PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ccnd3 Aurka 22024926 biogrid exp G G G G G G G G G G G G G G Aurka Srsf1 23663783 intact exp G G G G G G G G G G G G G G Aurka Sirt2 22014574 biogrid exp G G G G G G G G G G G G G G Aurka Fbxl7 22306998 biogrid exp Aurka Srsf2 23663783 intact exp G G G G G G G G G G G G G G H3f3a, H3f3b Aurka 21274965 biogrid exp Aurka Chfr 15793587 biogrid exp, ortho G G G G G G G G G G G G G G Setd2 Aurka ortho Tp53 Aurka ortho G G G G G G G G G G G G G G Aurka Cdc20 ortho G G G G G G G G G G G G G Rpl23 Aurka ortho Srpk2 Aurka ortho G G G G G G G G G G G G G G Tubg1 Aurka ortho G G G G G G G G G G G G G G Hsp90aa1 Aurka ortho G G G G G G G G G G G G G G Aurka Dab2 ortho G G G G G G G G G G G G G Aurka Bora ortho Aurka Hars2 ortho G G G G G G G G G G G G G G Aurkb Aurka ortho G G G G G G G G G G G G Aurka Angptl4 ortho G G G G G G G G G G G G Bard1 Aurka ortho Aurka Dicer1 ortho G G G G G G G G G G G G G Usp2 Aurka ortho G G G G G G G G G G Jun Aurka ortho G G G G G G G G G G G G G Aurka Ttc4 ortho G G G G G G G G G G G G G G Aurka Gsk3b ortho G G G G G G G G G G G G G G Aurka Taf9 ortho Aurka Osbpl3 ortho Aurka Skp1 ortho G G G G G G G G G G G G G G Ctps1 Aurka ortho G G G G G G G G G G G G G G Aurka Snw1 ortho G G G G G G G G G G G G G G Hspa2 Aurka ortho G G G G G G G G G G G Aurka Ascc1 ortho G G G G G G G G G G G G G G Aurka Mrps35 ortho G G G G G G G G G G G G G G Aurka Hnrnpu ortho G G G G G G G G G G G G G G Aurka Eprs ortho G G G G G G G G G G G G G G Aurka Cdkn2a ortho Aurka Nap1 ortho Aurka Mrpl24 ortho G G G G G G G G G G G G G G Mycn Aurka ortho G G G Rps14 Aurka ortho G G G G G G G G G G G G G G Lig1 Aurka ortho G G G G G G G G G G G G G G Aurka Sirt7 ortho G G G G G G G G G G G G G G Tpx2 Aurka ortho G G G G G G G G G G G G G Aurka Epsti1 ortho G G G G G G G G G G G G G G Mcm3 Aurka ortho G G G G G G G G G G G G G Aurka Hemgn ortho G G G Vhl Aurka ortho G G G G G G G G G G G G G Aurka Rpl11 ortho G G G G G G G G G G G G G G Mcm6 Aurka ortho G G G G G G G G G G G G G G Nat1 Aurka ortho Lef1 Aurka ortho G G G Aurka Hmmr ortho G G G G G G G G G G G G Aurka Zswim8 ortho Aurka Ppp6r2 ortho G G G G Aurka Arfgap1 ortho G G G G G G G G G G G G G G Aurka Mrpl28 ortho G G G G G G G G G G G G G G Aurka Ilf3 ortho G G G G G G G G G G G G G G Aurka Ppp6c ortho G G G G G G G G G G G G G G Dcaf7 Aurka ortho Aurka Incenp ortho G G G G G G G G G G G G Aurka Errfi1 ortho G G G G G G G G G G G G G G Aurka Chuk ortho G G G G G G G G G G G G G G Aurka Pask ortho G G G G Psmb7 Aurka ortho G G G G G G G G G G G G G G Aurka Aurka ortho G G G G G G G G G G G G G G Aurka Wif1 ortho G G Aurka Arpc2 ortho G G G G G G G G G G G G G G App Aurka ortho G G G G G G G G G G G G G G Hnrnpk Aurka ortho G G G G G G G G G G G G G G Ppp1cb Aurka ortho G G G G G G G G G G G G G G Hnrnpa2b1 Aurka ortho G G G G G G G G G G G G G G Aurka Mapre3 