PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Sema4a Optn 22465952 biogrid exp Ikbkb Optn 21862579 biogrid exp Hace1 Optn 25026213 biogrid,intact exp, ortho Fos Optn 15867431 biogrid,i2d exp, ortho Optn Optn 24983867 biogrid exp, ortho Tnfrsf1a Optn 17702576 innatedb exp, ortho Optn Tbk1 20174559,21862579 innatedb,biogrid exp, ortho Ripk1 Optn 17702576 innatedb exp, ortho Rab11a Optn 22465952 biogrid exp, ortho Sqstm1 Optn 25026213 biogrid,intact exp, ortho Rab10 Optn ortho Zdhhc17 Optn ortho Pparg Optn ortho Dzip1 Optn ortho Optn Rab14 ortho Fam175b Optn ortho Protein Zfp384 Optn ortho Kansl1l Optn ortho Sod1 Optn ortho Snx6 Optn ortho Htt Optn ortho Gnas Optn ortho Optn Ebna1bp2 ortho Vwf Optn ortho Rif1 Optn ortho Protein Zfp398 Optn ortho Znf329 Optn ortho Hspb1 Optn ortho Fth1 Optn ortho Optn Rnf11 ortho Mpp1 Optn ortho Grm1 Optn ortho Optn Tbc1d15 ortho Optn Map1lc3b ortho Optn Mpp6 ortho Vcp Optn ortho Optn Uqcrq ortho Optn Ccdc53 ortho Optn Bre ortho Optn Pias4 ortho Ubc Optn ortho Znf711 Optn ortho Optn Rab3il1 ortho Optn Dazap2 ortho Eif4g2 Optn ortho Traf3 Optn ortho Protein Kctd17 Optn ortho Ywhaz Optn ortho Cenpb Optn ortho Rab12 Optn ortho Optn Znf426 ortho Fam189a2 Optn ortho Hspa9 Optn ortho Optn Map1lc3a ortho MCG14935, isoform CRA_a, WD repeat-containing protein 20 Optn ortho Optn Ywhab ortho Ttn Optn ortho Cdc23 Optn ortho Tbc1d17 Optn ortho Rab11b Optn ortho Optn Zmat2 ortho Optn Lnx2 ortho Tradd Optn ortho Myh3 Optn ortho Cdkn1a Optn ortho Optn Tnip1 ortho Optn Rab25 ortho Eps15 Optn ortho Optn Rtn3 ortho Rab8a Optn ortho Optn Park2 ortho Rpl37a Optn ortho Tfrc Optn ortho Tax1bp1 Optn ortho Ywhah Optn ortho Optn Dysf ortho Eif5a2 Optn ortho Syngap1 Optn ortho Akap6 Optn ortho Cyld Optn ortho Optn Stx12 ortho Myo6 Optn ortho Nrl Optn ortho Ndufaf2 Optn ortho Cltc Optn ortho Fam178a Optn ortho Optn Gtf3a ortho Optn Gabarap ortho Optn Flii ortho Tnf Optn ortho Gabarapl2 Optn ortho Ywhag Optn ortho Slmap Optn ortho Optn Gabarapl1 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8K3K8 P01101 - 15867431 - X 2 Q8K3K8 Q9WUN2 affinity chromatography technology 21862579 physical association X 2 Q8K3K8 Q9WUN2 enzymatic study 21862579 direct interaction X 2 Q8K3K8 enzymatic study 21862579 direct interaction X 2 Q8K3K8 P01101 pull down 15867431 direct interaction X 2 Q8K3K8 Q8K3K8 affinity chromatography technology 24983867 physical association X 2 Q8K3K8 Q3U0D9 pull down 25026213 direct interaction X 2 Q64337 Q8K3K8 pull down 25026213 direct interaction X 2 Q8K3K8 anti bait coimmunoprecipitation 25026213 association C 3

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Fos Optn MI:0096(pull down) 15867431 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_322570 bait prey Optn Tbk1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21862579 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_321759|BIOGRID_321756 prey|prey bait|bait Ikbkb Optn MI:0004(affinity chromatography technology) 21862579 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_321761 bait prey

PPI - HINT Gene A Gene B PMID Method Quality IKBKB OPTN 21862579 0415 LC OPTN TBK1 21862579,21862579 0004,0415 LC FOS OPTN 15867431,15867431 0096,0004 LC TNFRSF1A OPTN 17702576 0007 LC RAB11A OPTN 22465952 0004 LC HACE1 OPTN 25026213,25026213 0096,0006 LC RIPK1 OPTN 17702576 0007 LC SEMA4A OPTN 22465952 0004 LC SQSTM1 OPTN 25026213,25026213 0096,0006 LC OPTN OPTN 24983867 0004 LC OPTN TBK1 21862579,21862579,20174559 0004,0415,0007 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8K3K8 Q62178 OPTN SEMA4A 0.376 22465952 Q9WUN2 Q8K3K8 TBK1 OPTN 0.569 27086836,21862579 Q8K3K8 O88351 OPTN IKBKB 0.309 21862579 Q8K3K8 P01101 OPTN FOS 0.309 15867431 Q8K3K8 Q3U0D9 OPTN HACE1 0.454 25026213 Q8K3K8 Q64337 OPTN SQSTM1 0.454 25026213 Q8K3K8 P62492 OPTN RAB11A 0.376 22465952