PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Eps15 Ap2b1 9182572 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Ywhae 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Sgip1 17626015 intact exp G G G G G G G Eps15 Eps15l1 9446614 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Egfr 16862145,10953014 biogrid,mint,intact exp, ortho GP G G G G G G G G G G G G G G G G G Ap2a2 Eps15 12057195,10430869 mint,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Agfg1 9303539 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Park2 20064468 biogrid exp, ortho G G G G Eps15 Numb 9303539 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Eps15 9182572,18154663 biogrid,mint,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Dab2 22648170 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Itsn1 10064583 biogrid,mint,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Ap2a1 Eps15 17626015 intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Ube2e1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Scamp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Synj1 ortho P Eps15 Gtse1 ortho G G G G G Hspa1l Eps15 ortho P G G G Eps15 Epn2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Myh9 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gria1 Eps15 ortho G G G G G G G G Eps15 Myo19 ortho G G G G G G G G G G G G G G G Vcam1 Eps15 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Krt14 ortho GP G G G G G G Eps15 Laptm5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Erbb2 ortho P G G G G G G G G G G G G Eps15 Ube2d2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dnm2 Eps15 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa9 Eps15 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Numbl Eps15 ortho G G G G G G G G G G G G G G G G G G G G G Eps15 Usp8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Itga4 ortho G G G G Eps15 Vprbp ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gja1 Eps15 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Krt32 ortho P G G G G G G Eps15 Eps8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Mapre1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Hip1r ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Elavl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Kpnb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Nagpa ortho P Eps15 Ubqln1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Rps6ka5 ortho Eps15 Ubqln2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Stambp ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Ube2d3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fn1 Eps15 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Cltb ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Eps15 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dnm1 Eps15 ortho GP G G G G G G G G G G G G G G G G G G G G G Ap1b1 Eps15 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Krt86 ortho G Eps15 Gak ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Cct3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Tubb5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Epn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Slc25a41 ortho Traf2 Eps15 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Bcr ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Clint1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Eps15 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Reps2 ortho P Eps15 Actb ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Fcho2 ortho P Eps15 Epha2 ortho G G G G G G G G G G G G G G G G G G Eps15 Cltc ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Flna ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cd4 Eps15 ortho G G Eps15 Nck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Eps15 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tfap2a Eps15 ortho G G G G G G Eps15 Krt79 ortho GP G G G G G Eps15 Cdc40 ortho P Eps15 Ube2h ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Hgs ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Krt16 ortho P G G Eps15 Picalm ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Xpo1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Tmem17 ortho Eps15 Anln ortho G G G G G G G G G G G G G G G G G G G G G G Eps15 Spc25 ortho G G G G G G G G G G G G G G G G G G G Krt36 Eps15 ortho P Eps15 Pdlim7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Rabl6 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Agfg2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Krt17 ortho P G Eps15 Krt73 ortho P Krt1 Eps15 ortho P G G G G G G G G Eps15 Epn3 ortho P G G G G G G G G G G Eps15 Krt35 ortho Eps15 Ap2m1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Crkl ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Ocln ortho G G G G G G G G G G G G G G G G G G G G G G Eps15 Krt82 ortho Eps15 Vsig8 ortho Eps15 Krt5 ortho GP G G G G G G G G Eps15 Iqgap1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa5 Eps15 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Sh3bp4 ortho GP G G G G G G G G G G G G G G G G Eps15 Optn ortho Tgfb1 Eps15 ortho G G G G G G G G G G G G G G G G G G G G G Eps15 Rad23a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Ntrk1 ortho Eps15 Grb2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Ppp1cb ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Ap2s1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rab11fip2 Eps15 ortho Eps15 Bmp2k ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Pccb ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Krt75 ortho P Eps15 Mob4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Nme2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Krt34 ortho Eps15 Ston2 ortho Fyn Eps15 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Hspa8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Necap2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Necap1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Syt1 ortho P G G G G G G G G G Eps15 Lima1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Slc6a3 ortho G Eps15 Grb7 ortho GP G G G G G G G G G G G G G G G G G G Eps15 Synpo ortho P G G G G G G G G G G G G G G G G G G G G G Map4 Eps15 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Mccc2 ortho GP G G G G G G G G G G G G G G G G G G G G G G Eps15 Crk ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prdx1 Eps15 ortho P Eps15 Snap91 ortho P G G G G G G G G G G G Abl1 Eps15 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Tfrc ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Hist1h4a, Hist1h4b, Hist1h4c, Hist1h4d, Hist1h4f, Hist1h4h, Hist1h4i, Hist1h4j, Hist1h4k, Hist1h4m, Hist2h4a, Hist4h4 ortho P G G G G G G G G G G G G G G Eps15 Capza2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Krt83 ortho G Krt4 Eps15 ortho P G G G G Eps15 Aurka ortho G G G G G G G G G G G G G G Eps15 Nono ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Ston1 ortho Eps15 Dbn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Itsn2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Elf3 ortho G G G G G G G G G G G G G G G G G G G G Eps15 Ube2d1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P42567 coimmunoprecipitation 12551915 association C 3 P42567 coimmunoprecipitation 12551915 association C 3 P42567 P63048 surface plasmon resonance 16462748 direct interaction X 2 P42567 cosedimentation 16615898 colocalization C 1216 P42567 anti bait coimmunoprecipitation 17626015 association C 3 P42567 confocal microscopy 17626015 colocalization C 3 P98078 P42567 pull down 22648170 direct interaction X 2 P98078 P42567 pull down 22648170 direct interaction X 2 P42567 Q9Z0R4 two hybrid 10064583 physical association X 2 P42567 Q9Z0R4 fluorescence microscopy 10064583 colocalization X 2 P42567 Q9Z0R4 coimmunoprecipitation 10064583 physical association X 2 P42567 Q8NFH8 pull down 18154663 physical association X 2 P42567 Q8NFH8 pull down 18154663 physical association X 2 P42567 P42567 pull down 18154663 physical association X 2 P42567 P42567 pull down 18154663 physical association X 2 P42567 P42567 pull down 18154663 physical association X 2 P42567 P42567 pull down 18154663 physical association X 2 P42567 Q8NFH8 pull down 18154663 physical association X 2 P42567 Q8NFH8 peptide array 18154663 direct interaction X 2 P42567 Q8NFH8 peptide array 18154663 direct interaction X 2 P42567 Q8NFH8 peptide array 18154663 direct interaction X 2 P42567 Q8NFH8 peptide array 18154663 direct interaction X 2 P42567 Q8NFH8 pull down 18154663 physical association X 2 P42567 Q8NFH8 pull down 18154663 physical association X 2 P42567 Q8NFH8 pull down 18154663 physical association X 2 A5PKW4 P42567 pull down 20339350 physical association X 2 Q60902 P42567 coimmunoprecipitation 9446614 physical association X 2 Q60902 P42567 coimmunoprecipitation 9446614 physical association X 2 P17427 P42567 pull down 10430869 direct interaction X 2 P17427 P42567 pull down 12057195 physical association X 2 P17427 P42567 x-ray crystallography 12057195 direct interaction X 2 P0CG48 P42567 surface plasmon resonance 12750381 direct interaction X 2 Q01279 P42567 anti tag coimmunoprecipitation 10953014 phosphorylation reaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Eps15 Agfg1 MI:0027(cosedimentation)|MI:0686(unspecified method) 16615898,9303539 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association) (intact)|(biogrid) UniProt_167131|BIOGRID_311960 neutral component|prey neutral component|bait Eps15 