PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Rbck1 Eya4 20956555 biogrid exp G Eya1 Rbck1 20956555 intact exp Ikbkb Rbck1 19136968 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Chuk Rbck1 19136968 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eya2 Rbck1 20956555 intact exp G G G G G Rnf31 Rbck1 21455180,24461064,19136968,21455181,23942237 biogrid,intact,dip exp, ortho P Sharpin Rbck1 21455180,21455181,23942237 biogrid,intact,dip exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2l3 Rbck1 11722579,10431818 biogrid exp, ortho P Ikbkg Rbck1 19136968 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rbck1 Park2 ortho G G G G Traf6 Rbck1 ortho G G G G G G G G G G G G G G G G G G G G Tab3 Rbck1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2n Rbck1 ortho P Uhrf2 Rbck1 ortho Trim21 Rbck1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Pml Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G Triml1 Rbck1 ortho P Trim25 Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nr1i2 Rbck1 ortho G G G G G Naa10 Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d2 Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Irf3 Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp15 Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pcgf2 Rbck1 ortho G G G G G Otulin Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bach1 Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2v1 Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp7 Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k1 Rbck1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Ube2l6 Rbck1 ortho G G G G G G G G G Ube2d1 Rbck1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mkrn2 Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnfaip3 Rbck1 ortho G G G G G Nr2c2 Rbck1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkcz Rbck1 ortho G G G G G G G G G G G G G G G G G G G G G G Ltbr Rbck1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ldlrad4 Rbck1 ortho G Ubiquitin carboxyl-terminal hydrolase Rbck1 ortho P Usp21 Rbck1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp49 Rbck1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddx58 Rbck1 ortho P Ube2s Rbck1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Rbck1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Otub2 Rbck1 ortho G G G G G G G G G G G G Otud6a Rbck1 ortho Traf1 Rbck1 ortho G G G Trim65 Rbck1 ortho Birc3 Rbck1 ortho G G G G G G G G G G G G G G G G G G G G G G G G Nod2 Rbck1 ortho Syce1 Rbck1 ortho Socs6 Rbck1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d3 Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Crebbp Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkca Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G G Arnt2 Rbck1 ortho G G G G Rbck1 Uchl5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd4 Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d2b Rbck1 ortho P G Rnf181 Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Esr1 Rbck1 ortho G G G G G Ube2g1 Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ripk1 Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Ndufaf3 Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rbck1 Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tab2 Rbck1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ireb2 Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkcb Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Tssk3 Rbck1 ortho G Uba1 Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G App Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnf Rbck1 ortho Fkbpl Rbck1 ortho G G G G G G G G G G G G G G G G G G G Ube2u Rbck1 ortho Hsp90aa1 Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pan2 Rbck1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9WUB0 enzymatic study 25260751 direct interaction X 2 Q9WUB0 P97767-2 affinity chromatography technology 20956555 physical association X 2 Q9WUB0 O88522 affinity chromatography technology 19136968 physical association X 2 Q9WUB0 O88522 affinity chromatography technology 19136968 physical association X 2 Q9WUB0 O88522 enzymatic study 19136968 direct interaction X 2 Q9WUB0 Q3TPN9 affinity chromatography technology 19136968 physical association X 2 Q9WUB0 O88522 pull down 19136968 direct interaction X 2 Q9WUB0 O88522 affinity chromatography technology 19136968 physical association X 2 Q9WUB0 O14933-2 two hybrid 11722579 direct interaction X 2 Q9WUB0 Q924T7 affinity chromatography technology 24461064 physical association X 2 Q9WUB0 Q924T7 affinity chromatography technology 21455181 physical association X 2 Q9WUB0 Q924T7 affinity chromatography technology 21455181 physical association X 2 Q9WUB0 Q91WA6 affinity chromatography technology 21455181 physical association X 2 Q9WUB0 Q91WA6 affinity chromatography technology 21455181 physical association X 2 Q9WUB0 Q924T7 affinity chromatography technology 19136968 physical association X 2 Q9WUB0 Q924T7 affinity chromatography technology 19136968 physical association X 2 Q9WUB0 affinity chromatography technology 19136968 physical association X 2 P68037 Q9WUB0 two hybrid 11722579 direct interaction X 2 P68037 Q9WUB0 affinity chromatography technology 10431818 physical association X 2 P68037 Q9WUB0 two hybrid 10431818 direct interaction X 2 Q9WUB0 anti bait coimmunoprecipitation 21455180 physical association C 3 Q9WUB0 molecular sieving 21455180 physical association C 3 Q9WUB0 anti bait coimmunoprecipitation 21455181 physical association C 3 Q9WUB0 anti bait coimmunoprecipitation 21455180 physical association C 3 Q9WUB0 anti bait coimmunoprecipitation 21455180 physical association C 3 Q9WUB0 molecular sieving 21455180 physical association C 3 Q9WUB0 Q924T7 anti bait coimmunoprecipitation 21455181 physical association X 2 Q9WUB0 Q924T7 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9WUB0 Q924T7 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9WUB0 Q924T7 anti bait coimmunoprecipitation 21455181 physical association X 2 Q9WUB0 Q924T7 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9WUB0 Q924T7 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9WUB0 Q924T7 molecular sieving 21455180 physical association X 2 Q9WUB0 Q91WA6 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9WUB0 Q91WA6 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9WUB0 anti bait coimmunoprecipitation 23942237 association C 4 Q9WUB0 P97767 anti tag coimmunoprecipitation 20956555 physical association X 2 Q9WUB0 P97767 pull down 20956555 physical association X 2 Q9WUB0 O08575 pull down 20956555 physical association X 2 Q9WUB0 molecular sieving 23942237 association C 3

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9WUB0 O14933 RBCK1 UBE2L6 0.309 11722579 Q9WUB0 O88522 RBCK1 IKBKG 0.569 19136968 Q9WUB0 O88351 RBCK1 IKBKB 0.21 19136968 Q9WUB0 P97767 RBCK1 EYA1 0.507 20956555 Q9WUB0 Q91WA6 RBCK1 SHARPIN 0.61 21455181,23942237 Q9WUB0 P68037 RBCK1 UBE2L3 0.623 10431818,11722579 Q9WUB0 Q924T7 RBCK1 RNF31 0.757 21455181,19136968,24461064,23942237 Q9WUB0 O08575 RBCK1 EYA2 0.21 20956555