ortho G G G G G G G G G Aurka Uqcc2 ortho G G G G G G G G G G G G G G Ccnf Aurka ortho G G G G G G G G G G G Srpk1 Aurka ortho G G G G G G G G G G G G G G Aurka Coro2a ortho G G G G G G G G G G G G Rps16 Aurka ortho Aurka Kirrel2 ortho Aurka Rqcd1 ortho G G G G G G G G G G G G G G Aurka Ric3 ortho Aurka Tnrc6c ortho G G G G G G G G G G G G G G Aurka Klf4 ortho G G G G G G G G G G G G G G Ckap5 Aurka ortho G G G G G G G G G G G G G G Aurka Fbxw7 ortho G G G G G G G G G G G G G G Aurka Baat ortho Aurka Plk4 ortho G G G G G G G G G G G G Wee1 Aurka ortho G G G G G G G G G G G G G G Rps10 Aurka ortho G G G G G G G G G G G G G G Aurka Pdlim2 ortho G G G G G G G G G G G G G G Ezr Aurka ortho G G G G G G G G G G G G G G Aurka Plk1 ortho G G G G G G G G G G G G G Aurka Hnrnpd ortho G G G G G G G G G G G G G G Bub1 Aurka ortho G G G G G G G G G G G G Aurka Mapre1 ortho G G G G G G G G G G G G G G Ppp1ca Aurka ortho G G G G G G G G G G G G G G Hspd1 Aurka ortho G G G G G G G G G G G G G G Rplp0 Aurka ortho G G G G G G G G G G G G G G Hspa9 Aurka ortho G G G G G G G G G G G G G G Ybx1 Aurka ortho G G G G G G G G G G G G G G Aurka Igf2bp3 ortho G G Tgfb1 Aurka ortho G G G G G G G G G G G G Aurka Mcm7 ortho G G G G G G G G G G G G G G Rel Aurka ortho G G G G Aurka Kif2c ortho G G G G G G G G G G G G Aurka Cep128 ortho Znf239 Aurka ortho G G G G G G G G G G G G Aurka Osbpl6 ortho G G G G G G G G G G G G G G Ikbkg Aurka ortho G G G G G G G G G G G G G Aurka Nek4 ortho G G G G G G G G G G G Ube2n Aurka ortho Aurka Larp1 ortho G G G G G G G G G G G G G G Aurka Kif11 ortho G G G G G G G G G G Fth1 Aurka ortho G G G G G G G G G G G G G G Tyms Aurka ortho G G Aurka Dlgap5 ortho G G G G G G G G Aurka Arpc1b ortho Aurka Pum2 ortho G G G G G G G G G G G G G G Aurka Psma1 ortho G G G G G G G G G G G G G G Aurka Rassf1 ortho G G G G G G G G G G G G G G Protein Rasa1 Aurka ortho G G G G G G G G G G G G G G Aurka Ccne2 ortho G G G G G G G G G G Aurka Wapal ortho Dgcr14 Aurka ortho G G G G G G G G G Aurka Snx18 ortho G G G G G G G G G G G G G G Srp9 Aurka ortho G G G G G G G G G G G G G G Aurka Wdr62 ortho G Prkaca Aurka ortho G G G G G G G G G G G G G G Aurka Cntrob ortho G G G G G G G G G G G G G G Aurka Kallikrein 1-related peptidase b5, Kallikrein related-peptidase 5 ortho Ywhae Aurka ortho G G G G G G G G G G G G G G Aurka Hdac6 ortho G G G G G G G G G G G G G Cdc25b Aurka ortho G G G G G G G G G G G Aurka Cdk8 ortho G G G G G G G G G G G G G G Aurka Ncor2 ortho G G G G G G G G G G G G G G Ctnnd1 Aurka ortho G G G G G G G G G G G G G Cdk4 Aurka ortho G G G G G G G G G G G G G G Ube2i Aurka ortho G G G G G G G G G G G G G G Aurka Aurkaip1 ortho G G G G G G G G G G G G G G Aurka Xpa ortho G G G G G G G G G G G G Aurka Ik ortho G G G G G G G G G G G G G G Sssca1 Aurka ortho G G G G G G G G G G G G G G Rps11 Aurka ortho G G G G G G G G G G G G G G Aurka Ncapd2 ortho G G G G G G G G G G