PTM - CPLM Gene Name UniProt ID Type Position Code Eps15 P42567 Ubiquitination 227 K Eps15 P42567 Ubiquitination 386 K Eps15 P42567 Ubiquitination 449 K Eps15 P42567 Ubiquitination 472 K Eps15 P42567 Ubiquitination 638 K Eps15 P42567 Ubiquitination 795 K Eps15 P42567 Ubiquitination 803 K Eps15 P42567 Ubiquitination 818 K Eps15 P42567 Ubiquitination 820 K

PTM - dbPAF Gene Name UniProt ID Position Type Species Eps15 P42567 106 S Mus musculus(Mouse) Eps15 P42567 107 S Mus musculus(Mouse) Eps15 P42567 108 S Mus musculus(Mouse) Eps15 P42567 113 S Mus musculus(Mouse) Eps15 P42567 140 S Mus musculus(Mouse) Eps15 P42567 221 S Mus musculus(Mouse) Eps15 P42567 242 Y Mus musculus(Mouse) Eps15 P42567 321 T Mus musculus(Mouse) Eps15 P42567 323 S Mus musculus(Mouse) Eps15 P42567 324 S Mus musculus(Mouse) Eps15 P42567 367 T Mus musculus(Mouse) Eps15 P42567 561 S Mus musculus(Mouse) Eps15 P42567 562 S Mus musculus(Mouse) Eps15 P42567 574 S Mus musculus(Mouse) Eps15 P42567 586 T Mus musculus(Mouse) Eps15 P42567 662 T Mus musculus(Mouse) Eps15 P42567 670 S Mus musculus(Mouse) Eps15 P42567 681 S Mus musculus(Mouse) Eps15 P42567 747 S Mus musculus(Mouse) Eps15 P42567 748 S Mus musculus(Mouse) Eps15 P42567 750 S Mus musculus(Mouse) Eps15 P42567 751 S Mus musculus(Mouse) Eps15 P42567 764 S Mus musculus(Mouse) Eps15 P42567 766 S Mus musculus(Mouse) Eps15 P42567 779 T Mus musculus(Mouse) Eps15 P42567 781 T Mus musculus(Mouse) Eps15 P42567 798 S Mus musculus(Mouse) Eps15 P42567 799 S Mus musculus(Mouse) Eps15 P42567 8 S Mus musculus(Mouse) Eps15 P42567 816 S Mus musculus(Mouse) Eps15 P42567 850 Y Mus musculus(Mouse) Eps15 P42567 852 S Mus musculus(Mouse)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA P42567 S106-p Phosphorylation PPPRFHDsssPLLTs P42567 S107-p Phosphorylation PPRFHDsssPLLTsG P42567 S108-p Phosphorylation PRFHDsssPLLTsGP P42567 S113-p Phosphorylation sssPLLTsGPSVAEL P42567 S221-p Phosphorylation KRKTWVVsPAEKAkY P42567 Y242-p Phosphorylation TDKDMDGyVSGLEVR P42567 T321-p Phosphorylation SSLQKNItGSsPVAD P42567 S324-p Phosphorylation QKNItGSsPVADFSA P42567 S561-p Phosphorylation HQESSVRssPEIAPS P42567 S562-p Phosphorylation QESSVRssPEIAPSD P42567 S764-p Phosphorylation PMLEETAsKSEDVPP P42567 T779-p Phosphorylation ALPPKVGtPtRPCPP P42567 T781-p Phosphorylation PPKVGtPtRPCPPPP P42567 S798-p Phosphorylation RPINkLDssDPLkLN P42567 S799-p Phosphorylation PINkLDssDPLkLND P42567 S816-p Phosphorylation QPFPGNDsPkEkDPD P42567 Y850-p Phosphorylation NFANFSAyPsEEDMI P42567 S852-p Phosphorylation ANFSAyPsEEDMIEW P42567 K227-ub Ubiquitination VsPAEKAkYDEIFLK P42567 K386-ub Ubiquitination RESINLQkLQAQKQQ P42567 K449-ub Ubiquitination SYEEELLkAREELSR P42567 K472-ub Ubiquitination EESVESGkAQLEPLQ P42567 K638-ub Ubiquitination FKDDPFGkIDPFGGD P42567 K648-ub Ubiquitination PFGGDPFkGSDPFAS P42567 K795-ub Ubiquitination PGKRPINkLDssDPL P42567 K803-ub Ubiquitination LDssDPLkLNDPFQP P42567 K818-ub Ubiquitination FPGNDsPkEkDPDMF P42567 K820-ub Ubiquitination GNDsPkEkDPDMFCD

