PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Axin1 Rnf11 16601693 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Traf6 Rnf11 20185725,21765415 innatedb,biogrid,intact exp G G G G G G G G G G G G G G G G G G G G Ralbp1 Rnf11 19131965 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Axin2 Rnf11 16601693 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G Nedd4 Rnf11 11042109 biogrid,i2d,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Traf2 Rnf11 20185725 innatedb,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G Tnfaip3 Rnf11 19131965,22975135,21765415 biogrid,intact exp, ortho G G G G G Tax1bp1 Rnf11 19131965,21765415 biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ripk1 Rnf11 21765415 biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Itch Rnf11 21765415 biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stambp Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2e1 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ikbkg Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ap2a1 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ankrd13a Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Myo6 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd4 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf168 Rnf11 ortho Epn3 Rnf11 ortho G G G G G G G G G G Smurf1 Rnf11 ortho Protein Ercc6 Rnf11 ortho Rnf11 Dcun1d1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf11 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wwp2 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gga1 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd6 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hgs Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln4 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf11 Tbk1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2v1 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd7 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Huwe1 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rps27a Rnf11 ortho Smad4 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Epn1 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd14 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Akt1 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sprtn Rnf11 ortho Psmd12 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Optn Rnf11 ortho Ube2e3 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cblb Rnf11 ortho Rnf11 Pdcd6ip ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf11 Tnip1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf11 Psmd10 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf11 Ubqln2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Poli Rnf11 ortho G G G G G G G G G G G G G G G G G G Eps15 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Zfyve16 Rnf11 ortho G G G G G G G G G G G G G G G G G G Ubac1 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ccdc127 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ptprd Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Csnk2b Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd2 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d3 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Aup1 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Herc2 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d2 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Epn2 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wwp1 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd1 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G App Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gtf2h1 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rabgef1 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Myo18a Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd3 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Spta1 Rnf11 ortho G G G G G Ube2u Rnf11 ortho Smurf2 Rnf11 ortho Snrnp70 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Csnk2a1 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2e2 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ap2m1 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf11 Ikbke ortho G G G G G G G G G G G G G Gga2 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d2b Rnf11 ortho G Sdcbp Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ankrd28 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stat1 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd11 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp14 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tfrc Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ap2s1 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd4l Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Ascc2 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2n Rnf11 ortho Gtf2h4 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf11 Psmd13 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd5 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2o Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G Gga3 Rnf11 ortho Psmd8 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Herc1 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MCG17975, Protein Zfyve9 Rnf11 ortho Usp7 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf216 Rnf11 ortho Ube2d1 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2v2 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tom1l2 Rnf11 ortho G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants B2RSC8 Q9QYK7 - 11042109 - X 2 Q9QYK7 O88566 affinity chromatography technology 16601693 physical association X 2 Q9QYK7 P70196 affinity chromatography technology 20185725 physical association X 2 Q9QYK7 P70196 affinity chromatography technology 21765415 physical association X 2 Q9QYK7 Q3UKC1 affinity chromatography technology 21765415 physical association X 2 Q9QYK7 P70196 affinity chromatography technology 21765415 physical association X 2 Q8C863 Q9QYK7 affinity chromatography technology 21765415 physical association X 2 E9QMJ8 Q9QYK7 imaging technique 16601693 colocalization X 2 Q60855 Q9QYK7 affinity chromatography technology 21765415 physical association X 2 P39429 Q9QYK7 affinity chromatography technology 20185725 physical association X 2 Q9QYK7 Q3TBB9 affinity chromatography technology 22975135 physical association X 2 Q9QYK7 Q3TBB9 affinity chromatography technology 21765415 physical association X 2 B2RSC8 Q9QYK7 far western blotting 11042109 direct interaction X 2 B2RSC8 Q9QYK7 far western blotting 11042109 direct interaction X 2 Q9QYK7 anti bait coimmunoprecipitation 21765415 association C 5 Q9QYK7 anti bait coimmunoprecipitation 21765415 association C 7 Q9QYK7 anti bait coimmunoprecipitation 19131965 association C 4 Q9QYK7 anti bait coimmunoprecipitation 21765415 association C 5 B2RSC8 Q9QYK7 far western blotting 11042109 physical association X 2 B2RSC8 Q9QYK7 far western blotting 11042109 physical association X 2 B2RSC8 Q9QYK7 affinity technology 11042109 physical association X 2 B2RSC8 Q9QYK7 far western blotting 11042109 physical association X 2

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9QYK7 Q60769 RNF11 TNFAIP3 0.61 22975135,21765415,19131965 Q9QYK7 O88566 RNF11 AXIN2 0.21 16601693 Q9QYK7 P39429 RNF11 TRAF2 0.21 20185725 Q9QYK7 P70196 RNF11 TRAF6 0.507 20185725,21765415 Q9QYK7 O35625 RNF11 AXIN1 0.126 16601693 Q9QYK7 Q60855 RNF11 RIPK1 0.21 21765415 Q9QYK7 Q62172 RNF11 RALBP1 0.376 19131965 Q9QYK7 Q8C863 RNF11 ITCH 0.21 21765415 Q9QYK7 P46935 RNF11 NEDD4 0.702 11042109 Q9QYK7 Q3UKC1 RNF11 TAX1BP1 0.507 19131965,21765415