G G Aurka Scyl1 ortho G G G G G G G G G G G G G G Aurka Lrpprc ortho G G G G G G G G G G G G G G Aurka Zwint ortho G G G G G G G G G G G G G G Rps3 Aurka ortho G G G G G G G G G G G G G G Aurka Scgb3a1 ortho G G G G Aurka Xpo1 ortho G G G G G G G G G G G G G G Aurka Chmp5 ortho G G G G G G G G G G G G G G Aurka Stk39 ortho G G G G G G G G G G G G Rps6 Aurka ortho G G G G G G G G G G G G G G Rpia Aurka ortho G G G G G G G G G G G G G G Aurka S100a14 ortho G G G Aurka Mbd3 ortho G G G G G G G G G G G G G G Aurka Med16 ortho G G G G G G G G G G G G G G Aurka Csnk2a1 ortho G G G G G G G G G G G G G G Jtb Aurka ortho G G G G G G G G G G G G G G Aurka Rfc4 ortho G G G G G G G G G G G G G Tfap2a Aurka ortho G Aurka Cdkn3 ortho Aurka Ppp3r2 ortho Mdm2 Aurka ortho G G G G G G G G G G G G G G Tnks1bp1 Aurka ortho G G G G G G G G G Aurka Pttg1 ortho G G G G G G G G G G G G G G Cdk1 Aurka ortho G G G G G G G G G G G G G Aurka Mecr ortho G G G G G G G G G G G G G Nfkb1 Aurka ortho G G G G G G G G G G G G G G Igfbp3 Aurka ortho G G G G G G G G G G G G G Eef1a2 Aurka ortho G G G G G G G G G G G G G G Plk2 Aurka ortho G G G G G G G G G G G G Aurka Heatr5b ortho Aurka Larp7 ortho G G G G G G G G G G G G G G Brca1 Aurka ortho G G G G G G G G G G G Aurka Protein Zmym1, Zinc finger, MYM domain containing 1, isoform CRA_b ortho G G G G G G G G G G G G G G Aurka Egfr ortho G G G G G G G G G Wrn Aurka ortho G G G G G G G G G G G G Aurka Dkk3 ortho G G G G G G G G G Aurka Ilf2 ortho G G G G G G G G G G G G G G Aurka Smc2 ortho G G G G G G G G G G G G G Fbp2 Aurka ortho G G G G G G G Rpl27 Aurka ortho G G G G G G G G G G G G G G Aurka Iars ortho G G G G G G G G G G G G G G Aurka Lats2 ortho G G G G G G G G G G G G G G Aurka Tlk1 ortho Aurka Nuf2 ortho G G G G G G G G G G G G Aurka Fbn2 ortho G G G G G Aurka Synrg ortho G G G G G G G G G G Psmc3ip Aurka ortho G G G G G G G Aurka Peak1 ortho G G G Aurka Mtmr4 ortho G G G G G G G G G G G G G G Elof1 Aurka ortho G G G G G G G G G G G G G G Rps5 Aurka ortho G G G G G G G G G G G G G G Fen1 Aurka ortho G G G G G G G G G G G G G G Aurka Cdc37 ortho G G G G G G G G G G G G G G Dhx9 Aurka ortho G G G G G G G G G G G G G G Usp9x Aurka ortho G G G G G G G G G G G G G G Aurka Wdr35 ortho Aurka Cnot7 ortho G G G G G G G G G G G G G G Aurka Snx9 ortho G G G G G G G G G G G G G G Cdc25a Aurka ortho G G G G G G G G G G G G G G Pfkm Aurka ortho G G G G G G G G G G G G G G Aurka Mrpl16 ortho G G G G G G G G G G G G G G Aurka Mrps22 ortho G G G G G G G G G G G G G G Aurka Cnot2 ortho G G G G G G G G G G G G G G Tlk2 Aurka ortho G G G G G G G G G G G G G G Aurka Prrc2c ortho Sod2 Aurka ortho G G G G G G G G G G G G G G Aurka Mta3 ortho G G G G G G G G G G G G G G Ppp2cb Aurka ortho G G G G G G G G G G G G G G Erbb2 Aurka ortho G G G G G G G Calu Aurka ortho G G G G G G G G G G G G G G Ncl Aurka ortho G G G G G G G G G G G G G G Aurka Magi2 ortho G G G