PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A2APS1 Q61140 - 10739664 - X 2 P10126 A2APS1 affinity chromatography technology 21565611 physical association X 2 P10853 A2APS1 affinity chromatography technology 21565611 physical association X 2 P07091 A2APS1 affinity chromatography technology 21565611 physical association X 2 Q3TTY5 A2APS1 affinity chromatography technology 21565611 physical association X 2 P11499 A2APS1 affinity chromatography technology 21565611 physical association X 2 P08779 A2APS1 affinity chromatography technology 21565611 physical association X 2 P48678 A2APS1 affinity chromatography technology 21565611 physical association X 2 P05213 A2APS1 affinity chromatography technology 21565611 physical association X 2 P38647 A2APS1 affinity chromatography technology 21565611 physical association X 2 B9EI85 A2APS1 affinity chromatography technology 21565611 physical association X 2 P01027 A2APS1 affinity chromatography technology 21565611 physical association X 2 B2RRX1 A2APS1 affinity chromatography technology 21565611 physical association X 2 P07724 A2APS1 affinity chromatography technology 21565611 physical association X 2 Q922U2 A2APS1 affinity chromatography technology 21565611 physical association X 2 P63260 A2APS1 affinity chromatography technology 21565611 physical association X 2 Q14525 A2APS1 affinity chromatography technology 21565611 physical association X 2 P63017 A2APS1 affinity chromatography technology 21565611 physical association X 2 Q91YN9 A2APS1 affinity chromatography technology 21565611 physical association X 2 Q3U7T8 A2APS1 affinity chromatography technology 21565611 physical association X 2 A2APS1 Q9QZN4 affinity chromatography technology 21565611 physical association X 2 A2APS1 Q8VHX6 affinity chromatography technology 21565611 physical association X 2 A2APS1 Q8VDD5 affinity chromatography technology 21565611 physical association X 2 A2APS1 Q6NXH9 affinity chromatography technology 21565611 physical association X 2 A2APS1 affinity chromatography technology 21565611 physical association X 2 A2APS1 A2APS1 affinity chromatography technology 21565611 physical association X 2 A2APS1 affinity chromatography technology 21565611 physical association X 2 A2APS1 B2RQC6 affinity chromatography technology 21565611 physical association X 2 P20152 A2APS1 affinity chromatography technology 21565611 physical association X 2 P58252 A2APS1 affinity chromatography technology 21565611 physical association X 2 P99024 A2APS1 affinity chromatography technology 21565611 physical association X 2 B2RTM0 A2APS1 affinity chromatography technology 21565611 physical association X 2 P04104 A2APS1 affinity chromatography technology 21565611 physical association X 2 P02538 A2APS1 affinity chromatography technology 21565611 physical association X 2 G5E8N5 A2APS1 affinity chromatography technology 21565611 physical association X 2 P07356 A2APS1 affinity chromatography technology 21565611 physical association X 2 P62983 A2APS1 affinity chromatography technology 21565611 physical association X 2 P10107 A2APS1 affinity chromatography technology 21565611 physical association X 2 Q6IFZ6 A2APS1 affinity chromatography technology 21565611 physical association X 2 P59240 A2APS1 affinity chromatography technology 21565611 physical association X 2 P59240 A2APS1 affinity chromatography technology 21565611 physical association X 2 P59240 A2APS1 pull down 21565611 direct interaction X 2 P59240 A2APS1 pull down 21565611 direct interaction X 2 Q8BP00 A2APS1 affinity chromatography technology 21565611 physical association X 2 P04264 A2APS1 affinity chromatography technology 21565611 physical association X 2 A2APS1 affinity chromatography technology 21565611 physical association X 2 O89019 A2APS1 affinity chromatography technology 21565611 physical association X 2 O89019 A2APS1 affinity chromatography technology 21565611 physical association X 2 P22752 A2APS1 affinity chromatography technology 21565611 physical association X 2 Q8CG73 A2APS1 affinity chromatography technology 21565611 physical association X 2 Q8CG73 A2APS1 affinity chromatography technology 