PTM - dbPTM UniProt ID Position Code Type Resources References P42567 106 S Phosphorylation Swiss-Prot 1010711 17242355 P42567 324 S Phosphorylation Swiss-Prot 1010711 17242355 P42567 561 S Phosphorylation Swiss-Prot 1010711 17242355 P42567 562 S Phosphorylation Swiss-Prot 1010711 17242355 P42567 779 T Phosphorylation Swiss-Prot 1010711 19144319 P42567 781 T Phosphorylation Swiss-Prot 1010711 17242355 P42567 816 S Phosphorylation Swiss-Prot 1010711 19144319 P42567 850 Y Phosphorylation Swiss-Prot 1010711 10953014 P42567 106 S Phosphorylation PhosphoELM.10011 17242355 P42567 324 S Phosphorylation PhosphoELM.10011 19144319;17242355 P42567 561 S Phosphorylation PhosphoELM.10011 17242355 P42567 562 S Phosphorylation PhosphoELM.10011 17242355 P42567 816 S Phosphorylation PhosphoELM.10011 19144319 P42567 779 T Phosphorylation PhosphoELM.10011 19144319 P42567 781 T Phosphorylation PhosphoELM.10011 17242355 P42567 850 Y Phosphorylation PhosphoELM.10011 10953014 P42567 106 S Phosphorylation Phosphositeplus.1010730 20139300 P42567 108 S Phosphorylation Phosphositeplus.1010730 20139300;20415495 P42567 140 S Phosphorylation Phosphositeplus.1010730 21183079 P42567 324 S Phosphorylation Phosphositeplus.1010730 17242355;18846507;19144319;19367708;19737024;19854140;20415495;21183079;21659604 P42567 561 S Phosphorylation Phosphositeplus.1010730 21183079 P42567 562 S Phosphorylation Phosphositeplus.1010730 21183079 P42567 798 S Phosphorylation Phosphositeplus.1010730 18779572;19367708;20415495;21183079;21659604 P42567 816 S Phosphorylation Phosphositeplus.1010730 18846507;19144319;19367708;19854140;20415495;20531401;21183079;21659604;21659605 P42567 321 T Phosphorylation Phosphositeplus.1010730 21183079;21659604 P42567 779 T Phosphorylation Phosphositeplus.1010730 17242355;19144319;20139300;21183079;21659605 P42567 781 T Phosphorylation Phosphositeplus.1010730 21183079 P42567 850 Y Phosphorylation Phosphositeplus.1010730 10953014;18515860;20116462 P42567 106 S Phosphorylation SysPTM 1.1 17242355 P42567 324 S Phosphorylation SysPTM 1.1 17242355;18846507 P42567 561 S Phosphorylation SysPTM 1.1 17242355 P42567 562 S Phosphorylation SysPTM 1.1 17242355 P42567 798 S Phosphorylation SysPTM 1.1 18779572 P42567 816 S Phosphorylation SysPTM 1.1 18846507 P42567 779 T Phosphorylation SysPTM 1.1 17242355 P42567 781 T Phosphorylation SysPTM 1.1 17242355 P42567 242 Y Phosphorylation SysPTM 1.1 17242355 P42567 850 Y Phosphorylation SysPTM 1.1 18515860

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type P42567 324 S 19144319 HTP Phosphorylation P42567 324 S 17242355 HTP Phosphorylation P42567 106 S 17242355 HTP Phosphorylation P42567 779 T 19144319 HTP Phosphorylation P42567 781 T 17242355 HTP Phosphorylation P42567 816 S 19144319 HTP Phosphorylation P42567 561 S 17242355 HTP Phosphorylation P42567 850 Y 10953014 EGFR LTP Phosphorylation P42567 562 S 17242355 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs P42567 140 Phosphoserine 21183079 P42567 321 Phosphothreonine 21183079 P42567 324 Phosphoserine 19144319;21183079 P42567 561 Phosphoserine 21183079 P42567 562 Phosphoserine 21183079 P42567 779 Phosphothreonine 17242355 P42567 781 Phosphothreonine 21183079 P42567 816 Phosphoserine 21183079 P42567 850 Phosphotyrosine; by EGFR 10953014

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type Eps15 IPI00117454 S 108 RFHDSSpSPLLTSG phosphorylation Eps15 IPI00117454 S 324 KNITGSpSPVADFS phosphorylation Eps15 IPI00117454 S 798 PINKLDpSSDPLKL phosphorylation Eps15 IPI00117454 S 816 PFPGNDpSPKEKDP phosphorylation Eps15 IPI00117454 T 781 PKVGTPpTRPCPPP phosphorylation

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID Eps15 Mus musculus (Mouse) 820; 803; 818; 795; 449; 638; 386; 472; 227 "820,NDSPKEKDPDMFC; 803,DSSDPLKLNDPFQ; 818,PGNDSPKEKDPDM; 795,GKRPINKLDSSDP; 449,YEEELLKAREELS; 638,KDDPFGKIDPFGG; 386,ESINLQKLQAQKQ; 472,ESVESGKAQLEPL; 227,SPAEKAKYDEIFL" 820:22790023; 803:22790023; 818:22790023; 795:22790023; 449:22790023; 638:22790023; 386:22790023; 472:22790023; 227:22790023