Nme1 Aurka ortho G G G G G G G G G G G G G G Aurka Atg2a ortho G G G G G G G G G G G G G G Hdac2 Aurka ortho G G G G G G G G G G G G G G Cdc25c Aurka ortho G G G Rpl12 Aurka ortho G G G G G G G G G G G G G G Aurka Limd1 ortho G G G G G G G G G G G G G G Aurka Btrc ortho G G G G G G G G G G G G G G Aurka Tacc3 ortho G G G G G G G G G G Aurka Cep131 ortho G Aurka Psma6 ortho G G G G G G G G G G G G G G Aurka Sfrp4 ortho G G G G G G G G G G G G G Pten Aurka ortho G G G G G G G G G G G G G G Hspa5 Aurka ortho G G G G G G G G G G G G G G Aurka Rps19 ortho G G G G G G G G G G G G G G Tarbp2 Aurka ortho G G G G G G G G G G G G G G Aurka Ndc80 ortho G G G G Aurka Trim28 ortho G G G G G G G G G G G G G G Cdk2 Aurka ortho G G G G G G G G G G G G G G Aurka Uba1 ortho G G G G G G G G G G G G G G Ikbkb Aurka ortho G G G G G G G G G G G G G G Aurka Mfap4 ortho G G G G G G Aurka Tp73 ortho G Aurka Ptpn23 ortho G G G G G G G G G Cbx3 Aurka ortho G G Aurka Ube2c ortho G G G G G G G G G G G G G Hsp90ab1 Aurka ortho G G G G G G G G G G G G G G Aurka Itpkc ortho Aurka Ppp6r3 ortho G G G G G G G G G G G G G G Aurka Psrc1 ortho G G G G G G G G G Tuba1c Aurka ortho Cit Aurka ortho Cks2 Aurka ortho G G G G G G G G G G G G G G Aurka Mapk6 ortho G G G G G G G G G G G G G Kif16b Aurka ortho G G G G G G G G G G G G G G Rpl30 Aurka ortho Protein Mki67 Aurka ortho G G G G G G G G G G G G G Aurka Thrsp ortho G G G G G G G G G G Aurka Spag5 ortho G G G G G G G Aurka Usp47 ortho G G G G G G G G G G G G G G Aurka N-acetylneuraminic acid synthase (Sialic acid synthase), Protein Nans ortho G G G G G G G G G G G G G G Aurka Rpl38 ortho G G G G G G G G G G G G G G Ppp1cc Aurka ortho G G G G G G G G G G G G G G Rab10 Aurka ortho G G G G G G G G G G G G G G Aurka Cdh13 ortho G G G G G G Aurka Cdc7 ortho G G G G G G G G G G G Sdccag3 Aurka ortho G G G G G G G G G G G G G Pcna Aurka ortho G G G G G G G G G G G G G G Eef2 Aurka ortho G G G G G G G G G G G G G G Aurka Nfkbia ortho G G G G G G G G G G G G G G Hspa8 Aurka ortho G G G G G G G G G G G G G G Ube2l3 Aurka ortho Aurka Top2a ortho G G G G G G G G G G G G G Aurka Stx17 ortho G G G G G G G G G G G G G G Akt1 Aurka ortho G G G G G G G G G G G G G G Ccna2 Aurka ortho G G G G G G G G G G G G G Bcl2l11 Aurka ortho G G G G G G G G G G G G G G Ttk Aurka ortho G G G G G G G G Aurka Mllt4 ortho Rpl22 Aurka ortho G G G G G G G G G G G G G G Birc5 Aurka ortho G G G G G G G G G G G G Nedd9 Aurka ortho G G G G G G G G G G G G G Aurka Npm1 ortho G G G G G G G G G G G G G G Aurka Tars ortho G G G G G G G G G G G G G G Tbc1d2 Aurka ortho Aurka Mapkapk3 ortho Aurka Melk ortho G G G G G G G G G G G Aurka Fabp5 ortho G G G G G G G G G G G G G G Aurka Mtmr3 ortho G G G G G G G G G G G G G G Map2k1 Aurka ortho G G G G G G G G G G G G G G Aurka Tstd2 ortho Aurka Ctnnb1 ortho G G G G G G G G G G G G G G Aurka Calcoco1 ortho Sorl1 Aurka ortho G G G G G G G G G G G G