21565611 physical association X 2 Q8CG73 A2APS1 pull down 21565611 direct interaction X 2 P52480 A2APS1 affinity chromatography technology 21565611 physical association X 2 P45376 A2APS1 affinity chromatography technology 21565611 physical association X 2 A2APS1 P62204 affinity chromatography technology 21565611 physical association X 2 A2APS1 affinity chromatography technology 21565611 physical association X 2 A2APS1 Q6S385 affinity chromatography technology 21565611 physical association X 2 A2APS1 P35527 affinity chromatography technology 21565611 physical association X 2 A2APS1 affinity chromatography technology 21565611 physical association X 2 A2APS1 P07901 affinity chromatography technology 21565611 physical association X 2 P81605 A2APS1 affinity chromatography technology 21565611 physical association X 2 P13647 A2APS1 affinity chromatography technology 21565611 physical association X 2 Q04695 A2APS1 affinity chromatography technology 21565611 physical association X 2 P63038 A2APS1 affinity chromatography technology 21565611 physical association X 2 A2APS1 anti tag coimmunoprecipitation 21565611 association C 7 A2APS1 anti tag coimmunoprecipitation 21565611 association C 48 A2APS1 anti tag coimmunoprecipitation 21565611 association C 38

PPI - HINT Gene A Gene B PMID Method Quality NPHP4 NPHP1 21565611,21565611,21565611,21565611 0416,0096,0004,0007 LC BCAR1 NPHP1 10739664,10739664 0019,0018 LC A1E2B8 NPHP1 21565611 0007 HT CAD NPHP1 21565611,21565611 0004,0007 HT IGH NPHP1 21565611 0007 HT DDC NPHP1 21565611 0007 HT INVS NPHP1 21565611,21565611 0004,0007 HT C3 NPHP1 21565611,21565611 0004,0007 HT KRT10 NPHP1 21565611 0004 HT KRT1 NPHP1 21565611 0004 HT TUBA1B NPHP1 21565611,21565611 0004,0007 HT LDHA NPHP1 21565611,21565611 0004,0007 HT S100A4 NPHP1 21565611,21565611 0004,0007 HT ANXA2 NPHP1 21565611,21565611 0004,0007 HT ALB NPHP1 21565611,21565611 0004,0007 HT HSP90AA1 NPHP1 21565611,21565611 0004,0007 HT UBC NPHP1 21565611 0007 HT ANXA1 NPHP1 21565611,21565611 0004,0007 HT EEF1A1 NPHP1 21565611,21565611 0004,0007 HT HIST1H2BF|HIST1H2BJ|HIST1H2BL|HIST1H2BN NPHP1 21565611,21565611 0004,0007 HT HSP90AB1 NPHP1 21565611,21565611 0004,0007 HT HSPA5 NPHP1 21565611,21565611 0004,0007 HT VIM NPHP1 21565611,21565611 0004,0007 HT HIST1H2AB|HIST1H2AC|HIST1H2AD|HIST1H2AE|HIST1H2AG|HIST1H2AI|HIST1H2AN|HIST1H2AO NPHP1 21565611 0004 HT HSPA9 NPHP1 21565611,21565611 0004,0007 HT AKR1B1 NPHP1 21565611,21565611 0004,0007 HT LMNA NPHP1 21565611,21565611 0004,0007 HT PKM NPHP1 21565611,21565611 0004,0007 HT EEF2 NPHP1 21565611,21565611 0004,0007 HT NPHP4 NPHP1 21565611,21565611,21565611,21565611 0416,0096,0004,0007 HT ACTB NPHP1 21565611,21565611 0004,0007 HT CALM1|CALM2|CALM3 NPHP1 21565611,21565611 0004,0007 HT HIST1H4A|HIST1H4B|HIST1H4C|HIST1H4D|HIST1H4F|HIST1H4H|HIST1H4I|HIST1H4J|HIST1H4K|HIST1H4M|HIST2H4A|HIST4H4 NPHP1 21565611 0004 HT RPS27A NPHP1 21565611,21565611 0004,0007 HT HSPA8 NPHP1 21565611,21565611 0004,0007 HT HSPD1 NPHP1 21565611,21565611 0004,0007 HT ACTG1 NPHP1 21565611,21565611 0004,0007 HT HIST1H3B|HIST1H3C|HIST1H3D|HIST1H3E|HIST1H3F|HIST2H3B|HIST2H3C1|HIST2H3C2 NPHP1 21565611,21565611 0004,0007 HT TUBB5 NPHP1 21565611,21565611 0004,0007 HT KRT2 NPHP1 21565611 0004 HT KRT77 NPHP1 21565611 0004 HT KRT73 NPHP1 21565611 0004 HT NPHP3 NPHP1 21565611 0007 HT IQCB1 NPHP1 21565611,21565611 0004,0007 HT RPGRIP1L NPHP1 21565611,21565611,21565611 0096,0004,0007 HT HIST1H2AH NPHP1 21565611 0007 HT MYH9 NPHP1 21565611 0004 HT FLNC NPHP1 21565611,21565611 0004,0007 HT RNH1 NPHP1 21565611,21565611 0004,0007 HT BAG2 NPHP1 21565611,21565611 0004,0007 HT KRT5 NPHP1 21565611 0004 HT PLEC NPHP1 21565611,21565611 0004,0007 HT NPHP1 NPHP1 21565611 0007 HT NPHP1 FBXO6 21565611 0004 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID A2APS1 A2AM57 NPHP1 INVS 0.126 21565611 P05213 A2APS1 TUBA1B NPHP1 0.126 21565611 P59240 A2APS1 NPHP4 NPHP1 0.126 21565611 P63038 A2APS1 HSPD1 NPHP1 0.126 21565611 P99024 A2APS1 TUBB5 NPHP1 0.126 21565611 Q3UM23 A2APS1 RNH1 NPHP1 0.126 21565611 O75161 A2APS1 NPHP4 NPHP1 0.126 21565611 Q8BP00 A2APS1 IQCB1 NPHP1 0.126 21565611