Eps15l1 MI:0027(cosedimentation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation) 16615898,9446614 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_167131|UniProt_176344|UniProt_176345 neutral component|bait|prey neutral component|prey|bait Eps15 Itsn1 MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0416(fluorescence microscopy)|MI:0004(affinity chromatography technology)|MI:0027(cosedimentation)|MI:0416(fluorescence microscopy)|MI:0004(affinity chromatography technology)|MI:0019(coimmunoprecipitation)|MI:0416(fluorescence microscopy) 10064583,16615898 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|MI:0471(mint)|(biogrid)|(intact)|MI:0471(mint)|(biogrid)|(intact)|MI:0471(mint) UniProt_161637|UniProt_161635|MINT_78111|BIOGRID_322806|UniProt_167131|MINT_59123|BIOGRID_322807|UniProt_161633|MINT_78112 neutral component|prey|prey|prey|neutral component|neutral component|bait|prey|prey neutral component|bait|bait|bait|neutral component|neutral component|prey|bait|bait Eps15 Dab2 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 22648170 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(intact) UniProt_173977|UniProt_173978 bait|unspecified role prey|prey Ap2a2 Eps15 MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0114(x-ray crystallography)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0114(x-ray crystallography)|MI:0096(pull down)|MI:0096(pull down) 10430869,12057195,16615898 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|(intact)|MI:0471(mint)|(intact)|(intact) UniProt_167131|UniProt_167130|UniProt_167136|UniProt_167135|UniProt_71024|UniProt_71033|UniProt_181755|MINT_58231|MINT_58238|UniProt_181746|UniProt_163522|UniProt_181418|MINT_58239|UniProt_163531|UniProt_160950 neutral component|neutral component|neutral component|neutral component|bait|unspecified role|unspecified role|bait|unspecified role|bait|bait|bait|bait|unspecified role|bait neutral component|neutral component|neutral component|neutral component|prey|unspecified role|unspecified role|prey|unspecified role|prey|prey|prey|prey|unspecified role|prey Eps15 Ap2b1 MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0096(pull down) 16615898,9182572 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0403(colocalization)|MI:0915(physical association) (intact)|(intact)|(biogrid) UniProt_167131|UniProt_167130|BIOGRID_311921 neutral component|neutral component|prey neutral component|neutral component|bait Eps15 Numb MI:0686(unspecified method) 9303539 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_311959 prey bait Eps15 Egfr MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation) 10953014,16862145 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0217(phosphorylation reaction)|MI:0915(physical association)|MI:0217(phosphorylation reaction) MI:0471(mint)|(biogrid)|(intact) MINT_57920|BIOGRID_312516|UniProt_161843 unspecified role|prey|unspecified role unspecified role|bait|unspecified role

PPI - HINT Gene A Gene B PMID Method Quality AP2A2 EPS15 12057195,12057195 0114,0096 LC EPS15 EPS15 9182572,9182572 0096,0401 LC EPS15 YWHAE 16615898 0027 LC EPS15 EPS15L1 9446614 0019 LC EPS15 ITSN1 10064583,10064583,10064583,10064583 0004,0019,0416,0018 LC AP2A1 EPS15 17626015 0663 LC AP2A2 EPS15 12057195,10430869,12057195 0114,0096,0096 LC GJA1 EPS15 25605500 0004 LC EPS15 EPS15 18154663,9182572,9182572 0096,0096,0401 LC EPS15 DAB2 22648170 0096 LC EPS15 EGFR 10953014,16862145 0007,0004 LC EPS15 AGFG1 9303539 0004 LC EPS15 SGIP1 17626015 0006 LC EPS15 AP2B1 9182572 0004 LC EPS15 Q9EQR1 16862145 0004 LC EPS15 NUMB 9303539 0004 LC EPS15 PARK2 20064468 0096 LC EPS15 ITSN1 10064583,10064583,10064583,10064583 0004,0019,0416,0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P42567 P23242 EPS15 GJA1 0.21 25605500 P62259 P42567 YWHAE EPS15 0.081 16615898 Q8K2K6 P42567 AGFG1 EPS15 0.21 9303539 P42567 P0CG48 EPS15 UBC 0.309 12750381 P42567 O95782 EPS15 AP2A1 0.309 12057195 Q8NFH8 P42567 REPS2 EPS15 0.454 18154663 Q01279 P42567 EGFR EPS15 0.236 16862145,10953014 P42567 O60508 EPS15 CDC40 0.523 9303539 P42567 O95081 EPS15 AGFG2 0.523 9303539 P42567 O95208 EPS15 EPN2 0.523 9303539 P49757 P42567 NUMB EPS15 0.523 9303539 P52594 P42567 AGFG1 EPS15 0.523 9303539 Q9Y6R0 P42567 NUMBL EPS15 0.523 9303539 P42567 P42567 EPS15 EPS15 0.569 9182572,18154663 Q9DBG3 P42567 AP2B1 EPS15 0.21 9182572 Q9QZS3 P42567 NUMB EPS15 0.21 9303539 P62990 P42567 UBA52 EPS15 0.309 16462748 P42567 A5PKW4 EPS15 PSD 0.21 20339350 Q9Z0R4 P42567 ITSN1 EPS15 0.623 10064583 P42567 O60260 EPS15 PARK2 0.21 16862145 Q9WVS6 P42567 PARK2 EPS15 0.309 20064468 Q05193 P42567 DNM1 EPS15 0.309 11483962 Q60902 P42567 EPS15L1 EPS15 0.376 9446614 P42567 P17427 EPS15 AP2A2 0.623 12057195,10430869