G G Aurka Vrk1 ortho G G G G G G G G G G G G G Gadd45a Aurka ortho G G G G G G G G G G G G G Aurka Gapvd1 ortho Aurka Ranbp3 ortho G G G G G G G G G G G G G G Hist1h3b, Hist1h3c, Hist1h3d, Hist1h3e, Hist1h3f, Hist2h3b, Hist2h3c1, Hist2h3c2 Aurka ortho G G Aurka Gtf3c2 ortho G G G G G G G G G G G G G G Aurka Cep55 ortho G G G G G G G G G G G G Aunip Aurka ortho Prkcsh Aurka ortho G G G G G G G G G G G G G G Igf2bp1 Aurka ortho G Gmnn Aurka ortho G G G G G G G G G G G G G G Aurka Pml ortho G G G G G G G G G G G G Aurka Matr3 ortho G G G G G G G G G G G G G G Aurka Bub1b ortho G G G G G G G G G G G G Aurka Fbxo30 ortho Aurka Ddb1 ortho G G G G G G G G G G G G G G Aurka Sec61b ortho G G G G G G G G G G G G G G Protein Cep192 Aurka ortho Aurka Tacc1 ortho Aurka Zfp189 ortho G Eps15 Aurka ortho G G G G G G G G G G G G G G Ccnb2 Aurka ortho G G G G G G G G G G G G Pdcd6 Aurka ortho G G G G G G G G G G G G G G Aurka Nin ortho G G G G G G G G Eef1a1 Aurka ortho G G G G G G G G G G G G G G Aurka Tubb5 ortho G G G G G G G G G G G G G G Psmb5 Aurka ortho G G G G G G G G G G G G G G Aurka Ddx5 ortho G G G G G G G G G G G G G G Tubb4b Aurka ortho G G G G G G G G G G G G G G Aurka Amer1 ortho Aurka Rplp2 ortho G G G G G G G G G G G G G G Csn2 Aurka ortho G G Aurka Sh3gl1 ortho G G G G G G G G G G G G G G Aurka Cnot8 ortho G G G G G G G G G G G G G G Aurka Lypd3 ortho G G Aurka Psma5 ortho G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P97477 P04198 anti tag coimmunoprecipitation 23792191 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Ccnd3 Aurka MI:0415(enzymatic study) 22024926 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_323631 bait prey Aurka Chfr MI:0004(affinity chromatography technology) 15793587 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_316007 prey bait Aurka Sirt2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22014574 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_326194|BIOGRID_326193 bait|prey prey|bait Aurka Fbxl7 MI:0096(pull down) 22306998 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_328991 prey bait Aurka H3f3a MI:0004(affinity chromatography technology) 21274965 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_315899 prey bait

PPI - HINT Gene A Gene B PMID Method Quality AURKA FBXL7 22306998 0415 LC AURKA CHFR 15793587,15793587 0096,0415 LC NEDD9 AURKA 24574519 0004 LC CCND3 AURKA 22024926 0004 LC H3F3A|H3F3B AURKA 21274965 0004 LC AURKA CTTN 24574519 0004 LC AURKA CHFR 15793587,15793587 0096,0415 LC AURKA SIRT2 22014574 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5BJ29 P97477 FBXL7 AURKA 0.309 22306998 P97477 P04198 AURKA MYCN 0.376 23792191,25533335 Q810L3 P97477 CHFR AURKA 0.523 15793587 P97477 P30282 AURKA CCND3 0.21 22024926 P97477 P84244 AURKA H3F3B 0.21 21274965 P97477 O35177 AURKA NEDD9 0.376 24574519 Q60598 P97477 CTTN AURKA 0.21 24574519 Q8VDQ8 P97477 SIRT2 AURKA 0.236 22014574