 affinity chromatography technology 19483718 physical association X 2 Q80UF7 Q8BH75 affinity chromatography technology 19483718 physical association X 2 Q8BH75 two hybrid 18986647 direct interaction X 2 Q3UHJ1 Q8BH75 affinity chromatography technology 19483718 physical association X 2 O88738 Q8BH75 anti bait coimmunoprecipitation 19527720 association X 2 Q8BH75 Q80U30-2 anti tag coimmunoprecipitation 24949970 physical association X 2 Q8BH75 Q80U30-2 anti tag coimmunoprecipitation 24949970 physical association X 2 Q8BH75 Q80U30-2 anti bait coimmunoprecipitation 24949970 physical association X 2 Q80U87 Q8BH75 anti bait coimmunoprecipitation 19527720 association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Enoph1 Rnf41 MI:0018(two hybrid) 18986647 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_320559 prey bait Rnf41 Cog2 MI:0018(two hybrid) 18986647 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_320554 bait prey Csf2rb Rnf41 MI:0004(affinity chromatography technology) 18495327 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_321901 bait prey Rnf41 Arl6ip4 MI:0018(two hybrid) 18986647 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_320551 bait prey Dclk2 Rnf41 MI:0018(two hybrid) 18986647 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_320561 prey bait Irf3 Rnf41 MI:0004(affinity chromatography technology) 19483718 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_321647 prey bait Usp8 Rnf41 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19527720 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0915(physical association) (intact)|MI:0471(mint)|(biogrid) UniProt_171004|MINT_71623|BIOGRID_315986 prey|prey|prey bait|bait|bait Rnf41 Ncor1 MI:0018(two hybrid) 18986647 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_320560 bait prey Smarce1 Rnf41 MI:0018(two hybrid) 18986647 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_320558 prey bait Rnf41 Hbb-b1 MI:0018(two hybrid) 18986647 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_320555 bait prey Ogfod1 Rnf41 MI:0018(two hybrid) 18986647 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_320556 prey bait Birc6 Rnf41 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19527720 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0915(physical association) (intact)|MI:0471(mint)|(biogrid) UniProt_171005|MINT_71624|BIOGRID_315985 prey|prey|prey bait|bait|bait Traf6 Rnf41 MI:0004(affinity chromatography technology) 19483718 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_321643 prey bait Rnf41 Sap130 MI:0018(two hybrid) 18986647 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_320557 bait prey Traf3 Rnf41 MI:0004(affinity chromatography technology) 19483718 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_321646 prey bait Rnf41 Rtn4 MI:0018(two hybrid) 18986647 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_320553 bait prey Ticam1 Rnf41 MI:0004(affinity chromatography technology) 19483718 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_321644 prey bait Epor Rnf41 MI:0004(affinity chromatography technology) 18495327 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_321900 bait prey Cebpb Rnf41 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22707723 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_321989|BIOGRID_321988 bait|prey prey|bait Rnf41 Tbk1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19483718 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_321645|BIOGRID_321651 bait|bait prey|prey Kdm3b Rnf41 MI:0018(two hybrid) 18986647 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_320552 prey bait

PPI - HINT Gene A Gene B PMID Method Quality HBBT1 RNF41 18986647 0018 LC SMARCE1 RNF41 18986647 0018 LC HBB-B1 RNF41 18986647 0018 LC MYD88 RNF41 19483718,19483718,19483718 0004,0415,0007 LC OGFOD1 RNF41 18986647 0018 LC NCOR1 RNF41 18986647 0018 LC DCLK2 RNF41 18986647 0018 LC KDM3B RNF41 18986647 0018 LC ENOPH1 RNF41 18986647 0018 LC RNF41 RNF41 17384230 0114 LC RNF41 SAP130 18986647 0018 LC RNF41 COG2 18986647 0018 LC RNF41 RTN4 18986647 0018 LC RNF41 ARL6IP4 18986647 0018 LC RNF41 TBK1 19483718,19483718,19483718 0004,0415,0007 LC BIRC6 RNF41 19527720,19527720 0004,0006 LC EPOR RNF41 18495327 0004 LC MYD88 RNF41 19483718,19483718,19483718 0004,0415,0007 LC CSF2RB RNF41 18495327 0004 LC CEBPB RNF41 22707723 0004 LC UBE2D1 RNF41 19483718 0096 LC UBE2N RNF41 19483718 0096 LC TRAF6 RNF41 19483718,19483718 0004,0007 LC IRF3 RNF41 19483718,19483718 0004,0007 LC TRAF3 RNF41 19483718,19483718 0004,0007 LC IRAK1 RNF41 19483718,19483718 0004,0007 LC CLEC16A RNF41 24949970,24949970,24949970 0004,0007,0006 LC USP8 RNF41 19527720,19527720 0004,0006 LC TICAM1 RNF41 19483718 0004 LC RNF41 TBK1 19483718,19483718,19483718 0004,0415,0007 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8BH75 Q80U30 RNF41 CLEC16A 0.61 24949970 Q8BH75 O54941 RNF41 SMARCE1 0.309 18986647 Q8BH75 P02088 RNF41 HBB-B1 0.309 18986647 Q8BH75 P61080 RNF41 UBE2D1 0.309 19483718 Q8BH75 P61089 RNF41 UBE2N 0.309 19483718 Q8BH75 P70196 RNF41 TRAF6 0.21 19483718 Q8BH75 P70671 RNF41 IRF3 0.21 19483718 Q8BH75 Q3U0K8 RNF41 OGFOD1 0.309 18986647 Q8BH75 Q60803 RNF41 TRAF3 0.21 19483718 Q8BH75 Q62406 RNF41 IRAK1 0.21 19483718 Q8BH75 Q6PGN3 RNF41 DCLK2 0.309 18986647 Q8BH75 Q80UF7 RNF41 TICAM1 0.21 19483718 Q8BH75 Q8BGB7 RNF41 ENOPH1 0.309 18986647 Q8BIH0 Q8BH75 SAP130 RNF41 0.309 18986647 Q921L5 Q8BH75 COG2 RNF41 0.309 18986647 Q99P72 Q8BH75 RTN4 RNF41 0.309 18986647 Q9JM93 Q8BH75 ARL6IP4 RNF41 0.309 18986647 Q8BH75 Q80U87 RNF41 USP8 0.376 19527720 Q8BH75 O88738 RNF41 BIRC6 0.376 19527720 Q8BH75 P22366 RNF41 MYD88 0.454 19483718 Q9WUN2 Q8BH75 TBK1 RNF41 0.454 19483718 Q8BH75 P28033 RNF41 CEBPB 0.376 22707723 Q8BH75 P26955 RNF41 CSF2RB 0.21 18495327 Q8BH75 P14753 RNF41 EPOR 0.21 18495327